ATE500808T1 - Onkolytische virustherapie - Google Patents
Onkolytische virustherapieInfo
- Publication number
- ATE500808T1 ATE500808T1 AT02725980T AT02725980T ATE500808T1 AT E500808 T1 ATE500808 T1 AT E500808T1 AT 02725980 T AT02725980 T AT 02725980T AT 02725980 T AT02725980 T AT 02725980T AT E500808 T1 ATE500808 T1 AT E500808T1
- Authority
- AT
- Austria
- Prior art keywords
- oncolytic virus
- pharmaceutical composition
- virus therapy
- subject
- human leukocytes
- Prior art date
Links
- 244000309459 oncolytic virus Species 0.000 title abstract 3
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 210000000265 leukocyte Anatomy 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/19—Platelets; Megacaryocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/46—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29005101P | 2001-05-11 | 2001-05-11 | |
| PCT/US2002/014642 WO2002091997A2 (en) | 2001-05-11 | 2002-05-09 | Oncolytic virus therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE500808T1 true ATE500808T1 (de) | 2011-03-15 |
Family
ID=23114328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02725980T ATE500808T1 (de) | 2001-05-11 | 2002-05-09 | Onkolytische virustherapie |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US7122182B2 (de) |
| EP (1) | EP1385466B1 (de) |
| JP (1) | JP4916641B2 (de) |
| CN (1) | CN1332712C (de) |
| AT (1) | ATE500808T1 (de) |
| AU (1) | AU2002256510B2 (de) |
| CA (1) | CA2442648C (de) |
| DE (1) | DE60239394D1 (de) |
| HU (1) | HUP0400882A3 (de) |
| IL (1) | IL157504A0 (de) |
| MX (1) | MXPA03010278A (de) |
| NZ (1) | NZ527687A (de) |
| WO (1) | WO2002091997A2 (de) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030044384A1 (en) * | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
| US7780962B2 (en) * | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
| NZ550861A (en) * | 1999-04-15 | 2009-03-31 | Wellstat Biologics Corp | Treatment of neoplasms with viruses |
| AUPQ425699A0 (en) | 1999-11-25 | 1999-12-23 | University Of Newcastle Research Associates Limited, The | A method of treating a malignancy in a subject and a pharmaceutical composition for use in same |
| IL157504A0 (en) | 2001-05-11 | 2004-03-28 | Wellstat Biologics Corp | Oncolytic virus therapy |
| US7615209B2 (en) | 2001-09-12 | 2009-11-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions of NDV and methods of use thereof for treatment of cancer |
| IL145397A0 (en) * | 2001-09-12 | 2002-06-30 | Yissum Res Dev Co | Compositions and methods for treatment of cancer |
| AU2002953436A0 (en) | 2002-12-18 | 2003-01-09 | The University Of Newcastle Research Associates Limited | A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis |
| US20050214266A1 (en) * | 2004-03-12 | 2005-09-29 | Oncolytics Biotech Inc. | Combination of transplantation and oncolytic virus treatment |
| EP1793851B1 (de) * | 2004-08-20 | 2016-10-05 | Viralytics Limited | Verfahren und zusammensetzungen zur behandlung von blutkrebs |
| WO2007099401A2 (en) * | 2005-08-01 | 2007-09-07 | University Technologies International, Inc. | Oncolytic attenuated reoviruses for treatment of proliferative disorders |
| US10668119B2 (en) | 2005-08-01 | 2020-06-02 | Virocure, Inc. | Attenuated reovirus |
| US20070077231A1 (en) * | 2005-09-30 | 2007-04-05 | Contag Christopher H | Immune effector cells pre-infected with oncolytic virus |
| WO2008009115A1 (en) * | 2006-07-18 | 2008-01-24 | Ottawa Health Research Institute | Disparate suicide carrier cells for tumor targeting of promiscuous oncolytic viruses |
| US10369171B2 (en) | 2007-03-13 | 2019-08-06 | Virocure, Inc. | Attenuated reoviruses for selection of cell populations |
| US9241998B2 (en) * | 2007-05-21 | 2016-01-26 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of cancer using oncolytic RSV activity |
| WO2009067808A1 (en) * | 2007-11-27 | 2009-06-04 | Ottawa Health Research Institute | Amplification of cancer-specific oncolytic viral infection by histone deacetylase inhibitors |
| WO2010020247A1 (en) * | 2008-08-22 | 2010-02-25 | Reapplix Aps | Multilayered blood product |
| WO2010080909A1 (en) * | 2009-01-08 | 2010-07-15 | Yale University | Compositions and methods of use of an oncolytic vesicular stomatitis virus |
| ES2385251B1 (es) | 2009-05-06 | 2013-05-06 | Fundació Privada Institut D'investigació Biomèdica De Bellvitge | Adenovirus oncolíticos para el tratamiento del cáncer. |
| CA2689707A1 (en) | 2009-11-16 | 2011-05-16 | Jean-Simon Diallo | Identification of the novel small molecule viral sensitizer vse1 using high-throughput screening |
| US8859256B2 (en) | 2011-10-05 | 2014-10-14 | Genelux Corporation | Method for detecting replication or colonization of a biological therapeutic |
| WO2013138522A2 (en) | 2012-03-16 | 2013-09-19 | Genelux Corporation | Methods for assessing effectiveness and monitoring oncolytic virus treatment |
| WO2013158265A1 (en) | 2012-04-20 | 2013-10-24 | Genelux Corporation | Imaging methods for oncolytic virus therapy |
| US20140140959A1 (en) | 2012-10-05 | 2014-05-22 | Aladar A. Szalay | Energy Absorbing-Based Diagnostic and Therapeutic Methods Employing Nucleic Acid Molecules Encoding Chromophore-Producing Enzymes |
| WO2015103438A2 (en) | 2014-01-02 | 2015-07-09 | Genelux Corporation | Oncolytic virus adjunct therapy with agents that increase virus infectivity |
| BR112017007765B1 (pt) | 2014-10-14 | 2023-10-03 | Halozyme, Inc | Composições de adenosina deaminase-2 (ada2), variantes do mesmo e métodos de usar o mesmo |
| EP4219457A1 (de) | 2015-01-26 | 2023-08-02 | Ottawa Hospital Research Institute | 3-(2h)-pyridazinone derivate, deren zusammensetzungen und verfahren zur virussensibilisierung |
| GB201504251D0 (en) | 2015-03-13 | 2015-04-29 | Virttu Biolog Ltd And University Of Sheffield The | Oncolytic herpes simplex virus infected cells |
| KR20180108649A (ko) | 2016-01-06 | 2018-10-04 | 레아플릭스 에이피에스 | 차후의 자가 사용을 위한 응혈 촉진 인자 |
| MX2018012472A (es) | 2016-04-15 | 2019-08-12 | Alpine Immune Sciences Inc | Proteinas inmunomoduladoras variantes de ligando icos y sus usos. |
| IL310729A (en) | 2016-04-15 | 2024-04-01 | Alpine Immune Sciences Inc | Immunomodulatory proteins that are variants of CD80 and their uses |
| EP3491013A1 (de) | 2016-07-28 | 2019-06-05 | Alpine Immune Sciences, Inc. | Cd155-variante immunmodulatorische proteine und verwendungen davon |
| WO2018022945A1 (en) | 2016-07-28 | 2018-02-01 | Alpine Immune Sciences, Inc. | Cd112 variant immunomodulatory proteins and uses thereof |
| US11471488B2 (en) | 2016-07-28 | 2022-10-18 | Alpine Immune Sciences, Inc. | CD155 variant immunomodulatory proteins and uses thereof |
| CN110022889B (zh) | 2016-10-03 | 2024-05-10 | 渥太华医院研究所 | 用于提高溶瘤rna病毒的生长、传播和溶瘤与免疫治疗效果的组合物和方法 |
| AU2017345764A1 (en) | 2016-10-20 | 2019-05-02 | Alpine Immune Sciences, Inc. | Secretable variant immunomodulatory proteins and engineered cell therapy |
| CA3052473A1 (en) | 2017-02-09 | 2018-08-16 | Indapta Therapeutics, Inc. | Engineered natural killer (nk) cells and compositions and methods thereof |
| EP3596114A2 (de) | 2017-03-16 | 2020-01-22 | Alpine Immune Sciences, Inc. | Cd80-variante immunmodulatorische proteine und verwendungen davon |
| IL320149A (en) | 2017-03-16 | 2025-06-01 | Alpine Immune Sciences Inc | Pd-l1 variant immunomodulatory proteins and uses thereof |
| JP2020511144A (ja) | 2017-03-16 | 2020-04-16 | アルパイン イミューン サイエンシズ インコーポレイテッド | Pd−l2バリアント免疫調節タンパク質及びその使用 |
| JP7282760B2 (ja) | 2017-10-18 | 2023-05-29 | アルパイン イミューン サイエンシズ インコーポレイテッド | バリアントicosリガンド免疫調節タンパク質ならびに関連する組成物および方法 |
| AU2018373508A1 (en) | 2017-11-24 | 2020-04-30 | Ottawa Hospital Research Institute | Compositions and methods for enhancing production, growth, spread, or oncolytic and immunotherapeutic efficacy of interferon-sensitive viruses |
| WO2019136179A1 (en) | 2018-01-03 | 2019-07-11 | Alpine Immune Sciences, Inc. | Multi-domain immunomodulatory proteins and methods of use thereof |
| US11505782B2 (en) | 2018-06-04 | 2022-11-22 | Calidi Biotherapeutics, Inc. | Cell-based vehicles for potentiation of viral therapy |
| CA3177467A1 (en) | 2018-06-04 | 2019-12-12 | Calidi Biotherapeutics, Inc. | Cell-based vehicles for potentiation of viral therapy |
| US12065476B2 (en) | 2018-06-15 | 2024-08-20 | Alpine Immune Sciences, Inc. | PD-1 variant immunomodulatory proteins and uses thereof |
| US11242528B2 (en) | 2018-08-28 | 2022-02-08 | Actym Therapeutics, Inc. | Engineered immunostimulatory bacterial strains and uses thereof |
| CN113271955A (zh) | 2018-11-06 | 2021-08-17 | 卡利迪生物治疗有限公司 | 用于细胞介导的溶瘤病毒疗法的增强的系统 |
| US12410402B2 (en) | 2018-11-21 | 2025-09-09 | Indapta Therapeutics, Inc. | Methods for expansion of natural killer (NK) cell subset and related compositions and methods |
| JP7713886B2 (ja) | 2018-11-30 | 2025-07-28 | アルパイン イミューン サイエンシズ インコーポレイテッド | Cd86バリアント免疫調節タンパク質およびその使用 |
| US12024709B2 (en) | 2019-02-27 | 2024-07-02 | Actym Therapeutics, Inc. | Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment |
| CA3131017C (en) | 2019-02-27 | 2025-05-13 | Actym Therapeutics, Inc. | Immunostimulatory bacteria modified to colonize tumors, tumor-resident immune cells, and the tumor microenvironment |
| AU2021258194A1 (en) | 2020-04-22 | 2022-11-24 | Indapta Therapeutics, Inc. | Natural killer (NK) cell compositions and methods for generating same |
| WO2022147481A1 (en) | 2020-12-30 | 2022-07-07 | Ansun Biopharma Inc. | Combination therapy of an oncolytic virus delivering a foreign antigen and an engineered immune cell expressing a chimeric receptor targeting the foreign antigen |
| CN117379389B (zh) * | 2022-07-12 | 2026-03-06 | 四川大学 | 血小板-溶瘤病毒复合物、其制备方法及其应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5126132A (en) * | 1989-08-21 | 1992-06-30 | The United States Of America As Represented By The Department Of Health And Human Services | Tumor infiltrating lymphocytes as a treatment modality for human cancer |
| PT696326E (pt) * | 1993-04-30 | 2003-08-29 | Wellstat Biologics Corp | Utilizacao de ndv no fabrico de um medicamento para tratamento do cancro |
| US5595739A (en) * | 1993-05-07 | 1997-01-21 | Abbott Laboratories | Hepatitis B virus mutants, reagents and methods for detection |
| US5910434A (en) * | 1995-12-15 | 1999-06-08 | Systemix, Inc. | Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant |
| DE69718029T2 (de) * | 1996-10-11 | 2003-10-16 | The Regents Of The University Of California, Oakland | Krebs immuntherapie unter verwendung von tumorzellen kombiniert mit lymphozytmischungen |
| NZ503664A (en) | 1997-10-09 | 2002-08-28 | Pro Virus Inc | A method for purifying an RNA virus comprising generating a clonal virus and purifying the clonal virus by ultracentrifugation without pelleting |
| US6177076B1 (en) * | 1997-12-09 | 2001-01-23 | Thomas Jefferson University | Method of treating bladder cancer with wild type vaccinia virus |
| WO1999045783A1 (en) * | 1998-03-12 | 1999-09-16 | The Trustees Of The University Of Pennsylvania | Producer cells for replication selective viruses in the treatment of malignancy |
| US6428968B1 (en) * | 1999-03-15 | 2002-08-06 | The Trustees Of The University Of Pennsylvania | Combined therapy with a chemotherapeutic agent and an oncolytic virus for killing tumor cells in a subject |
| NZ550861A (en) * | 1999-04-15 | 2009-03-31 | Wellstat Biologics Corp | Treatment of neoplasms with viruses |
| JP3639772B2 (ja) * | 1999-06-30 | 2005-04-20 | キヤノン株式会社 | 情報処理装置および印刷システムおよび印刷制御方法およびコンピュータが読み出し可能なプログラムを格納した記憶媒体 |
| DE60041210D1 (de) | 1999-09-17 | 2009-02-05 | Wellstat Biologics Corp | Onkolytisches Virus |
| US6270147B1 (en) * | 2000-01-07 | 2001-08-07 | Daimlerchrysler Corporation | Drive arrangement for a power liftgate including clutching mechanism |
| CN1250711C (zh) * | 2000-06-26 | 2006-04-12 | 威尔斯达特生物制剂公司 | 用病毒清除细胞 |
| IL157504A0 (en) * | 2001-05-11 | 2004-03-28 | Wellstat Biologics Corp | Oncolytic virus therapy |
-
2002
- 2002-05-09 IL IL15750402A patent/IL157504A0/xx not_active IP Right Cessation
- 2002-05-09 AU AU2002256510A patent/AU2002256510B2/en not_active Ceased
- 2002-05-09 HU HU0400882A patent/HUP0400882A3/hu unknown
- 2002-05-09 US US10/142,405 patent/US7122182B2/en not_active Expired - Fee Related
- 2002-05-09 CA CA2442648A patent/CA2442648C/en not_active Expired - Fee Related
- 2002-05-09 MX MXPA03010278A patent/MXPA03010278A/es active IP Right Grant
- 2002-05-09 WO PCT/US2002/014642 patent/WO2002091997A2/en not_active Ceased
- 2002-05-09 NZ NZ527687A patent/NZ527687A/en not_active IP Right Cessation
- 2002-05-09 CN CNB028097009A patent/CN1332712C/zh not_active Expired - Fee Related
- 2002-05-09 EP EP02725980A patent/EP1385466B1/de not_active Expired - Lifetime
- 2002-05-09 DE DE60239394T patent/DE60239394D1/de not_active Expired - Lifetime
- 2002-05-09 AT AT02725980T patent/ATE500808T1/de not_active IP Right Cessation
- 2002-05-09 JP JP2002588916A patent/JP4916641B2/ja not_active Expired - Fee Related
-
2005
- 2005-05-05 US US11/122,690 patent/US7595042B2/en not_active Expired - Fee Related
-
2009
- 2009-03-26 US US12/412,035 patent/US8137663B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4916641B2 (ja) | 2012-04-18 |
| US7595042B2 (en) | 2009-09-29 |
| US20090180994A1 (en) | 2009-07-16 |
| EP1385466B1 (de) | 2011-03-09 |
| HUP0400882A2 (hu) | 2004-07-28 |
| DE60239394D1 (de) | 2011-04-21 |
| JP2004521938A (ja) | 2004-07-22 |
| MXPA03010278A (es) | 2004-12-06 |
| CN1514688A (zh) | 2004-07-21 |
| IL157504A0 (en) | 2004-03-28 |
| US8137663B2 (en) | 2012-03-20 |
| AU2002256510B2 (en) | 2007-08-30 |
| EP1385466A4 (de) | 2005-10-12 |
| CN1332712C (zh) | 2007-08-22 |
| WO2002091997A2 (en) | 2002-11-21 |
| NZ527687A (en) | 2005-10-28 |
| WO2002091997A3 (en) | 2003-03-13 |
| CA2442648C (en) | 2012-10-16 |
| CA2442648A1 (en) | 2002-11-21 |
| EP1385466A2 (de) | 2004-02-04 |
| US20030077819A1 (en) | 2003-04-24 |
| HUP0400882A3 (en) | 2011-01-28 |
| US20050208024A1 (en) | 2005-09-22 |
| US7122182B2 (en) | 2006-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |