ATE501166T1 - Isotopenmarkiertes einfangmittel und verfahren zur identifizierung reaktiver metaboliten - Google Patents

Isotopenmarkiertes einfangmittel und verfahren zur identifizierung reaktiver metaboliten

Info

Publication number
ATE501166T1
ATE501166T1 AT07843067T AT07843067T ATE501166T1 AT E501166 T1 ATE501166 T1 AT E501166T1 AT 07843067 T AT07843067 T AT 07843067T AT 07843067 T AT07843067 T AT 07843067T AT E501166 T1 ATE501166 T1 AT E501166T1
Authority
AT
Austria
Prior art keywords
isotopically labeled
reactive metabolites
capture agent
labeled capture
identifying reactive
Prior art date
Application number
AT07843067T
Other languages
English (en)
Inventor
Norman D Huebert
Yan Zhengyin
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE501166T1 publication Critical patent/ATE501166T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/90245—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • G01N2333/90258—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15) in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT07843067T 2006-09-29 2007-09-24 Isotopenmarkiertes einfangmittel und verfahren zur identifizierung reaktiver metaboliten ATE501166T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82752606P 2006-09-29 2006-09-29
PCT/US2007/079298 WO2008042634A2 (en) 2006-09-29 2007-09-24 Isotopically labeled trapping agent and method for identifying reactive metabolites

Publications (1)

Publication Number Publication Date
ATE501166T1 true ATE501166T1 (de) 2011-03-15

Family

ID=39144614

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07843067T ATE501166T1 (de) 2006-09-29 2007-09-24 Isotopenmarkiertes einfangmittel und verfahren zur identifizierung reaktiver metaboliten

Country Status (10)

Country Link
US (1) US7884186B2 (de)
EP (1) EP2078033B1 (de)
JP (1) JP5268920B2 (de)
CN (1) CN101568548B (de)
AT (1) ATE501166T1 (de)
AU (1) AU2007305011B9 (de)
CA (1) CA2664904C (de)
DE (1) DE602007013080D1 (de)
ES (1) ES2359109T3 (de)
WO (1) WO2008042634A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006012154A1 (en) * 2004-06-28 2006-02-02 Janssen Pharmaceutica, N.V. A method for detecting reactive metabolites using stable-isotope trapping and mass spectroscopy
CN1785284B (zh) 2004-12-10 2012-04-18 天津天士力制药股份有限公司 一种含有何首乌的药物组合物
WO2008050341A2 (en) * 2006-10-25 2008-05-02 Ramot At Tel-Aviv University Ltd Novel psychotropic agents having glutamate nmda activity
WO2010122673A1 (en) * 2009-04-23 2010-10-28 Eisai R&D Management Co., Ltd. Trapping compounds and method for identifying reactive metabolites
EP2587928B1 (de) 2010-07-01 2018-05-23 General Mills, Inc. Zuckerbeschichtungen mit reduziertem saccharoseanteil für getreide sowie verfahren zu ihrer herstellung
EP2852678B1 (de) * 2012-05-22 2017-08-23 Biogen MA Inc. Fangreagenzien zum screenen von reaktiven metaboliten
CN103852497B (zh) * 2012-11-29 2015-12-02 北京市药品检验所 快速检测制品中非法添加双氯芬酸类物质的方法
CN105424821B (zh) * 2014-09-11 2018-02-13 上海佰年诗丹德检测技术有限公司 一种筛选天然产物中具有遗传毒性的成分的方法
GB201519186D0 (en) 2015-10-30 2015-12-16 Electrophoretics Ltd Isotopic methods for measurement of tryptophan and metabolites thereof
EP3586137A4 (de) 2017-02-24 2020-11-04 Iroa Technologies, LLC Iroa-metabolomik-arbeitsfluss für verbesserte genauigkeit, identifizierung und quantifizierung

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL96682A0 (en) 1989-12-15 1991-09-16 Amgen Inc Production of biologically active platelet-derived growth factor from high expression host cell systems
DE69903800T2 (de) * 1998-03-18 2003-10-02 Massachusetts Institute Of Technology, Cambridge Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
US6830897B2 (en) * 2000-04-26 2004-12-14 Pfizer Inc. High throughput screen for reducing drug candidate attrition
WO2003027682A2 (en) 2001-09-27 2003-04-03 Purdue Research Foundation Controlling isotope effects during fractionation of analytes
CA2377446C (en) * 2002-03-20 2008-01-29 Harvey Kaplan Increased sensitivity of peptide detection with matrix-assisted laser desorption/ionization mass spectrometry by in vacuo methylation of amino groups
US7169576B2 (en) * 2004-01-08 2007-01-30 Bristol-Myers Squibb Company Method for identifying drug metabolites with dansylated glutathione
WO2006012154A1 (en) 2004-06-28 2006-02-02 Janssen Pharmaceutica, N.V. A method for detecting reactive metabolites using stable-isotope trapping and mass spectroscopy

Also Published As

Publication number Publication date
US20080081349A1 (en) 2008-04-03
EP2078033A2 (de) 2009-07-15
CN101568548A (zh) 2009-10-28
WO2008042634A3 (en) 2008-07-31
CN101568548B (zh) 2014-12-03
AU2007305011A1 (en) 2008-04-10
CA2664904A1 (en) 2008-04-10
AU2007305011B2 (en) 2014-02-20
CA2664904C (en) 2015-09-01
ES2359109T3 (es) 2011-05-18
JP5268920B2 (ja) 2013-08-21
EP2078033B1 (de) 2011-03-09
JP2010504991A (ja) 2010-02-18
AU2007305011B9 (en) 2014-05-15
DE602007013080D1 (de) 2011-04-21
WO2008042634A2 (en) 2008-04-10
US7884186B2 (en) 2011-02-08

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