ATE501716T1 - Verwendung des enantiomers (1s, 2r) von milnacipran zur herstellung eines arzneimittels - Google Patents

Verwendung des enantiomers (1s, 2r) von milnacipran zur herstellung eines arzneimittels

Info

Publication number: ATE501716T1
Authority: AT; Austria
Prior art keywords: active; serotonin; noradrenaline; capture; enantiomer
Prior art date: 2003-02-14

Application number

AT07123564T

Other languages

English (en)

Inventor

Jean Deregnaucourt

Richard Grosse

Original Assignee

Pf Medicament

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-02-14

Filing date

2004-02-16

Publication date

2011-04-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32749596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE501716(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-02-16 Application filed by Pf Medicament filed Critical Pf Medicament

2011-04-15 Application granted granted Critical

2011-04-15 Publication of ATE501716T1 publication Critical patent/ATE501716T1/de

Links

GJJFMKBJSRMPLA-HIFRSBDPSA-N (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-1-cyclopropanecarboxamide Chemical compound C=1C=CC=CC=1[C@@]1(C(=O)N(CC)CC)C[C@@H]1CN GJJFMKBJSRMPLA-HIFRSBDPSA-N 0.000 title abstract 8
229960000600 milnacipran Drugs 0.000 title abstract 2
229940126601 medicinal product Drugs 0.000 title 1
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 8
SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 4
229960002748 norepinephrine Drugs 0.000 abstract 4
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 4
229940076279 serotonin Drugs 0.000 abstract 4
AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 abstract 2
AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 abstract 2
239000003112 inhibitor Substances 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
229960002296 paroxetine Drugs 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
241000700159 Rattus Species 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000002526 effect on cardiovascular system Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000002955 immunomodulating agent Substances 0.000 abstract 1
229940121354 immunomodulator Drugs 0.000 abstract 1
230000002584 immunomodulator Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
230000010534 mechanism of action Effects 0.000 abstract 1
239000002207 metabolite Substances 0.000 abstract 1
230000001575 pathological effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A61P9/12—Antihypertensives

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Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Child & Adolescent Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT07123564T 2003-02-14 2004-02-16 Verwendung des enantiomers (1s, 2r) von milnacipran zur herstellung eines arzneimittels ATE501716T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0301849A FR2851163B1 (fr)	2003-02-14	2003-02-14	Utilisation de l'enantiomere dextrogyre du milnacipran pour la preparation d'un medicament
US10/453,574 US7005452B2 (en)	2003-02-14	2003-06-03	Use of the dextrogyral enantiomer of milnacipran for the preparation of a drug

Publications (1)

Publication Number	Publication Date
ATE501716T1 true ATE501716T1 (de)	2011-04-15

Family

ID=32749596

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07123564T ATE501716T1 (de)	2003-02-14	2004-02-16	Verwendung des enantiomers (1s, 2r) von milnacipran zur herstellung eines arzneimittels

Country Status (18)

Country	Link
US (2)	US7005452B2 (de)
EP (1)	EP2305225A1 (de)
JP (2)	JP4515446B2 (de)
CN (1)	CN1750817B (de)
AT (1)	ATE501716T1 (de)
CY (1)	CY1108287T1 (de)
DE (1)	DE602004031893D1 (de)
DK (1)	DK1908461T3 (de)
ES (1)	ES2359441T3 (de)
FR (1)	FR2851163B1 (de)
IL (2)	IL170117A (de)
NZ (1)	NZ575218A (de)
PL (1)	PL402987A1 (de)
PT (1)	PT1908461E (de)
SI (1)	SI1908461T1 (de)
TN (1)	TNSN05195A1 (de)
UA (1)	UA84697C2 (de)
ZA (1)	ZA200506566B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6602911B2 (en) *	2001-11-05	2003-08-05	Cypress Bioscience, Inc.	Methods of treating fibromyalgia
US7704527B2 (en) *	2002-10-25	2010-04-27	Collegium Pharmaceutical, Inc.	Modified release compositions of milnacipran
PT1601349E (pt) *	2003-02-14	2008-10-27	Pf Medicament	Utilização do enantiómero (1s, 2r) do milnaciprano para a preparação de um medicamento
AU2005266997A1 (en) *	2004-07-22	2006-02-02	Wyeth	Method for treating nervous system disorders and conditions
CA2574315A1 (en) *	2004-07-22	2006-02-02	Wyeth	Method for treating nervous system disorders and conditions
US20060020015A1 (en) *	2004-07-22	2006-01-26	Wyeth	Method for treating nervous system disorders and conditions
US7119211B2 (en) *	2004-09-23	2006-10-10	Yamakawa Chemical Industry Co., Ltd.	Process for preparing optically active 3-(methylamino)-1-(2-thienyl) propan-1-ol and intermediates for preparation
JP2009502798A (ja) *	2005-07-21	2009-01-29	ワイス	神経系障害および状態の処置方法
US7994220B2 (en) *	2005-09-28	2011-08-09	Cypress Bioscience, Inc.	Milnacipran for the long-term treatment of fibromyalgia syndrome
US20080319083A1 (en) *	2006-01-27	2008-12-25	Asahi Kasei Pharma Corporation	Medicine for transnasal administration
CN101374552A (zh) *	2006-01-27	2009-02-25	旭化成制药株式会社	经鼻给药用药剂
CN101195583B (zh) *	2006-12-04	2012-07-04	四川抗菌素工业研究所有限公司	一种光学纯米那普仑及其盐的制备方法
US20090048233A1 (en) *	2007-08-16	2009-02-19	Cypress Biosciences, Inc.	Enhancing the Tolerability of a Seratonin Antagonist and a NSRI, a SNRI or a RIMA by Using Them in Combination
EP2110129A1 (de)	2008-04-18	2009-10-21	Pierre Fabre Medicament	Verwendung von Enanotimer (1S, 2R) Milnacipran-Hydrochlorid zur präventiven Behandlung von Suizidverhalten bei depressiven Patienten
US20100197797A1 (en) *	2009-02-05	2010-08-05	Rao Srinivas G	Methods of managing fibromyalgia using milnacipran
WO2011057176A1 (en) *	2009-11-06	2011-05-12	Forest Laboratories Holding Limited	Novel crystalline forms of (1s,2r)-2-(amino methyl)-n,n-diethyl-1-phenyl cyclopropane carboxamide
CA2790933A1 (en) *	2010-01-14	2011-07-21	Forest Laboratories Holdings Limited	Stable dosage forms of levomilnacipran
US20120289744A1 (en)	2010-11-03	2012-11-15	Arch Pharmalabs Limited	Process for preparing optically pure milnacipran and its pharmaceutically acceptable salts
FR2978350B1 (fr) *	2011-07-28	2013-11-08	Pf Medicament	Medicament a base de levomilnacipran pour la rehabilitation fonctionnelle apres accident neurologique aigu
IN2013MU03122A (de)	2013-09-30	2015-07-17	Cadila Healthcare Ltd
CN106928080B (zh) *	2015-12-31	2020-12-25	四川海思科制药有限公司	稠合环γ-氨基酸衍生物及其制备方法和在医药上的应用
CN109678747A (zh) *	2019-02-21	2019-04-26	南京恩泰医药科技有限公司	一种左旋米那普伦非对映异构体的制备方法
CN114128672B (zh) *	2021-11-21	2023-04-07	河南省儿童医院郑州儿童医院	一种孤独症大鼠模型的构建方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2508035A1 (fr)	1981-06-23	1982-12-24	Fabre Sa Pierre	Derives d'aryl-1-aminomethyl-2 cyclopropanes carboxamides (z), leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central
JP2759906B2 (ja)	1990-05-08	1998-05-28	東芝タンガロイ株式会社	乾式焼結摩擦材料
JP2769290B2 (ja)	1994-03-31	1998-06-25	科学技術振興事業団	ミスト熱分解法によるセラミック微粉末の製造方法
CA2134038C (en) *	1994-06-16	1997-06-03	David Taiwai Wong	Potentiation of drug response
FR2746314B1 (fr)	1996-03-25	1998-06-12	Pf Medicament	Produit contenant du milnacipran et de l'idazoxan comme preparation pharmaceutique combinee
FR2752732B1 (fr)	1996-08-28	1998-11-20	Pf Medicament	Forme galenique a liberation prolongee de milnacipran
FR2759290B1 (fr)	1997-02-13	2004-06-18	Pf Medicament	Minalcipran pour le traitement de l'incontinence urinaire
FR2759906B1 (fr)	1997-02-21	2004-06-04	Pf Medicament	Utilisation de milnacipran et de ses derives pour la preparation d'un medicament destine au traitement de certaines maladies psychiatriques
UA56257C2 (uk) *	1997-09-23	2003-05-15	Елі Ліллі Енд Компані	Спосіб лікування неадекватної визивної поведінки
UA57107C2 (uk) *	1997-09-23	2003-06-16	Елі Ліллі Енд Компані	Спосіб лікування розладу поведінки
WO1999059593A1 (en) *	1998-05-21	1999-11-25	Eli Lilly And Company	Combination therapy for treatment of depression
HUP0101901A3 (en) *	1998-05-22	2002-06-28	Lilly Co Eli	Pharmaceutical composition for combined therapeutic treatment of refractory depression and combined treating process
BR9911068A (pt) *	1998-05-29	2001-02-06	Lilly Co Eli	Terapia combinada para tratamento de distúrbios bipolares
GB2355191A (en)	1999-10-12	2001-04-18	Laxdale Ltd	Combination formulations for fatigue, head injury and strokes
PT1257277E (pt) *	2000-02-24	2005-09-30	Pharmacia & Upjohn Co Llc	Novas combinacoes de farmacos
CA2431041A1 (en) *	2001-01-02	2002-07-11	Pharmacia & Upjohn Company	New drug combinations of norepinehrine reuptake inhibitors and neuroleptic agents
US6635675B2 (en) *	2001-11-05	2003-10-21	Cypress Bioscience, Inc.	Method of treating chronic fatigue syndrome
US6602911B2 (en)	2001-11-05	2003-08-05	Cypress Bioscience, Inc.	Methods of treating fibromyalgia
US20040034101A1 (en) *	2001-11-05	2004-02-19	Cypress Bioscience, Inc.	Treatment and prevention of depression secondary to pain (DSP)
CA2475763A1 (en)	2002-02-12	2003-08-21	Cypress Bioscience, Inc.	Methods of treating attention deficit/hyperactivity disorder (adhd)
CA2479350A1 (en) *	2002-03-15	2003-09-25	Cypress Bioscience, Inc.	Ne and 5-ht reuptake inhibitors for treating visceral pain syndromes
CN1662231A (zh) *	2002-04-24	2005-08-31	柏树生物科学公司	包括应激相关障碍在内的功能性躯体障碍的预防与治疗
EP1558231A4 (de)	2002-10-03	2010-09-08	Cypress Bioscience Inc	Dosiseskalation und geteilte tagesdosis von antidepressiva zurbehandlung von neurologischen erkrankungen
US20040121010A1 (en) *	2002-10-25	2004-06-24	Collegium Pharmaceutical, Inc.	Pulsatile release compositions of milnacipran
WO2004105690A2 (en) *	2003-05-23	2004-12-09	Cypress Bioscience, Inc.	Treatment of chronic pain associated with drug or radiation therapy

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Also Published As

Publication number	Publication date
JP2010090143A (ja)	2010-04-22
DE602004031893D1 (de)	2011-04-28
IL201038A (en)	2015-05-31
US20040162334A1 (en)	2004-08-19
EP2305225A1 (de)	2011-04-06
IL201038A0 (en)	2010-05-17
NZ575218A (en)	2010-07-30
JP4515446B2 (ja)	2010-07-28
HK1115329A1 (en)	2008-11-28
FR2851163B1 (fr)	2007-04-27
JP2006517571A (ja)	2006-07-27
TNSN05195A1 (fr)	2007-06-11
FR2851163A1 (fr)	2004-08-20
PL402987A1 (pl)	2013-08-19
USRE43879E1 (en)	2012-12-25
CN1750817A (zh)	2006-03-22
JP5431136B2 (ja)	2014-03-05
CN1750817B (zh)	2010-12-01
US7005452B2 (en)	2006-02-28
PT1908461E (pt)	2011-05-31
IL170117A (en)	2010-05-17
SI1908461T1 (sl)	2011-04-29
DK1908461T3 (da)	2011-05-16
CY1108287T1 (el)	2014-02-12
ZA200506566B (en)	2006-05-31
UA84697C2 (ru)	2008-11-25
ES2359441T3 (es)	2011-05-23

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