ATE502016T1 - Triazolo-ä1,5-aü-chinoline als adenosin-a3- rezeptorliganden - Google Patents

Triazolo-ä1,5-aü-chinoline als adenosin-a3- rezeptorliganden

Info

Publication number: ATE502016T1
Authority: AT; Austria
Prior art keywords: quinolines; triazolo; adenosine; receptor ligands; ligands
Prior art date: 2007-06-07

Application number

AT08762666T

Other languages

English (en)

Inventor

N Edit Sus

Kinga Boer

Zoltan Kapui

Ri Geza Tim

Tori Sandor B

Vik Zoltan Szl

Endre Mikus

Ne Szeredi Judit Varg

Michel Finet

N Szaba Katalin Urb

Tibor Szaba

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-06-07

Filing date

2008-06-02

Publication date

2011-04-15

2008-06-02 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2011-04-15 Application granted granted Critical

2011-04-15 Publication of ATE502016T1 publication Critical patent/ATE502016T1/de

Links

102000008161 Adenosine A3 Receptor Human genes 0.000 title 1
108010060261 Adenosine A3 Receptor Proteins 0.000 title 1
229940111121 antirheumatic drug quinolines Drugs 0.000 title 1
239000003446 ligand Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Ophthalmology & Optometry (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Transplantation (AREA)
Psychology (AREA)
Otolaryngology (AREA)

AT08762666T 2007-06-07 2008-06-02 Triazolo-ä1,5-aü-chinoline als adenosin-a3- rezeptorliganden ATE502016T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU0700395A HUP0700395A2 (en)	2007-06-07	2007-06-07	Substituted [1,2,4] triazolo [1,5-a] quinolines, process for their preparation, pharmaceutical compositions thereof, and intermediates
PCT/HU2008/000063 WO2008149168A1 (en)	2007-06-07	2008-06-02	Triazolo [1, 5-a] quinolines as adenosine a3 receptor ligands

Publications (1)

Publication Number	Publication Date
ATE502016T1 true ATE502016T1 (de)	2011-04-15

Family

ID=89987565

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08762666T ATE502016T1 (de)	2007-06-07	2008-06-02	Triazolo-ä1,5-aü-chinoline als adenosin-a3- rezeptorliganden

Country Status (44)

Country	Link
US (1)	US8338411B2 (de)
EP (1)	EP2167470B1 (de)
JP (1)	JP5487100B2 (de)
KR (1)	KR20100031610A (de)
CN (1)	CN101679272B (de)
AR (1)	AR066873A1 (de)
AT (1)	ATE502016T1 (de)
AU (1)	AU2008259534B2 (de)
BR (1)	BRPI0812257A2 (de)
CA (1)	CA2689612A1 (de)
CL (1)	CL2008001648A1 (de)
CO (1)	CO6270233A2 (de)
CR (1)	CR11171A (de)
CY (1)	CY1111644T1 (de)
DE (1)	DE602008005589D1 (de)
DK (1)	DK2167470T3 (de)
DO (1)	DOP2009000276A (de)
EC (1)	ECSP099783A (de)
ES (1)	ES2363672T3 (de)
GT (1)	GT200900301A (de)
HN (1)	HN2009003357A (de)
HR (1)	HRP20110332T1 (de)
HU (1)	HUP0700395A2 (de)
IL (1)	IL202471A0 (de)
JO (1)	JO2689B1 (de)
MA (1)	MA31738B1 (de)
ME (1)	ME00958B (de)
MX (1)	MX2009013209A (de)
MY (1)	MY148654A (de)
NI (1)	NI200900210A (de)
NZ (1)	NZ581186A (de)
PA (1)	PA8782901A1 (de)
PE (1)	PE20090325A1 (de)
PL (1)	PL2167470T3 (de)
PT (1)	PT2167470E (de)
RU (1)	RU2489432C2 (de)
SI (1)	SI2167470T1 (de)
SV (1)	SV2009003420A (de)
TN (1)	TN2009000482A1 (de)
TW (1)	TWI424998B (de)
UA (1)	UA99463C2 (de)
UY (1)	UY31130A1 (de)
WO (1)	WO2008149168A1 (de)
ZA (1)	ZA200908280B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2540232T3 (es)	2009-07-08	2015-07-09	Dermira (Canada), Inc.	Análogos de TOFA útiles en el tratamiento de trastornos o afecciones dermatológicas
FR3053968A1 (fr) *	2016-07-13	2018-01-19	Biomerieux	Reactifs pour la protection reversible de molecules biologiques
EP3517113A4 (de)	2016-09-24	2020-07-08	KBP Biosciences Co., Ltd.	Pharmazeutische zusammensetzung mit einem mineralkortikoid-rezeptorantagonisten und verwendung davon
US20190292188A1 (en)	2018-02-27	2019-09-26	Incyte Corporation	Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors
MA52940A (fr)	2018-05-18	2021-04-28	Incyte Corp	Dérivés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de a2a/a2b
CN113166153B (zh)	2018-07-05	2024-11-01	因赛特公司	作为a2a/a2b抑制剂的稠合吡嗪衍生物
KR102653800B1 (ko)	2018-11-30	2024-04-01	머크 샤프 앤드 돔 엘엘씨	아데노신 수용체 길항제로서의 9-치환된 아미노 트리아졸로 퀴나졸린 유도체, 제약 조성물 및 그의 용도
KR20210116488A (ko)	2018-12-20	2021-09-27	인사이트 코포레이션	액티빈 수용체-유사 키나제-2의 억제제로서의 이미다조피리다진 및 이미다조피리딘 화합물
TWI829857B (zh)	2019-01-29	2024-01-21	美商英塞特公司	作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1479759A (en) *	1974-11-23	1977-07-13	Lepetit Spa	Heterocyclic fused derivatives of indole and quinoline
GR76063B (de) *	1981-04-03	1984-08-03	Roussel Uclaf
ZA836701B (en) *	1982-10-01	1984-10-31	Roussel Uclaf	Imidazo(1,2-a)quinolines
GB0108475D0 (en)	2001-04-04	2001-05-23	Merck Sharp & Dohme	New compounds
KR100745307B1 (ko) *	2001-05-31	2007-08-01	사노피-아벤티스	아미노퀴놀린 유도체 및 아데노신 ａ３ 리간드로서의 이의 용도
US6514989B1 (en)	2001-07-20	2003-02-04	Hoffmann-La Roche Inc.	Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives
HUP0105407A3 (en) *	2001-12-21	2004-04-28	Sanofi Aventis	Triazolo[1,5-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
HUP0105406A3 (en) *	2001-12-21	2003-12-29	Sanofi Aventis	Imidazo[1,2-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates
ATE318268T1 (de)	2001-12-21	2006-03-15	Jsw Res Forschungslabor Gmbh	Pyrazolyl-substituierte triazolochinoxaline
HUP0203976A3 (en) *	2002-11-15	2004-08-30	Sanofi Aventis	Adenozine a3 receptors, process for their preparation and pharmaceutical compositions containing them
KR20060065662A (ko) *	2003-07-31	2006-06-14	사노피-아벤티스	아미노퀴놀린 유도체 및 아데노신 ａ3 리간드로서의 이의용도

2007
- 2007-06-07 HU HU0700395A patent/HUP0700395A2/hu unknown
2008
- 2008-02-06 UA UAA200913976A patent/UA99463C2/ru unknown
- 2008-06-02 AT AT08762666T patent/ATE502016T1/de active
- 2008-06-02 AU AU2008259534A patent/AU2008259534B2/en not_active Ceased
- 2008-06-02 DE DE602008005589T patent/DE602008005589D1/de active Active
- 2008-06-02 SI SI200830255T patent/SI2167470T1/sl unknown
- 2008-06-02 MY MYPI20095180A patent/MY148654A/en unknown
- 2008-06-02 NZ NZ581186A patent/NZ581186A/en not_active IP Right Cessation
- 2008-06-02 WO PCT/HU2008/000063 patent/WO2008149168A1/en not_active Ceased
- 2008-06-02 CN CN2008800191923A patent/CN101679272B/zh not_active Expired - Fee Related
- 2008-06-02 HR HR20110332T patent/HRP20110332T1/hr unknown
- 2008-06-02 CA CA002689612A patent/CA2689612A1/en not_active Abandoned
- 2008-06-02 PT PT08762666T patent/PT2167470E/pt unknown
- 2008-06-02 ME MEP-2009-340A patent/ME00958B/me unknown
- 2008-06-02 DK DK08762666.9T patent/DK2167470T3/da active
- 2008-06-02 KR KR1020107000342A patent/KR20100031610A/ko not_active Ceased
- 2008-06-02 ES ES08762666T patent/ES2363672T3/es active Active
- 2008-06-02 JP JP2010510891A patent/JP5487100B2/ja not_active Expired - Fee Related
- 2008-06-02 EP EP08762666A patent/EP2167470B1/de active Active
- 2008-06-02 MX MX2009013209A patent/MX2009013209A/es active IP Right Grant
- 2008-06-02 RU RU2009149518/04A patent/RU2489432C2/ru not_active IP Right Cessation
- 2008-06-02 BR BRPI0812257-1A2A patent/BRPI0812257A2/pt not_active IP Right Cessation
- 2008-06-02 PL PL08762666T patent/PL2167470T3/pl unknown
- 2008-06-05 PE PE2008000960A patent/PE20090325A1/es not_active Application Discontinuation
- 2008-06-05 JO JO2008263A patent/JO2689B1/en active
- 2008-06-05 AR ARP080102391A patent/AR066873A1/es not_active Application Discontinuation
- 2008-06-05 CL CL200801648A patent/CL2008001648A1/es unknown
- 2008-06-05 PA PA20088782901A patent/PA8782901A1/es unknown
- 2008-06-06 TW TW097121025A patent/TWI424998B/zh not_active IP Right Cessation
- 2008-06-06 UY UY31130A patent/UY31130A1/es not_active Application Discontinuation
2009
- 2009-11-13 TN TNP2009000482A patent/TN2009000482A1/fr unknown
- 2009-11-20 GT GT200900301A patent/GT200900301A/es unknown
- 2009-11-23 ZA ZA2009/08280A patent/ZA200908280B/en unknown
- 2009-11-24 SV SV2009003420A patent/SV2009003420A/es unknown
- 2009-12-02 IL IL202471A patent/IL202471A0/en unknown
- 2009-12-03 NI NI200900210A patent/NI200900210A/es unknown
- 2009-12-04 DO DO2009000276A patent/DOP2009000276A/es unknown
- 2009-12-04 HN HN2009003357A patent/HN2009003357A/es unknown
- 2009-12-04 US US12/631,139 patent/US8338411B2/en not_active Expired - Fee Related
- 2009-12-04 EC EC2009009783A patent/ECSP099783A/es unknown
- 2009-12-16 CR CR11171A patent/CR11171A/es unknown
2010
- 2010-01-06 CO CO10001036A patent/CO6270233A2/es active IP Right Grant
- 2010-01-07 MA MA32498A patent/MA31738B1/fr unknown
2011
- 2011-05-30 CY CY20111100519T patent/CY1111644T1/el unknown

Also Published As

Publication number	Publication date
MA31738B1 (fr)	2010-10-01
AR066873A1 (es)	2009-09-16
GT200900301A (es)	2010-04-22
WO2008149168A1 (en)	2008-12-11
EP2167470A1 (de)	2010-03-31
CL2008001648A1 (es)	2008-10-10
NI200900210A (es)	2010-07-15
CN101679272A (zh)	2010-03-24
NZ581186A (en)	2012-03-30
ZA200908280B (en)	2010-07-28
UY31130A1 (es)	2009-01-30
PA8782901A1 (es)	2009-01-23
DK2167470T3 (da)	2011-06-27
HU0700395D0 (en)	2007-07-30
HK1138581A1 (en)	2010-08-27
CA2689612A1 (en)	2008-12-11
ECSP099783A (es)	2010-01-29
DOP2009000276A (es)	2010-01-31
JO2689B1 (en)	2013-03-03
SV2009003420A (es)	2010-04-26
US8338411B2 (en)	2012-12-25
UA99463C2 (en)	2012-08-27
WO2008149168A8 (en)	2010-01-07
AU2008259534A1 (en)	2008-12-11
PL2167470T3 (pl)	2011-08-31
ME00958B (me)	2012-06-20
CO6270233A2 (es)	2011-04-20
RU2489432C2 (ru)	2013-08-10
CY1111644T1 (el)	2015-10-07
US20100216786A1 (en)	2010-08-26
BRPI0812257A2 (pt)	2014-12-23
MY148654A (en)	2013-05-15
PE20090325A1 (es)	2009-04-17
KR20100031610A (ko)	2010-03-23
AU2008259534B2 (en)	2012-07-05
SI2167470T1 (sl)	2011-06-30
HUP0700395A2 (en)	2009-03-02
IL202471A0 (en)	2010-06-30
CN101679272B (zh)	2013-02-06
RU2009149518A (ru)	2011-07-20
EP2167470B1 (de)	2011-03-16
TW200914451A (en)	2009-04-01
HRP20110332T1 (hr)	2011-06-30
JP5487100B2 (ja)	2014-05-07
PT2167470E (pt)	2011-05-16
MX2009013209A (es)	2010-04-09
TWI424998B (zh)	2014-02-01
ES2363672T3 (es)	2011-08-11
JP2010529100A (ja)	2010-08-26
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