ATE502110T1 - Rekombinanter mycobakterienstamm zur durch einen bei hypoxie aktiven promotor gesteuerten expression eines mykobakteriellen fap-proteins und seine anwendung zur krebstherapie - Google Patents

Rekombinanter mycobakterienstamm zur durch einen bei hypoxie aktiven promotor gesteuerten expression eines mykobakteriellen fap-proteins und seine anwendung zur krebstherapie

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Publication number
ATE502110T1
ATE502110T1 AT07825556T AT07825556T ATE502110T1 AT E502110 T1 ATE502110 T1 AT E502110T1 AT 07825556 T AT07825556 T AT 07825556T AT 07825556 T AT07825556 T AT 07825556T AT E502110 T1 ATE502110 T1 AT E502110T1
Authority
AT
Austria
Prior art keywords
mycobacterial
hypoxia
expression
application
promoter active
Prior art date
Application number
AT07825556T
Other languages
English (en)
Inventor
Gilles Marchal
Mohammad Abolhassani
Original Assignee
Pasteur Institut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut filed Critical Pasteur Institut
Application granted granted Critical
Publication of ATE502110T1 publication Critical patent/ATE502110T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
AT07825556T 2006-07-25 2007-07-25 Rekombinanter mycobakterienstamm zur durch einen bei hypoxie aktiven promotor gesteuerten expression eines mykobakteriellen fap-proteins und seine anwendung zur krebstherapie ATE502110T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06291205A EP1882741B1 (de) 2006-07-25 2006-07-25 Rekombinanter Mycobakteriumstamm, der ein FAP Protein aus Mycobakterium unter der Kontrolle eines Promotors, der unter hypoxischen Konditionen aktiv ist, exprimiert, und dessen Verwendung zur Tumortherapie
PCT/IB2007/003300 WO2008012693A2 (en) 2006-07-25 2007-07-25 Recombinant mycobacterium strain expressing a mycobacterial fap protein under the control of a promoter active under hypoxia and its application for cancer therapy

Publications (1)

Publication Number Publication Date
ATE502110T1 true ATE502110T1 (de) 2011-04-15

Family

ID=37026080

Family Applications (2)

Application Number Title Priority Date Filing Date
AT06291205T ATE472602T1 (de) 2006-07-25 2006-07-25 Rekombinanter mycobakteriumstamm, der ein fap protein aus mycobakterium unter der kontrolle eines promotors, der unter hypoxischen konditionen aktiv ist, exprimiert, und dessen verwendung zur tumortherapie
AT07825556T ATE502110T1 (de) 2006-07-25 2007-07-25 Rekombinanter mycobakterienstamm zur durch einen bei hypoxie aktiven promotor gesteuerten expression eines mykobakteriellen fap-proteins und seine anwendung zur krebstherapie

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT06291205T ATE472602T1 (de) 2006-07-25 2006-07-25 Rekombinanter mycobakteriumstamm, der ein fap protein aus mycobakterium unter der kontrolle eines promotors, der unter hypoxischen konditionen aktiv ist, exprimiert, und dessen verwendung zur tumortherapie

Country Status (9)

Country Link
US (2) US20090304637A1 (de)
EP (2) EP1882741B1 (de)
JP (1) JP2009544305A (de)
AT (2) ATE472602T1 (de)
CA (1) CA2658713A1 (de)
DE (2) DE602006015180D1 (de)
DK (1) DK1882741T3 (de)
ES (1) ES2347812T3 (de)
WO (1) WO2008012693A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008140598A2 (en) * 2006-12-04 2008-11-20 Bacilligen, Inc. Novel immunotherapeutic mycobacteria, pharmaceutic formulations and uses thereof
EP2620159A1 (de) 2012-01-24 2013-07-31 Institut Pasteur Verbesserte Krebsbehandlung durch Immuntherapie mit BCG- oder antigenetisch ähnlichen nicht-pathogenen Mykobakterien
WO2014025892A1 (en) * 2012-08-10 2014-02-13 Memorial Sloan-Kettering Cancer Center Predicting bladder cancer responsiveness to bcg
WO2016026453A2 (zh) * 2014-08-20 2016-02-25 北京百诺奇生物科技有限公司 一种检测样品中靶核酸的试剂盒及检测方法
CN116474108A (zh) 2016-12-14 2023-07-25 普渡研究基金会 成纤维细胞活化蛋白(fap)-靶向成像和治疗
WO2020115161A1 (en) 2018-12-04 2020-06-11 Sabiotec Spin-Off Sl Immunostimulant for use against pathogens

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6599510B1 (en) * 1993-11-23 2003-07-29 The Regents Of The University Of California Abundant extracellular products and methods for their production and use
US5834306A (en) * 1994-12-23 1998-11-10 Sri International Tissue specific hypoxia regulated therapeutic constructs
AU3593200A (en) * 1999-02-09 2000-08-29 Powderject Vaccines, Inc. (mycobacterium tuberculosis), immunization
WO2004006952A2 (en) * 2002-07-13 2004-01-22 Statens Serum Institut Therapeutic tuberculosis vaccines
DK2206514T3 (da) * 2003-10-16 2014-04-22 Univ California Rekombinante intracellulære patogene immunogene sammensætninger og metoder til anvendelse
CA2549188A1 (fr) * 2003-12-02 2005-06-23 Universite Paris 7 Utilisation des proteines et des peptides codes par le genome d'une nouvelle souche de coronavirus associe au sras

Also Published As

Publication number Publication date
WO2008012693A3 (en) 2008-04-24
EP1882741A1 (de) 2008-01-30
DE602007013248D1 (de) 2011-04-28
US20090304637A1 (en) 2009-12-10
WO2008012693A2 (en) 2008-01-31
DK1882741T3 (da) 2010-10-11
DE602006015180D1 (de) 2010-08-12
EP2049667B1 (de) 2011-03-16
EP1882741B1 (de) 2010-06-30
CA2658713A1 (en) 2008-01-31
HK1112753A1 (en) 2008-09-12
US20120156169A1 (en) 2012-06-21
JP2009544305A (ja) 2009-12-17
ES2347812T3 (es) 2010-11-04
ATE472602T1 (de) 2010-07-15
EP2049667A2 (de) 2009-04-22

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