ATE502578T1 - Messung der protein-syntheseraten bei menschen und in experimentellen systemen durch verwendung von isotopisch markiertem wasser - Google Patents
Messung der protein-syntheseraten bei menschen und in experimentellen systemen durch verwendung von isotopisch markiertem wasserInfo
- Publication number
- ATE502578T1 ATE502578T1 AT02806603T AT02806603T ATE502578T1 AT E502578 T1 ATE502578 T1 AT E502578T1 AT 02806603 T AT02806603 T AT 02806603T AT 02806603 T AT02806603 T AT 02806603T AT E502578 T1 ATE502578 T1 AT E502578T1
- Authority
- AT
- Austria
- Prior art keywords
- humans
- measurement
- protein synthesis
- isotopically labeled
- experimental systems
- Prior art date
Links
- 230000014616 translation Effects 0.000 title abstract 2
- 238000005259 measurement Methods 0.000 title 1
- 238000001243 protein synthesis Methods 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- 230000002285 radioactive effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Endocrinology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33502901P | 2001-10-24 | 2001-10-24 | |
| PCT/US2002/033996 WO2003061479A1 (en) | 2001-10-24 | 2002-10-23 | Measurement of protein synthesis rates in humans and experimental systems by use of isotopically labeled water |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE502578T1 true ATE502578T1 (de) | 2011-04-15 |
Family
ID=27613201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02806603T ATE502578T1 (de) | 2001-10-24 | 2002-10-23 | Messung der protein-syntheseraten bei menschen und in experimentellen systemen durch verwendung von isotopisch markiertem wasser |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7001587B2 (de) |
| EP (1) | EP1437966B1 (de) |
| JP (1) | JP2005515452A (de) |
| AT (1) | ATE502578T1 (de) |
| AU (1) | AU2002365268B2 (de) |
| CA (1) | CA2464474C (de) |
| DE (1) | DE60239552D1 (de) |
| DK (1) | DK1437966T3 (de) |
| IL (1) | IL161498A0 (de) |
| WO (1) | WO2003061479A1 (de) |
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| ATE502578T1 (de) | 2001-10-24 | 2011-04-15 | Univ California | Messung der protein-syntheseraten bei menschen und in experimentellen systemen durch verwendung von isotopisch markiertem wasser |
| AU2003217385B2 (en) * | 2002-02-12 | 2008-09-11 | The Regents Of The University Of California | Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation |
| CA2503681A1 (en) * | 2002-04-05 | 2003-10-23 | Marc K. Hellerstein | Method for isolating and measuring proliferation of long-term label retaining cells and stem cells |
| EP1546364A4 (de) | 2002-07-30 | 2006-09-06 | Univ California | Verfahren zur automatischen messung im grossmassstab der molekularen flussgeschwindigkeiten des proteoms oder des organoms mittels massenspektrometrie |
| DE20211783U1 (de) * | 2002-07-31 | 2002-11-07 | Fa. Hermann Heye i.Ins., 31683 Obernkirchen | Pressstempelmechanismus einer Glasformmaschine |
| US20060105339A1 (en) * | 2002-09-04 | 2006-05-18 | Marc Hellerstein | Methods for measuring the rates of replication and death of microbial infectious agents in an infected |
| CA2498378C (en) * | 2002-09-13 | 2013-12-17 | The Regents Of The University Of California | Methods for measuring rates of reverse cholesterol transport in vivo, as an index of anti-atherogenesis |
| US20070248540A1 (en) * | 2002-09-16 | 2007-10-25 | The Regents Of The University Of California | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
| SG152923A1 (en) * | 2002-09-16 | 2009-06-29 | Univ California | Biochemical methods for measuring metabolic fitness of tissues or whole organisms |
| WO2004042360A2 (en) | 2002-11-04 | 2004-05-21 | The Regents Of The Univeristy Of California | Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body |
| US7262020B2 (en) * | 2003-07-03 | 2007-08-28 | The Regents Of The University Of California | Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol |
| US20050202406A1 (en) * | 2003-11-25 | 2005-09-15 | The Regents Of The University Of California | Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems |
| TW200538738A (en) | 2004-02-20 | 2005-12-01 | Univ California | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity |
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| WO2005094327A2 (en) * | 2004-03-29 | 2005-10-13 | The Regents Of The University Of California | Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling |
| US7476546B2 (en) * | 2004-11-15 | 2009-01-13 | University Of North Dakota | Method for single oxygen atom incorporation into digested peptides using peptidases |
| JP4118918B2 (ja) * | 2005-02-28 | 2008-07-16 | シャープ株式会社 | 信号品質評価装置、情報記録再生装置、信号品質評価方法、記録条件決定方法、信号品質評価プログラム、信号品質評価プログラムを記録したコンピュータ読み取り可能な記録媒体 |
| CN101374555B (zh) | 2005-04-06 | 2013-04-17 | 圣路易斯华盛顿州立大学 | 神经衍生的生物分子体内代谢的检测方法 |
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| US8574543B2 (en) | 2007-12-14 | 2013-11-05 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Method of isotope labeling and determining protein synthesis, quantitation and protein expression |
| US9110008B2 (en) | 2010-07-26 | 2015-08-18 | Los Gatos Research | Method for isotopic analysis of water in bodily fluids |
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| US20050255509A1 (en) * | 2004-03-30 | 2005-11-17 | Kinemed, Inc. | In vivo measurement of the relative fluxes through ribonucleotide reductase vs. deoxyribonucleoside pathways using isotopes |
| JP4654592B2 (ja) * | 2004-04-02 | 2011-03-23 | 味の素株式会社 | 代謝フラックスの決定方法 |
| US20060120961A1 (en) * | 2004-10-29 | 2006-06-08 | Target Discovery, Inc. | Glycan analysis using deuterated glucose |
| WO2006081521A2 (en) | 2005-01-26 | 2006-08-03 | The Regents Of The University Of Colorado | Methods for diagnosis and intervention of hepatic disorders |
| CN101374555B (zh) | 2005-04-06 | 2013-04-17 | 圣路易斯华盛顿州立大学 | 神经衍生的生物分子体内代谢的检测方法 |
| US20060251576A1 (en) * | 2005-05-03 | 2006-11-09 | The Regents Of The University Of California | Methods for measuring cholesterol metabolism and transport |
| TW200711660A (en) * | 2005-06-10 | 2007-04-01 | Univ California | Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development |
-
2002
- 2002-10-23 AT AT02806603T patent/ATE502578T1/de active
- 2002-10-23 JP JP2003561427A patent/JP2005515452A/ja active Pending
- 2002-10-23 IL IL16149802A patent/IL161498A0/xx not_active IP Right Cessation
- 2002-10-23 AU AU2002365268A patent/AU2002365268B2/en not_active Ceased
- 2002-10-23 DE DE60239552T patent/DE60239552D1/de not_active Expired - Lifetime
- 2002-10-23 EP EP02806603A patent/EP1437966B1/de not_active Expired - Lifetime
- 2002-10-23 US US10/279,399 patent/US7001587B2/en not_active Expired - Lifetime
- 2002-10-23 WO PCT/US2002/033996 patent/WO2003061479A1/en not_active Ceased
- 2002-10-23 DK DK02806603.3T patent/DK1437966T3/da active
- 2002-10-23 CA CA2464474A patent/CA2464474C/en not_active Expired - Lifetime
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2004
- 2004-10-12 US US10/963,967 patent/US7307059B2/en not_active Expired - Lifetime
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2002365268B2 (en) | 2008-02-28 |
| CA2464474C (en) | 2011-12-20 |
| DE60239552D1 (de) | 2011-05-05 |
| US7307059B2 (en) | 2007-12-11 |
| US7410633B2 (en) | 2008-08-12 |
| CA2464474A1 (en) | 2003-07-31 |
| EP1437966A1 (de) | 2004-07-21 |
| DK1437966T3 (da) | 2011-07-04 |
| US20030133871A1 (en) | 2003-07-17 |
| US7001587B2 (en) | 2006-02-21 |
| US20060029549A1 (en) | 2006-02-09 |
| JP2005515452A (ja) | 2005-05-26 |
| EP1437966B1 (de) | 2011-03-23 |
| IL161498A0 (en) | 2004-09-27 |
| WO2003061479A1 (en) | 2003-07-31 |
| US20050147558A1 (en) | 2005-07-07 |
| EP1437966A4 (de) | 2006-08-23 |
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