ATE502939T1 - Disubstituierte alkyl-8-azabicycloä3.2.1üoktan- verbindungen als mu-opioid-rezeptorantagonisten - Google Patents

Disubstituierte alkyl-8-azabicycloä3.2.1üoktan- verbindungen als mu-opioid-rezeptorantagonisten

Info

Publication number
ATE502939T1
ATE502939T1 AT08795603T AT08795603T ATE502939T1 AT E502939 T1 ATE502939 T1 AT E502939T1 AT 08795603 T AT08795603 T AT 08795603T AT 08795603 T AT08795603 T AT 08795603T AT E502939 T1 ATE502939 T1 AT E502939T1
Authority
AT
Austria
Prior art keywords
compounds
opioid receptor
receptor antagonists
disubstituted alkyl
disubstituted
Prior art date
Application number
AT08795603T
Other languages
English (en)
Inventor
Daisuke Saito
Daniel Long
John Jacobsen
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Application granted granted Critical
Publication of ATE502939T1 publication Critical patent/ATE502939T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT08795603T 2007-08-27 2008-08-26 Disubstituierte alkyl-8-azabicycloä3.2.1üoktan- verbindungen als mu-opioid-rezeptorantagonisten ATE502939T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96628107P 2007-08-27 2007-08-27
PCT/US2008/010101 WO2009029257A1 (en) 2007-08-27 2008-08-26 Disubstituted alkyl-8-azabicyclo [3.2.1.] octane compounds as mu opioid receptor antagonists

Publications (1)

Publication Number Publication Date
ATE502939T1 true ATE502939T1 (de) 2011-04-15

Family

ID=39967733

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08795603T ATE502939T1 (de) 2007-08-27 2008-08-26 Disubstituierte alkyl-8-azabicycloä3.2.1üoktan- verbindungen als mu-opioid-rezeptorantagonisten

Country Status (6)

Country Link
US (2) US7947710B2 (de)
EP (1) EP2195314B1 (de)
AT (1) ATE502939T1 (de)
DE (1) DE602008005771D1 (de)
ES (1) ES2364686T3 (de)
WO (1) WO2009029257A1 (de)

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Also Published As

Publication number Publication date
DE602008005771D1 (de) 2011-05-05
EP2195314A1 (de) 2010-06-16
WO2009029257A1 (en) 2009-03-05
US7947710B2 (en) 2011-05-24
US20090062332A1 (en) 2009-03-05
EP2195314B1 (de) 2011-03-23
US20110144152A1 (en) 2011-06-16
ES2364686T3 (es) 2011-09-12
US8268863B2 (en) 2012-09-18

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