ATE503845T1 - Verfahren zur behandlung von psychosen und schizophrenie auf der basis eines polymorphismus im cntf gen - Google Patents

Verfahren zur behandlung von psychosen und schizophrenie auf der basis eines polymorphismus im cntf gen

Info

Publication number
ATE503845T1
ATE503845T1 AT02791794T AT02791794T ATE503845T1 AT E503845 T1 ATE503845 T1 AT E503845T1 AT 02791794 T AT02791794 T AT 02791794T AT 02791794 T AT02791794 T AT 02791794T AT E503845 T1 ATE503845 T1 AT E503845T1
Authority
AT
Austria
Prior art keywords
polymorphism
psychoses
treatment
cntf gene
schizophrenia based
Prior art date
Application number
AT02791794T
Other languages
English (en)
Inventor
Sridhar Kudaravalli
Mihael Polymeropoulos
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE503845T1 publication Critical patent/ATE503845T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/30—Psychoses; Psychiatry
    • G01N2800/302—Schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT02791794T 2001-12-10 2002-12-09 Verfahren zur behandlung von psychosen und schizophrenie auf der basis eines polymorphismus im cntf gen ATE503845T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33983501P 2001-12-10 2001-12-10
PCT/EP2002/013937 WO2003054226A2 (en) 2001-12-10 2002-12-09 Methods of treating psychosis and schizophrenia based on a polymorphism in the ctf gene

Publications (1)

Publication Number Publication Date
ATE503845T1 true ATE503845T1 (de) 2011-04-15

Family

ID=23330814

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02791794T ATE503845T1 (de) 2001-12-10 2002-12-09 Verfahren zur behandlung von psychosen und schizophrenie auf der basis eines polymorphismus im cntf gen

Country Status (15)

Country Link
US (3) US20050059006A1 (de)
EP (1) EP1458888B1 (de)
JP (2) JP2005512576A (de)
CN (1) CN1612941B (de)
AT (1) ATE503845T1 (de)
AU (1) AU2002358110A1 (de)
BR (1) BRPI0214821B8 (de)
CA (1) CA2468972A1 (de)
CY (1) CY1111594T1 (de)
DE (1) DE60239634D1 (de)
DK (1) DK1458888T3 (de)
ES (1) ES2364037T3 (de)
PT (1) PT1458888E (de)
SI (1) SI1458888T1 (de)
WO (1) WO2003054226A2 (de)

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EP3075865B1 (de) 2007-05-18 2018-05-09 Vanda Pharmaceuticals Inc. Genetische marker für die wirkung von iloperidon bei der behandlung psychotischer symptome
JP5653753B2 (ja) * 2007-09-10 2015-01-14 ヴァンダ ファーマシューティカルズ インコーポレイテッド Ｓｎｐ遺伝子型に基づくｑｔ延長の予測
WO2009036056A1 (en) * 2007-09-10 2009-03-19 Vanda Pharmaceuticals, Inc. Antipsychotic treatment based on snp genotype
EP2222301B1 (de) 2007-12-13 2014-10-08 Vanda Pharmaceuticals Inc. Verfahren und zusammensetzung zur behandlung einer erkrankung, die durch den alpha-adrenozeptor vermittelt wird
EP2222300B1 (de) 2007-12-13 2014-06-11 Vanda Pharmaceuticals Inc. Verfahren und zusammensetzung zur behandlung eines zustands, der durch den serotonin-rezeptor vermittelt wird
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WO2010132866A1 (en) * 2009-05-15 2010-11-18 Vanda Pharmaceuticals Inc. Antipsychotic treatment based on drd2 or ankk1 snp genotype
KR20170008327A (ko) 2012-03-14 2017-01-23 반다 파마슈티칼즈, 인코퍼레이티드. 정신적 질환의 치료 용도를 위한 일로페리돈 대사물질
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EP3844758A1 (de) * 2018-08-28 2021-07-07 Koninklijke Philips N.V. Verfahren zur bestimmung einer genomausrichtungsbasis
US11214827B2 (en) * 2018-08-30 2022-01-04 Vanda Pharmaceuticals Inc. Genetic markers for enhancing efficacy of antipsychotic treatment with iloperidone
WO2020216832A1 (en) * 2019-04-24 2020-10-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for predicting the response of antipsychotic drugs
CN110184345B (zh) * 2019-07-11 2020-05-05 南京先声医学检验有限公司 用于检测精神及神经类疾病用药相关snp位点的引物组、应用、产品及方法
CN111187829A (zh) * 2020-02-24 2020-05-22 内蒙古医科大学 Lp基因启动子区甲基化检测引物与检测方法及其应用

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Also Published As

Publication number Publication date
WO2003054226A3 (en) 2004-04-01
CN1612941A (zh) 2005-05-04
CA2468972A1 (en) 2003-07-03
US20090239908A1 (en) 2009-09-24
JP2005512576A (ja) 2005-05-12
SI1458888T1 (sl) 2011-07-29
HK1069413A1 (en) 2005-05-20
BRPI0214821B1 (pt) 2015-07-07
DE60239634D1 (de) 2011-05-12
CY1111594T1 (el) 2015-10-07
BRPI0214821B8 (pt) 2021-07-27
ES2364037T3 (es) 2011-08-23
US20050059006A1 (en) 2005-03-17
JP5785697B2 (ja) 2015-09-30
AU2002358110A1 (en) 2003-07-09
US20080027106A1 (en) 2008-01-31
US8460867B2 (en) 2013-06-11
JP2011006422A (ja) 2011-01-13
EP1458888A2 (de) 2004-09-22
DK1458888T3 (da) 2011-06-20
WO2003054226A2 (en) 2003-07-03
PT1458888E (pt) 2011-06-01
CN1612941B (zh) 2011-11-16
AU2002358110A8 (en) 2003-07-09
BR0214821A (pt) 2004-11-03
EP1458888B1 (de) 2011-03-30

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