ATE504308T1 - Antimikrobielle kationische peptide und diese enthaltende formulierungen - Google Patents

Antimikrobielle kationische peptide und diese enthaltende formulierungen

Info

Publication number
ATE504308T1
ATE504308T1 AT02759416T AT02759416T ATE504308T1 AT E504308 T1 ATE504308 T1 AT E504308T1 AT 02759416 T AT02759416 T AT 02759416T AT 02759416 T AT02759416 T AT 02759416T AT E504308 T1 ATE504308 T1 AT E504308T1
Authority
AT
Austria
Prior art keywords
antimicrobial cationic
cationic peptides
formulations containing
containing same
infections
Prior art date
Application number
AT02759416T
Other languages
English (en)
Inventor
Timothy Krieger
Patricia Mcnicol
Original Assignee
Migenix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Migenix Inc filed Critical Migenix Inc
Application granted granted Critical
Publication of ATE504308T1 publication Critical patent/ATE504308T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT02759416T 2001-08-21 2002-08-21 Antimikrobielle kationische peptide und diese enthaltende formulierungen ATE504308T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31423201P 2001-08-21 2001-08-21
US10/225,087 US6835536B2 (en) 2001-08-21 2002-08-20 Antimicrobial cationic peptides and formulations thereof
PCT/US2002/026525 WO2003015809A2 (en) 2001-08-21 2002-08-21 Antimicrobial cationic peptides and formulations thereof

Publications (1)

Publication Number Publication Date
ATE504308T1 true ATE504308T1 (de) 2011-04-15

Family

ID=26919289

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02759416T ATE504308T1 (de) 2001-08-21 2002-08-21 Antimikrobielle kationische peptide und diese enthaltende formulierungen

Country Status (8)

Country Link
US (5) US6835536B2 (de)
EP (1) EP1469876B1 (de)
JP (3) JP4932136B2 (de)
AT (1) ATE504308T1 (de)
AU (1) AU2002324752B2 (de)
CA (1) CA2456477C (de)
DE (1) DE60239707D1 (de)
WO (1) WO2003015809A2 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7550558B2 (en) * 2001-06-01 2009-06-23 Fundacao De Ampara A Pesquiso Do Estado De Sao Paolo (Fapesp) Antimicrobial peptides and methods for identifying and using such peptides
US6835536B2 (en) 2001-08-21 2004-12-28 Micrologix Biotech Inc. Antimicrobial cationic peptides and formulations thereof
JP4511173B2 (ja) 2001-08-24 2010-07-28 マイジェニックス インコーポレイテッド 抗菌性および抗炎症性ペプチド
US7507787B2 (en) 2001-12-03 2009-03-24 The University Of British Columbia Effectors of innate immunity
US7687454B2 (en) 2001-12-03 2010-03-30 The University Of British Columbia Effectors of innate immunity determination
US20030144362A1 (en) * 2002-01-28 2003-07-31 Utterberg David S. High viscosity antibacterials for cannulae
US20060128614A1 (en) * 2002-09-20 2006-06-15 Jya-Wei Cheng Antimicrobial peptides with reduced hemolysis and methods of their use
BRPI0413521A (pt) 2003-08-14 2006-10-10 Diatos seqüências de aminoácidos que facilitam a penetração de uma substáncia de interesse nas células e/ou no núcleos celulares
WO2005019241A2 (en) * 2003-08-18 2005-03-03 E.I. Dupont De Nemours And Company Cationic antimicrobial peptides and compositions thereof
MXPA06002828A (es) * 2003-09-12 2006-06-23 Univ British Columbia Efectores de determinacion de inmunidad innata.
US20070270378A1 (en) * 2004-05-27 2007-11-22 Santen Pharmaceutical Co., Ltd. Viscous Agent for Ophthalmic Use
JP4736540B2 (ja) * 2004-05-27 2011-07-27 参天製薬株式会社 眼科用粘稠化剤
CA2629751A1 (en) * 2004-11-12 2006-05-18 The University Of British Columbia Antimicrobial peptides
BRPI0614530A2 (pt) * 2005-08-01 2011-08-09 Univ Louisiana State uso de um peptìdeo, peptìdeo, composição farmacêutica, e, ácido nucleico
AU2006295340B2 (en) * 2005-08-05 2010-11-11 Amgen Inc. Stable aqueous protein or antibody pharmaceutical formulations and their preparation
US7902327B2 (en) * 2007-05-22 2011-03-08 New York University School Of Medicine Dendrimeric peptides, pharmaceutical compositions and methods of using the same
US9314524B2 (en) * 2007-12-31 2016-04-19 Calla Therapeutics Llc Topical formulations of Flucytosine
US20100055158A1 (en) * 2008-08-28 2010-03-04 Tyco Healthcare Group Lp Environmentally Activated Compositions, Articles and Methods
US20120213843A1 (en) * 2009-11-03 2012-08-23 Lipidor Ab Composition for promoting wound healing
US8916171B2 (en) 2010-04-27 2014-12-23 Topical Sinus Therapeutics, Inc. Topical delivery of viscous medications for the treatment of diseases associated with chronic sinusitis
CN103502321B (zh) * 2011-05-25 2017-05-10 英派尔科技开发有限公司 处理木质纤维素材料
WO2013039861A2 (en) 2011-09-12 2013-03-21 modeRNA Therapeutics Engineered nucleic acids and methods of use thereof
JP5894457B2 (ja) * 2012-02-22 2016-03-30 株式会社Adeka ペプチド含有抗菌性組成物
KR102266659B1 (ko) 2012-03-23 2021-06-17 아미크로베, 인코포레이티드. 조직-적합성 특성을 갖는 항균물질의 조성물 및 용도
WO2013151663A1 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of membrane proteins
CN108949772A (zh) 2012-04-02 2018-12-07 现代泰克斯公司 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸
US11168131B2 (en) 2015-11-10 2021-11-09 Visterra, Inc. Antibody molecule-drug conjugates and uses thereof
JP2019510076A (ja) * 2016-02-19 2019-04-11 フォルシュングスツェントルム ボルシュテル ライプニッツツェントルム フュール メディツィン ウント ビオヴィッセンシャフテン 細菌感染症を治療するための手段と方法
ES2994374T3 (en) 2017-01-18 2025-01-23 Visterra Inc Antibody molecule-drug conjugates and uses thereof
KR102679493B1 (ko) 2017-01-31 2024-07-01 킴벌리-클라크 월드와이드, 인크. 벤조산 에스테르를 포함하는 항균 조성물 및 이를 이용한 세균 생장 억제 방법
WO2018160791A1 (en) 2017-03-03 2018-09-07 Massachusetts Institute Of Technology Antimicrobial constructs and uses thereof
AU2018249552A1 (en) * 2017-04-06 2019-10-31 Amicrobe, Inc. Compositions and uses of locally-applied antimicrobial synthetic cationic polypeptide(s) with enhanced performance and safety
WO2019089657A1 (en) 2017-10-30 2019-05-09 Allvivo Vascular, Inc. Delivery systems for administration of cationic biological actives
WO2020162582A1 (en) * 2019-02-08 2020-08-13 Maruho Co., Ltd. Methods of treating non-virally-induced cancers
TWI755710B (zh) 2019-04-16 2022-02-21 中央研究院 塗覆抗微生物肽於生物材料之方法及藉此塗覆之生物材料
EP3797800A1 (de) * 2019-05-02 2021-03-31 Institut National De La Sante Et De La Recherche Medicale - Inserm Hyaluronsäurehydrogele mit verlängerter antimikrobieller wirkung
WO2021092382A1 (en) * 2019-11-08 2021-05-14 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Compositions comprising antimicrobial peptides
EP4126064A1 (de) 2020-04-03 2023-02-08 Visterra, Inc. Antikörpermolekül-wirkstoff-konjugate und verwendungen davon
CZ309857B6 (cs) 2022-03-31 2023-12-20 Contipro A.S. Hexapeptid, kompozice zahrnující tento hexapeptid a jejich topické použití

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2128617A (en) 1982-10-06 1984-05-02 Martti Vaara Polypeptides for use in antibacterial therapy
US4816449A (en) 1984-08-09 1989-03-28 Immunetech Pharmaceuticals Immunotherapeutic anti-inflammatory peptide agents
JPH0645535B2 (ja) * 1987-05-20 1994-06-15 サンスタ−株式会社 歯槽骨代謝治療用組成物
US5705485A (en) * 1987-09-18 1998-01-06 Ethicon, Inc. Gel formulations containing growth factors
US4956184A (en) 1988-05-06 1990-09-11 Alcide Corporation Topical treatment of genital herpes lesions
NZ237202A (en) 1990-02-23 1994-01-26 Bristol Myers Squibb Co Composition containing beta-lactam antibiotic and cationic oligopeptide
US5776892A (en) 1990-12-21 1998-07-07 Curative Health Services, Inc. Anti-inflammatory peptides
WO1992015286A1 (en) 1991-02-27 1992-09-17 Nova Pharmaceutical Corporation Anti-infective and anti-inflammatory releasing systems for medical devices
US5547939A (en) 1991-06-14 1996-08-20 The Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
US5324716A (en) 1991-06-14 1994-06-28 Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
CA2135194A1 (en) 1992-05-22 1993-12-09 Charles L. Bevins Gastrointestinal defensins, cdna sequences and method for the production and use thereof
US5593866A (en) 1992-08-21 1997-01-14 The University Of British Columbia Cationic peptides and method for production
ES2079994B1 (es) 1992-10-07 1996-08-01 Cusi Lab Formulacion farmaceutica a base de polimixina-trimetoprim y un agente antiinflamatorio para su utilizacion topica oftalmica y otica.
GB9224598D0 (en) 1992-11-24 1993-01-13 Smithkline Beecham Plc Novel compositions
US5436222A (en) 1993-03-15 1995-07-25 The Research Foundation Of State University Of New York Use of platelet factor 4 to treat inflammatory diseases
US5459235A (en) 1993-03-19 1995-10-17 The Regents Of The University Of California Antimicrobial peptides antibodies and nucleic acid molecules from bovine neutrophils
US5681811A (en) 1993-05-10 1997-10-28 Protein Delivery, Inc. Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
US5359030A (en) 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
EP0759774B1 (de) 1993-09-22 2002-06-12 XOMA Technology Ltd. Verfahren zur behandlung von gram-negativen bakterien infektion durch verabreichung von bakterientötendem/durchlässigkeiterhöhendem (bpi) proteinprodukt und antibiotikum
WO1995019180A1 (en) 1994-01-14 1995-07-20 Xoma Corporation Anti-gram-positive bacterial methods and materials
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US5505949A (en) 1994-10-13 1996-04-09 Benitez; Juan E. Topical treatment for acne
US5834430A (en) 1995-05-31 1998-11-10 Biosynth S.R.L. Potentiation of antibiotics
US6057291A (en) * 1995-06-02 2000-05-02 University Of British Columbia Antimicrobial cationic peptides
US5877274A (en) 1995-06-02 1999-03-02 University Of British Columbia Antimicrobial cationic peptides
AU6940796A (en) 1995-08-23 1997-03-19 University Of British Columbia, The Antimicrobial cationic peptides and methods of screening for the same
US5994308A (en) 1996-02-28 1999-11-30 Board Of Trustees Of Southern Illinois University Broad spectrum antimicrobial peptides containing a tryptophan triplet and methods of use
US6180604B1 (en) 1996-08-21 2001-01-30 Micrologix Biotech Inc. Compositions and methods for treating infections using analogues of indolicidin
US6503881B2 (en) * 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
US6551994B1 (en) 1997-04-10 2003-04-22 Mcgill University Compounds and methods for inhibiting the interaction between α-catenin and β-catenin
US5997893A (en) 1998-01-20 1999-12-07 Ethicon, Inc. Alcohol based anti-microbial compositions with cosmetic appearance
US6248343B1 (en) 1998-01-20 2001-06-19 Ethicon, Inc. Therapeutic antimicrobial compositions
WO1999043357A1 (en) 1998-02-25 1999-09-02 Micrologix Biotech Inc. Indolicidin and cationic peptides conjugated with polymers
US6303575B1 (en) 1998-05-12 2001-10-16 The Regents Of The University Of California Indolicidin analogs and methods of using same
AU4253799A (en) 1998-06-12 2000-01-05 Micrologix Biotech, Inc. Cancer therapy with cationic peptides
US6444645B1 (en) 1998-06-18 2002-09-03 The Regents Of The University Of California Crosslink-stabilized indolicidin analogs
NZ509101A (en) 1998-06-26 2003-07-25 N Pharmaceutical preparations for use in combatting or preventing surface infections caused by microorganisms
US6025394A (en) 1999-01-29 2000-02-15 Cell Pathways, Inc. Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols
JP2002536397A (ja) * 1999-02-12 2002-10-29 ザ、プロクター、エンド、ギャンブル、カンパニー 皮膚消毒剤組成物
US6482799B1 (en) 1999-05-25 2002-11-19 The Regents Of The University Of California Self-preserving multipurpose ophthalmic solutions incorporating a polypeptide antimicrobial
KR20020010920A (ko) * 1999-06-02 2002-02-06 추후제출 각질세포 성장 인자-2 제제
US6835536B2 (en) 2001-08-21 2004-12-28 Micrologix Biotech Inc. Antimicrobial cationic peptides and formulations thereof

Also Published As

Publication number Publication date
US20050049182A1 (en) 2005-03-03
JP5684098B2 (ja) 2015-03-11
CA2456477A1 (en) 2003-02-27
US20130296227A1 (en) 2013-11-07
US20030171281A1 (en) 2003-09-11
US8466102B2 (en) 2013-06-18
CA2456477C (en) 2016-02-16
WO2003015809A3 (en) 2004-03-18
US8138144B2 (en) 2012-03-20
US8927487B2 (en) 2015-01-06
JP2005504769A (ja) 2005-02-17
US6835536B2 (en) 2004-12-28
US20120202735A1 (en) 2012-08-09
EP1469876A2 (de) 2004-10-27
US20150087580A1 (en) 2015-03-26
WO2003015809A9 (en) 2004-04-22
WO2003015809A2 (en) 2003-02-27
DE60239707D1 (de) 2011-05-19
JP4932136B2 (ja) 2012-05-16
EP1469876B1 (de) 2011-04-06
JP2015028082A (ja) 2015-02-12
AU2002324752B2 (en) 2008-07-03
JP2012041367A (ja) 2012-03-01
US9227999B2 (en) 2016-01-05

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