ATE504566T1 - Zur behandlung von auf eine modulation des dopamin-d3-rezeptors ansprechende erkrankungen geeignete heterocyclische verbindungen - Google Patents

Zur behandlung von auf eine modulation des dopamin-d3-rezeptors ansprechende erkrankungen geeignete heterocyclische verbindungen

Info

Publication number: ATE504566T1
Authority: AT; Austria
Prior art keywords: alkyl; fluorinated; treatment; cycloalkyl; dopamine
Prior art date: 2004-10-14

Application number

AT05805167T

Other languages

English (en)

Inventor

Karla Drescher

Andreas Haupt

Liliane Unger

Sean Turner

Wilfried Braje

Roland Grandel

Christophe Henry

Gisela Backfisch

Armin Beyerbach

Wilfried Lubisch

Original Assignee

Abbott Gmbh & Co Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-14

Filing date

2005-10-14

Publication date

2011-04-15

2005-10-14 Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg

2011-04-15 Application granted granted Critical

2011-04-15 Publication of ATE504566T1 publication Critical patent/ATE504566T1/de

Links

102000004073 Dopamine D3 Receptors Human genes 0.000 title abstract 2
108090000525 Dopamine D3 Receptors Proteins 0.000 title abstract 2
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
150000002391 heterocyclic compounds Chemical class 0.000 title 1
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 3
229910052799 carbon Inorganic materials 0.000 abstract 3
125000005842 heteroatom Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
125000001054 5 membered carbocyclic group Chemical group 0.000 abstract 1
125000004008 6 membered carbocyclic group Chemical group 0.000 abstract 1
125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 abstract 1
125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
125000005550 pyrazinylene group Chemical group 0.000 abstract 1
125000005551 pyridylene group Chemical group 0.000 abstract 1
-1 pyrimidylene Chemical group 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000005730 thiophenylene group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)

AT05805167T 2004-10-14 2005-10-14 Zur behandlung von auf eine modulation des dopamin-d3-rezeptors ansprechende erkrankungen geeignete heterocyclische verbindungen ATE504566T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US61887804P	2004-10-14	2004-10-14
PCT/EP2005/011106 WO2006040182A1 (en)	2004-10-14	2005-10-14	Heterocyclic compounds suitable for treating disorders that respond to modulation of the dopamine d3 receptor

Publications (1)

Publication Number	Publication Date
ATE504566T1 true ATE504566T1 (de)	2011-04-15

Family

ID=35744845

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05805167T ATE504566T1 (de)	2004-10-14	2005-10-14	Zur behandlung von auf eine modulation des dopamin-d3-rezeptors ansprechende erkrankungen geeignete heterocyclische verbindungen

Country Status (17)

Country	Link
US (2)	US7851463B2 (de)
EP (3)	EP2311802A1 (de)
JP (1)	JP4904277B2 (de)
KR (1)	KR101315192B1 (de)
CN (1)	CN101039904B (de)
AT (1)	ATE504566T1 (de)
AU (1)	AU2005293698B2 (de)
BR (1)	BRPI0515998A (de)
CA (1)	CA2583983C (de)
DE (1)	DE602005027382D1 (de)
ES (1)	ES2364488T3 (de)
IL (1)	IL182431A (de)
MX (1)	MX2007004359A (de)
NZ (1)	NZ555123A (de)
TW (1)	TWI364414B (de)
WO (1)	WO2006040182A1 (de)
ZA (1)	ZA200703061B (de)

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US20040204422A1 (en)	2003-04-14	2004-10-14	Abbott Gmbh & Co. Kg.	N-[(Piperazinyl)hetaryl]arylsulfonamide compounds
ATE504566T1 (de) *	2004-10-14	2011-04-15	Abbott Gmbh & Co Kg	Zur behandlung von auf eine modulation des dopamin-d3-rezeptors ansprechende erkrankungen geeignete heterocyclische verbindungen
US7615569B2 (en) *	2005-08-16	2009-11-10	Icagen, Inc.	Inhibitors of ion channels
TW200808762A (en)	2006-04-19	2008-02-16	Abbott Gmbh & Co Kg	Heterocyclic compounds suitable for treating disorders that respond to modulation of the serotonin 5HT6 receptor
BRPI0710177A2 (pt) *	2006-04-19	2012-05-29	Abbott Gmbh & Co Kg	arilsulfonas heterocìclicas adequadas para tratar distúrbios que respondem à modulação do receptor 5ht6 de serotonina
DE102007036068A1 (de)	2007-08-01	2009-02-05	Wacker Chemie Ag	Verfahren zur Herstellung von Alkyl-methoxymethyl-trimethylsilanylmethylaminen
DE102008022221A1 (de)	2008-05-06	2009-11-12	Universität des Saarlandes	Inhibitoren der humanen Aldosteronsynthase CYP11B2
US8541404B2 (en)	2009-11-09	2013-09-24	Elexopharm Gmbh	Inhibitors of the human aldosterone synthase CYP11B2
CN102276511A (zh) *	2011-06-20	2011-12-14	兰州博实生化科技有限责任公司	1-叔丁氧羰基-3-碘氮杂环丁烷的合成方法
WO2016100940A1 (en)	2014-12-19	2016-06-23	The Broad Institute, Inc.	Dopamine d2 receptor ligands
US10752588B2 (en)	2014-12-19	2020-08-25	The Broad Institute, Inc.	Dopamine D2 receptor ligands
CN109503449A (zh) *	2018-12-17	2019-03-22	天津药明康德新药开发有限公司	一种3-硝基吖丁啶-1-甲酸叔丁酯的合成方法
JP7787812B2 (ja)	2019-11-25	2025-12-17	アルカームスインコーポレーテッド	置換大環状化合物および関連する治療方法
US11760747B2 (en)	2020-12-21	2023-09-19	Alkermes, Inc.	Substituted piperidino compounds and related methods of treatment
WO2023249875A1 (en) *	2022-06-21	2023-12-28	Alkermes, Inc.	Substituted pyrrolidinyl and piperidinyl compounds and related methods of treatment

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CN85106905A (zh) *	1985-08-08	1987-02-04	Fmc公司	含有1-芳基-δ2-1，2，4，-三唑啉-5-酮类的除草剂及其制备方法
WO1990009787A1 (en)	1989-02-27	1990-09-07	The Du Pont Merck Pharmaceutical Company	Novel sulfonamides as radiosensitizers
DE4303376A1 (de)	1993-02-05	1994-08-11	Bayer Ag	Substituierte Triazolinone
FR2703688B1 (fr)	1993-04-09	1995-05-19	Rhone Poulenc Chimie	Réactif de désallylation, procédé de désallylation utilisant ledit réactif.
AU7186994A (en) *	1993-06-25	1995-01-17	Smithkline Beecham Plc	Phenyrrole derivatives and their use as dopamine d3 antagonists
AU7513494A (en)	1993-08-06	1995-02-28	Upjohn Company, The	2-aminoindans as selective dopamine d3 ligands
DE4425143A1 (de) *	1994-07-15	1996-01-18	Basf Ag	Substituierte Pyrimidinverbindungen und deren Verwendung
DE19500689A1 (de) *	1995-01-12	1996-07-18	Merck Patent Gmbh	Indolpiperidin-Derivate
HU224354B1 (hu)	1995-02-01	2005-08-29	Pharmacia & Upjohn Company	2-Aminoindán-származékok alkalmazása és az ezeket tartalmazó gyógyszerkészítmények
ATE232894T1 (de)	1996-05-30	2003-03-15	Baker Hughes Inc	Naphtensäurekorrosionskontrolle mit thiophosphorverbindungen
ATE247639T1 (de)	1996-05-31	2003-09-15	Upjohn Co	Arylsubstituierte cyclische amine als selektive dopamin-d3-liganden
DZ2376A1 (fr) *	1996-12-19	2002-12-28	Smithkline Beecham Plc	Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
TW450954B (en)	1998-05-14	2001-08-21	Pharmacia & Amp Upjohn Company	Phenylsulfonamide-phenylethylamines useful as dopamine receptors
JP2002521377A (ja) *	1998-07-20	2002-07-16	メルクパテントゲゼルシャフトミットベシュレンクテルハフトング	ビフェニル誘導体
DE19922443A1 (de)	1999-05-07	2000-11-09	Basf Ag	Verwendung von Dopamin-D3-Rezeptorliganden zur Herstellung von Arzneimittel für die Behandlung von Nierenfunktionsstörungen
ATE504566T1 (de) *	2004-10-14	2011-04-15	Abbott Gmbh & Co Kg	Zur behandlung von auf eine modulation des dopamin-d3-rezeptors ansprechende erkrankungen geeignete heterocyclische verbindungen
BRPI0710177A2 (pt) *	2006-04-19	2012-05-29	Abbott Gmbh & Co Kg	arilsulfonas heterocìclicas adequadas para tratar distúrbios que respondem à modulação do receptor 5ht6 de serotonina

2005
- 2005-10-14 AT AT05805167T patent/ATE504566T1/de not_active IP Right Cessation
- 2005-10-14 EP EP10183328A patent/EP2311802A1/de not_active Withdrawn
- 2005-10-14 US US11/665,399 patent/US7851463B2/en not_active Expired - Fee Related
- 2005-10-14 ES ES05805167T patent/ES2364488T3/es not_active Expired - Lifetime
- 2005-10-14 CA CA2583983A patent/CA2583983C/en not_active Expired - Fee Related
- 2005-10-14 NZ NZ555123A patent/NZ555123A/en not_active IP Right Cessation
- 2005-10-14 BR BRPI0515998-9A patent/BRPI0515998A/pt not_active IP Right Cessation
- 2005-10-14 MX MX2007004359A patent/MX2007004359A/es active IP Right Grant
- 2005-10-14 KR KR1020077010955A patent/KR101315192B1/ko not_active Expired - Fee Related
- 2005-10-14 WO PCT/EP2005/011106 patent/WO2006040182A1/en not_active Ceased
- 2005-10-14 AU AU2005293698A patent/AU2005293698B2/en not_active Ceased
- 2005-10-14 TW TW094136070A patent/TWI364414B/zh not_active IP Right Cessation
- 2005-10-14 CN CN200580035304.0A patent/CN101039904B/zh not_active Expired - Fee Related
- 2005-10-14 JP JP2007536111A patent/JP4904277B2/ja not_active Expired - Fee Related
- 2005-10-14 EP EP05805167A patent/EP1814849B1/de not_active Expired - Lifetime
- 2005-10-14 EP EP10183342A patent/EP2311803A1/de not_active Withdrawn
- 2005-10-14 DE DE602005027382T patent/DE602005027382D1/de not_active Expired - Lifetime
2007
- 2007-04-10 IL IL182431A patent/IL182431A/en not_active IP Right Cessation
- 2007-04-13 ZA ZA200703061A patent/ZA200703061B/xx unknown
2010
- 2010-08-25 US US12/868,480 patent/US8470810B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2364488T3 (es)	2011-09-05
US20080045493A1 (en)	2008-02-21
JP2008516918A (ja)	2008-05-22
AU2005293698B2 (en)	2011-12-15
WO2006040182A1 (en)	2006-04-20
AU2005293698A1 (en)	2006-04-20
TW200619195A (en)	2006-06-16
TWI364414B (en)	2012-05-21
BRPI0515998A (pt)	2008-08-19
US7851463B2 (en)	2010-12-14
MX2007004359A (es)	2007-07-17
CA2583983C (en)	2013-07-16
US8470810B2 (en)	2013-06-25
EP2311803A1 (de)	2011-04-20
IL182431A (en)	2012-04-30
CA2583983A1 (en)	2006-04-20
IL182431A0 (en)	2007-07-24
JP4904277B2 (ja)	2012-03-28
HK1111681A1 (en)	2008-08-15
US20110160176A1 (en)	2011-06-30
CN101039904B (zh)	2014-09-24
NZ555123A (en)	2011-01-28
EP1814849A1 (de)	2007-08-08
KR20070084208A (ko)	2007-08-24
EP1814849B1 (de)	2011-04-06
EP2311802A1 (de)	2011-04-20
DE602005027382D1 (de)	2011-05-19
CN101039904A (zh)	2007-09-19
KR101315192B1 (ko)	2013-10-10
ZA200703061B (en)	2008-09-25

Legal Events

Date	Code	Title	Description
2011-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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