ATE504570T1 - Tartratsalz aus isofagomin und verwendungsverfahren dafür - Google Patents
Tartratsalz aus isofagomin und verwendungsverfahren dafürInfo
- Publication number
- ATE504570T1 ATE504570T1 AT07252109T AT07252109T ATE504570T1 AT E504570 T1 ATE504570 T1 AT E504570T1 AT 07252109 T AT07252109 T AT 07252109T AT 07252109 T AT07252109 T AT 07252109T AT E504570 T1 ATE504570 T1 AT E504570T1
- Authority
- AT
- Austria
- Prior art keywords
- isofagomin
- salt
- tartrate salt
- gaucher disease
- isofagomine tartrate
- Prior art date
Links
- 150000003892 tartrate salts Chemical class 0.000 title abstract 2
- ULBPPCHRAVUQMC-MUMXBIPUSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;(3r,4r,5r)-5-(hydroxymethyl)piperidine-3,4-diol Chemical compound OC[C@H]1CNC[C@@H](O)[C@@H]1O.OC(=O)[C@H](O)[C@@H](O)C(O)=O ULBPPCHRAVUQMC-MUMXBIPUSA-N 0.000 abstract 2
- 208000015872 Gaucher disease Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80802006P | 2006-05-24 | 2006-05-24 | |
| US89071907P | 2007-02-20 | 2007-02-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE504570T1 true ATE504570T1 (de) | 2011-04-15 |
Family
ID=38462442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07252109T ATE504570T1 (de) | 2006-05-24 | 2007-05-23 | Tartratsalz aus isofagomin und verwendungsverfahren dafür |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7501439B2 (de) |
| EP (1) | EP1860101B1 (de) |
| JP (1) | JP5292605B2 (de) |
| AT (1) | ATE504570T1 (de) |
| AU (1) | AU2007202359B2 (de) |
| BR (1) | BRPI0706114A2 (de) |
| CA (1) | CA2590122C (de) |
| DE (1) | DE602007013648D1 (de) |
| DK (1) | DK1860101T3 (de) |
| IL (1) | IL183415A (de) |
| MX (1) | MX2007006175A (de) |
| PL (1) | PL1860101T3 (de) |
| PT (1) | PT1860101E (de) |
| WO (1) | WO2007140212A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006254796B2 (en) * | 2005-06-08 | 2012-08-16 | Amicus Therapeutics, Inc. | Treatment of CNS disorders associated with mutations in genes encoding lysosomal enzymes |
| PT2040548E (pt) | 2006-06-23 | 2012-08-02 | Amicus Therapeutics Inc | Método para o tratamento de distúrbios neurológicos através do aumento da atividade da -glucocerebrosidase |
| CN104530068B (zh) | 2007-05-22 | 2017-05-03 | 阿米库斯治疗学公司 | 用于制备异法戈明的化合物 |
| PL2252313T3 (pl) | 2008-02-12 | 2015-09-30 | Amicus Therapeutics Inc | Sposób przewidywania odpowiedzi na leczenie chorób farmakologicznymi białkami chaperonowymi |
| JP2012508740A (ja) * | 2008-11-14 | 2012-04-12 | パーキンソンズ インスティテュート | 変性α−シヌクレイン機能の治療のための組成物および方法 |
| RU2733466C2 (ru) | 2009-07-28 | 2020-10-01 | Шайр Хьюман Дженетик Терапиз | Композиции и способы для лечения болезни гоше |
| CA2778349C (en) * | 2009-10-19 | 2018-12-04 | Amicus Therapeutics, Inc. | Novel compositions for preventing and/or treating lysosomal storage disorders |
| EP3143875B1 (de) | 2009-10-19 | 2020-05-27 | Amicus Therapeutics, Inc. | Neuartige zusammensetzungen zur prävention und/oder behandlung von degenerativen erkrankungen des zentralen nervensystems |
| PT2707101T (pt) | 2011-05-12 | 2019-05-30 | Proteostasis Therapeutics Inc | Reguladores da proteostase |
| EP2723384B1 (de) * | 2011-06-22 | 2018-08-29 | The General Hospital Corporation | Behandlung von proteinopathien |
| WO2013112706A1 (en) | 2012-01-25 | 2013-08-01 | Proteostasis Therapeutics, Inc. | Proteasome activity modulating compounds |
| WO2013130963A1 (en) | 2012-03-02 | 2013-09-06 | Shire Human Genetic Therapies, Inc. | Compositions and methods for treating type iii gaucher disease |
| EP2831043B1 (de) | 2012-03-27 | 2022-07-27 | Amicus Therapeutics, Inc. | Neuartige verbindungen zur prophylaxe und/oder behandlung lysosomaler speicherkrankheiten und/oder degenerativer erkrankungen des zentralen nervensystems |
| AU2013240187A1 (en) | 2012-03-28 | 2014-10-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Salicylic acid derivatives useful as glucocerebrosidase activators |
| EP3318277A1 (de) | 2016-11-04 | 2018-05-09 | Institut du Cerveau et de la Moelle Epiniere-ICM | Inhibitoren der glucosylceramidsynthase zur behandlung von motoneuronerkrankungen |
| DE102017103346A1 (de) * | 2017-02-17 | 2018-08-23 | Lts Lohmann Therapie-Systeme Ag | Strukturierte orodispergierbare Filme |
| CN111278439A (zh) * | 2017-10-26 | 2020-06-12 | 夏尔人类遗传性治疗公司 | 包含葡萄糖脑苷脂酶和异烟肼的调配物 |
| WO2020006269A1 (en) | 2018-06-27 | 2020-01-02 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
| JP7561632B2 (ja) | 2018-06-27 | 2024-10-04 | キネタ， インコーポレイテッド | プロテアソーム活性増強化合物 |
| US20220184185A1 (en) | 2018-07-25 | 2022-06-16 | Modernatx, Inc. | Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders |
| CN113906012A (zh) * | 2019-04-25 | 2022-01-07 | 武田药品工业有限公司 | 异法戈明盐、使用方法和调配物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5844102A (en) * | 1994-07-07 | 1998-12-01 | University Of Maryland Baltimore County | Glycohydrolase inhibitors, their preparation and use thereof |
| US6274597B1 (en) * | 1998-06-01 | 2001-08-14 | Mount Sinai School Of Medicine Of New York University | Method of enhancing lysosomal α-Galactosidase A |
-
2007
- 2007-05-23 DK DK07252109.9T patent/DK1860101T3/da active
- 2007-05-23 PT PT07252109T patent/PT1860101E/pt unknown
- 2007-05-23 DE DE602007013648T patent/DE602007013648D1/de active Active
- 2007-05-23 US US11/752,658 patent/US7501439B2/en active Active
- 2007-05-23 MX MX2007006175A patent/MX2007006175A/es active IP Right Grant
- 2007-05-23 AT AT07252109T patent/ATE504570T1/de active
- 2007-05-23 PL PL07252109T patent/PL1860101T3/pl unknown
- 2007-05-23 WO PCT/US2007/069550 patent/WO2007140212A2/en not_active Ceased
- 2007-05-23 EP EP07252109A patent/EP1860101B1/de not_active Not-in-force
- 2007-05-24 IL IL183415A patent/IL183415A/en active IP Right Grant
- 2007-05-24 BR BRPI0706114-5A patent/BRPI0706114A2/pt not_active Application Discontinuation
- 2007-05-24 JP JP2007138358A patent/JP5292605B2/ja not_active Expired - Fee Related
- 2007-05-24 AU AU2007202359A patent/AU2007202359B2/en not_active Ceased
- 2007-05-24 CA CA 2590122 patent/CA2590122C/en not_active Expired - Fee Related
-
2009
- 2009-02-23 US US12/391,049 patent/US7863453B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1860101B1 (de) | 2011-04-06 |
| JP2007314540A (ja) | 2007-12-06 |
| EP1860101A1 (de) | 2007-11-28 |
| JP5292605B2 (ja) | 2013-09-18 |
| WO2007140212A3 (en) | 2008-12-24 |
| BRPI0706114A2 (pt) | 2008-11-18 |
| US7501439B2 (en) | 2009-03-10 |
| US7863453B2 (en) | 2011-01-04 |
| MX2007006175A (es) | 2009-02-16 |
| US20070281975A1 (en) | 2007-12-06 |
| IL183415A0 (en) | 2007-09-20 |
| IL183415A (en) | 2012-03-29 |
| DE602007013648D1 (de) | 2011-05-19 |
| CA2590122C (en) | 2015-03-31 |
| WO2007140212A2 (en) | 2007-12-06 |
| PT1860101E (pt) | 2011-07-12 |
| US20090176830A1 (en) | 2009-07-09 |
| AU2007202359B2 (en) | 2012-02-16 |
| PL1860101T3 (pl) | 2011-10-31 |
| CA2590122A1 (en) | 2007-11-24 |
| DK1860101T3 (da) | 2011-07-25 |
| AU2007202359A1 (en) | 2007-12-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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