ATE504582T1 - Substituierte benzopyrane als selektive östrogenrezeptor-beta-agonisten - Google Patents
Substituierte benzopyrane als selektive östrogenrezeptor-beta-agonistenInfo
- Publication number
- ATE504582T1 ATE504582T1 AT05807448T AT05807448T ATE504582T1 AT E504582 T1 ATE504582 T1 AT E504582T1 AT 05807448 T AT05807448 T AT 05807448T AT 05807448 T AT05807448 T AT 05807448T AT E504582 T1 ATE504582 T1 AT E504582T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- sup
- alkyl
- estrogen receptor
- selective estrogen
- Prior art date
Links
- 150000001562 benzopyrans Chemical class 0.000 title 1
- 239000000900 selective estrogen receptor beta agonist Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 108010041356 Estrogen Receptor beta Proteins 0.000 abstract 2
- 102100029951 Estrogen receptor beta Human genes 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
- KYNSBQPICQTCGU-UHFFFAOYSA-N Benzopyrane Chemical compound C1=CC=C2C=CCOC2=C1 KYNSBQPICQTCGU-UHFFFAOYSA-N 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010021639 Incontinence Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000036576 Obstructive uropathy Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229940125388 beta agonist Drugs 0.000 abstract 1
- 208000029742 colonic neoplasm Diseases 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- -1 cyano, hydroxyl Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 208000000509 infertility Diseases 0.000 abstract 1
- 230000036512 infertility Effects 0.000 abstract 1
- 231100000535 infertility Toxicity 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 206010029446 nocturia Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000002327 urinary tract obstruction Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61962704P | 2004-10-18 | 2004-10-18 | |
| PCT/US2005/035472 WO2006044176A1 (en) | 2004-10-18 | 2005-10-05 | Substituted benzopyrans as selective estrogen receptor-beta agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE504582T1 true ATE504582T1 (de) | 2011-04-15 |
Family
ID=36010977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05807448T ATE504582T1 (de) | 2004-10-18 | 2005-10-05 | Substituierte benzopyrane als selektive östrogenrezeptor-beta-agonisten |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7354951B2 (de) |
| EP (1) | EP1805160B1 (de) |
| JP (1) | JP2008516949A (de) |
| AT (1) | ATE504582T1 (de) |
| CA (1) | CA2578300A1 (de) |
| DE (1) | DE602005027378D1 (de) |
| ES (1) | ES2361031T3 (de) |
| WO (1) | WO2006044176A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1626974B1 (de) * | 2003-04-21 | 2008-08-27 | Eli Lilly And Company | Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta |
| US8093302B2 (en) | 2005-02-15 | 2012-01-10 | Eli Lilly And Company | Substituted tetralins as selective estrogen receptor-β agonists |
| US9623021B2 (en) | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| KR101638035B1 (ko) | 2007-01-22 | 2016-07-11 | 지티엑스, 인코포레이티드 | 핵 수용체에 결합하는 물질 |
| US10154988B2 (en) | 2012-11-14 | 2018-12-18 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| CA2904767C (en) | 2013-03-15 | 2022-06-21 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
| US10806717B2 (en) | 2013-03-15 | 2020-10-20 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| CN105960236A (zh) | 2013-12-05 | 2016-09-21 | 卡罗医药股份公司 | 用于治疗间皮瘤的雌激素受体β激动剂 |
| EA034167B8 (ru) | 2015-05-22 | 2021-04-27 | Эйджинбайо, Инк. | Фармацевтические композиции леветирацетама пролонгированного высвобождения |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7214706B2 (en) | 2000-03-01 | 2007-05-08 | Akzo Nobel N.V. | Chroman derivatives as estrogenic compounds |
| DE60220179T2 (de) | 2001-11-19 | 2008-02-07 | Eli Lilly And Co., Indianapolis | Substituierte benzopyrane als selektive agonisten am östrogenrezeptor-beta |
| US6630508B1 (en) * | 2002-02-11 | 2003-10-07 | Eli Lilly And Company | Substituted benzopyrans as selective estrogen receptor β agonists |
| US7279499B2 (en) * | 2003-04-21 | 2007-10-09 | Eli Lilly And Company | Substituted benzopyrans as selective estrogen receptor-beta agonists |
| EP1626974B1 (de) * | 2003-04-21 | 2008-08-27 | Eli Lilly And Company | Substituierte benzopyrane als selektive antagonisten am östrogenrezeptor-beta |
-
2005
- 2005-10-05 AT AT05807448T patent/ATE504582T1/de not_active IP Right Cessation
- 2005-10-05 DE DE602005027378T patent/DE602005027378D1/de not_active Expired - Lifetime
- 2005-10-05 EP EP05807448A patent/EP1805160B1/de not_active Expired - Lifetime
- 2005-10-05 WO PCT/US2005/035472 patent/WO2006044176A1/en not_active Ceased
- 2005-10-05 CA CA002578300A patent/CA2578300A1/en not_active Abandoned
- 2005-10-05 JP JP2007536726A patent/JP2008516949A/ja not_active Ceased
- 2005-10-05 US US11/574,034 patent/US7354951B2/en not_active Expired - Fee Related
- 2005-10-05 ES ES05807448T patent/ES2361031T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US7354951B2 (en) | 2008-04-08 |
| EP1805160B1 (de) | 2011-04-06 |
| JP2008516949A (ja) | 2008-05-22 |
| CA2578300A1 (en) | 2006-04-27 |
| US20080064742A1 (en) | 2008-03-13 |
| DE602005027378D1 (de) | 2011-05-19 |
| EP1805160A1 (de) | 2007-07-11 |
| WO2006044176A1 (en) | 2006-04-27 |
| ES2361031T3 (es) | 2011-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |