ATE505481T1 - Fusionsproteine der tnf-superfamilie - Google Patents
Fusionsproteine der tnf-superfamilieInfo
- Publication number
- ATE505481T1 ATE505481T1 AT07801940T AT07801940T ATE505481T1 AT E505481 T1 ATE505481 T1 AT E505481T1 AT 07801940 T AT07801940 T AT 07801940T AT 07801940 T AT07801940 T AT 07801940T AT E505481 T1 ATE505481 T1 AT E505481T1
- Authority
- AT
- Austria
- Prior art keywords
- fusion proteins
- tnf superfamily
- present
- fusion protein
- tnfsf
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06017891A EP1894940A1 (de) | 2006-08-28 | 2006-08-28 | TNF Superfamilie Fusionsproteine |
| PCT/EP2007/007517 WO2008025516A2 (en) | 2006-08-28 | 2007-08-28 | Tnf superfamily fusion proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE505481T1 true ATE505481T1 (de) | 2011-04-15 |
Family
ID=37836940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07801940T ATE505481T1 (de) | 2006-08-28 | 2007-08-28 | Fusionsproteine der tnf-superfamilie |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8147843B2 (de) |
| EP (2) | EP1894940A1 (de) |
| JP (1) | JP5274464B2 (de) |
| AT (1) | ATE505481T1 (de) |
| AU (1) | AU2007291490A1 (de) |
| CA (2) | CA2860945C (de) |
| DE (1) | DE602007013920D1 (de) |
| WO (1) | WO2008025516A2 (de) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2484691B1 (de) | 2007-07-10 | 2016-01-13 | Apogenix GmbH | TNF-Superfamilie-Collectinfusionsproteine |
| EP2310409A2 (de) * | 2008-06-17 | 2011-04-20 | Apogenix GmbH | Multimere tnf-rezeptoren |
| US20110189194A1 (en) * | 2008-07-14 | 2011-08-04 | Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts | Use of cd95 inhibitors for the treatment of inflammatory disorders |
| PL2604693T3 (pl) | 2008-07-21 | 2016-09-30 | Jednołańcuchowe cząsteczki TNFSF | |
| WO2010078966A1 (en) | 2009-01-09 | 2010-07-15 | Apogenix Gmbh | Fusion proteins forming trimers |
| TWI476001B (zh) | 2011-12-26 | 2015-03-11 | Ind Tech Res Inst | 三倍體Fc融合蛋白及其用途 |
| EP2877205A4 (de) | 2012-07-26 | 2016-04-06 | Jackson H M Found Military Med | Impfstoff mit einem multimeren fusionsprotein und immuntherapeutikum |
| US10246503B2 (en) * | 2012-12-24 | 2019-04-02 | Beijing Anxinhuaide Biotech. Co., Ltd. | Method of improving the pharmacokinetic profile of a therapeutic polypeptide and the use thereof |
| NO2776305T3 (de) | 2014-04-23 | 2018-01-27 | ||
| BR102014031185A8 (pt) * | 2014-12-12 | 2021-05-04 | Fund De Amparo A Pesquisa Do Estado De Sao Paulo Fapesp | proteína recombinante indutora da apoptose; processo de obtenção da dita proteína e o seu uso no tratamento do câncer |
| PT3247728T (pt) | 2015-01-20 | 2020-07-16 | Igm Biosciences Inc | Moléculas de ligação do recetor da superfamília do fator de necrose tumoral (fnt) e utilização das mesmas |
| MA41460A (fr) | 2015-02-03 | 2017-12-12 | Oncomed Pharm Inc | Agents de liaison à la tnfrsf et leurs utilisations |
| EP3076179A1 (de) | 2015-03-30 | 2016-10-05 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Diagnose und behandlung von minderwertigen glioma |
| AU2016325482B2 (en) | 2015-09-23 | 2020-09-03 | Apogenix Ag | Anti-CD95L antibody |
| EP3374504B1 (de) * | 2015-11-09 | 2025-03-19 | CureVac SE | Optimierte nukleinsäuremoleküle |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| AU2018205234B2 (en) | 2017-01-06 | 2024-09-19 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes (TILs) with tumor necrosis factor receptor superfamily (TNFRSF) agonists and therapeutic combinations of TILs and TNFRSF agonists |
| ES3055314T3 (en) | 2017-01-06 | 2026-02-11 | Iovance Biotherapeutics Inc | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
| WO2018209115A1 (en) | 2017-05-10 | 2018-11-15 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof |
| TW201919662A (zh) | 2017-06-05 | 2019-06-01 | 美商艾歐凡斯生物治療公司 | 對雙重難治性黑色素瘤使用腫瘤浸潤性淋巴細胞之方法 |
| US11578315B2 (en) | 2017-08-11 | 2023-02-14 | The Board Of Trustees Of The University Of Illinois | Truncated guinea pig L-asparaginase variants and methods of use |
| JP7557367B2 (ja) | 2017-11-17 | 2024-09-27 | アイオバンス バイオセラピューティクス,インコーポレイテッド | 細針吸引及び小生検からのtil拡大培養 |
| JP2021503885A (ja) | 2017-11-22 | 2021-02-15 | アイオバンス バイオセラピューティクス,インコーポレイテッド | 末梢血からの末梢血リンパ球(pbl)の拡大培養 |
| EP3724885A2 (de) | 2017-12-15 | 2020-10-21 | Iovance Biotherapeutics, Inc. | Systeme und verfahren zur bestimmung der nützlichen verabreichung von tumorinfiltrierenden lymphozyten und verfahren zu deren verwendung sowie nützliche verabreichung von tumorinfiltrierenden lymphozyten und verfahren zu deren verwendung |
| US11713446B2 (en) | 2018-01-08 | 2023-08-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific T-cells |
| WO2019136459A1 (en) | 2018-01-08 | 2019-07-11 | Iovance Biotherapeutics, Inc. | Processes for generating til products enriched for tumor antigen-specific t-cells |
| EP3737743A1 (de) | 2018-01-08 | 2020-11-18 | Iovance Biotherapeutics, Inc. | Verfahren zur erzeugung von til-produkten, die für tumorantigenspezifische t-zellen angereichert sind |
| CA3090795A1 (en) | 2018-02-13 | 2019-08-22 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes (tils) with adenosine a2a receptor antagonists and therapeutic combinations of tils and adenosine a2a receptor antagonists |
| EA202092319A1 (ru) | 2018-03-29 | 2021-03-04 | Айовэнс Байотерапьютикс, Инк. | Способы получения опухоль-инфильтрирующих лимфоцитов и применения их в иммунотерапии |
| WO2019210131A1 (en) | 2018-04-27 | 2019-10-31 | Iovance Biotherapeutics, Inc. | Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| WO2019217753A1 (en) | 2018-05-10 | 2019-11-14 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| WO2020018715A1 (en) | 2018-07-17 | 2020-01-23 | Massachusetts Institute Of Technology | Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof |
| TW202031273A (zh) | 2018-08-31 | 2020-09-01 | 美商艾歐凡斯生物治療公司 | 抗pd-1抗體難治療性之非小細胞肺癌(nsclc)病患的治療 |
| SG11202101787XA (en) | 2018-09-20 | 2021-04-29 | Iovance Biotherapeutics Inc | Expansion of tils from cryopreserved tumor samples |
| CA3118493A1 (en) | 2018-11-05 | 2020-05-14 | Iovance Biotherapeutics, Inc. | Expansion of tils utilizing akt pathway inhibitors |
| BR112021008549A2 (pt) | 2018-11-05 | 2022-01-04 | Iovance Biotherapeutics Inc | Método de tratamento de carcinoma pulmonar de células não pequenas com uma população de linfócitos infiltrantes de tumor |
| IL282775B1 (en) | 2018-11-05 | 2026-05-01 | Iovance Biotherapeutics Inc | Selection of enhanced carrier-reactive T cells |
| US12453697B2 (en) | 2018-11-05 | 2025-10-28 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| WO2020131547A1 (en) | 2018-12-19 | 2020-06-25 | Iovance Biotherapeutics, Inc. | Methods of expanding tumor infiltrating lymphocytes using engineered cytokine receptor pairs and uses thereof |
| SG11202109331QA (en) | 2019-03-01 | 2021-09-29 | Iovance Biotherapeutics Inc | Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof |
| CN114269370A (zh) | 2019-03-29 | 2022-04-01 | 迈斯特治疗公司 | 离体产生t细胞治疗剂的方法以及相关的组合物和方法 |
| WO2020232029A1 (en) | 2019-05-13 | 2020-11-19 | Iovance Biotherapeutics, Inc. | Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| EP4048295A1 (de) | 2019-10-25 | 2022-08-31 | Iovance Biotherapeutics, Inc. | Genbearbeitung von tumorinfiltrierenden lymphozyten und deren verwendungen in der immuntherapie |
| IL293350A (en) | 2019-11-27 | 2022-07-01 | Myst Therapeutics Llc | Method of producing tumor-reactive t cell composition using modulatory agents |
| US12516291B2 (en) | 2019-12-11 | 2026-01-06 | Iovance Biotherapeutics, Inc. | Processes for the production of tumor infiltrating lymphocytes (TILs) and methods of using the same |
| EP4110799B1 (de) | 2020-02-27 | 2024-11-06 | Turnstone Biologics Corp. | Verfahren zur ex-vivo-anreicherung und vermehrung von tumorreaktiven t-zellen und verwandten zusammensetzungen davon |
| WO2021226061A1 (en) | 2020-05-04 | 2021-11-11 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| EP4146793A1 (de) | 2020-05-04 | 2023-03-15 | Iovance Biotherapeutics, Inc. | Auswahl von verbesserten tumorreaktiven t-zellen |
| CN116472280A (zh) * | 2020-08-24 | 2023-07-21 | 圣诺菲·帕斯图尔公司 | 针对SARS-CoV-2感染的疫苗 |
| KR20230054719A (ko) * | 2020-08-24 | 2023-04-25 | 사노피 파스퇴르 인크 | Sars-cov-2 감염에 대한 백신 |
| CA3195019A1 (en) | 2020-10-06 | 2022-04-14 | Maria Fardis | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| WO2022076606A1 (en) | 2020-10-06 | 2022-04-14 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
| JP2024501452A (ja) | 2020-12-11 | 2024-01-12 | アイオバンス バイオセラピューティクス,インコーポレイテッド | Braf阻害剤及び/またはmek阻害剤と併用した腫瘍浸潤リンパ球治療によるがん患者の治療 |
| JP2023554395A (ja) | 2020-12-17 | 2023-12-27 | アイオバンス バイオセラピューティクス,インコーポレイテッド | Ctla-4及びpd-1阻害剤と併用した腫瘍浸潤リンパ球療法による治療 |
| US20240123067A1 (en) | 2020-12-17 | 2024-04-18 | Iovance Biotherapeutics, Inc. | Treatment of cancers with tumor infiltrating lymphocyte therapies |
| US20240299540A1 (en) | 2021-02-05 | 2024-09-12 | Iovance Biotherapeutics, Inc. | Adjuvant therapy for cancer |
| JP2024509184A (ja) | 2021-03-05 | 2024-02-29 | アイオバンス バイオセラピューティクス,インコーポレイテッド | 腫瘍保存及び細胞培養組成物 |
| EP4314253A2 (de) | 2021-03-25 | 2024-02-07 | Iovance Biotherapeutics, Inc. | Verfahren und zusammensetzungen für t-zell-kokulturpotenztests und verwendung mit zelltherapieprodukten |
| AU2022263418A1 (en) | 2021-04-19 | 2023-10-26 | Iovance Biotherapeutics, Inc. | Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies |
| US20240269180A1 (en) | 2021-05-17 | 2024-08-15 | Iovance Biotherapeutics, Inc. | Pd-1 gene-edited tumor infiltrating lymphocytes and uses of same in immunotherapy |
| CN117396520A (zh) * | 2021-05-27 | 2024-01-12 | 北京安信怀德生物技术有限公司 | 包含两个trail三聚体的超trail分子 |
| CA3226942A1 (en) | 2021-07-28 | 2023-02-02 | Iovance Biotherapeutics, Inc. | Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors |
| US20250000903A1 (en) | 2021-09-24 | 2025-01-02 | Iovance Biotherapeutics, Inc. | Expansion processes and agents for tumor infiltrating lymphocytes |
| US20230187042A1 (en) | 2021-10-27 | 2023-06-15 | Iovance Biotherapeutics, Inc. | Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy |
| AU2022388729A1 (en) | 2021-11-10 | 2024-05-16 | Iovance Biotherapeutics, Inc. | Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes |
| JP2025503987A (ja) | 2022-01-28 | 2025-02-06 | アイオバンス バイオセラピューティクス,インコーポレイテッド | ペイロードを発現するように操作された腫瘍浸潤リンパ球 |
| EP4507704A1 (de) | 2022-04-15 | 2025-02-19 | Iovance Biotherapeutics, Inc. | Til-expansionsverfahren unter verwendung spezifischer zytokinkombinationen und/oder einer akti-behandlung |
| EP4565683A1 (de) | 2022-08-01 | 2025-06-11 | Iovance Biotherapeutics, Inc. | Chimäre kostimulatorische rezeptoren, chemokinrezeptoren und deren verwendung in zellulären immuntherapien |
| US20260124242A1 (en) | 2022-11-04 | 2026-05-07 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof |
| WO2024151885A1 (en) | 2023-01-13 | 2024-07-18 | Iovance Biotherapeutics, Inc. | Use of til as maintenance therapy for nsclc patients who achieved pr/cr after prior therapy |
| CN122070297A (zh) | 2023-10-06 | 2026-05-19 | 盐野义制药株式会社 | 冠状病毒刺突蛋白变体 |
| IL328125A (en) | 2023-11-06 | 2026-06-01 | Iovance Biotherapeutics Inc | Treatment of endometrial cancers with tumor infiltrating lymphocyte therapies |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001260633A1 (en) * | 2000-05-26 | 2001-12-03 | Mochida Pharmaceutical Co., Ltd. | Fas ligand-fused proteins |
-
2006
- 2006-08-28 EP EP06017891A patent/EP1894940A1/de not_active Withdrawn
-
2007
- 2007-08-28 CA CA2860945A patent/CA2860945C/en not_active Expired - Fee Related
- 2007-08-28 AT AT07801940T patent/ATE505481T1/de not_active IP Right Cessation
- 2007-08-28 JP JP2009525967A patent/JP5274464B2/ja not_active Expired - Fee Related
- 2007-08-28 AU AU2007291490A patent/AU2007291490A1/en not_active Abandoned
- 2007-08-28 CA CA2661599A patent/CA2661599C/en not_active Expired - Fee Related
- 2007-08-28 WO PCT/EP2007/007517 patent/WO2008025516A2/en not_active Ceased
- 2007-08-28 EP EP07801940A patent/EP2069392B1/de not_active Not-in-force
- 2007-08-28 US US12/439,486 patent/US8147843B2/en not_active Expired - Fee Related
- 2007-08-28 DE DE602007013920T patent/DE602007013920D1/de active Active
-
2012
- 2012-02-23 US US13/403,826 patent/US8580273B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2069392A2 (de) | 2009-06-17 |
| DE602007013920D1 (de) | 2011-05-26 |
| US8147843B2 (en) | 2012-04-03 |
| JP2010501191A (ja) | 2010-01-21 |
| JP5274464B2 (ja) | 2013-08-28 |
| EP2069392B1 (de) | 2011-04-13 |
| AU2007291490A1 (en) | 2008-03-06 |
| CA2860945C (en) | 2015-12-29 |
| WO2008025516A2 (en) | 2008-03-06 |
| US20110027218A1 (en) | 2011-02-03 |
| CA2661599C (en) | 2015-06-09 |
| US8580273B2 (en) | 2013-11-12 |
| US20120148527A1 (en) | 2012-06-14 |
| CA2860945A1 (en) | 2008-03-06 |
| CA2661599A1 (en) | 2008-03-06 |
| EP1894940A1 (de) | 2008-03-05 |
| WO2008025516A3 (en) | 2008-04-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE602007013920D1 (de) | Fusionsproteine der tnf-superfamilie | |
| WO2009007120A3 (en) | Tnf superfamily collectin fusion proteins | |
| WO2010003766A3 (en) | Multimeric tnf receptors | |
| CY1116288T1 (el) | Tnfsf απλης αλυσου μορια | |
| WO2009068627A3 (en) | Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same | |
| BR0315327A (pt) | Antagonistas de il-15 | |
| WO2008074867A3 (en) | Anti-fc-receptor single domain antibodies (nanobodies-tm) and therapeutic use | |
| DK1767546T3 (da) | Angiogenese-inhiberende kimært protein og dets anvendelse | |
| PH12015500806A1 (en) | Binding molecules to the human ox40 receptor | |
| WO2007104529A3 (en) | Amino acid sequences directed against il-6 and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling | |
| NO20053872L (no) | Fusjonskonstruksjoner og anvendelse av disse for fremstilling av antistoffer med okt FC-reseptorbindingsaffinitet og effektorfunksjon. | |
| WO2008066752A3 (en) | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir | |
| EA202092589A2 (ru) | Cxcr2-связывающие полипептиды | |
| UA113609C2 (xx) | Антигензв'язуючий білок, який зв'язує людський il-23 | |
| UA100682C2 (ru) | АНТИТЕЛО, КОТОРОЕ НЕЙТРАЛИЗУЕТ ЧЕЛОВЕЧЕСКИЙ ЦИТОМЕГАЛОВИРУС (hCMV), И ЕГО ПРИМЕНЕНИЕ | |
| ATE533782T1 (de) | Impfstoffe und immuntherapeutika mit codon- optimiertem il-15 und verwendungsverfahren dafür | |
| BR112014006390A2 (pt) | anticorpos, domínios variáveis e cadeias feitos especialmente para uso humano | |
| ECSP12011698A (es) | Anticuerpos cea | |
| WO2008077945A3 (en) | Anti-chemokine (ccl2, ccl3, ccl5, cxcl11, cxcl12) single-domain antibodies | |
| WO2009095489A3 (en) | Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling | |
| MX2010003055A (es) | Nuevas citocinas aviares y secuencias geneticas que las codifican. | |
| JP2010501191A5 (de) | ||
| CR20240493A (es) | Proteínas de fusión de hmpv de prefusión estabilizadas | |
| WO2005021578A3 (en) | A novel chimeric polypeptide and use thereof | |
| DK1051491T3 (da) | Equin Fc Epsilon receptor-alfa-kæde-nukleinsyremolekyler, korresponderende proteiner og anvendelse heraf |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |