ATE505484T1 - Trimer-proteine zur trimer-zytokine - Google Patents

Trimer-proteine zur trimer-zytokine

Info

Publication number
ATE505484T1
ATE505484T1 AT03769251T AT03769251T ATE505484T1 AT E505484 T1 ATE505484 T1 AT E505484T1 AT 03769251 T AT03769251 T AT 03769251T AT 03769251 T AT03769251 T AT 03769251T AT E505484 T1 ATE505484 T1 AT E505484T1
Authority
AT
Austria
Prior art keywords
trimer
cytokine
proteins
trimer proteins
trimer cytokine
Prior art date
Application number
AT03769251T
Other languages
English (en)
Inventor
Thor HOLTET
Mikkel Andersen
Helle Ottow
Original Assignee
Anaphore Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anaphore Inc filed Critical Anaphore Inc
Priority claimed from PCT/DK2003/000735 external-priority patent/WO2004039841A2/en
Application granted granted Critical
Publication of ATE505484T1 publication Critical patent/ATE505484T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT03769251T 2002-10-29 2003-10-29 Trimer-proteine zur trimer-zytokine ATE505484T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42180702P 2002-10-29 2002-10-29
DKPA200201634 2002-10-29
PCT/DK2003/000735 WO2004039841A2 (en) 2002-10-29 2003-10-29 Trimeric binding proteins for trimeric cytokines

Publications (1)

Publication Number Publication Date
ATE505484T1 true ATE505484T1 (de) 2011-04-15

Family

ID=35931707

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03769251T ATE505484T1 (de) 2002-10-29 2003-10-29 Trimer-proteine zur trimer-zytokine

Country Status (6)

Country Link
JP (1) JP4690044B2 (de)
CN (1) CN1720263A (de)
AT (1) ATE505484T1 (de)
DE (1) DE60336746D1 (de)
DK (1) DK1558640T3 (de)
ES (1) ES2367749T3 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102137869B (zh) * 2008-06-30 2018-07-06 宾夕法尼亚大学 Fn14/TRAIL融合蛋白
TWI476001B (zh) * 2011-12-26 2015-03-11 Ind Tech Res Inst 三倍體Fc融合蛋白及其用途
CN103172748B (zh) * 2013-01-29 2014-11-05 中国人民解放军第三军医大学 一种抗恶性淋巴瘤融合蛋白及其制备方法
EP3243836A1 (de) * 2016-05-11 2017-11-15 F. Hoffmann-La Roche AG C-terminal-fusionierte antigenbindende moleküle mit ligandentrimer der tnf-familie
CA3087476A1 (en) * 2018-01-10 2019-07-18 The General Hospital Corporation Immune cells expressing a chimeric antigen receptor
WO2022089426A1 (zh) * 2020-10-27 2022-05-05 细胞图谱有限公司 外周血样本分析方法和试剂盒

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT672141E (pt) * 1992-10-23 2003-09-30 Immunex Corp Metodos de preparacao de proteinas oligomericas soluveis
AU736707B2 (en) * 1997-06-11 2001-08-02 Anaphore, Inc. Trimerising module
US10183986B2 (en) * 2005-12-15 2019-01-22 Industrial Technology Research Institute Trimeric collagen scaffold antibodies

Also Published As

Publication number Publication date
DK1558640T3 (da) 2011-07-25
CN1720263A (zh) 2006-01-11
JP4690044B2 (ja) 2011-06-01
ES2367749T3 (es) 2011-11-08
DE60336746D1 (de) 2011-05-26
JP2006520318A (ja) 2006-09-07

Similar Documents

Publication Publication Date Title
DK1567112T3 (da) Thiazolidin-4-oner til at hæmme hYAK3-proteiner
SI1641823T1 (sl) Fuzijski proteini analogni glp-1
DK1543038T4 (da) Proteinoprensning
DE502004009865D1 (de) Ür knochen
DE602004022855D1 (de) Interleukin-10-antikörper
IL171109A (en) Glycopegylation methods and proteins/peptides produced by the methods
DK1711207T3 (da) Interferon-alpha-antistoffer og anvendelse heraf
ATE480567T1 (de) Hochkonzentrierter antikörper und proteinformulierungen
DK3722533T3 (da) Flisebelysningsfremgangsmåder og systemer
DE602004031341D1 (de) Multifunktionelle cytokine
EP1503795A4 (de) Verwendung von hitzschockproteinen zur verstärkung der wirksamkeit von antikörper-therapeutika
ATA19522003A (de) Gag-bindungsproteine
EP1460900A4 (de) Sezernierte humanproteine
DK1490404T3 (da) Laktoferrin
DK1658515T3 (da) Afisningsinformationssystem
DE60336746D1 (de) Trimer-proteine zur trimer-zytokine
AU2003304476A8 (en) Cyclic bis-compounds clearing malformed proteins
ATE450173T1 (de) Tischdecke
NO20054900D0 (no) Sekrert proteinfamilie
NO20053512D0 (no) IL-8-liknende proteiner
DK1706417T3 (da) Anvendelse pollenisolerede proteiner til inhibering af anthraxtoxinaktivitet
ATA522002A (de) Vmp-bindungsprotein
ATA18572003A (de) Analoguhr
FI20031368A0 (fi) Langaton toimistojärjestelmä ja ratkaisu
FIU20030451U0 (fi) Pakoporras

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties