ATE505559T1 - Produktion von polyhydroxyalkanoat mittels coenzym-a-abhängiger aldehyd-dehydrogenase-wege - Google Patents

Produktion von polyhydroxyalkanoat mittels coenzym-a-abhängiger aldehyd-dehydrogenase-wege

Info

Publication number: ATE505559T1
Authority: AT; Austria
Prior art keywords: coa; organism; aldehyde dehydrogenase; dependent aldehyde; pha
Prior art date: 2002-09-12

Application number

AT03749656T

Other languages

English (en)

Inventor

Frank Skraly

Original Assignee

Metabolix Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-12

Filing date

2003-09-12

Publication date

2011-04-15

2003-09-12 Application filed by Metabolix Inc filed Critical Metabolix Inc

2011-04-15 Application granted granted Critical

2011-04-15 Publication of ATE505559T1 publication Critical patent/ATE505559T1/de

Links

108020002663 Aldehyde Dehydrogenase Proteins 0.000 title abstract 6
102000005369 Aldehyde Dehydrogenase Human genes 0.000 title abstract 5
239000005014 poly(hydroxyalkanoate) Substances 0.000 title abstract 5
229920000903 polyhydroxyalkanoate Polymers 0.000 title abstract 3
230000037361 pathway Effects 0.000 title abstract 2
239000005515 coenzyme Substances 0.000 title 1
230000001419 dependent effect Effects 0.000 abstract 5
239000000178 monomer Substances 0.000 abstract 3
229920000642 polymer Polymers 0.000 abstract 3
REKYPYSUBKSCAT-UHFFFAOYSA-N 3-hydroxypentanoic acid Chemical compound CCC(O)CC(O)=O REKYPYSUBKSCAT-UHFFFAOYSA-N 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
HPMGFDVTYHWBAG-UHFFFAOYSA-N 3-hydroxyhexanoic acid Chemical compound CCCC(O)CC(O)=O HPMGFDVTYHWBAG-UHFFFAOYSA-N 0.000 abstract 1
ALRHLSYJTWAHJZ-UHFFFAOYSA-M 3-hydroxypropionate Chemical compound OCCC([O-])=O ALRHLSYJTWAHJZ-UHFFFAOYSA-M 0.000 abstract 1
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
FMHKPLXYWVCLME-UHFFFAOYSA-N 4-hydroxy-valeric acid Chemical compound CC(O)CCC(O)=O FMHKPLXYWVCLME-UHFFFAOYSA-N 0.000 abstract 1
SJZRECIVHVDYJC-UHFFFAOYSA-M 4-hydroxybutyrate Chemical compound OCCCC([O-])=O SJZRECIVHVDYJC-UHFFFAOYSA-M 0.000 abstract 1
PHOJOSOUIAQEDH-UHFFFAOYSA-N 5-hydroxypentanoic acid Chemical compound OCCCCC(O)=O PHOJOSOUIAQEDH-UHFFFAOYSA-N 0.000 abstract 1
241000588724 Escherichia coli Species 0.000 abstract 1
206010064571 Gene mutation Diseases 0.000 abstract 1
108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
108091034117 Oligonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
101150041588 eutE gene Proteins 0.000 abstract 1
108010010718 poly(3-hydroxyalkanoic acid) synthase Proteins 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- C12P7/625—Polyesters of hydroxy carboxylic acids

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Materials For Medical Uses (AREA)
Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Medicinal Preparation (AREA)
Prostheses (AREA)
Enzymes And Modification Thereof (AREA)
Adhesives Or Adhesive Processes (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT03749656T 2002-09-12 2003-09-12 Produktion von polyhydroxyalkanoat mittels coenzym-a-abhängiger aldehyd-dehydrogenase-wege ATE505559T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US41008702P	2002-09-12	2002-09-12
PCT/US2003/028842 WO2004024876A2 (en)	2002-09-12	2003-09-12	Polyhydroxyalkanoate production by coenzyme a-dependent aldehyde dehydrogenase pathways

Publications (1)

Publication Number	Publication Date
ATE505559T1 true ATE505559T1 (de)	2011-04-15

Family

ID=31994056

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03749656T ATE505559T1 (de)	2002-09-12	2003-09-12	Produktion von polyhydroxyalkanoat mittels coenzym-a-abhängiger aldehyd-dehydrogenase-wege

Country Status (8)

Country	Link
US (1)	US8071355B2 (de)
EP (2)	EP2365088B1 (de)
JP (2)	JP4628103B2 (de)
AT (1)	ATE505559T1 (de)
AU (1)	AU2003267185A1 (de)
DE (2)	DE10075400T8 (de)
ES (1)	ES2395053T3 (de)
WO (1)	WO2004024876A2 (de)

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TWI568847B (zh)	2007-03-16	2017-02-01	奇諾麥提卡公司	用於１，４-丁二醇及其前驅物之生物合成的組合物及方法
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WO2009157702A2 (ko) *	2008-06-24	2009-12-30	(주)Lg화학	폴리락테이트와 그 공중합체 생성능이 개선된 변이 미생물을 이용한 폴리락테이트와 그 공중합체의 제조방법
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CN102317437B (zh)	2008-12-12	2013-08-21	麦特波力克斯公司	用于制备聚(5-羟基戊酸)和5碳化合物的绿色工艺和组合物
KR101293886B1 (ko) *	2009-02-05	2013-08-07	주식회사 엘지화학	폴리락틱산 또는 폴리락틱산 공중합체 생성능을 지닌 재조합 랄스토니아 유트로파 및 이것을 이용하여 폴리락틱산 또는 폴리락틱산 공중합체를 제조하는 방법
PL2438036T3 (pl) *	2009-06-04	2017-09-29	Genomatica, Inc.	Sposób oddzielania składników brzeczki fermentacyjnej
BRPI1010581A2 (pt)	2009-06-04	2016-11-08	Genomatica Inc	micro-organismos para a produção de 1,4-butanodiol e métodos relacionados
AU2010306785B2 (en) *	2009-10-13	2016-01-14	Genomatica, Inc.	Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA, putrescine and related compounds, and methods related thereto
US8530210B2 (en)	2009-11-25	2013-09-10	Genomatica, Inc.	Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
US8048661B2 (en) *	2010-02-23	2011-11-01	Genomatica, Inc.	Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US8637286B2 (en)	2010-02-23	2014-01-28	Genomatica, Inc.	Methods for increasing product yields
FR2964014B1 (fr) *	2010-08-31	2013-04-05	Ifremer	Nucleus enrobe d'un revetement filmogene aux proprietes antibacteriennes et cicatrisantes et procede d'obtention.
FR2968506B1 (fr) *	2010-12-14	2013-02-08	Ifremer	Nucleus recouvert de pha
CN102212501B (zh) *	2011-03-31	2013-06-12	山东大学	一种重组大肠杆菌及应用其以单一碳源生产phbv的方法
EP2702138A2 (de) *	2011-04-29	2014-03-05	Metabolix, Inc.	Grünes verfahren zur herstellung von polyhydroxyalkanoaten und chemikalien unter verwendung eines erneuerbaren rohstoffes
CN103890185A (zh)	2011-08-19	2014-06-25	基因组股份公司	用于生产2,4-戊二烯酸、丁二烯、丙烯、1,3-丁二醇和相关醇的微生物和方法
WO2013067432A1 (en)	2011-11-02	2013-05-10	Genomatica, Inc.	Microorganisms and methods for the production of caprolactone
CN111705028A (zh)	2012-06-04	2020-09-25	基因组股份公司	制造4-羟基丁酸酯、1，4-丁二醇和相关化合物的微生物和方法
MY195138A (en)	2012-10-15	2023-01-11	Genomatica Inc	Microorganisms and Methods for Production of Specific Length Fatty Alcohols and Related Compounds
WO2014152434A2 (en)	2013-03-15	2014-09-25	Genomatica, Inc.	Microorganisms and methods for producing butadiene and related compounds by formate assimilation
WO2015077752A1 (en)	2013-11-25	2015-05-28	Genomatica, Inc.	Methods for enhancing microbial production of specific length fatty alcohols in the presence of methanol
US10487342B2 (en)	2014-07-11	2019-11-26	Genomatica, Inc.	Microorganisms and methods for the production of butadiene using acetyl-CoA
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2003
- 2003-09-12 AT AT03749656T patent/ATE505559T1/de not_active IP Right Cessation
- 2003-09-12 DE DE10075400T patent/DE10075400T8/de active Active
- 2003-09-12 EP EP10075400.1A patent/EP2365088B1/de not_active Expired - Lifetime
- 2003-09-12 US US10/661,939 patent/US8071355B2/en active Active
- 2003-09-12 WO PCT/US2003/028842 patent/WO2004024876A2/en not_active Ceased
- 2003-09-12 DE DE60336757T patent/DE60336757D1/de not_active Expired - Lifetime
- 2003-09-12 ES ES10075400.1T patent/ES2395053T3/es not_active Expired - Lifetime
- 2003-09-12 EP EP03749656A patent/EP1581619B1/de not_active Expired - Lifetime
- 2003-09-12 JP JP2004536287A patent/JP4628103B2/ja not_active Expired - Lifetime
- 2003-09-12 AU AU2003267185A patent/AU2003267185A1/en not_active Abandoned
2010
- 2010-06-16 JP JP2010137010A patent/JP2010268797A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
EP2365088B1 (de)	2015-05-27
EP2365088A2 (de)	2011-09-14
JP4628103B2 (ja)	2011-02-09
EP1581619A2 (de)	2005-10-05
EP1581619A4 (de)	2007-02-14
US20040106176A1 (en)	2004-06-03
WO2004024876A2 (en)	2004-03-25
WO2004024876A3 (en)	2006-05-26
DE10075400T8 (de)	2013-04-25
AU2003267185A1 (en)	2004-04-30
DE10075400T1 (de)	2012-10-11
ES2395053T1 (es)	2013-02-07
JP2006507811A (ja)	2006-03-09
AU2003267185A8 (en)	2004-04-30
EP2365088A3 (de)	2012-01-11
DE60336757D1 (de)	2011-05-26
US8071355B2 (en)	2011-12-06
ES2395053T3 (es)	2015-10-08
EP1581619B1 (de)	2011-04-13
JP2010268797A (ja)	2010-12-02

Legal Events

Date	Code	Title	Description
2011-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60336757D1 (de)	2011-05-26	Produktion von polyhydroxyalkanoat mittels coenzym-a-abhängiger aldehyd-dehydrogenase-wege
DK2201115T4 (en)	2016-11-07	Mutants with ability to produce 1,4-butanediol and the process for producing 1,4-butanediol by the use thereof
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ATE385521T1 (de)	2008-02-15	Herstellung von polyhydroxyalkanoaten aus polyolen
JP4264819B2 (ja)	2009-05-20	生分解性ポリエステルの製造方法
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