ATE506349T1 - Verfahren zur herstellung von 7-chinolinyl-3,5- dihydroxyhept-6-enoat - Google Patents

Verfahren zur herstellung von 7-chinolinyl-3,5- dihydroxyhept-6-enoat

Info

Publication number: ATE506349T1
Authority: AT; Austria
Prior art keywords: formula; dihydroxyhept; enoate; chem; compound represented
Prior art date: 2001-04-05

Application number

AT02707129T

Other languages

English (en)

Inventor

Kenichi Tokunaga

Masami Kozawa

Kenji Suzuki

Original Assignee

Nissan Chemical Ind Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-05

Filing date

2002-03-22

Publication date

2011-05-15

2002-03-22 Application filed by Nissan Chemical Ind Ltd filed Critical Nissan Chemical Ind Ltd

2011-05-15 Application granted granted Critical

2011-05-15 Publication of ATE506349T1 publication Critical patent/ATE506349T1/de

Links

NEHKARMWCGDCNP-UHFFFAOYSA-N 3,5-dihydroxy-7-quinolin-2-ylhept-6-enoic acid Chemical compound C1=CC=CC2=NC(C=CC(O)CC(O)CC(O)=O)=CC=C21 NEHKARMWCGDCNP-UHFFFAOYSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000007864 aqueous solution Substances 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
150000001639 boron compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
239000012279 sodium borohydride Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Quinoline Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT02707129T 2001-04-05 2002-03-22 Verfahren zur herstellung von 7-chinolinyl-3,5- dihydroxyhept-6-enoat ATE506349T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2001106820		2001-04-05
PCT/JP2002/002779 WO2002081451A1 (en)	2001-04-05	2002-03-22	Method for preparing 7-quinolinyl-3,5-dihydroxyhept-6-enoate

Publications (1)

Publication Number	Publication Date
ATE506349T1 true ATE506349T1 (de)	2011-05-15

Family

ID=18959261

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02707129T ATE506349T1 (de)	2001-04-05	2002-03-22	Verfahren zur herstellung von 7-chinolinyl-3,5- dihydroxyhept-6-enoat

Country Status (21)

Country	Link
US (1)	US7038056B2 (de)
EP (1)	EP1375485B1 (de)
JP (1)	JP4380160B2 (de)
KR (1)	KR100838135B1 (de)
CN (1)	CN1241914C (de)
AT (1)	ATE506349T1 (de)
AU (1)	AU2002241271B2 (de)
CA (1)	CA2442713C (de)
CZ (1)	CZ20032633A3 (de)
DE (1)	DE60239793D1 (de)
HU (1)	HUP0401401A3 (de)
IL (2)	IL158151A0 (de)
MX (1)	MXPA03009095A (de)
NO (1)	NO326089B1 (de)
NZ (1)	NZ528149A (de)
RU (1)	RU2260001C2 (de)
SK (1)	SK287922B6 (de)
TW (1)	TWI317356B (de)
UA (1)	UA76984C2 (de)
WO (1)	WO2002081451A1 (de)
ZA (1)	ZA200307704B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN100445267C (zh) *	2005-10-21	2008-12-24	上海医药工业研究院	4-(4-氟-苯基)-3-羟甲基-2-环丙基-喹啉的制备方法
KR101160152B1 (ko) *	2009-02-24	2012-06-27	한미사이언스 주식회사	스타틴 화합물 또는 그 염의 신규 제조방법, 및 이에 사용되는 중간체 화합물

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4248882A (en) *	1980-02-12	1981-02-03	Pfizer Inc.	Treating diabetes-associated complications with hydantoin amines
US4645854A (en) *	1985-04-25	1987-02-24	Merck & Co., Inc.	Process for preparing HMG-CoA reductase inhibitors with a 3,5-dihydroxypentanoate subunit
DE3580863D1 (de)	1984-06-04	1991-01-24	Merck & Co Inc	Herstellungsverfahren von hemmstoffen der hmg-coa-reduktase mit einer 3,5-dihydroxypentanoatteilstruktur.
JP2569746B2 (ja) *	1987-08-20	1997-01-08	日産化学工業株式会社	キノリン系メバロノラクトン類
CA1336714C (en)	1987-08-20	1995-08-15	Yoshihiro Fujikawa	Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis
US5753675A (en) *	1989-03-03	1998-05-19	Novartis Pharmaceuticals Corporation	Quinoline analogs of mevalonolactone and derivatives thereof
JP3528186B2 (ja) *	1991-06-24	2004-05-17	日産化学工業株式会社	光学活性キノリンメバロン酸のジアステレオマー塩
JP3130342B2 (ja) *	1991-10-04	2001-01-31	日産化学工業株式会社	動脈硬化性血管内膜肥厚抑制薬
JP3554036B2 (ja) *	1994-09-06	2004-08-11	宇部興産株式会社	光学活性な７−置換キノリル−３，５−ジヒドロキシ−ヘプト−６−エン酸エステル誘導体の製造方法
ES2284219T3 (es) *	1997-12-19	2007-11-01	Pfizer Ireland Pharmaceuticals	Procedimiento de sintesis de 1,3-dioles.
JP4236463B2 (ja) *	2000-10-13	2009-03-11	ダイセル化学工業株式会社	光学活性な（３ｒ，５ｓ，６ｅ）−７−［２−シクロプロピル−４−（４−フルオロフェニル）キノリン−３−イル］−３，５−ジヒドロキシ−６−ヘプテン酸エチルの製造方法
KR100883874B1 (ko) *	2001-02-02	2009-02-17	미쯔비시 가가꾸 가부시끼가이샤	(3ｒ,5ｓ)-(ｅ)-7-[2-시클로프로필-4-(4-플루오로페닐)-퀴노린-3-일]-3,5-디하이드록시헵트-6-엔산 에스테르류의 제조방법

2002
- 2002-03-22 UA UA2003098877A patent/UA76984C2/uk unknown
- 2002-03-22 NZ NZ528149A patent/NZ528149A/en not_active IP Right Cessation
- 2002-03-22 AT AT02707129T patent/ATE506349T1/de not_active IP Right Cessation
- 2002-03-22 SK SK1237-2003A patent/SK287922B6/sk not_active IP Right Cessation
- 2002-03-22 EP EP02707129A patent/EP1375485B1/de not_active Expired - Lifetime
- 2002-03-22 KR KR1020037012898A patent/KR100838135B1/ko not_active Expired - Fee Related
- 2002-03-22 CA CA2442713A patent/CA2442713C/en not_active Expired - Fee Related
- 2002-03-22 CZ CZ20032633A patent/CZ20032633A3/cs unknown
- 2002-03-22 RU RU2003132440/04A patent/RU2260001C2/ru not_active IP Right Cessation
- 2002-03-22 AU AU2002241271A patent/AU2002241271B2/en not_active Ceased
- 2002-03-22 US US10/473,132 patent/US7038056B2/en not_active Expired - Fee Related
- 2002-03-22 CN CNB028078454A patent/CN1241914C/zh not_active Expired - Fee Related
- 2002-03-22 DE DE60239793T patent/DE60239793D1/de not_active Expired - Lifetime
- 2002-03-22 WO PCT/JP2002/002779 patent/WO2002081451A1/ja not_active Ceased
- 2002-03-22 IL IL15815102A patent/IL158151A0/xx unknown
- 2002-03-22 MX MXPA03009095A patent/MXPA03009095A/es active IP Right Grant
- 2002-03-22 JP JP2002579439A patent/JP4380160B2/ja not_active Expired - Lifetime
- 2002-03-22 HU HU0401401A patent/HUP0401401A3/hu unknown
- 2002-04-02 TW TW091106610A patent/TWI317356B/zh active
2003
- 2003-09-29 IL IL158151A patent/IL158151A/en not_active IP Right Cessation
- 2003-10-02 ZA ZA200307704A patent/ZA200307704B/xx unknown
- 2003-10-03 NO NO20034438A patent/NO326089B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
HUP0401401A2 (hu)	2004-12-28
JPWO2002081451A1 (ja)	2004-07-29
JP4380160B2 (ja)	2009-12-09
NO20034438D0 (no)	2003-10-03
NZ528149A (en)	2005-05-27
NO326089B1 (no)	2008-09-15
CN1241914C (zh)	2006-02-15
IL158151A0 (en)	2004-03-28
RU2260001C2 (ru)	2005-09-10
EP1375485B1 (de)	2011-04-20
CA2442713A1 (en)	2002-10-17
SK287922B6 (sk)	2012-04-03
RU2003132440A (ru)	2005-01-10
EP1375485A4 (de)	2005-03-23
NO20034438L (no)	2003-10-03
SK12372003A3 (sk)	2004-04-06
IL158151A (en)	2009-09-22
CZ20032633A3 (cs)	2003-12-17
UA76984C2 (en)	2006-10-16
AU2002241271B2 (en)	2007-01-25
CA2442713C (en)	2010-05-18
EP1375485A1 (de)	2004-01-02
TWI317356B (de)	2009-11-21
US7038056B2 (en)	2006-05-02
HUP0401401A3 (en)	2012-05-02
US20050014947A1 (en)	2005-01-20
WO2002081451A1 (en)	2002-10-17
ZA200307704B (en)	2004-10-04
MXPA03009095A (es)	2004-02-12
DE60239793D1 (de)	2011-06-01
CN1500079A (zh)	2004-05-26
KR20030086342A (ko)	2003-11-07
KR100838135B1 (ko)	2008-06-13

Legal Events

Date	Code	Title	Description
2011-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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