ATE506450T1 - Synthese von oligosacchariden, glykolipiden und glykoproteinen unter verwendung bakterieller glykosyltransferasen - Google Patents
Synthese von oligosacchariden, glykolipiden und glykoproteinen unter verwendung bakterieller glykosyltransferasenInfo
- Publication number
- ATE506450T1 ATE506450T1 AT03766005T AT03766005T ATE506450T1 AT E506450 T1 ATE506450 T1 AT E506450T1 AT 03766005 T AT03766005 T AT 03766005T AT 03766005 T AT03766005 T AT 03766005T AT E506450 T1 ATE506450 T1 AT E506450T1
- Authority
- AT
- Austria
- Prior art keywords
- glycolipids
- glycoproteins
- oligosaccharides
- synthesis
- glycosyl transferases
- Prior art date
Links
- 229930186217 Glycolipid Natural products 0.000 title abstract 2
- 102000003886 Glycoproteins Human genes 0.000 title abstract 2
- 108090000288 Glycoproteins Proteins 0.000 title abstract 2
- 229920001542 oligosaccharide Polymers 0.000 title abstract 2
- 150000002482 oligosaccharides Chemical class 0.000 title abstract 2
- 102000051366 Glycosyltransferases Human genes 0.000 title 1
- 108700023372 Glycosyltransferases Proteins 0.000 title 1
- 230000001580 bacterial effect Effects 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 108700014210 glycosyltransferase activity proteins Proteins 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 102000006471 Fucosyltransferases Human genes 0.000 abstract 2
- 108010019236 Fucosyltransferases Proteins 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39815602P | 2002-07-23 | 2002-07-23 | |
| US42489402P | 2002-11-08 | 2002-11-08 | |
| PCT/US2003/023155 WO2004009793A2 (en) | 2002-07-23 | 2003-07-23 | Synthesis of glycoproteins using bacterial gycosyltransferases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE506450T1 true ATE506450T1 (de) | 2011-05-15 |
Family
ID=30773066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03766005T ATE506450T1 (de) | 2002-07-23 | 2003-07-23 | Synthese von oligosacchariden, glykolipiden und glykoproteinen unter verwendung bakterieller glykosyltransferasen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7524655B2 (de) |
| EP (1) | EP1539989B1 (de) |
| JP (1) | JP2005533525A (de) |
| AT (1) | ATE506450T1 (de) |
| AU (2) | AU2003256754A1 (de) |
| CA (1) | CA2493258C (de) |
| DE (1) | DE60336826D1 (de) |
| MX (1) | MXPA05000872A (de) |
| NZ (1) | NZ538439A (de) |
| WO (2) | WO2004009838A2 (de) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
| NZ542094A (en) | 2003-03-14 | 2008-12-24 | Neose Technologies Inc | Branched polymer conjugates comprising a peptide and water-soluble polymer chains |
| US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
| PL1615945T3 (pl) | 2003-04-09 | 2012-03-30 | Ratiopharm Gmbh | Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami |
| JP2007523630A (ja) | 2003-05-09 | 2007-08-23 | ネオス テクノロジーズ インコーポレイテッド | ヒト成長ホルモングリコシル化突然変異体の組成と調合法 |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
| US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
| US7842661B2 (en) | 2003-11-24 | 2010-11-30 | Novo Nordisk A/S | Glycopegylated erythropoietin formulations |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| US7956032B2 (en) | 2003-12-03 | 2011-06-07 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| NZ548123A (en) | 2004-01-08 | 2010-05-28 | Novo Nordisk As | O-linked glycosylation of peptides |
| US20080300173A1 (en) | 2004-07-13 | 2008-12-04 | Defrees Shawn | Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1] |
| WO2006031811A2 (en) | 2004-09-10 | 2006-03-23 | Neose Technologies, Inc. | Glycopegylated interferon alpha |
| WO2006050247A2 (en) | 2004-10-29 | 2006-05-11 | Neose Technologies, Inc. | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
| US9029331B2 (en) | 2005-01-10 | 2015-05-12 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| WO2006121569A2 (en) | 2005-04-08 | 2006-11-16 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| US8278069B2 (en) | 2005-04-11 | 2012-10-02 | National Research Council Of Canada | Identification of a β-1,3-N-acetylgalactosaminyltransferase (CGTE) from Campylobacter jejuni LIO87 |
| EP2975135A1 (de) | 2005-05-25 | 2016-01-20 | Novo Nordisk A/S | Glykopegylierter Faktor IX |
| FI20055398A0 (fi) | 2005-07-08 | 2005-07-08 | Suomen Punainen Risti Veripalv | Menetelmä solupopulaatioiden evaluoimiseksi |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| US8969033B2 (en) * | 2005-11-02 | 2015-03-03 | Battelle Energy Alliance, Llc | Alteration and modulation of protein activity by varying post-translational modification |
| WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
| EP2049144B8 (de) | 2006-07-21 | 2015-02-18 | ratiopharm GmbH | Glycosylierung von peptiden über o-verbundene glycosylierungssequenzen |
| EP2054521A4 (de) | 2006-10-03 | 2012-12-19 | Novo Nordisk As | Verfahren zur reinigung von polypeptid-konjugate |
| HRP20130382T1 (hr) | 2007-04-03 | 2013-05-31 | Biogenerix Ag | Postupci lijeäśenja pomoä†u glikopegiliranog g-csf |
| CA2690611C (en) | 2007-06-12 | 2015-12-08 | Novo Nordisk A/S | Improved process for the production of nucleotide sugars |
| US8207112B2 (en) | 2007-08-29 | 2012-06-26 | Biogenerix Ag | Liquid formulation of G-CSF conjugate |
| US7923234B2 (en) * | 2008-01-25 | 2011-04-12 | Battelle Energy Alliance, Llc | Thermal and acid tolerant beta-xylosidases, genes encoding, related organisms, and methods |
| US8492114B2 (en) | 2008-01-25 | 2013-07-23 | Battelle Energy Alliance, Llc | Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes |
| US9732330B2 (en) | 2008-01-25 | 2017-08-15 | Battelle Energy Alliance, Llc | Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes |
| US8497110B2 (en) * | 2008-01-31 | 2013-07-30 | Battelle Energy Alliance, Llc | Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods |
| NZ585950A (en) | 2008-01-31 | 2012-06-29 | Battelle Energy Alliance Llc | Thermophilic and thermoacidophilic biopolymer- degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods |
| US8557557B2 (en) * | 2008-01-31 | 2013-10-15 | Battelle Energy Alliance, Llc | Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from Alicyclobacillus acidocaldarius and related organisms, methods |
| US8426185B2 (en) * | 2008-01-31 | 2013-04-23 | Battelle Energy Alliance, Llc | Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from Alicyclobacillus acidocaldarius and related organisms, methods |
| MX2010008575A (es) * | 2008-02-22 | 2010-12-07 | Battelle Energy Alliance Llc | Control transcripcional en alicyclobacillus acidocaldarius y genes, proteinas y metodos asociados. |
| BRPI0907629A2 (pt) | 2008-02-26 | 2019-01-15 | Battelle Energy Alliance Llc | enzimas e genes transportadores de açúcar termoacidofílico e termofílico de alicyclobacillus acidocaldarius e organismos relacionados e métodos |
| JP2011517931A (ja) * | 2008-02-27 | 2011-06-23 | バテル エナジー アライアンス,エルエルシー | アリサイクロバチルス・アシドカルダリウスおよび関連生物体からの好熱性および好熱好酸性グリコシル化遺伝子および酵素、方法 |
| PL2257311T3 (pl) | 2008-02-27 | 2014-09-30 | Novo Nordisk As | Koniugaty cząsteczek czynnika VIII |
| EP2245143A4 (de) * | 2008-02-28 | 2013-07-31 | Battelle Energy Alliance Llc | Thermophile und thermoacidophile stoffwechselgene und enzyme aus alicyclobacillus acidocaldarius sowie entsprechende organismen und verfahren |
| EP2166085A1 (de) | 2008-07-16 | 2010-03-24 | Suomen Punainen Risti Veripalvelu | Divalente modifizierte Zellen |
| US8827992B2 (en) | 2010-03-26 | 2014-09-09 | Aesculap Ag | Impedance mediated control of power delivery for electrosurgery |
| US20110275135A1 (en) | 2010-05-05 | 2011-11-10 | Battelle Energy Alliance, Llc | Genetic elements, proteins, and associated methods including application of additional genetic information to gram (+) thermoacidophiles |
| CN107001528A (zh) * | 2014-07-09 | 2017-08-01 | 米德瑞(美国)有限公司 | 低聚糖组合物及其制备方法 |
| AU2015315110B2 (en) * | 2014-09-09 | 2021-04-08 | Glycosyn LLC | Alpha (1,3) fucosyltransferases for use in the production of fucosylated oligosaccharides |
| PT3071235T (pt) | 2015-01-26 | 2018-02-21 | Kaleido Biosciences Inc | Produtos terapêuticos de glicanos e respetivos métodos relacionados |
| HK1246600B (en) | 2015-01-26 | 2020-04-09 | Cadena Bio, Inc. | Oligosaccharide compositions for use animal feed and methods of producing thereof |
| CA2983236A1 (en) | 2015-04-23 | 2016-10-27 | Kaleido Biosciences, Inc. | Glycan therapeutics and methods of treatment |
| CN109312379B (zh) | 2016-04-05 | 2022-04-12 | 科学与工业研究委员会 | 多功能重组核苷酸依赖性糖基转移酶蛋白及其糖基化的方法 |
| IL272987B (en) | 2017-09-04 | 2022-08-01 | 89Bio Ltd | fgf-21 mutant peptide conjugates and uses thereof |
| EP3703705B1 (de) | 2017-11-03 | 2024-05-15 | DSM Nutritional Products, LLC | Glukose-enthaltende glykanpräparate zur behandlung der hyperammonämie |
| WO2019090181A1 (en) | 2017-11-03 | 2019-05-09 | Kaleido Biosciences, Inc. | Methods of producing glycan polymers |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4935349A (en) | 1986-01-17 | 1990-06-19 | Zymogenetics, Inc. | Expression of higher eucaryotic genes in aspergillus |
| US5272066A (en) | 1986-03-07 | 1993-12-21 | Massachusetts Institute Of Technology | Synthetic method for enhancing glycoprotein stability |
| US5595900A (en) | 1990-02-14 | 1997-01-21 | The Regents Of The University Of Michigan | Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules, and for the isolation of cloned genetic sequences that determine these structures |
| EP0576592B1 (de) | 1991-03-18 | 2000-05-31 | The Scripps Research Institute | Oligosaccharide als enzymsubstrate und -inhibitoren: verfahren und zusammensetzungen |
| KR950704497A (ko) | 1992-11-27 | 1995-11-20 | 베르너 발데크 | 글리코실트랜스퍼라제 활성을 가진 단백질(Proteins Having Glycosyltransferase Activity) |
| US5409817A (en) | 1993-05-04 | 1995-04-25 | Cytel, Inc. | Use of trans-sialidase and sialyltransferase for synthesis of sialylα2→3βgalactosides |
| US5374541A (en) | 1993-05-04 | 1994-12-20 | The Scripps Research Institute | Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides |
| US5426039A (en) | 1993-09-08 | 1995-06-20 | Bio-Rad Laboratories, Inc. | Direct molecular cloning of primer extended DNA containing an alkane diol |
| KR20000068934A (ko) | 1996-11-08 | 2000-11-25 | 스티븐 로쓰 | 개선된 발현 벡터 |
| AU8005098A (en) * | 1997-06-06 | 1998-12-21 | Governors Of The University Of Alberta, The | Alpha1,3-fucosyltransferase of helicobacter pylori |
| US6500661B1 (en) | 1998-01-15 | 2002-12-31 | Neose Technologies, Inc. | Enzymatic conversion of GDP-mannose to GDP-fucose |
-
2003
- 2003-07-23 AT AT03766005T patent/ATE506450T1/de not_active IP Right Cessation
- 2003-07-23 WO PCT/US2003/023057 patent/WO2004009838A2/en not_active Ceased
- 2003-07-23 WO PCT/US2003/023155 patent/WO2004009793A2/en not_active Ceased
- 2003-07-23 EP EP03766005A patent/EP1539989B1/de not_active Expired - Lifetime
- 2003-07-23 NZ NZ538439A patent/NZ538439A/en not_active IP Right Cessation
- 2003-07-23 MX MXPA05000872A patent/MXPA05000872A/es not_active Application Discontinuation
- 2003-07-23 US US10/521,138 patent/US7524655B2/en not_active Expired - Fee Related
- 2003-07-23 DE DE60336826T patent/DE60336826D1/de not_active Expired - Lifetime
- 2003-07-23 JP JP2005505547A patent/JP2005533525A/ja active Pending
- 2003-07-23 AU AU2003256754A patent/AU2003256754A1/en not_active Abandoned
- 2003-07-23 CA CA2493258A patent/CA2493258C/en not_active Expired - Fee Related
- 2003-07-23 AU AU2003254139A patent/AU2003254139A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1539989A2 (de) | 2005-06-15 |
| NZ538439A (en) | 2007-02-23 |
| WO2004009793A3 (en) | 2004-05-13 |
| US20070148728A1 (en) | 2007-06-28 |
| EP1539989B1 (de) | 2011-04-20 |
| WO2004009838A3 (en) | 2006-04-06 |
| US7524655B2 (en) | 2009-04-28 |
| CA2493258A1 (en) | 2004-01-29 |
| AU2003254139A1 (en) | 2004-02-09 |
| WO2004009838A2 (en) | 2004-01-29 |
| MXPA05000872A (es) | 2005-04-28 |
| WO2004009793A2 (en) | 2004-01-29 |
| CA2493258C (en) | 2015-10-20 |
| JP2005533525A (ja) | 2005-11-10 |
| AU2003256754A1 (en) | 2004-02-09 |
| DE60336826D1 (de) | 2011-06-01 |
| AU2003254139A8 (en) | 2004-02-09 |
| EP1539989A4 (de) | 2006-09-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60336826D1 (de) | Synthese von oligosacchariden, glykolipiden und glykoproteinen unter verwendung bakterieller glykosyltransferasen | |
| ATE222294T1 (de) | Verbesserte verfahren zur enzymatischen synthese von oligosacchariden | |
| DE60028541D1 (de) | Campylobacter glycolsyltransferasen zur verwendung bei der biosynthese von gangliosiden und ganglioside imitatoren | |
| BR9810870A (pt) | Regulação de expressão de quinolato fosforibosil transferase | |
| ATE303435T1 (de) | Alternansucrase-kodierende nukleinsäure moleküle | |
| ZA200603731B (en) | Plasmid system for multiple expression | |
| MY147970A (en) | 2'-fluoro-2'deoxytetrahydrouridines as cytidine deaminase inhibitors | |
| NO20054185D0 (no) | Methods of radiofluorination of biologically active vectors | |
| ATE477224T1 (de) | Verwendung von miniatursierten vorrichtungen zur herstellung von radiomarkierten verbindungen | |
| IL190665B (en) | Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human cd38 | |
| NO20042570L (no) | Antimikrobielle polypeptider fra Pseudoplectania nigrella | |
| NO20082783L (no) | Induserbare ekspresjonssystemer | |
| ITRM20030376A1 (it) | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. | |
| LTPA2018502I1 (lt) | Per burną vartojamos kladribino kompozicijos | |
| ATE532861T1 (de) | Expressionsvektor | |
| WO2005069921A3 (en) | H. pylori fucosyltransferases | |
| DK1458869T3 (da) | Alleler af glucokinasegenet af coryneforme bakterier | |
| MXPA04003969A (es) | Sistema de expresion de acido nucleico regulado. | |
| DK0852623T3 (da) | Nukleinsyremolekyler kodende for proteiner, som medierer adhæsionen af Neisseria-celler til humane celler | |
| TW200502253A (en) | Antimicrobial polypeptides | |
| DE60029786D1 (de) | GLOBALER REGULATOR, VERWENDET ZUR ERHöHUNG DER SYNTHESE VON AROMATISCHEN SUBSTANZEN | |
| ATE359811T1 (de) | Verwendung von trehalose produzierenden prokaryotischen zellen als impfstoffe | |
| GB0304681D0 (en) | Radiolabelled structures | |
| TW200505413A (en) | Intermediates useful in the synthesis of hiv-protease inhibitors and methods for preparing the same | |
| ITMI20022273A1 (it) | Sintesi enzimatica di (s)-1, 2-0-1, 2-0-isopropilidenglicerolo. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |