ATE506450T1 - Synthese von oligosacchariden, glykolipiden und glykoproteinen unter verwendung bakterieller glykosyltransferasen - Google Patents

Synthese von oligosacchariden, glykolipiden und glykoproteinen unter verwendung bakterieller glykosyltransferasen

Info

Publication number
ATE506450T1
ATE506450T1 AT03766005T AT03766005T ATE506450T1 AT E506450 T1 ATE506450 T1 AT E506450T1 AT 03766005 T AT03766005 T AT 03766005T AT 03766005 T AT03766005 T AT 03766005T AT E506450 T1 ATE506450 T1 AT E506450T1
Authority
AT
Austria
Prior art keywords
glycolipids
glycoproteins
oligosaccharides
synthesis
glycosyl transferases
Prior art date
Application number
AT03766005T
Other languages
English (en)
Inventor
Karl Johnson
Daniel Bezila
Joanne Simala-Grant
Diane Taylor
David Rasko
Original Assignee
Biogenerix Ag
Univ Alberta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogenerix Ag, Univ Alberta filed Critical Biogenerix Ag
Application granted granted Critical
Publication of ATE506450T1 publication Critical patent/ATE506450T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AT03766005T 2002-07-23 2003-07-23 Synthese von oligosacchariden, glykolipiden und glykoproteinen unter verwendung bakterieller glykosyltransferasen ATE506450T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39815602P 2002-07-23 2002-07-23
US42489402P 2002-11-08 2002-11-08
PCT/US2003/023155 WO2004009793A2 (en) 2002-07-23 2003-07-23 Synthesis of glycoproteins using bacterial gycosyltransferases

Publications (1)

Publication Number Publication Date
ATE506450T1 true ATE506450T1 (de) 2011-05-15

Family

ID=30773066

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03766005T ATE506450T1 (de) 2002-07-23 2003-07-23 Synthese von oligosacchariden, glykolipiden und glykoproteinen unter verwendung bakterieller glykosyltransferasen

Country Status (10)

Country Link
US (1) US7524655B2 (de)
EP (1) EP1539989B1 (de)
JP (1) JP2005533525A (de)
AT (1) ATE506450T1 (de)
AU (2) AU2003256754A1 (de)
CA (1) CA2493258C (de)
DE (1) DE60336826D1 (de)
MX (1) MXPA05000872A (de)
NZ (1) NZ538439A (de)
WO (2) WO2004009838A2 (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
JP2006523211A (ja) 2003-03-14 2006-10-12 ネオス テクノロジーズ インコーポレイテッド 分岐水溶性ポリマーとその複合物
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
NZ542586A (en) 2003-04-09 2009-11-27 Biogenerix Ag Method of forming a covalent conjugate between a G-CSF peptide and PEG
WO2006127896A2 (en) 2005-05-25 2006-11-30 Neose Technologies, Inc. Glycopegylated factor ix
AU2004240553A1 (en) 2003-05-09 2004-12-02 Neose Technologies, Inc. Compositions and methods for the preparation of human growth hormone glycosylation mutants
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US20060040856A1 (en) 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
US7956032B2 (en) 2003-12-03 2011-06-07 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
US7338933B2 (en) 2004-01-08 2008-03-04 Neose Technologies, Inc. O-linked glycosylation of peptides
WO2006010143A2 (en) 2004-07-13 2006-01-26 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
EP1799249A2 (de) 2004-09-10 2007-06-27 Neose Technologies, Inc. Glycopegyliertes interferon alpha
EP3061461A1 (de) 2004-10-29 2016-08-31 ratiopharm GmbH Remodellierung und glykopegylierung von fibroblasten-wachstumsfaktor (fgf)
US9029331B2 (en) 2005-01-10 2015-05-12 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
EP1871795A4 (de) 2005-04-08 2010-03-31 Biogenerix Ag Zusammensetzungen und verfahren zur herstellung von glycosylierungsmutanten eines proteaseresistenten menschlichen wachstumshormons
US8278069B2 (en) 2005-04-11 2012-10-02 National Research Council Of Canada Identification of a β-1,3-N-acetylgalactosaminyltransferase (CGTE) from Campylobacter jejuni LIO87
WO2006127910A2 (en) 2005-05-25 2006-11-30 Neose Technologies, Inc. Glycopegylated erythropoietin formulations
FI20055398A0 (fi) 2005-07-08 2005-07-08 Suomen Punainen Risti Veripalv Menetelmä solupopulaatioiden evaluoimiseksi
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US8969033B2 (en) 2005-11-02 2015-03-03 Battelle Energy Alliance, Llc Alteration and modulation of protein activity by varying post-translational modification
WO2007056191A2 (en) 2005-11-03 2007-05-18 Neose Technologies, Inc. Nucleotide sugar purification using membranes
US20080242607A1 (en) 2006-07-21 2008-10-02 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
US8969532B2 (en) 2006-10-03 2015-03-03 Novo Nordisk A/S Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
CN101796063B (zh) 2007-04-03 2017-03-22 拉蒂奥法姆有限责任公司 使用糖聚乙二醇化g‑csf的治疗方法
US9493499B2 (en) 2007-06-12 2016-11-15 Novo Nordisk A/S Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography
US8207112B2 (en) 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
US9732330B2 (en) 2008-01-25 2017-08-15 Battelle Energy Alliance, Llc Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes
US8492114B2 (en) 2008-01-25 2013-07-23 Battelle Energy Alliance, Llc Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes
JP2011523346A (ja) * 2008-01-25 2011-08-11 バテル エナジー アライアンス,エルエルシー 熱耐性および酸耐性β‐キシロシダーゼ、遺伝子コード化、関連生物体、および方法
US8426185B2 (en) * 2008-01-31 2013-04-23 Battelle Energy Alliance, Llc Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from Alicyclobacillus acidocaldarius and related organisms, methods
EP2235174A4 (de) 2008-01-31 2012-05-09 Battelle Energy Alliance Llc Thermophile und thermoacidophile biopolymerabbaugene, enzyme aus alicyclobacillus acidocaldarius sowie entsprechende organismen und verfahren
US8497110B2 (en) 2008-01-31 2013-07-30 Battelle Energy Alliance, Llc Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods
US8557557B2 (en) * 2008-01-31 2013-10-15 Battelle Energy Alliance, Llc Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from Alicyclobacillus acidocaldarius and related organisms, methods
EP2245040A4 (de) 2008-02-22 2013-06-05 Battelle Energy Alliance Llc Steuerung der transkription bei alicyclobacillus acidocaldarius und damit assoziierte gene, proteine und verfahren
EP2257566A4 (de) 2008-02-26 2012-05-30 Battelle Energy Alliance Llc Thermophile und thermoacidophile zuckertransportergene und enzyme aus alicyclobacillus acidocaldarius und damit in zusammenhang stehende organismen, verfahren
AU2009310370A1 (en) * 2008-02-27 2010-05-06 Battelle Energy Alliance, Llc Thermophilic and thermoacidophilic glycosylation genes and enzymes from Alicyclobacillus acidocaldarius and related organisms, methods
DK2257311T3 (da) 2008-02-27 2014-06-30 Novo Nordisk As Konjugerede Faktor VIII-Molekyler
CN102216451A (zh) 2008-02-28 2011-10-12 巴特勒能源同盟有限公司 来自酸热脂环酸杆菌的嗜热的与嗜热嗜酸的代谢基因和酶以及相关生物
EP2166085A1 (de) 2008-07-16 2010-03-24 Suomen Punainen Risti Veripalvelu Divalente modifizierte Zellen
US8827992B2 (en) 2010-03-26 2014-09-09 Aesculap Ag Impedance mediated control of power delivery for electrosurgery
US20110275135A1 (en) 2010-05-05 2011-11-10 Battelle Energy Alliance, Llc Genetic elements, proteins, and associated methods including application of additional genetic information to gram (+) thermoacidophiles
WO2016007778A1 (en) * 2014-07-09 2016-01-14 Midori Usa, Inc. Oligosaccharide compositions and methods for producing thereof
CA2960835A1 (en) * 2014-09-09 2016-03-17 Glycosyn LLC Alpha (1,3) fucosyltransferases for use in the production of fucosylated oligosaccharides
EP4209130A1 (de) 2015-01-26 2023-07-12 DSM Nutritional Products, LLC Oligosaccharidzusammensetzungen zur verwendung in tierfutter und verfahren zur herstellung davon
CA2973617A1 (en) 2015-01-26 2016-08-04 Kaleido Biosciences, Inc. Glycan therapeutics and related methods thereof
EP3964234A1 (de) 2015-04-23 2022-03-09 Kaleido Biosciences, Inc. Glycantherapeutika und verfahren zur behandlung
EP3423587B1 (de) 2016-04-05 2020-06-24 Council of Scientific & Industrial Research Multifunktionelles rekombinantes nukleotidabhängiges glycosyltransferaseprotein und dessen verfahren zur glycosylierung
KR102229037B1 (ko) 2017-09-04 2021-03-17 89바이오 리미티드 돌연변이 fgf-21 펩티드 접합체 및 이의 용도
JP7576375B2 (ja) 2017-11-03 2024-10-31 カレイド・バイオサイエンシズ・インコーポレイテッド グリカン調製物及び高アンモニア血症のための使用方法
EP3704161A1 (de) 2017-11-03 2020-09-09 Kaleido Biosciences, Inc. Verfahren zur herstellung von glycanpolymeren

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4935349A (en) 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
US5272066A (en) 1986-03-07 1993-12-21 Massachusetts Institute Of Technology Synthetic method for enhancing glycoprotein stability
US5595900A (en) 1990-02-14 1997-01-21 The Regents Of The University Of Michigan Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules, and for the isolation of cloned genetic sequences that determine these structures
AU668505B2 (en) 1991-03-18 1996-05-09 Scripps Research Institute, The Oligosaccharide enzyme substrates and inhibitors: methods and compositions
KR950704497A (ko) 1992-11-27 1995-11-20 베르너 발데크 글리코실트랜스퍼라제 활성을 가진 단백질(Proteins Having Glycosyltransferase Activity)
US5374541A (en) 1993-05-04 1994-12-20 The Scripps Research Institute Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides
US5409817A (en) 1993-05-04 1995-04-25 Cytel, Inc. Use of trans-sialidase and sialyltransferase for synthesis of sialylα2→3βgalactosides
US5426039A (en) 1993-09-08 1995-06-20 Bio-Rad Laboratories, Inc. Direct molecular cloning of primer extended DNA containing an alkane diol
ATE386126T1 (de) 1996-11-08 2008-03-15 Neose Technologies Inc Verbesserte expressionsvektoren
WO1998055630A2 (en) * 1997-06-06 1998-12-10 The Governors Of The University Of Alberta Alpha-1,3-fucosyltransferase of helicobacter pylori
US6500661B1 (en) 1998-01-15 2002-12-31 Neose Technologies, Inc. Enzymatic conversion of GDP-mannose to GDP-fucose

Also Published As

Publication number Publication date
WO2004009838A3 (en) 2006-04-06
EP1539989A2 (de) 2005-06-15
AU2003254139A1 (en) 2004-02-09
JP2005533525A (ja) 2005-11-10
US20070148728A1 (en) 2007-06-28
NZ538439A (en) 2007-02-23
WO2004009838A2 (en) 2004-01-29
WO2004009793A3 (en) 2004-05-13
EP1539989A4 (de) 2006-09-13
US7524655B2 (en) 2009-04-28
CA2493258C (en) 2015-10-20
CA2493258A1 (en) 2004-01-29
DE60336826D1 (de) 2011-06-01
AU2003256754A1 (en) 2004-02-09
AU2003254139A8 (en) 2004-02-09
WO2004009793A2 (en) 2004-01-29
MXPA05000872A (es) 2005-04-28
EP1539989B1 (de) 2011-04-20

Similar Documents

Publication Publication Date Title
DE60336826D1 (de) Synthese von oligosacchariden, glykolipiden und glykoproteinen unter verwendung bakterieller glykosyltransferasen
ATE222294T1 (de) Verbesserte verfahren zur enzymatischen synthese von oligosacchariden
DE60028541D1 (de) Campylobacter glycolsyltransferasen zur verwendung bei der biosynthese von gangliosiden und ganglioside imitatoren
ATE303435T1 (de) Alternansucrase-kodierende nukleinsäure moleküle
NO20054185D0 (no) Methods of radiofluorination of biologically active vectors
ATE477224T1 (de) Verwendung von miniatursierten vorrichtungen zur herstellung von radiomarkierten verbindungen
ATE514783T1 (de) Plasmidsystem zur expression mehrerer gene
IL190665B (en) Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human cd38
WO2004002417A3 (en) Mammalian ch1 deleted mimetibodies, compositions, methods and uses
NO20042570L (no) Antimikrobielle polypeptider fra Pseudoplectania nigrella
WO2003084477A3 (en) Mammalian cdr mimetibodies, compositions, methods and uses
ITRM20030376A1 (it) Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
EP4105644A3 (de) Systeme und vorrichtungen zur "sequence-by-synthesis"-analyse
DK1954811T3 (da) Inducerbare ekspressionssystemer
DK1379695T3 (da) Nye polynukleotider og polypeptider af IFNalfa-21-genet
ATE532861T1 (de) Expressionsvektor
WO2005069921A3 (en) H. pylori fucosyltransferases
DK1458869T3 (da) Alleler af glucokinasegenet af coryneforme bakterier
MXPA04003969A (es) Sistema de expresion de acido nucleico regulado.
DK0852623T3 (da) Nukleinsyremolekyler kodende for proteiner, som medierer adhæsionen af Neisseria-celler til humane celler
TW200502253A (en) Antimicrobial polypeptides
WO2003100020A3 (en) Methods and constructs for high yield expression of clostripain
BRPI0417531A (pt) canal de sódio
DE69735131D1 (de) Für die gdp-fucose-pyrophosphorylase kodierende nukleinsäure
DE60029786D1 (de) GLOBALER REGULATOR, VERWENDET ZUR ERHöHUNG DER SYNTHESE VON AROMATISCHEN SUBSTANZEN

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties