ATE506450T1 - Synthese von oligosacchariden, glykolipiden und glykoproteinen unter verwendung bakterieller glykosyltransferasen - Google Patents
Synthese von oligosacchariden, glykolipiden und glykoproteinen unter verwendung bakterieller glykosyltransferasenInfo
- Publication number
- ATE506450T1 ATE506450T1 AT03766005T AT03766005T ATE506450T1 AT E506450 T1 ATE506450 T1 AT E506450T1 AT 03766005 T AT03766005 T AT 03766005T AT 03766005 T AT03766005 T AT 03766005T AT E506450 T1 ATE506450 T1 AT E506450T1
- Authority
- AT
- Austria
- Prior art keywords
- glycolipids
- glycoproteins
- oligosaccharides
- synthesis
- glycosyl transferases
- Prior art date
Links
- 229930186217 Glycolipid Natural products 0.000 title abstract 2
- 102000003886 Glycoproteins Human genes 0.000 title abstract 2
- 108090000288 Glycoproteins Proteins 0.000 title abstract 2
- 229920001542 oligosaccharide Polymers 0.000 title abstract 2
- 150000002482 oligosaccharides Chemical class 0.000 title abstract 2
- 102000051366 Glycosyltransferases Human genes 0.000 title 1
- 108700023372 Glycosyltransferases Proteins 0.000 title 1
- 230000001580 bacterial effect Effects 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 108700014210 glycosyltransferase activity proteins Proteins 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 102000006471 Fucosyltransferases Human genes 0.000 abstract 2
- 108010019236 Fucosyltransferases Proteins 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39815602P | 2002-07-23 | 2002-07-23 | |
| US42489402P | 2002-11-08 | 2002-11-08 | |
| PCT/US2003/023155 WO2004009793A2 (en) | 2002-07-23 | 2003-07-23 | Synthesis of glycoproteins using bacterial gycosyltransferases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE506450T1 true ATE506450T1 (de) | 2011-05-15 |
Family
ID=30773066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03766005T ATE506450T1 (de) | 2002-07-23 | 2003-07-23 | Synthese von oligosacchariden, glykolipiden und glykoproteinen unter verwendung bakterieller glykosyltransferasen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7524655B2 (de) |
| EP (1) | EP1539989B1 (de) |
| JP (1) | JP2005533525A (de) |
| AT (1) | ATE506450T1 (de) |
| AU (2) | AU2003256754A1 (de) |
| CA (1) | CA2493258C (de) |
| DE (1) | DE60336826D1 (de) |
| MX (1) | MXPA05000872A (de) |
| NZ (1) | NZ538439A (de) |
| WO (2) | WO2004009838A2 (de) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| JP2006523211A (ja) | 2003-03-14 | 2006-10-12 | ネオス テクノロジーズ インコーポレイテッド | 分岐水溶性ポリマーとその複合物 |
| US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
| NZ542586A (en) | 2003-04-09 | 2009-11-27 | Biogenerix Ag | Method of forming a covalent conjugate between a G-CSF peptide and PEG |
| WO2006127896A2 (en) | 2005-05-25 | 2006-11-30 | Neose Technologies, Inc. | Glycopegylated factor ix |
| AU2004240553A1 (en) | 2003-05-09 | 2004-12-02 | Neose Technologies, Inc. | Compositions and methods for the preparation of human growth hormone glycosylation mutants |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
| US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| US7956032B2 (en) | 2003-12-03 | 2011-06-07 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| US7338933B2 (en) | 2004-01-08 | 2008-03-04 | Neose Technologies, Inc. | O-linked glycosylation of peptides |
| WO2006010143A2 (en) | 2004-07-13 | 2006-01-26 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1] |
| EP1799249A2 (de) | 2004-09-10 | 2007-06-27 | Neose Technologies, Inc. | Glycopegyliertes interferon alpha |
| EP3061461A1 (de) | 2004-10-29 | 2016-08-31 | ratiopharm GmbH | Remodellierung und glykopegylierung von fibroblasten-wachstumsfaktor (fgf) |
| US9029331B2 (en) | 2005-01-10 | 2015-05-12 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| EP1871795A4 (de) | 2005-04-08 | 2010-03-31 | Biogenerix Ag | Zusammensetzungen und verfahren zur herstellung von glycosylierungsmutanten eines proteaseresistenten menschlichen wachstumshormons |
| US8278069B2 (en) | 2005-04-11 | 2012-10-02 | National Research Council Of Canada | Identification of a β-1,3-N-acetylgalactosaminyltransferase (CGTE) from Campylobacter jejuni LIO87 |
| WO2006127910A2 (en) | 2005-05-25 | 2006-11-30 | Neose Technologies, Inc. | Glycopegylated erythropoietin formulations |
| FI20055398A0 (fi) | 2005-07-08 | 2005-07-08 | Suomen Punainen Risti Veripalv | Menetelmä solupopulaatioiden evaluoimiseksi |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| US8969033B2 (en) | 2005-11-02 | 2015-03-03 | Battelle Energy Alliance, Llc | Alteration and modulation of protein activity by varying post-translational modification |
| WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
| US20080242607A1 (en) | 2006-07-21 | 2008-10-02 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
| US8969532B2 (en) | 2006-10-03 | 2015-03-03 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography |
| CN101796063B (zh) | 2007-04-03 | 2017-03-22 | 拉蒂奥法姆有限责任公司 | 使用糖聚乙二醇化g‑csf的治疗方法 |
| US9493499B2 (en) | 2007-06-12 | 2016-11-15 | Novo Nordisk A/S | Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography |
| US8207112B2 (en) | 2007-08-29 | 2012-06-26 | Biogenerix Ag | Liquid formulation of G-CSF conjugate |
| US9732330B2 (en) | 2008-01-25 | 2017-08-15 | Battelle Energy Alliance, Llc | Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes |
| US8492114B2 (en) | 2008-01-25 | 2013-07-23 | Battelle Energy Alliance, Llc | Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes |
| JP2011523346A (ja) * | 2008-01-25 | 2011-08-11 | バテル エナジー アライアンス,エルエルシー | 熱耐性および酸耐性β‐キシロシダーゼ、遺伝子コード化、関連生物体、および方法 |
| US8426185B2 (en) * | 2008-01-31 | 2013-04-23 | Battelle Energy Alliance, Llc | Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from Alicyclobacillus acidocaldarius and related organisms, methods |
| EP2235174A4 (de) | 2008-01-31 | 2012-05-09 | Battelle Energy Alliance Llc | Thermophile und thermoacidophile biopolymerabbaugene, enzyme aus alicyclobacillus acidocaldarius sowie entsprechende organismen und verfahren |
| US8497110B2 (en) | 2008-01-31 | 2013-07-30 | Battelle Energy Alliance, Llc | Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods |
| US8557557B2 (en) * | 2008-01-31 | 2013-10-15 | Battelle Energy Alliance, Llc | Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from Alicyclobacillus acidocaldarius and related organisms, methods |
| EP2245040A4 (de) | 2008-02-22 | 2013-06-05 | Battelle Energy Alliance Llc | Steuerung der transkription bei alicyclobacillus acidocaldarius und damit assoziierte gene, proteine und verfahren |
| EP2257566A4 (de) | 2008-02-26 | 2012-05-30 | Battelle Energy Alliance Llc | Thermophile und thermoacidophile zuckertransportergene und enzyme aus alicyclobacillus acidocaldarius und damit in zusammenhang stehende organismen, verfahren |
| AU2009310370A1 (en) * | 2008-02-27 | 2010-05-06 | Battelle Energy Alliance, Llc | Thermophilic and thermoacidophilic glycosylation genes and enzymes from Alicyclobacillus acidocaldarius and related organisms, methods |
| DK2257311T3 (da) | 2008-02-27 | 2014-06-30 | Novo Nordisk As | Konjugerede Faktor VIII-Molekyler |
| CN102216451A (zh) | 2008-02-28 | 2011-10-12 | 巴特勒能源同盟有限公司 | 来自酸热脂环酸杆菌的嗜热的与嗜热嗜酸的代谢基因和酶以及相关生物 |
| EP2166085A1 (de) | 2008-07-16 | 2010-03-24 | Suomen Punainen Risti Veripalvelu | Divalente modifizierte Zellen |
| US8827992B2 (en) | 2010-03-26 | 2014-09-09 | Aesculap Ag | Impedance mediated control of power delivery for electrosurgery |
| US20110275135A1 (en) | 2010-05-05 | 2011-11-10 | Battelle Energy Alliance, Llc | Genetic elements, proteins, and associated methods including application of additional genetic information to gram (+) thermoacidophiles |
| WO2016007778A1 (en) * | 2014-07-09 | 2016-01-14 | Midori Usa, Inc. | Oligosaccharide compositions and methods for producing thereof |
| CA2960835A1 (en) * | 2014-09-09 | 2016-03-17 | Glycosyn LLC | Alpha (1,3) fucosyltransferases for use in the production of fucosylated oligosaccharides |
| EP4209130A1 (de) | 2015-01-26 | 2023-07-12 | DSM Nutritional Products, LLC | Oligosaccharidzusammensetzungen zur verwendung in tierfutter und verfahren zur herstellung davon |
| CA2973617A1 (en) | 2015-01-26 | 2016-08-04 | Kaleido Biosciences, Inc. | Glycan therapeutics and related methods thereof |
| EP3964234A1 (de) | 2015-04-23 | 2022-03-09 | Kaleido Biosciences, Inc. | Glycantherapeutika und verfahren zur behandlung |
| EP3423587B1 (de) | 2016-04-05 | 2020-06-24 | Council of Scientific & Industrial Research | Multifunktionelles rekombinantes nukleotidabhängiges glycosyltransferaseprotein und dessen verfahren zur glycosylierung |
| KR102229037B1 (ko) | 2017-09-04 | 2021-03-17 | 89바이오 리미티드 | 돌연변이 fgf-21 펩티드 접합체 및 이의 용도 |
| JP7576375B2 (ja) | 2017-11-03 | 2024-10-31 | カレイド・バイオサイエンシズ・インコーポレイテッド | グリカン調製物及び高アンモニア血症のための使用方法 |
| EP3704161A1 (de) | 2017-11-03 | 2020-09-09 | Kaleido Biosciences, Inc. | Verfahren zur herstellung von glycanpolymeren |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4935349A (en) | 1986-01-17 | 1990-06-19 | Zymogenetics, Inc. | Expression of higher eucaryotic genes in aspergillus |
| US5272066A (en) | 1986-03-07 | 1993-12-21 | Massachusetts Institute Of Technology | Synthetic method for enhancing glycoprotein stability |
| US5595900A (en) | 1990-02-14 | 1997-01-21 | The Regents Of The University Of Michigan | Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules, and for the isolation of cloned genetic sequences that determine these structures |
| AU668505B2 (en) | 1991-03-18 | 1996-05-09 | Scripps Research Institute, The | Oligosaccharide enzyme substrates and inhibitors: methods and compositions |
| KR950704497A (ko) | 1992-11-27 | 1995-11-20 | 베르너 발데크 | 글리코실트랜스퍼라제 활성을 가진 단백질(Proteins Having Glycosyltransferase Activity) |
| US5374541A (en) | 1993-05-04 | 1994-12-20 | The Scripps Research Institute | Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides |
| US5409817A (en) | 1993-05-04 | 1995-04-25 | Cytel, Inc. | Use of trans-sialidase and sialyltransferase for synthesis of sialylα2→3βgalactosides |
| US5426039A (en) | 1993-09-08 | 1995-06-20 | Bio-Rad Laboratories, Inc. | Direct molecular cloning of primer extended DNA containing an alkane diol |
| ATE386126T1 (de) | 1996-11-08 | 2008-03-15 | Neose Technologies Inc | Verbesserte expressionsvektoren |
| WO1998055630A2 (en) * | 1997-06-06 | 1998-12-10 | The Governors Of The University Of Alberta | Alpha-1,3-fucosyltransferase of helicobacter pylori |
| US6500661B1 (en) | 1998-01-15 | 2002-12-31 | Neose Technologies, Inc. | Enzymatic conversion of GDP-mannose to GDP-fucose |
-
2003
- 2003-07-23 WO PCT/US2003/023057 patent/WO2004009838A2/en not_active Ceased
- 2003-07-23 AT AT03766005T patent/ATE506450T1/de not_active IP Right Cessation
- 2003-07-23 NZ NZ538439A patent/NZ538439A/en not_active IP Right Cessation
- 2003-07-23 US US10/521,138 patent/US7524655B2/en not_active Expired - Fee Related
- 2003-07-23 AU AU2003256754A patent/AU2003256754A1/en not_active Abandoned
- 2003-07-23 CA CA2493258A patent/CA2493258C/en not_active Expired - Fee Related
- 2003-07-23 JP JP2005505547A patent/JP2005533525A/ja active Pending
- 2003-07-23 MX MXPA05000872A patent/MXPA05000872A/es not_active Application Discontinuation
- 2003-07-23 EP EP03766005A patent/EP1539989B1/de not_active Expired - Lifetime
- 2003-07-23 WO PCT/US2003/023155 patent/WO2004009793A2/en not_active Ceased
- 2003-07-23 AU AU2003254139A patent/AU2003254139A1/en not_active Abandoned
- 2003-07-23 DE DE60336826T patent/DE60336826D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004009838A3 (en) | 2006-04-06 |
| EP1539989A2 (de) | 2005-06-15 |
| AU2003254139A1 (en) | 2004-02-09 |
| JP2005533525A (ja) | 2005-11-10 |
| US20070148728A1 (en) | 2007-06-28 |
| NZ538439A (en) | 2007-02-23 |
| WO2004009838A2 (en) | 2004-01-29 |
| WO2004009793A3 (en) | 2004-05-13 |
| EP1539989A4 (de) | 2006-09-13 |
| US7524655B2 (en) | 2009-04-28 |
| CA2493258C (en) | 2015-10-20 |
| CA2493258A1 (en) | 2004-01-29 |
| DE60336826D1 (de) | 2011-06-01 |
| AU2003256754A1 (en) | 2004-02-09 |
| AU2003254139A8 (en) | 2004-02-09 |
| WO2004009793A2 (en) | 2004-01-29 |
| MXPA05000872A (es) | 2005-04-28 |
| EP1539989B1 (de) | 2011-04-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |