ATE510552T1 - Verfahren zur herstellung von sekretierte verkurzte varianten des humanen thyrotropinrezeptors - Google Patents

Verfahren zur herstellung von sekretierte verkurzte varianten des humanen thyrotropinrezeptors

Info

Publication number
ATE510552T1
ATE510552T1 AT97929783T AT97929783T ATE510552T1 AT E510552 T1 ATE510552 T1 AT E510552T1 AT 97929783 T AT97929783 T AT 97929783T AT 97929783 T AT97929783 T AT 97929783T AT E510552 T1 ATE510552 T1 AT E510552T1
Authority
AT
Austria
Prior art keywords
thyrotropine
receptor
human
producing secreted
short variants
Prior art date
Application number
AT97929783T
Other languages
English (en)
Inventor
Basil Rapoport
Sandra Mclachlan
Original Assignee
Basil Rapoport
Sandra Mclachlan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basil Rapoport, Sandra Mclachlan filed Critical Basil Rapoport
Application granted granted Critical
Publication of ATE510552T1 publication Critical patent/ATE510552T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT97929783T 1996-06-05 1997-06-05 Verfahren zur herstellung von sekretierte verkurzte varianten des humanen thyrotropinrezeptors ATE510552T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1917196P 1996-06-05 1996-06-05
PCT/US1997/009624 WO1997046206A2 (en) 1996-06-05 1997-06-05 Human thyrotropin receptor compositions and use thereof

Publications (1)

Publication Number Publication Date
ATE510552T1 true ATE510552T1 (de) 2011-06-15

Family

ID=21791804

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97929783T ATE510552T1 (de) 1996-06-05 1997-06-05 Verfahren zur herstellung von sekretierte verkurzte varianten des humanen thyrotropinrezeptors

Country Status (6)

Country Link
EP (1) EP0959896B1 (de)
JP (1) JP2000512280A (de)
AT (1) ATE510552T1 (de)
AU (1) AU3376297A (de)
CA (1) CA2258720A1 (de)
WO (1) WO1997046206A2 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2395096T3 (es) * 1999-06-29 2013-02-08 Mannkind Corporation Purificación y estabilización de agentes farmacéuticos a base de péptidos y proteínas
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US20030009778A1 (en) * 2000-10-26 2003-01-09 Allen Keith D. Transgenic mice containing thyroid stimulating hormone receptor (TSH-R) gene disruptions
WO2003080149A2 (en) 2002-03-20 2003-10-02 Mannkind Corporation Inhalation apparatus
ATE486064T1 (de) 2004-08-20 2010-11-15 Mannkind Corp Katalyse der diketopiperazinsynthese
HUE025151T2 (en) 2004-08-23 2016-01-28 Mannkind Corp Diceto-piperazine salts for drug delivery
KR101486397B1 (ko) 2005-09-14 2015-01-28 맨카인드 코포레이션 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법
KR20080096809A (ko) 2006-02-22 2008-11-03 맨카인드 코포레이션 디케토피페라진 및 활성제를 포함하는 마이크로입자의 약학특성의 개선 방법
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
ES2929343T3 (es) 2008-06-13 2022-11-28 Mannkind Corp Inhalador de polvo seco accionado por aspiración para la administración de fármacos
MX2010014240A (es) 2008-06-20 2011-03-25 Mankind Corp Un metodo y aparato interactivo para perfilar en tiempo real esfuerzos de inhalacion.
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
WO2010105094A1 (en) 2009-03-11 2010-09-16 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
MY157166A (en) 2009-06-12 2016-05-13 Mankind Corp Diketopiperazine microparticles with defined specific surface areas
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
BR112012033060A2 (pt) 2010-06-21 2018-02-27 Mannkind Corp métodos de sistema de liberação de fármaco em pó seco
AU2012236150B2 (en) 2011-04-01 2016-03-31 Mannkind Corporation Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
BR112014009686A2 (pt) 2011-10-24 2018-08-07 Mannkind Corp composição analgésica inalável, pó seco e método para tratar dor
AU2013289957B2 (en) 2012-07-12 2017-02-23 Mannkind Corporation Dry powder drug delivery systems and methods
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
KR102246914B1 (ko) 2013-03-15 2021-04-30 맨카인드 코포레이션 미세결정성 디케토피페라진 조성물 및 방법
ES2747634T3 (es) * 2013-05-14 2020-03-11 Siemens Healthcare Diagnostics Inc Formulaciones líquidas estabilizadas que contienen receptores
CN114848614A (zh) 2013-07-18 2022-08-05 曼金德公司 热稳定性干粉药物组合物和方法
EP3030294B1 (de) 2013-08-05 2020-10-07 MannKind Corporation Insufflationsvorrichtung
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2095013A1 (en) * 1990-11-15 1992-05-16 Takashi Akamizu Rat thyrotropin receptor gene and uses thereof

Also Published As

Publication number Publication date
EP0959896A4 (de) 2005-03-02
WO1997046206A2 (en) 1997-12-11
AU3376297A (en) 1998-01-05
EP0959896A2 (de) 1999-12-01
EP0959896B1 (de) 2011-05-25
JP2000512280A (ja) 2000-09-19
CA2258720A1 (en) 1997-12-11

Similar Documents

Publication Publication Date Title
ATE510552T1 (de) Verfahren zur herstellung von sekretierte verkurzte varianten des humanen thyrotropinrezeptors
TR199901172T2 (xx) Yeni ikame edilmi� pirazol t�revleri.
NO951138L (no) Mikropartikkelpreparater fremstilt fra biologisk nedbrytbare blandingspolymerer
ATE234124T1 (de) Verfahren zur herstellung von wirkstoffhaltigen knochenzementen
DE69506668D1 (de) Vorrichtung zur herstellung von weichen tissueprodukten
DE69327659D1 (de) Therapeutische und diagnostische bilderzeugungzusammensetzung und verfahren zur herstellung
ATE231724T1 (de) Kombinationstherapie für die behandlung von psychosen
ATE185971T1 (de) Kombinationspräparat zur behandlung hypogonadaler männer sowie männern mit hypophysenerkrankungen
MY129189A (en) Prostaglandin agonists and their use to treat bone disorders
IL128003A0 (en) Therapeutic multispecific compounds comprised of anti-fcalpha receptor antibodies
MXPA02011656A (es) Moleculas de acido nucleico nrg-2, polipeptidos, y metodos de diagnostico y terapeuticos.
PL332432A1 (en) Oxadiazoles, method of obtaining them as well as their application as therapeutic agents
DE69730224D1 (de) Verfahren und instrument zur untersuchung des herzens und der arterien
FI972703A0 (fi) Rekombinantti IL-5-antagonisteja, jotka ovat käyttökelpoisia hoidettaessa IL-5:een liittyviä sairauksia
ATE219767T1 (de) Verfahren zur herstellung von 2,4-dihydroxy- pyridin und 2,4-dihydroxy-3-nitropyridin
DE69626311D1 (de) Zusammensetzung zur behandlung von wäsche sowie verfahren hierfür
DE69405919D1 (de) Zusammensetzungen zur Behandlung von Keratinfasern
ATE221763T1 (de) Die verwendung von glyceryltriacetat zur behandlung von onychomykosen
DE60035693D1 (de) Zusammensetzung und verfahren zur behandlung von immunverwandten krankheiten
ATA232687A (de) Zahnpflegemittel, sowie verfahren zur herstellung des zahnpflegemittels
ATE204021T1 (de) Klonierung, expression und charakterisierung einer neuen form der phosphatidylinositol-3- kinase
DE69709655D1 (de) Verfahren zur herstellung von 17-estern von 9alpha,21-dihalopregan-11beta,17alpha-diol-20-onen
DE69822297D1 (de) Triptolid-derivate geeignet zur behandlung von autoimmunkrankheiten
TR200200278T2 (tr) Kalsilitik bileşimler
DE69626816D1 (de) Verwendung von selegilin zur behandlung von gehörverlust bei säugetieren

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties