ATE510843T1 - Verfahren zur synthese von peptiden ohne lösungsmittel - Google Patents

Verfahren zur synthese von peptiden ohne lösungsmittel

Info

Publication number: ATE510843T1
Authority: AT; Austria
Prior art keywords: group; alkyl; synthesing; peptides; solvents
Prior art date: 2007-03-21

Application number

AT08718144T

Other languages

English (en)

Inventor

Jean Martinez

Frederic Lamaty

Valerie Declerck

Original Assignee

Centre Nat Rech Scient

Univ Montpellier I

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-03-21

Filing date

2008-03-21

Publication date

2011-06-15

2008-03-21 Application filed by Centre Nat Rech Scient, Univ Montpellier I filed Critical Centre Nat Rech Scient

2011-06-15 Application granted granted Critical

2011-06-15 Publication of ATE510843T1 publication Critical patent/ATE510843T1/de

Links

238000000034 method Methods 0.000 title abstract 2
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
239000002904 solvent Substances 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT08718144T 2007-03-21 2008-03-21 Verfahren zur synthese von peptiden ohne lösungsmittel ATE510843T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0753970A FR2913978B1 (fr)	2007-03-21	2007-03-21	Procede de synthese de peptides sans solvant
PCT/EP2008/053444 WO2008125418A2 (fr)	2007-03-21	2008-03-21	Procede de synthese de peptides sans solvant

Publications (1)

Publication Number	Publication Date
ATE510843T1 true ATE510843T1 (de)	2011-06-15

Family

ID=38293308

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08718144T ATE510843T1 (de)	2007-03-21	2008-03-21	Verfahren zur synthese von peptiden ohne lösungsmittel

Country Status (8)

Country	Link
US (1)	US7960578B2 (de)
EP (1)	EP2139910B1 (de)
JP (1)	JP5362593B2 (de)
AT (1)	ATE510843T1 (de)
CA (1)	CA2681321A1 (de)
ES (1)	ES2366001T3 (de)
FR (1)	FR2913978B1 (de)
WO (1)	WO2008125418A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN106661033B (zh) *	2014-05-28	2018-11-06	阿斯利康(瑞典)有限公司	用于制备azd5363的方法和在其中使用的新颖中间体
EP3527580B1 (de) *	2018-02-16	2021-04-07	Centre National de la Recherche Scientifique CNRS	Kontinuierliche, lösungsmittelfreie und nicht-enzymatische peptidsynthese durch reaktive extrusion
JP7356707B2 (ja) *	2018-11-15	2023-10-05	国立大学法人神戸大学	アミノ酸－ｎ－カルボン酸無水物の製造方法
JPWO2024214716A1 (de) *	2023-04-10	2024-10-17

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU673731B2 (en) *	1993-06-03	1996-11-21	Banyu Pharmaceutical Co., Ltd.	Novel endothelin antagonistic peptide
FR2858976B1 (fr) *	2003-08-22	2006-02-10	Isochem Sa	Procede d'obtention de n-carboxyanhydrides d'alpha-aminoacides a protection urethane

2007
- 2007-03-21 FR FR0753970A patent/FR2913978B1/fr not_active Expired - Fee Related
2008
- 2008-03-21 WO PCT/EP2008/053444 patent/WO2008125418A2/fr not_active Ceased
- 2008-03-21 AT AT08718144T patent/ATE510843T1/de not_active IP Right Cessation
- 2008-03-21 ES ES08718144T patent/ES2366001T3/es active Active
- 2008-03-21 EP EP08718144A patent/EP2139910B1/de not_active Not-in-force
- 2008-03-21 JP JP2009554044A patent/JP5362593B2/ja not_active Expired - Fee Related
- 2008-03-21 CA CA002681321A patent/CA2681321A1/fr not_active Abandoned
- 2008-03-21 US US12/531,972 patent/US7960578B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
FR2913978A1 (fr)	2008-09-26
WO2008125418A3 (fr)	2008-12-18
JP5362593B2 (ja)	2013-12-11
FR2913978B1 (fr)	2009-07-03
EP2139910A2 (de)	2010-01-06
ES2366001T3 (es)	2011-10-14
US20100016631A1 (en)	2010-01-21
US7960578B2 (en)	2011-06-14
JP2010522144A (ja)	2010-07-01
WO2008125418A2 (fr)	2008-10-23
CA2681321A1 (fr)	2008-10-23
EP2139910B1 (de)	2011-05-25

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Legal Events

Date	Code	Title	Description
2011-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties