ATE510929T1 - Verfahren zur vorhersage einer immunantwort auf eine tumorerkrankung auf der grundlage eines mrna-expressionsprofils in tumorzellen und stimulierten leukozyten - Google Patents

Verfahren zur vorhersage einer immunantwort auf eine tumorerkrankung auf der grundlage eines mrna-expressionsprofils in tumorzellen und stimulierten leukozyten

Info

Publication number
ATE510929T1
ATE510929T1 AT06772657T AT06772657T ATE510929T1 AT E510929 T1 ATE510929 T1 AT E510929T1 AT 06772657 T AT06772657 T AT 06772657T AT 06772657 T AT06772657 T AT 06772657T AT E510929 T1 ATE510929 T1 AT E510929T1
Authority
AT
Austria
Prior art keywords
tnf
cancer
leukocytes
chemokines
immune response
Prior art date
Application number
AT06772657T
Other languages
English (en)
Inventor
Masato Mitsuhashi
Original Assignee
Hitachi Chemical Res Ct Inc
Hitachi Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi Chemical Res Ct Inc, Hitachi Chemical Co Ltd filed Critical Hitachi Chemical Res Ct Inc
Application granted granted Critical
Publication of ATE510929T1 publication Critical patent/ATE510929T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047Cells of the immune system
    • G01N33/505Cells of the immune system involving T-cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT06772657T 2005-06-08 2006-06-08 Verfahren zur vorhersage einer immunantwort auf eine tumorerkrankung auf der grundlage eines mrna-expressionsprofils in tumorzellen und stimulierten leukozyten ATE510929T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68874405P 2005-06-08 2005-06-08
US73550805P 2005-11-11 2005-11-11
PCT/US2006/022427 WO2006133399A1 (en) 2005-06-08 2006-06-08 METHOD FOR PREDICTING IMMUNE RESPONSE TO NEOPLASTIC DISEASE BASED ON mRNA EXPRESSION PROFILE IN NEOPLASTIC CELLS AND STIMULATED LEUKOCYTES

Publications (1)

Publication Number Publication Date
ATE510929T1 true ATE510929T1 (de) 2011-06-15

Family

ID=37498782

Family Applications (2)

Application Number Title Priority Date Filing Date
AT08008370T ATE493515T1 (de) 2005-06-08 2006-06-08 Verfahren zur vorhersage der immunreaktion auf neoplastische krankheiten auf der grundlage des mrna-ausdrucksprofil in neoplastischen zellen und stimulierten leukozyten
AT06772657T ATE510929T1 (de) 2005-06-08 2006-06-08 Verfahren zur vorhersage einer immunantwort auf eine tumorerkrankung auf der grundlage eines mrna-expressionsprofils in tumorzellen und stimulierten leukozyten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT08008370T ATE493515T1 (de) 2005-06-08 2006-06-08 Verfahren zur vorhersage der immunreaktion auf neoplastische krankheiten auf der grundlage des mrna-ausdrucksprofil in neoplastischen zellen und stimulierten leukozyten

Country Status (7)

Country Link
US (1) US7741023B2 (de)
EP (2) EP1904657B1 (de)
JP (1) JP4800384B2 (de)
CN (1) CN101194027B (de)
AT (2) ATE493515T1 (de)
DE (1) DE602006019312D1 (de)
WO (1) WO2006133399A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008503206A (ja) * 2004-05-25 2008-02-07 日立化成工業株式会社 癌感受性を測定する方法
CN101044249B (zh) * 2004-10-20 2012-09-05 日立化成工业株式会社 通过定量mRNA定制给药的方法
ATE512234T1 (de) * 2005-04-28 2011-06-15 Hitachi Chemical Res Ct Inc Ex-vivo-genexpression in vollblut als modell für die beurteilung von individueller variation gegenüber nahrungszusätzen
DE102007045562A1 (de) * 2007-09-24 2009-04-02 Robert Bosch Gmbh Steuereinrichtung für eine Anzeigeeinrichtung einer Einparkeinrichtung und Verfahren zur Darstellung
JP2011502535A (ja) * 2007-11-14 2011-01-27 日立化成工業株式会社 末梢血白血球における、Fc受容体を介した腫瘍壊死因子スーパーファミリーmRNA発現
NZ598712A (en) * 2009-08-28 2014-05-30 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2011084333A1 (en) * 2009-12-16 2011-07-14 Hitachi Chemical Co., Ltd. Method for characterizing host immune function by ex vivo induction of offensive and defensive immune markers
CN102947706B (zh) 2010-04-19 2018-04-13 生物标志物策略公司 预测药物敏感性、抗性和疾病进展的组合物和方法
WO2012007783A1 (en) * 2010-07-13 2012-01-19 Institut Gustave Roussy Kits and methods for detecting the ability to induce an immunogenic cancer cell death in a subject
US8828944B2 (en) 2010-04-22 2014-09-09 Institut Gustave Roussy Compounds and uses thereof to induce an immunogenic cancer cell death in a subject
WO2011131246A1 (en) * 2010-04-22 2011-10-27 Institut Gustave Roussy Compounds and uses thereof to induce an immunogenic cancer cell death in a subject
US8865653B2 (en) 2010-04-22 2014-10-21 Institut Gustave Roussy Method of treatment for immunogenic treatment resistant cancer
WO2011140125A1 (en) 2010-05-07 2011-11-10 Hitachi Chemical Co., Ltd. Methods of characterizing host responsiveness to interferon by ex vivo induction of interferon-responsive markers
EP2388312A1 (de) 2010-05-17 2011-11-23 Curetis AG Universell anwendbarer Lysepuffer und Verarbeitungsverfahren zur Lyse von Körperproben
WO2011156763A1 (en) 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Methods for characterizing kidney function
WO2011156734A2 (en) * 2010-06-11 2011-12-15 Hitachi Chemical Co., Ltd. Method of characterizing vascular diseases
JP5823031B2 (ja) 2011-06-10 2015-11-25 日立化成株式会社 小胞捕捉デバイスおよびそれを用いるための方法
EP2734233B1 (de) * 2011-07-18 2017-11-01 Hitachi Chemical Co., Ltd. Verfahren zur vorhersage des ansprechens eines wirtes auf krebsimmuntherapien durch ex-vivo-induktion von mit leukozytenfunktionen assoziierten mrnas
EP2751570A4 (de) * 2011-08-31 2015-08-12 Oncocyte Corp Verfahren und zusammensetzungen zur behandlung und diagnose von krebs
JP6059350B2 (ja) * 2012-09-06 2017-01-11 日立化成株式会社 ペプチド特異的免疫の評価のための方法
JP2014057582A (ja) * 2012-09-17 2014-04-03 Hitachi Chemical Co Ltd 細胞傷害活性を予測するための方法及びキット
CN103193886A (zh) * 2013-04-14 2013-07-10 浙江大学 鼠抗人T细胞抗原ZCH-2B8a荧光标记单抗的用途
WO2014182330A1 (en) 2013-05-06 2014-11-13 Hitachi Chemical Company Ltd Devices and methods for capturing target molecules
WO2016048388A1 (en) 2014-09-26 2016-03-31 Somalogic, Inc. Cardiovascular risk event prediction and uses thereof
US10266895B2 (en) 2014-11-05 2019-04-23 Hitachi Chemical Company Ltd. Exosomes and microvesicles in intestinal luminal fluids and stool and use of same for the assessment of inflammatory bowel disease
EP3218521B1 (de) 2014-11-12 2019-12-25 Hitachi Chemical Co., Ltd. Verfahren zur diagnose von organverletzung
DE112016003948T5 (de) 2015-08-31 2018-05-09 City Of Sapporo Molekulare verfahren zum beurteilen einer urothelialen erkrankung
AU2017261353A1 (en) * 2016-05-05 2018-11-08 Nantomics, Llc Checkpoint failure and methods therefor
CN110073221A (zh) * 2016-10-14 2019-07-30 思迪奇细胞私人有限公司 白细胞粘附功能测定、设备和/或用途

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925572A (en) * 1987-10-20 1990-05-15 Pall Corporation Device and method for depletion of the leukocyte content of blood and blood components
US4880548A (en) * 1988-02-17 1989-11-14 Pall Corporation Device and method for separating leucocytes from platelet concentrate
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5491063A (en) * 1994-09-01 1996-02-13 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
DE69739909D1 (de) * 1996-03-26 2010-07-29 Michael S Kopreski Methoden aus plasma oder serum extrahierte extrazelluraere rna zur diagnoseüberwachung oder evaluation von krebs verwenden
US5683698A (en) * 1996-08-02 1997-11-04 New England Deaconess Hospital Formulation for alleviating symptoms associated with arthritis
US7514232B2 (en) * 1996-12-06 2009-04-07 Becton, Dickinson And Company Method for detecting T cell response to specific antigens in whole blood
US6183951B1 (en) 1997-04-11 2001-02-06 Prometheus Laboratories, Inc. Methods of diagnosing clinical subtypes of crohn's disease with characteristic responsiveness to anti-Th1 cytokine therapy
US20020006613A1 (en) * 1998-01-20 2002-01-17 Shyjan Andrew W. Methods and compositions for the identification and assessment of cancer therapies
AU768189B2 (en) 1999-06-15 2003-12-04 Nutri-Logics, Inc. Nutrient formulations for disease reduction, and related treatment and component screening methods
US6692916B2 (en) * 1999-06-28 2004-02-17 Source Precision Medicine, Inc. Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
US6549616B1 (en) * 2000-03-20 2003-04-15 Serconet Ltd. Telephone outlet for implementing a local area network over telephone lines and a local area network using such outlets
US20020048566A1 (en) * 2000-09-14 2002-04-25 El-Deiry Wafik S. Modulation of cellular apoptosis and methods for treating cancer
US20020182274A1 (en) 2001-03-21 2002-12-05 Kung-Ming Lu Methods for inhibiting cancer growth, reducing infection and promoting general health with a fermented soy extract
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US6964850B2 (en) 2001-11-09 2005-11-15 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
US7767390B2 (en) * 2001-11-20 2010-08-03 Oncomedx, Inc. Methods for evaluating drug-resistance gene expression in the cancer patient
US7871619B2 (en) 2001-11-30 2011-01-18 Chemocentryx, Inc. Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
FI20020078A7 (fi) 2002-01-15 2003-07-16 Danisco Immuunijärjestelmän stimulointi polydextroosilla
US6878518B2 (en) * 2002-01-22 2005-04-12 The Trustees Of The University Of Pennsylvania Methods for determining steroid responsiveness
US7745180B2 (en) * 2002-04-24 2010-06-29 Hitachi Chemical Co., Ltd. Device and method for high-throughput quantification of mRNA from whole blood
AU2003232872A1 (en) 2002-05-27 2003-12-12 Ostergotlands Lans Landsting Method for determining immune system affecting compounds
AU2002953533A0 (en) * 2002-12-24 2003-01-16 Arthron Limited Fc receptor modulating compounds and compositions
JP2008503206A (ja) * 2004-05-25 2008-02-07 日立化成工業株式会社 癌感受性を測定する方法
EP1875246B1 (de) 2005-04-15 2016-10-05 CanImGuide Therapeutics AB Diagnoseverfahren zum nachweis von krebs durch messen der menge eines cytokinähnlichen il-6
ATE512234T1 (de) * 2005-04-28 2011-06-15 Hitachi Chemical Res Ct Inc Ex-vivo-genexpression in vollblut als modell für die beurteilung von individueller variation gegenüber nahrungszusätzen
EP1945814A2 (de) 2005-09-27 2008-07-23 Source MDX Erstellung von genexpressionsprofilen zur identifizierung , beobachtung und behandlung rheumatoider arthritis
US20100190162A1 (en) 2007-02-26 2010-07-29 Cedars-Sinai Medical Center Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease

Also Published As

Publication number Publication date
CN101194027B (zh) 2012-10-24
WO2006133399A1 (en) 2006-12-14
ATE493515T1 (de) 2011-01-15
JP4800384B2 (ja) 2011-10-26
US7741023B2 (en) 2010-06-22
WO2006133399A9 (en) 2007-03-01
EP1964931A3 (de) 2009-01-21
DE602006019312D1 (de) 2011-02-10
EP1904657A1 (de) 2008-04-02
JP2008543286A (ja) 2008-12-04
EP1964931B1 (de) 2010-12-29
EP1904657B1 (de) 2011-05-25
US20090111128A1 (en) 2009-04-30
EP1904657A4 (de) 2008-12-31
EP1964931A2 (de) 2008-09-03
CN101194027A (zh) 2008-06-04

Similar Documents

Publication Publication Date Title
ATE510929T1 (de) Verfahren zur vorhersage einer immunantwort auf eine tumorerkrankung auf der grundlage eines mrna-expressionsprofils in tumorzellen und stimulierten leukozyten
Chen et al. The theory of tumor ecosystem
Reiland et al. CXC‐chemokines stimulate invasion and chemotaxis in prostate carcinoma cells through the CXCR2 receptor
Balkwill Chemokine biology in cancer
Schalper PD-L1 expression and tumor-infiltrating lymphocytes: revisiting the antitumor immune response potential in breast cancer
Cristofanilli et al. Circulating tumor cells in metastatic breast cancer: biologic staging beyond tumor burden
Russo et al. Tumor inhibition or tumor promotion? The duplicity of CXCR3 in cancer
von Bergwelt-Baildon et al. CD40-activated B cells express full lymph node homing triad and induce T-cell chemotaxis: potential as cellular adjuvants
JP2013517461A5 (de)
WO2009037454A3 (en) Cancer marker and therapeutic target
McAllaster et al. Role of the lymphatics in cancer metastasis and chemotherapy applications
Serrano et al. Microfluidic‐based reconstitution of functional lymphatic microvasculature: elucidating the role of lymphatics in health and disease
Hayasaka et al. Neogenesis and development of the high endothelial venules that mediate lymphocyte trafficking
Larned et al. Interactions between the mat‐forming alga Didymosphenia geminata and its hydrodynamic environment
Siyasi et al. Study of VCAM-1 gene expression in normal and tumoral tissues in patients with colorectal cancer
Kim et al. Inflammatory mimetic microfluidic chip by immobilization of cell adhesion molecules for T cell adhesion
Peter DICE: a novel tumor surveillance mechanism—a new therapy for cancer?
Ruf et al. Abstract P021: Highly multiplexed spatial analysis of the HCC tumor immune microenvironment using CODEX imaging
Bekele et al. Anomalous pressure generation within the Alberta Basin: Implications for oil charge to the Viking Formation
Zimmerer et al. IFN-α-2b–Induced Signal Transduction and Gene Regulation in Patient Peripheral Blood Mononuclear Cells Is Not Enhanced by a Dose Increase from 5 to 10 Megaunits/m2
Shan et al. Increased stiffness of extracellular matrix enhanced chemoresistance in 3D-bioprinted ovarian cancer model
Kanakia et al. Development of CD137 (4-1BB) receptor occupancy assay using fluorescently labeled Bicycles®
Ingersoll et al. Functional characterization of a fluorescent highly tumorigenic ovarian cancer line to test cellular therapy in experimental models
Tai et al. Constitutive B-cell maturation antigen (BCMA) activation in human multiple myeloma cells promotes myeloma cell growth and survival in the bone marrow microenvironment via upregulated MCL-1 and NFκB signaling
Chakraborty et al. Fibroblasts drive differential response in immunotherapy via IL-6 in bioengineered 3D cancer constructs

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties