ATE511636T1 - METHOD FOR DETECTING BIOLOGICAL ORGANISMS USING RAMAN SCATTERING - Google Patents

METHOD FOR DETECTING BIOLOGICAL ORGANISMS USING RAMAN SCATTERING

Info

Publication number
ATE511636T1
ATE511636T1 AT06816934T AT06816934T ATE511636T1 AT E511636 T1 ATE511636 T1 AT E511636T1 AT 06816934 T AT06816934 T AT 06816934T AT 06816934 T AT06816934 T AT 06816934T AT E511636 T1 ATE511636 T1 AT E511636T1
Authority
AT
Austria
Prior art keywords
analyte
raman scattering
biological organisms
detecting biological
binding partner
Prior art date
Application number
AT06816934T
Other languages
German (de)
Inventor
Neal Siegel
David Fischell
Original Assignee
Sword Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sword Diagnostics Inc filed Critical Sword Diagnostics Inc
Application granted granted Critical
Publication of ATE511636T1 publication Critical patent/ATE511636T1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

A method for the detection of compounds, including biological macromolecules and cells, using changes in Raman spectroscopic properties upon binding of at least one analyte binding partner. The method comprises contacting at least one analyte with at least one analyte binding partner, binding at least one analyte to at least one analyte binding partner to form a complex, and detecting the complex using the change in Raman light scattering.
AT06816934T 2005-10-17 2006-10-16 METHOD FOR DETECTING BIOLOGICAL ORGANISMS USING RAMAN SCATTERING ATE511636T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72732805P 2005-10-17 2005-10-17
US83693606P 2006-08-11 2006-08-11
PCT/US2006/040234 WO2007047526A1 (en) 2005-10-17 2006-10-16 Method and apparatus for detection of biological organisms using raman scattering

Publications (1)

Publication Number Publication Date
ATE511636T1 true ATE511636T1 (en) 2011-06-15

Family

ID=37771029

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06816934T ATE511636T1 (en) 2005-10-17 2006-10-16 METHOD FOR DETECTING BIOLOGICAL ORGANISMS USING RAMAN SCATTERING

Country Status (9)

Country Link
US (2) US7599057B2 (en)
EP (2) EP2264440A3 (en)
AT (1) ATE511636T1 (en)
CA (1) CA2628968C (en)
CY (1) CY1112090T1 (en)
DK (1) DK1946083T3 (en)
PL (1) PL1946083T3 (en)
PT (1) PT1946083E (en)
WO (1) WO2007047526A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7947437B2 (en) * 2005-10-17 2011-05-24 Sword Diagnostics, Inc. Methods for detecting organisms and enzymatic reactions using raman spectroscopy
DK1946083T3 (en) * 2005-10-17 2011-09-19 Sword Diagnostics Inc Method for Detecting Biological Organisms Using Raman Spread
US20100041016A1 (en) 2005-10-17 2010-02-18 Sword Diagnostics, Inc. Methods for detecting organisms and enzymatic reactions using raman spectroscopy and aromatic compounds comprising phosphate
JP2011511933A (en) * 2008-01-07 2011-04-14 ダイナミック スループット インコーポレイテッド Discovery tool using integrated microfluidic biomarker optical detection array device and method of use
EP2414536B1 (en) * 2009-04-03 2014-06-18 Battelle Memorial Institute Fluorescence cued raman identification of viable organisms
US8279437B2 (en) 2010-07-14 2012-10-02 Hewlett-Packard Development Company, L.P. Multi-wavelength Raman light detection for detecting a species
US9662047B2 (en) 2010-08-05 2017-05-30 Massachusetts Institute Of Technology Portable raman diagnostic system
WO2018027213A1 (en) * 2016-08-05 2018-02-08 The Texas A&M University System Immobilized substrate enzymatic surface enhanced raman spectroscopy (sers) assays
MY204234A (en) 2018-08-27 2024-08-16 Regeneron Pharma Use of raman spectroscopy in downstream purification
CN113295672A (en) * 2021-06-02 2021-08-24 上海海洋大学 Method for quantitatively detecting alkaline phosphatase in seawater based on surface enhanced Raman spectroscopy technology

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0714025A1 (en) 1994-11-25 1996-05-29 Kyoto Dai-ichi Kagaku Co., Ltd. Method of and apparatus for determining hydrogen peroxide by Raman scattering
US5741660A (en) 1995-02-01 1998-04-21 Kyoto Dai-Ichi Kagaku Co., Ltd. Method of measuring enzyme reaction by Raman scattering
JP2965502B2 (en) 1996-02-20 1999-10-18 株式会社京都第一科学 Analysis method by surface enhanced Raman scattering measurement
US5866430A (en) * 1996-06-13 1999-02-02 Grow; Ann E. Raman optrode processes and devices for detection of chemicals and microorganisms
US7267948B2 (en) * 1997-11-26 2007-09-11 Ut-Battelle, Llc SERS diagnostic platforms, methods and systems microarrays, biosensors and biochips
JP2000258346A (en) 1999-03-08 2000-09-22 Arkray Inc Quantitative analytical method for substrate by raman spectroscopy
JP2005515423A (en) * 2002-01-10 2005-05-26 ケムルメイジ コーポレーション Method for detecting pathogenic microorganisms
GB0216197D0 (en) 2002-07-12 2002-08-21 Univ Strathclyde Serrs active particles
US20060199209A1 (en) 2005-03-03 2006-09-07 Neal Arthur Siegel Enhanced detection of biological and bioactive components by resonance Raman spectroscopy
US20060216835A1 (en) 2005-03-24 2006-09-28 General Electric Company Method of separating unattached Raman-active tag from bioassay or other reaction mixture
WO2007011778A2 (en) 2005-07-18 2007-01-25 Parallax Biosystems Use of raman spectroscopy in enzyme activity assays
DK1946083T3 (en) 2005-10-17 2011-09-19 Sword Diagnostics Inc Method for Detecting Biological Organisms Using Raman Spread
US7947437B2 (en) 2005-10-17 2011-05-24 Sword Diagnostics, Inc. Methods for detecting organisms and enzymatic reactions using raman spectroscopy
EP2019587B1 (en) 2006-05-03 2010-08-25 The Regents of the University of California Detection of protease and protease activity using a single nanocrescent sers probe

Also Published As

Publication number Publication date
EP1946083A1 (en) 2008-07-23
WO2007047526A1 (en) 2007-04-26
EP1946083B1 (en) 2011-06-01
EP2264440A2 (en) 2010-12-22
DK1946083T3 (en) 2011-09-19
CY1112090T1 (en) 2015-11-04
CA2628968C (en) 2016-10-11
PT1946083E (en) 2011-09-13
CA2628968A1 (en) 2007-04-26
US8243267B2 (en) 2012-08-14
US20070087430A1 (en) 2007-04-19
EP2264440A3 (en) 2011-10-19
US7599057B2 (en) 2009-10-06
PL1946083T3 (en) 2012-04-30
US20100092942A1 (en) 2010-04-15

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