ATE512365T1 - Map-2 proteolytische produkte als diagnostische biomarker fur neuralen verletzungen - Google Patents

Map-2 proteolytische produkte als diagnostische biomarker fur neuralen verletzungen

Info

Publication number
ATE512365T1
ATE512365T1 AT05779948T AT05779948T ATE512365T1 AT E512365 T1 ATE512365 T1 AT E512365T1 AT 05779948 T AT05779948 T AT 05779948T AT 05779948 T AT05779948 T AT 05779948T AT E512365 T1 ATE512365 T1 AT E512365T1
Authority
AT
Austria
Prior art keywords
injury
map
neural injury
diagnostic biomarkers
proteolytic products
Prior art date
Application number
AT05779948T
Other languages
English (en)
Inventor
Ka-Wang Wang
Ronald Hayes
Ming-Chen Liu
Monika Oli
Original Assignee
Univ Florida
Banyan Biomarkers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida, Banyan Biomarkers filed Critical Univ Florida
Application granted granted Critical
Publication of ATE512365T1 publication Critical patent/ATE512365T1/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
AT05779948T 2004-04-15 2005-04-15 Map-2 proteolytische produkte als diagnostische biomarker fur neuralen verletzungen ATE512365T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56281904P 2004-04-15 2004-04-15
PCT/US2005/013045 WO2005113798A2 (en) 2004-04-15 2005-04-15 Proteolytic markers as diagnostic biomarkers for cancer, organ injury and muscle rehabilitation/exercise overtraining

Publications (1)

Publication Number Publication Date
ATE512365T1 true ATE512365T1 (de) 2011-06-15

Family

ID=35428934

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05779948T ATE512365T1 (de) 2004-04-15 2005-04-15 Map-2 proteolytische produkte als diagnostische biomarker fur neuralen verletzungen

Country Status (8)

Country Link
US (2) US7456027B2 (de)
EP (1) EP1747282B1 (de)
JP (1) JP4885122B2 (de)
AT (1) ATE512365T1 (de)
AU (1) AU2005245785B2 (de)
CA (1) CA2578680C (de)
ES (1) ES2367311T3 (de)
WO (1) WO2005113798A2 (de)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8492107B2 (en) 2004-04-15 2013-07-23 University Of Florida Research Foundation, Inc. Neural proteins as biomarkers for nervous system injury and other neural disorders
EP1745149A4 (de) * 2004-04-15 2008-08-06 Univ Florida Neurale proteine als biomarker für eine verletzung des nervensystems und andere neurale störungen
US7883858B2 (en) * 2005-01-27 2011-02-08 Institute For Systems Biology Methods for identifying and monitoring drug side effects
US8048638B2 (en) * 2005-04-01 2011-11-01 University Of Florida Research Foundation, Inc. Biomarkers of liver injury
ES2732071T3 (es) * 2005-04-01 2019-11-20 Univ Florida Biomarcadores de lesiones hepáticas
CA2636990A1 (en) * 2006-01-13 2007-07-26 Battelle Memorial Institute Animal model for assessing copd-related diseases
EP1840574A1 (de) 2006-03-30 2007-10-03 Institut Pasteur Verwendung der alpha-Kette von Gehirnspektrin und Fragmente daraus zur Diagnose von Gehirnerkrankungen
WO2007140972A1 (en) * 2006-06-06 2007-12-13 F. Hoffmann-La Roche Ag Transgelin-3 as biomarker for alzheimer's disease
KR20090115930A (ko) * 2006-12-26 2009-11-10 브라이엄 영 유니버시티 혈청 단백질체학 시스템 및 관련 방법
HRP20140049T1 (hr) 2007-01-05 2014-02-28 University Of Zürich Anti beta-amiloid antitijela i njihova upotreba
WO2008097618A1 (en) * 2007-02-06 2008-08-14 University Of Florida Research Foundation, Inc. Synaptotagmin and collapsin response mediator protein as biomarkers for traumatic brain injury
US8652440B2 (en) 2007-05-10 2014-02-18 The Trustees Of Columbia University In The City Of New York Methods for diagnosing diseases and evaluating treatments therefor using PET
US9000134B2 (en) 2007-05-11 2015-04-07 Wallace B. Haigh Reagent and kit for early diagnosis of kidney disease
AU2013200258B2 (en) * 2007-09-13 2016-06-09 Peptcell Limited Peptide sequences and compositions
US20100209943A1 (en) * 2007-10-10 2010-08-19 David Goldberg Measurement Of Protease Activity In Post-Mortem Meat Samples
GB2453589A (en) 2007-10-12 2009-04-15 King S College London Protease inhibition
EP2105742A1 (de) * 2008-03-26 2009-09-30 Sanofi-Aventis Verwendung von Kathepsin-C
US12601749B2 (en) 2008-08-11 2026-04-14 Banyan Biomarkers, Inc. Biomarker detection process and assay of neurological condition
EP3336551B1 (de) * 2008-08-11 2023-05-31 Banyan Biomarkers, Inc. Verfahren für den nachweis von biomarkern und test für neurologische erkrankung
US10359425B2 (en) 2008-09-09 2019-07-23 Somalogic, Inc. Lung cancer biomarkers and uses thereof
HRP20160127T1 (hr) * 2008-09-09 2016-03-11 Somalogic, Inc. Biomarkeri raka pluä†a i njihove uporabe
US20100221752A2 (en) * 2008-10-06 2010-09-02 Somalogic, Inc. Ovarian Cancer Biomarkers and Uses Thereof
IT1392238B1 (it) * 2008-12-02 2012-02-22 Fond Santa Lucia Uso della caspasi-3 per la malattia dell'alzheimer
US7952068B2 (en) 2008-12-16 2011-05-31 Quest Diagnostics Investments Incorporated Methods for detecting catecholamines by mass spectrometry
EP2293072A1 (de) * 2009-08-31 2011-03-09 Sanofi-Aventis Verwendung von Kathepsin H
AU2010291933B2 (en) 2009-09-14 2016-09-08 Banyan Biomarkers, Inc. Micro-RNA, autoantibody and protein markers for diagnosis of neuronal injury
JP6063378B2 (ja) 2010-01-26 2017-01-18 バンヤン・バイオマーカーズ・インコーポレイテッド アルギニノコハク酸合成酵素に関係する組成物および方法
AU2011229918B2 (en) * 2010-03-24 2015-02-05 Parker Proteomics, Llc Methods for conducting genetic analysis using protein polymorphisms
US20130029362A1 (en) * 2010-04-01 2013-01-31 Andreas Jeromin Markers and assays for detection of neurotoxicity
WO2011160096A2 (en) * 2010-06-17 2011-12-22 Banyan Biomarkers, Inc. Glial fibrillary acidic protein, autoantigens and autoantibodies thereto as biomarkers of neural injury or neurological disorder or condition
JP5905003B2 (ja) 2010-07-09 2016-04-20 ソマロジック・インコーポレーテッド 肺癌バイオマーカーとその使用
MX350533B (es) 2010-08-13 2017-09-08 Somalogic Inc Biomarcadores de cancer pancreatico y usos de los mismos.
WO2012051519A2 (en) 2010-10-14 2012-04-19 The Johns Hopkins University Biomarkers of brain injury
EP2638403B1 (de) 2010-11-09 2017-03-22 Sarcotein Diagnostics LLC Bin1-expression als marker für die skelettmuskelmasse und die nerven betreffende erkrankungen
WO2012071584A2 (en) * 2010-11-26 2012-05-31 Brigham And Women's Hospital, Inc. Method for assessing repetitive head injuries with tow-dimensional magnetic resonance spectorscopy
KR101333207B1 (ko) * 2011-07-13 2013-11-26 부산대학교 산학협력단 자궁내막증과 연관된 유전자 마커 및 이의 용도
CA2850178C (en) 2011-09-30 2020-02-25 Sarcotein Diagnostics, Llc Bin1 expression as a marker of cancer
US8604016B2 (en) 2011-11-21 2013-12-10 Calithera Biosciences Inc. Heterocyclic inhibitors of glutaminase
WO2013138509A1 (en) 2012-03-13 2013-09-19 The Johns Hopkins University Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration
US20140024053A1 (en) * 2012-07-20 2014-01-23 Banyan Biomarkers, Inc. Methods, kits and devices for detecting bii-spectrin, and breakdown products thereof, as biomarkers for the diagnosis of neural injury
EP2885010B1 (de) 2012-08-16 2020-01-01 Ipierian, Inc. Verfahren zur behandlung einer tauopathie
HUE056078T2 (hu) 2012-11-16 2022-01-28 Calithera Biosciences Inc Heterociklusos glutamináz inhibitorok
HK1220640A1 (zh) * 2012-12-03 2017-05-12 Calithera Biosciences, Inc. 用谷氨醯胺酶的杂环抑制剂治疗癌症
US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
DE102012223378A1 (de) * 2012-12-17 2014-06-18 Charité - Universitätsmedizin Berlin In-vitro Verfahren und Kit zur Diagnose von akutem Koronarsyndrom
US8980270B2 (en) 2013-01-18 2015-03-17 Ipierian, Inc. Methods of treating a tauopathy
US10235339B2 (en) 2013-02-19 2019-03-19 Keysight Technologies, Inc. Digital measurement instrument triggered by signal pattern
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics
EP3022322A4 (de) 2013-07-17 2017-05-17 The Johns Hopkins University Multiprotein-biomarkertest für den nachweis von hirnläsionen und ergebnis
CN105939722A (zh) 2014-02-14 2016-09-14 伊皮埃里安股份有限公司 Tau肽,抗Tau抗体,及其使用方法
WO2015191825A1 (en) * 2014-06-13 2015-12-17 Biogen Ma Inc. Methods for the detection and measurement of amyloid beta in biological samples
SG11201610333VA (en) 2014-06-13 2017-01-27 Calithera Biosciences Inc Combination therapy with glutaminase inhibitors
JP6889101B2 (ja) 2014-08-07 2021-06-18 キャリセラ バイオサイエンシーズ, インコーポレイテッド グルタミナーゼ阻害剤の結晶形態
BR112017005730B1 (pt) 2014-09-26 2023-12-12 Somalogic Operating Co., Inc Método para triagem de um indivíduo quanto ao risco de um evento cardiovascular ou para predizer a probabilidade que um indivíduo tenha tal evento
WO2016069461A1 (en) * 2014-10-27 2016-05-06 The Trustees Of The University Of Pennsylvania A parkinson's disease diagnostic biomarker panel
MA41115A (fr) 2014-12-02 2017-10-10 Biogen Int Neuroscience Gmbh Procédé de traitement de la maladie d'alzheimer
US20180024145A1 (en) 2015-02-05 2018-01-25 Immunarray USA, Inc. Methods and compositions for diagnosing brain injury or neurodegeneration
HK1246394A1 (zh) 2015-03-02 2018-09-07 Sarcotein Diagnostics Llc 13+/17+bin1表达作为心脏病症的标记
BR112017021312A2 (pt) 2015-04-06 2018-06-26 Calithera Biosciences Inc tratamento de câncer de pulmão com inibidores de glutaminase
US10988528B2 (en) 2015-08-13 2021-04-27 New York University Antibody-based molecules specific for the truncated ASP421 epitope of Tau and their uses in the diagnosis and treatment of tauopathy
SG11201802830QA (en) 2015-10-05 2018-05-30 Calithera Biosciences Inc Combination therapy with glutaminase inhibitors and immuno-oncology agents
WO2017100789A1 (en) * 2015-12-11 2017-06-15 Expression Pathology, Inc. Srm/mrm assays
JP7177702B2 (ja) * 2016-05-06 2022-11-24 ナノソミックス・インコーポレイテッド アルツハイマー病および他の神経変性障害のシナプスタンパク質バイオマーカーおよび鑑別診断
WO2018039544A1 (en) 2016-08-25 2018-03-01 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors
WO2018039441A1 (en) 2016-08-25 2018-03-01 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors
JP2020500508A (ja) 2016-10-28 2020-01-16 バンヤン・バイオマーカーズ・インコーポレーテッド ユビキチンc末端ヒドロラーゼl1(uch−l1)およびグリア線維酸性タンパク質(gfap)に対する抗体および関連する方法
CA3053379A1 (en) 2017-02-17 2018-08-23 Denali Therapeutics Inc. Anti-tau antibodies and methods of use thereof
JP7346300B2 (ja) 2017-03-23 2023-09-19 アボット・ラボラトリーズ 早期バイオマーカーであるユビキチンカルボキシ末端ヒドロラーゼl1を使用する、ヒト対象における外傷性脳損傷の程度の診断及び決定の一助となるための方法
EP3610268B1 (de) 2017-04-15 2025-09-24 Abbott Laboratories Verfahren zur unterstützung der diagnose und der bestimmung von traumatischen gehirnschäden bei menschen mithilfe frühen biomarkern
JP7080899B2 (ja) 2017-04-28 2022-06-06 アボット・ラボラトリーズ 同じヒト対象に由来する少なくとも2つの試料に対して早期バイオマーカーを使用する、外傷性脳損傷の超急性の診断及び決定の一助となるための方法
US10866251B2 (en) 2017-05-25 2020-12-15 Abbott Laboratories Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers
WO2018222783A1 (en) 2017-05-30 2018-12-06 Abbott Laboratories Methods for aiding in diagnosing and evaluating a mild traumatic brain injury in a human subject using cardiac troponin i and early biomarkers
EP3649474A1 (de) 2017-07-03 2020-05-13 Abbott Laboratories Verbesserte verfahren zur messung von ubiquitin-carboxy-terminalen hydrolase-l1-konzentrationen in blut
RU2668534C1 (ru) * 2017-07-18 2018-10-01 Общество с ограниченной ответственностью "ДРД" Диагностический набор реагентов для выявления хронических патологий мозга ишемического генеза
EP3655545B1 (de) 2017-07-18 2023-10-18 The Research Foundation for The State University of New York Biomarker für intrakranielles aneurysma
MD3672631T3 (ro) 2017-08-22 2023-09-30 Biogen Ma Inc Compoziții farmaceutice conținând anticorpi anti-beta amiloidici
CN107976481B (zh) * 2017-11-01 2020-04-07 广西壮族自治区食品药品检验所 一种中药材中钪含量的检测方法
WO2019113525A2 (en) 2017-12-09 2019-06-13 Abbott Laboratories Methods for aiding in the diagnosis and evaluation of a subject who has sustained an orthopedic injury and that has or may have sustained an injury to the head, such as mild traumatic brain injury (tbi), using glial fibrillary acidic protein (gfap) and/or ubiquitin carboxy-terminal hydrolase l1 (uch-l1)
WO2019112860A1 (en) 2017-12-09 2019-06-13 Abbott Laboratories Methods for aiding in diagnosing and evaluating a traumatic brain injury in a human subject using a combination of gfap and uch-l1
WO2019133717A1 (en) 2017-12-29 2019-07-04 Abbott Laboratories Novel biomarkers and methods for diagnosing and evaluating traumatic brain injury
US12590974B2 (en) 2019-11-26 2026-03-31 Ohio State Innovation Foundation Methods and compositions for cardiovascular disease detection and management
WO2021234607A1 (en) * 2020-05-20 2021-11-25 St. Jude Children's Research Hospital Detection of alzheimer's disease using specific biomarkers
CN112661828B (zh) * 2021-01-15 2022-04-01 武汉大学 一种突触素的抗原肽及其抗体与应用
CN117098993A (zh) * 2021-03-08 2023-11-21 阿克斯胡斯大学医院Hf 清除测定
CA3231228A1 (en) 2021-09-09 2023-03-16 Andreas Jeromin Phospho-tau antibodies and methods of use
BR102021020613A2 (pt) * 2021-10-14 2023-04-18 Universidade Federal Do Rio De Janeiro Método de investigação proteômica em amostra para diagnóstico da rabdomiólise e kits para realização do mesmo
US11928221B2 (en) 2021-11-29 2024-03-12 Bank Of America Corporation Source code clustering for automatically identifying false positives generated through static application security testing
US11941115B2 (en) 2021-11-29 2024-03-26 Bank Of America Corporation Automatic vulnerability detection based on clustering of applications with similar structures and data flows
CN116297952B (zh) * 2023-03-10 2023-10-31 山东省食品药品检验研究院 一种基于肽组学的用于海马物种鉴别的肽生物标志物及其应用
KR102829879B1 (ko) * 2023-03-16 2025-07-04 단국대학교 천안캠퍼스 산학협력단 소변 대사 산물을 이용한 유소년 운동 선수의 건강 상태 진단 방법
CN117586956A (zh) * 2023-11-17 2024-02-23 杭州师范大学 一种用于制备人乳腺癌组织单细胞悬液的解离液组合、试剂盒及方法
CN122438860A (zh) * 2023-12-22 2026-07-21 豪夫迈·罗氏有限公司 抗骨骼肌肌钙蛋白t抗体及其诊断用途
WO2026163091A1 (en) 2025-01-29 2026-08-06 ENEA - Agenzia nazionale per le nuove tecnologie, l'energia e lo sviluppo economico sostenibile Stage-specific combined fecal microrna panels as biomarkers for early diagnosis, clinical stratification and monitoring of alzheimer's disease
CN119985970B (zh) * 2025-04-11 2025-07-25 山东第一医科大学(山东省医学科学院) 检测焦谷氨酸氨肽酶的试剂在制备类风湿性关节炎诊断产品中的应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118606A (en) * 1988-09-02 1992-06-02 The Regents Of The University Of California Methods for detecting cellular pathology by assaying spectrin and spectrin breakdown products
US5912121A (en) * 1992-12-11 1999-06-15 Bringham And Women's Hospital Methods for detecting mutations associated with hypertrophic cardiomyopathy
US5536639A (en) 1994-03-25 1996-07-16 Cephalon, Inc. Methods for detecting calpain activation by detection of calpain activated spectrin breakdown products
AU3805497A (en) * 1996-07-19 1998-02-10 Neurotrauma Therapeutics, Inc. Calpain inhibitors for the treatment of traumatic brain injury
US6048703A (en) * 1996-11-15 2000-04-11 Cephalon, Inc. Methods for detecting cell apoptosis
US7384751B1 (en) * 1997-07-16 2008-06-10 Queen's University At Kingston Methods of diagnosing muscle damage
CA2351562A1 (en) 1998-12-09 2000-06-15 Frank P. Zemlan A method for detecting neuronal cell damage by quantification of map-2 levels in biological fluids
US6589746B1 (en) * 1999-10-21 2003-07-08 University Of Cincinnati Method of detecting axonally-derived protein tau in patients with traumatic CNS injury
US6819325B2 (en) * 2000-03-07 2004-11-16 Microsoft Corporation API communications for vertex and pixel shaders
US20030040660A1 (en) * 2001-08-27 2003-02-27 George Jackowski Method for diagnosing and distinguishing traumatic brain injury and diagnostic devices for use therein
JP2005538380A (ja) * 2002-09-11 2005-12-15 ユニヴァーシティ オヴ フロリダ 神経細胞損傷の分析
US7196169B2 (en) * 2002-10-11 2007-03-27 Queen's University At Kingston Isolated post-translationally modified mammalian proteins for monitoring and diagnosing muscle damage
US20040241762A1 (en) * 2003-03-31 2004-12-02 Gerry Shaw Assessing neuronal damage from blood samples
US20050202508A1 (en) * 2003-11-12 2005-09-15 Pasinetti Guilio M. Biomarker for Parkinson's disease
EP1745149A4 (de) * 2004-04-15 2008-08-06 Univ Florida Neurale proteine als biomarker für eine verletzung des nervensystems und andere neurale störungen
ES2732071T3 (es) 2005-04-01 2019-11-20 Univ Florida Biomarcadores de lesiones hepáticas
US7398484B2 (en) * 2005-04-27 2008-07-08 Microsoft Corporation Memory efficient array transposition via multi pass tiling

Also Published As

Publication number Publication date
CA2578680A1 (en) 2005-12-01
US7456027B2 (en) 2008-11-25
EP1747282A4 (de) 2009-11-11
AU2005245785B2 (en) 2011-04-07
EP1747282B1 (de) 2011-06-08
WO2005113798A3 (en) 2008-10-23
CA2578680C (en) 2011-06-14
AU2005245785A1 (en) 2005-12-01
AU2005245785A2 (en) 2005-12-01
US20090317805A1 (en) 2009-12-24
EP1747282A2 (de) 2007-01-31
JP4885122B2 (ja) 2012-02-29
WO2005113798A2 (en) 2005-12-01
ES2367311T3 (es) 2011-11-02
US8298835B2 (en) 2012-10-30
JP2007535318A (ja) 2007-12-06
US20050260697A1 (en) 2005-11-24

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