ATE512952T1 - Indazole, benzisoxazole und benzisothiazole und deren verwendung als östrogene mittel - Google Patents

Indazole, benzisoxazole und benzisothiazole und deren verwendung als östrogene mittel

Info

Publication number: ATE512952T1
Authority: AT; Austria
Prior art keywords: benzisoxazoles; benzisothiazoles; indazoles; estrogenic agents; estrogenic
Prior art date: 2004-10-14

Application number

AT05794749T

Other languages

English (en)

Inventor

Benoit Rondot

Jean Lafay

Paule Bonnet

Thierry Clerc

Igor Duc

Eric Duranti

Francois Puccio

Jacqueline Shields

Christian Blot

Philippe Maillos

Original Assignee

Theramex

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-14

Filing date

2005-10-14

Publication date

2011-07-15

2005-10-14 Application filed by Theramex filed Critical Theramex

2011-07-15 Application granted granted Critical

2011-07-15 Publication of ATE512952T1 publication Critical patent/ATE512952T1/de

Links

BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 title 1
150000008316 benzisoxazoles Chemical class 0.000 title 1
239000000262 estrogen Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Reproductive Health (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Immunology (AREA)
Pregnancy & Childbirth (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT05794749T 2004-10-14 2005-10-14 Indazole, benzisoxazole und benzisothiazole und deren verwendung als östrogene mittel ATE512952T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP04292439A EP1647549A1 (de)	2004-10-14	2004-10-14	Indazole, Benzisoxazole und Benzisothiazole mit oestrogenen Eigenschaften
PCT/EP2005/055262 WO2006040351A1 (en)	2004-10-14	2005-10-14	Indazoles, benzisoxazoles and benzisothiazoles and their use as estrogenic agents

Publications (1)

Publication Number	Publication Date
ATE512952T1 true ATE512952T1 (de)	2011-07-15

Family

ID=34931452

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05794749T ATE512952T1 (de)	2004-10-14	2005-10-14	Indazole, benzisoxazole und benzisothiazole und deren verwendung als östrogene mittel

Country Status (24)

Country	Link
US (2)	US7977364B2 (de)
EP (2)	EP1647549A1 (de)
JP (1)	JP5047801B2 (de)
KR (1)	KR20070109976A (de)
CN (1)	CN101080395B (de)
AP (1)	AP2007003960A0 (de)
AR (1)	AR051457A1 (de)
AT (1)	ATE512952T1 (de)
AU (1)	AU2005293509B2 (de)
BR (1)	BRPI0516851A (de)
CA (1)	CA2582180C (de)
ES (1)	ES2368203T3 (de)
IL (1)	IL182047A (de)
MA (1)	MA28928B1 (de)
MX (1)	MX2007004372A (de)
NO (1)	NO20071922L (de)
NZ (1)	NZ554279A (de)
RU (1)	RU2402536C2 (de)
SG (1)	SG158886A1 (de)
TN (1)	TNSN07138A1 (de)
TW (1)	TW200619202A (de)
UA (1)	UA90280C2 (de)
WO (1)	WO2006040351A1 (de)
ZA (1)	ZA200702690B (de)

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GB0803017D0 (en) *	2008-02-19	2008-03-26	Glaxo Group Ltd	Compounds
ES2770550T3 (es) *	2011-05-17	2020-07-02	Univ California	Inhibidores de quinasa
US20150018398A1 (en) *	2013-07-15	2015-01-15	The Regents Of The University Of California	Methods of using estrogen receptor-beta ligands as radiation mitigators
DE102015012050A1 (de) *	2015-09-15	2017-03-16	Merck Patent Gmbh	Verbindungen als ASIC-Inhibitoren und deren Verwendungen
CN109111407A (zh) *	2017-06-23	2019-01-01	江苏恩华药业股份有限公司	一种苯并异恶唑类化合物衍生物及其应用
AU2018312349A1 (en)	2017-08-01	2020-02-06	Theravance Biopharma R&D Ip, Llc	Pyrazolo and triazolo bicyclic compounds as JAK kinase inhibitors
CN110117278B (zh) *	2018-02-07	2022-07-19	石家庄以岭药业股份有限公司	烷氧基苯并五元(六元)杂环胺类化合物及其药物用途
CN113498352A (zh)	2019-01-23	2021-10-12	施万生物制药研发Ip有限责任公司	作为jak抑制剂的咪唑并[1,5-a]吡啶、1,2,4-三唑并[4,3-a]吡啶和咪唑并[1,5-a]吡嗪

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WO2006010595A1 (en) *	2004-07-27	2006-02-02	Novartis Ag	Inhibitors of hsp90
EP1647549A1 (de) *	2004-10-14	2006-04-19	Laboratoire Theramex	Indazole, Benzisoxazole und Benzisothiazole mit oestrogenen Eigenschaften

2004
- 2004-10-14 EP EP04292439A patent/EP1647549A1/de not_active Withdrawn
2005
- 2005-10-14 US US11/664,887 patent/US7977364B2/en not_active Expired - Fee Related
- 2005-10-14 AU AU2005293509A patent/AU2005293509B2/en not_active Ceased
- 2005-10-14 TW TW094136060A patent/TW200619202A/zh unknown
- 2005-10-14 CA CA2582180A patent/CA2582180C/en not_active Expired - Fee Related
- 2005-10-14 ES ES05794749T patent/ES2368203T3/es not_active Expired - Lifetime
- 2005-10-14 MX MX2007004372A patent/MX2007004372A/es active IP Right Grant
- 2005-10-14 SG SG201000276-4A patent/SG158886A1/en unknown
- 2005-10-14 BR BRPI0516851-1A patent/BRPI0516851A/pt not_active IP Right Cessation
- 2005-10-14 AP AP2007003960A patent/AP2007003960A0/xx unknown
- 2005-10-14 CN CN2005800430259A patent/CN101080395B/zh not_active Expired - Fee Related
- 2005-10-14 WO PCT/EP2005/055262 patent/WO2006040351A1/en not_active Ceased
- 2005-10-14 AR ARP050104313A patent/AR051457A1/es not_active Application Discontinuation
- 2005-10-14 NZ NZ554279A patent/NZ554279A/en not_active IP Right Cessation
- 2005-10-14 ZA ZA200702690A patent/ZA200702690B/xx unknown
- 2005-10-14 JP JP2007536185A patent/JP5047801B2/ja not_active Expired - Fee Related
- 2005-10-14 EP EP05794749A patent/EP1812404B1/de not_active Expired - Lifetime
- 2005-10-14 UA UAA200704016A patent/UA90280C2/ru unknown
- 2005-10-14 RU RU2007117714/04A patent/RU2402536C2/ru not_active IP Right Cessation
- 2005-10-14 AT AT05794749T patent/ATE512952T1/de not_active IP Right Cessation
- 2005-10-14 KR KR1020077007907A patent/KR20070109976A/ko not_active Ceased
2007
- 2007-03-20 IL IL182047A patent/IL182047A/en not_active IP Right Cessation
- 2007-04-09 MA MA29816A patent/MA28928B1/fr unknown
- 2007-04-13 TN TNP2007000138A patent/TNSN07138A1/fr unknown
- 2007-04-16 NO NO20071922A patent/NO20071922L/no not_active Application Discontinuation
2011
- 2011-06-03 US US13/152,433 patent/US8173679B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2582180C (en)	2013-04-30
ZA200702690B (en)	2008-10-29
TNSN07138A1 (en)	2008-11-21
AR051457A1 (es)	2007-01-17
BRPI0516851A (pt)	2008-09-23
ES2368203T3 (es)	2011-11-15
US20090023779A1 (en)	2009-01-22
CA2582180A1 (en)	2006-04-20
NO20071922L (no)	2007-07-06
JP2008516929A (ja)	2008-05-22
EP1812404A1 (de)	2007-08-01
US7977364B2 (en)	2011-07-12
WO2006040351A1 (en)	2006-04-20
TW200619202A (en)	2006-06-16
CN101080395A (zh)	2007-11-28
JP5047801B2 (ja)	2012-10-10
AU2005293509A1 (en)	2006-04-20
IL182047A (en)	2013-03-24
SG158886A1 (en)	2010-02-26
MX2007004372A (es)	2007-06-07
RU2402536C2 (ru)	2010-10-27
MA28928B1 (fr)	2007-10-01
US20110237624A1 (en)	2011-09-29
US8173679B2 (en)	2012-05-08
IL182047A0 (en)	2007-07-24
KR20070109976A (ko)	2007-11-15
EP1647549A1 (de)	2006-04-19
AP2007003960A0 (en)	2007-04-30
AU2005293509B2 (en)	2012-01-12
UA90280C2 (ru)	2010-04-26
RU2007117714A (ru)	2008-11-20
CN101080395B (zh)	2011-08-17
EP1812404B1 (de)	2011-06-15
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