ATE513041T1 - Ghrelin bindende nukleinsäuren - Google Patents

Ghrelin bindende nukleinsäuren

Info

Publication number: ATE513041T1
Authority: AT; Austria
Prior art keywords: nucleic acids; binding nucleic; ghrelin binding; ghrelin; nucleic acid
Prior art date: 2002-08-01

Application number

AT03766390T

Other languages

English (en)

Inventor

Steffen Helmling

Dirk Eulberg

Christian Maasch

Sven Klussmann

Original Assignee

Noxxon Pharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-01

Filing date

2003-08-01

Publication date

2011-07-15

2002-08-01 Priority claimed from EP02017317A external-priority patent/EP1386972A1/de

2003-08-01 Application filed by Noxxon Pharma Ag filed Critical Noxxon Pharma Ag

2011-07-15 Application granted granted Critical

2011-07-15 Publication of ATE513041T1 publication Critical patent/ATE513041T1/de

Links

102000012004 Ghrelin Human genes 0.000 title abstract 2
101800001586 Ghrelin Proteins 0.000 title abstract 2
GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 title abstract 2
150000007523 nucleic acids Chemical class 0.000 title abstract 2
102000039446 nucleic acids Human genes 0.000 title abstract 2
108020004707 nucleic acids Proteins 0.000 title abstract 2
239000005557 antagonist Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Obesity (AREA)
Hematology (AREA)
Cardiology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Child & Adolescent Psychology (AREA)
Nutrition Science (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT03766390T 2002-08-01 2003-08-01 Ghrelin bindende nukleinsäuren ATE513041T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
EP02017317A EP1386972A1 (de)	2002-08-01	2002-08-01	Verfahren und Vorrichtung zum Entwurf einer Nukleinsäure mit einer gewünschten Eigenschaft
EP02023637		2002-10-19
EP03014111		2003-06-23
PCT/EP2003/008542 WO2004013274A2 (en)	2002-08-01	2003-08-01	Ghrelin binding nucleic acids

Publications (1)

Publication Number	Publication Date
ATE513041T1 true ATE513041T1 (de)	2011-07-15

Family

ID=31498967

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03766390T ATE513041T1 (de)	2002-08-01	2003-08-01	Ghrelin bindende nukleinsäuren

Country Status (6)

Country	Link
US (2)	US7750140B2 (de)
EP (1)	EP1530635B1 (de)
JP (1)	JP4644599B2 (de)
AT (1)	ATE513041T1 (de)
AU (1)	AU2003251681A1 (de)
WO (1)	WO2004013274A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2004291656A1 (en) *	2003-11-10	2005-06-02	Noxxon Pharma Ag	Nucleic acids specifically binding bioactive ghrelin
EP1746983A2 (de) *	2004-05-14	2007-01-31	Novo Nordisk A/S	Verwendung von ghrelin-antagonisten zur verbesserung von kognition und gedächtnis
WO2006058705A1 (de) *	2004-11-29	2006-06-08	Noxxon Pharma Ag	Vasopressin bindende l-nukleinsäure
UY29460A1 (es) *	2005-04-08	2006-11-30	Noxxon Pharma Ag	Acidos nucleicos de union a ghrelin
US8367629B2 (en) *	2006-02-14	2013-02-05	Noxxon Pharma Ag	MCP-1 binding nucleic acids and use thereof
AU2007214668B2 (en) *	2006-02-14	2012-05-24	TME Pharma AG	MCP-I binding nucleic acids
RU2542973C2 (ru) *	2007-11-30	2015-02-27	Ноксон Фарма Аг	Связывающая мср-1 нуклеиновая кислота и ее применение
JP2013506687A (ja) *	2009-09-30	2013-02-28	プレジデントアンドフェロウズオブハーバードカレッジ	オートファジー促進遺伝子産物の変調によりオートファジーを変調する方法
WO2011053821A1 (en)	2009-10-30	2011-05-05	Tranzyme Pharma, Inc.	Macrocyclic ghrelin receptor antagonists and inverse agonists and methods of using the same
DE102012020496A1 (de)	2012-10-18	2014-04-24	Charité - Universitätsmedizin Berlin	Biomarker zur Diagnostik und Behandlung von Neurofibromatose Typ 1

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5614395A (en) *	1988-03-08	1997-03-25	Ciba-Geigy Corporation	Chemically regulatable and anti-pathogenic DNA sequences and uses thereof
EP1493825A3 (de) *	1990-06-11	2005-02-09	Gilead Sciences, Inc.	Verfahren zur Herstellung von Nukleinsäureliganden
JPH11505527A (ja) *	1995-05-03	1999-05-21	ホワイトヘッドインスティチュートフォーバイオメディカルリサーチ	鏡像異性体リガンドの同定
DE19808591C2 (de) *	1998-02-28	2000-02-03	Univ Leipzig	Standardisierter durchflußzytometrischer Vollblutassay
AU2001259056A1 (en)	2000-05-17	2001-11-26	Eli Lilly And Company	Method for selectively inhibiting ghrelin action
US20030211967A1 (en) *	2001-05-07	2003-11-13	Bryant Henry Uhlman	Method for selectively inhibiting ghrelin action
WO2001092292A2 (en)	2000-05-30	2001-12-06	Merck & Co., Inc.	Ghrelin analogs
AU2004291656A1 (en) *	2003-11-10	2005-06-02	Noxxon Pharma Ag	Nucleic acids specifically binding bioactive ghrelin
UY29460A1 (es) *	2005-04-08	2006-11-30	Noxxon Pharma Ag	Acidos nucleicos de union a ghrelin

2003
- 2003-08-01 EP EP03766390A patent/EP1530635B1/de not_active Expired - Lifetime
- 2003-08-01 AT AT03766390T patent/ATE513041T1/de not_active IP Right Cessation
- 2003-08-01 AU AU2003251681A patent/AU2003251681A1/en not_active Abandoned
- 2003-08-01 WO PCT/EP2003/008542 patent/WO2004013274A2/en not_active Ceased
- 2003-08-01 JP JP2005506074A patent/JP4644599B2/ja not_active Expired - Fee Related
- 2003-08-01 US US10/522,582 patent/US7750140B2/en not_active Expired - Fee Related
2010
- 2010-05-08 US US12/776,377 patent/US20120083520A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU2003251681A1 (en)	2004-02-23
AU2003251681A8 (en)	2004-02-23
EP1530635A2 (de)	2005-05-18
EP1530635B1 (de)	2011-06-15
US20120083520A1 (en)	2012-04-05
JP4644599B2 (ja)	2011-03-02
US7750140B2 (en)	2010-07-06
WO2004013274A3 (en)	2004-05-13
JP2006501864A (ja)	2006-01-19
US20060257867A1 (en)	2006-11-16
WO2004013274A2 (en)	2004-02-12

Legal Events

Date	Code	Title	Description
2011-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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