ATE513041T1 - Ghrelin bindende nukleinsäuren - Google Patents

Ghrelin bindende nukleinsäuren

Info

Publication number: ATE513041T1
Authority: AT; Austria
Prior art keywords: nucleic acids; binding nucleic; ghrelin binding; ghrelin; nucleic acid
Prior art date: 2002-08-01

Application number

AT03766390T

Other languages

English (en)

Inventor

Steffen Helmling

Dirk Eulberg

Christian Maasch

Sven Klussmann

Original Assignee

Noxxon Pharma Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-01

Filing date

2003-08-01

Publication date

2011-07-15

2002-08-01 Priority claimed from EP02017317A external-priority patent/EP1386972A1/de

2003-08-01 Application filed by Noxxon Pharma Ag filed Critical Noxxon Pharma Ag

2011-07-15 Application granted granted Critical

2011-07-15 Publication of ATE513041T1 publication Critical patent/ATE513041T1/de

Links

102000012004 Ghrelin Human genes 0.000 title abstract 2
101800001586 Ghrelin Proteins 0.000 title abstract 2
GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 title abstract 2
150000007523 nucleic acids Chemical class 0.000 title abstract 2
102000039446 nucleic acids Human genes 0.000 title abstract 2
108020004707 nucleic acids Proteins 0.000 title abstract 2
239000005557 antagonist Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Obesity (AREA)
Hematology (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Nutrition Science (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT03766390T 2002-08-01 2003-08-01 Ghrelin bindende nukleinsäuren ATE513041T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
EP02017317A EP1386972A1 (de)	2002-08-01	2002-08-01	Verfahren und Vorrichtung zum Entwurf einer Nukleinsäure mit einer gewünschten Eigenschaft
EP02023637		2002-10-19
EP03014111		2003-06-23
PCT/EP2003/008542 WO2004013274A2 (en)	2002-08-01	2003-08-01	Ghrelin binding nucleic acids

Publications (1)

Publication Number	Publication Date
ATE513041T1 true ATE513041T1 (de)	2011-07-15

Family

ID=31498967

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03766390T ATE513041T1 (de)	2002-08-01	2003-08-01	Ghrelin bindende nukleinsäuren

Country Status (6)

Country	Link
US (2)	US7750140B2 (de)
EP (1)	EP1530635B1 (de)
JP (1)	JP4644599B2 (de)
AT (1)	ATE513041T1 (de)
AU (1)	AU2003251681A1 (de)
WO (1)	WO2004013274A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2004291656A1 (en) *	2003-11-10	2005-06-02	Noxxon Pharma Ag	Nucleic acids specifically binding bioactive ghrelin
JP2007537207A (ja) *	2004-05-14	2007-12-20	ノボ　ノルディスク　アクティーゼルスカブ	一定の中枢神経疾患の治療のためのグレリンアンタゴニストの使用
WO2006058705A1 (de) *	2004-11-29	2006-06-08	Noxxon Pharma Ag	Vasopressin bindende l-nukleinsäure
UY29460A1 (es) *	2005-04-08	2006-11-30	Noxxon Pharma Ag	Acidos nucleicos de union a ghrelin
US8367629B2 (en) *	2006-02-14	2013-02-05	Noxxon Pharma Ag	MCP-1 binding nucleic acids and use thereof
PL2135949T3 (pl) *	2006-02-14	2013-03-29	Noxxon Pharma Ag	Kwasy nukleinowe wiążące MCP-1
CA2707089A1 (en) *	2007-11-30	2009-06-04	Noxxon Pharma Ag	Mcp-1 binding nucleic acids and use thereof
CN102639700A (zh) *	2009-09-30	2012-08-15	哈佛大学校长及研究员协会	通过调节自噬增强基因产物调节自噬的方法
US20110105389A1 (en)	2009-10-30	2011-05-05	Hoveyda Hamid R	Macrocyclic Ghrelin Receptor Antagonists and Inverse Agonists and Methods of Using the Same
DE102012020496A1 (de)	2012-10-18	2014-04-24	Charité - Universitätsmedizin Berlin	Biomarker zur Diagnostik und Behandlung von Neurofibromatose Typ 1

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5614395A (en) *	1988-03-08	1997-03-25	Ciba-Geigy Corporation	Chemically regulatable and anti-pathogenic DNA sequences and uses thereof
ATE318832T1 (de) *	1990-06-11	2006-03-15	Gilead Sciences Inc	Verfahren zur vervendung von nukleinsäureliganden
WO1996034879A1 (en) *	1995-05-03	1996-11-07	Whitehead Institute For Biomedical Research	Identification of enantiomeric ligands
DE19808591C2 (de)	1998-02-28	2000-02-03	Univ Leipzig	Standardisierter durchflußzytometrischer Vollblutassay
EP1286697A2 (de) *	2000-05-17	2003-03-05	Eli Lilly And Company	Methode zur selektiven hemmung der aktivität von ghrelin
US20030211967A1 (en) *	2001-05-07	2003-11-13	Bryant Henry Uhlman	Method for selectively inhibiting ghrelin action
CA2411667A1 (en)	2000-05-30	2001-12-06	Merck & Co. Inc.	Ghrelin analogs
AU2004291656A1 (en)	2003-11-10	2005-06-02	Noxxon Pharma Ag	Nucleic acids specifically binding bioactive ghrelin
UY29460A1 (es)	2005-04-08	2006-11-30	Noxxon Pharma Ag	Acidos nucleicos de union a ghrelin

2003
- 2003-08-01 EP EP03766390A patent/EP1530635B1/de not_active Expired - Lifetime
- 2003-08-01 US US10/522,582 patent/US7750140B2/en not_active Expired - Fee Related
- 2003-08-01 JP JP2005506074A patent/JP4644599B2/ja not_active Expired - Fee Related
- 2003-08-01 AU AU2003251681A patent/AU2003251681A1/en not_active Abandoned
- 2003-08-01 WO PCT/EP2003/008542 patent/WO2004013274A2/en not_active Ceased
- 2003-08-01 AT AT03766390T patent/ATE513041T1/de not_active IP Right Cessation
2010
- 2010-05-08 US US12/776,377 patent/US20120083520A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20060257867A1 (en)	2006-11-16
AU2003251681A8 (en)	2004-02-23
JP4644599B2 (ja)	2011-03-02
JP2006501864A (ja)	2006-01-19
WO2004013274A2 (en)	2004-02-12
EP1530635B1 (de)	2011-06-15
WO2004013274A3 (en)	2004-05-13
US7750140B2 (en)	2010-07-06
AU2003251681A1 (en)	2004-02-23
US20120083520A1 (en)	2012-04-05
EP1530635A2 (de)	2005-05-18

Legal Events

Date	Code	Title	Description
2011-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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