ATE513801T1 - Verfahren zur synthese von propargylatierten aminoindanderivativen - Google Patents
Verfahren zur synthese von propargylatierten aminoindanderivativenInfo
- Publication number
- ATE513801T1 ATE513801T1 AT08863906T AT08863906T ATE513801T1 AT E513801 T1 ATE513801 T1 AT E513801T1 AT 08863906 T AT08863906 T AT 08863906T AT 08863906 T AT08863906 T AT 08863906T AT E513801 T1 ATE513801 T1 AT E513801T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- formula
- aminoindanderivatives
- propargylated
- synthesis
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 239000003960 organic solvent Substances 0.000 abstract 2
- XJEVHMGJSYVQBQ-UHFFFAOYSA-N 2,3-dihydro-1h-inden-1-amine Chemical compound C1=CC=C2C(N)CCC2=C1 XJEVHMGJSYVQBQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
- C07C209/08—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
- C07C209/74—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by halogenation, hydrohalogenation, dehalogenation, or dehydrohalogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
- C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
- C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2539MU2007 | 2007-12-24 | ||
| PCT/GB2008/004239 WO2009081148A1 (en) | 2007-12-24 | 2008-12-19 | Process for the synthesis of propargylated aminoindan derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE513801T1 true ATE513801T1 (de) | 2011-07-15 |
Family
ID=40469984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08863906T ATE513801T1 (de) | 2007-12-24 | 2008-12-19 | Verfahren zur synthese von propargylatierten aminoindanderivativen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8461388B2 (de) |
| EP (1) | EP2231582B1 (de) |
| JP (1) | JP5425806B2 (de) |
| KR (1) | KR101523195B1 (de) |
| AT (1) | ATE513801T1 (de) |
| AU (1) | AU2008339607B2 (de) |
| CA (1) | CA2708820C (de) |
| NZ (1) | NZ585752A (de) |
| WO (1) | WO2009081148A1 (de) |
| ZA (1) | ZA201003751B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5701485B2 (ja) | 2006-02-21 | 2015-04-15 | テバ ファーマシューティカル インダストリーズ リミティド | 多系統萎縮症の治療のためのラサギリンの使用 |
| CA2646250A1 (en) | 2006-04-03 | 2007-10-18 | Teva Pharmaceutical Industries Ltd. | Use of rasagiline for the treatment of restless legs syndrome |
| US8188149B2 (en) | 2007-09-17 | 2012-05-29 | Teva Pharmaceutical Industries, Ltd. | Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss |
| CA2708820C (en) | 2007-12-24 | 2016-05-10 | Cipla Limited | Process for the synthesis of propargylated aminoindan derivatives |
| MX2010013875A (es) | 2008-06-19 | 2011-01-20 | Teva Pharma | Proceso para preparar y secar base de rasagilina solida. |
| US20100189790A1 (en) | 2009-01-23 | 2010-07-29 | Teva Pharmaceutical Industries, Ltd. | Delayed release rasagiline formulation |
| US20110015274A1 (en) * | 2009-07-20 | 2011-01-20 | Ester Masllorens Llinas | Form of an aminoindan mesylate derivative |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3123642A (en) * | 1964-03-03 | Indanyl and tetrahydronaphthyl | ||
| US3253037A (en) | 1962-06-19 | 1966-05-24 | Ciba Geigy Corp | N-2-alkynyl-amino-benzocylo-alkanes |
| GB1037014A (en) | 1963-08-02 | 1966-07-20 | Aspro Nicholas Ltd | Derivatives of 1-aminoindane |
| GB1187017A (en) * | 1966-07-16 | 1970-04-08 | Aspro Nicholas Ltd | Substituted 1-Amino Indanes and Tetrahydronaphthalens |
| JP2865211B2 (ja) * | 1988-09-15 | 1999-03-08 | ファルマシア・アンド・アップジョン・カンパニー | ５’―インドリニル―５β―アミドメチルオキサゾリジン―２―オン類、３―（縮合環置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類および３―（窒素原子置換）フェニル―５β―アミドメチルオキサゾリジン―２―オン類 |
| IL92952A (en) * | 1990-01-03 | 1994-06-24 | Teva Pharma | R-enantiomers of n-propargyl-1-aminoindan compounds, their preparation and pharmaceutical compositions containing them |
| IL111240A (en) * | 1993-10-18 | 2001-10-31 | Teva Pharma | Salts of r(+) - enantiomers of n- propargyl-1-aminoindan and pharmaceutical compositions comprising them |
| TR200302026T4 (tr) * | 2000-02-22 | 2004-01-21 | Pharmacia & Upjohn Company | (2S)-aminoindan türevleri, hazırlanmaları için bir işlem ve seçici dopamin D3 ligandları olarak kullanımları. |
| EP1851188A1 (de) * | 2005-02-22 | 2007-11-07 | Teva Pharmaceutical Industries Limited | Verbessertes verfahren zur synthese enantiomerischer indanylamin-derivate |
| EP1954667B1 (de) * | 2005-11-17 | 2017-02-08 | Teva Pharmaceutical Industries Ltd | Verfahren zur isolierung propargylierter aminoindane |
| CA2708820C (en) | 2007-12-24 | 2016-05-10 | Cipla Limited | Process for the synthesis of propargylated aminoindan derivatives |
-
2008
- 2008-12-19 CA CA2708820A patent/CA2708820C/en not_active Expired - Fee Related
- 2008-12-19 US US12/810,300 patent/US8461388B2/en not_active Expired - Fee Related
- 2008-12-19 EP EP08863906A patent/EP2231582B1/de not_active Not-in-force
- 2008-12-19 NZ NZ585752A patent/NZ585752A/en not_active IP Right Cessation
- 2008-12-19 KR KR1020107016426A patent/KR101523195B1/ko not_active Expired - Fee Related
- 2008-12-19 AU AU2008339607A patent/AU2008339607B2/en not_active Ceased
- 2008-12-19 JP JP2010540170A patent/JP5425806B2/ja not_active Expired - Fee Related
- 2008-12-19 WO PCT/GB2008/004239 patent/WO2009081148A1/en not_active Ceased
- 2008-12-19 AT AT08863906T patent/ATE513801T1/de not_active IP Right Cessation
-
2010
- 2010-05-26 ZA ZA2010/03751A patent/ZA201003751B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ585752A (en) | 2011-11-25 |
| KR20100108400A (ko) | 2010-10-06 |
| JP5425806B2 (ja) | 2014-02-26 |
| CA2708820A1 (en) | 2009-07-02 |
| US8461388B2 (en) | 2013-06-11 |
| JP2011507939A (ja) | 2011-03-10 |
| AU2008339607A1 (en) | 2009-07-02 |
| AU2008339607B2 (en) | 2012-08-02 |
| ZA201003751B (en) | 2011-03-30 |
| US20110054218A1 (en) | 2011-03-03 |
| KR101523195B1 (ko) | 2015-05-27 |
| CA2708820C (en) | 2016-05-10 |
| EP2231582A1 (de) | 2010-09-29 |
| EP2231582B1 (de) | 2011-06-22 |
| WO2009081148A1 (en) | 2009-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |