ATE514699T1 - Substituierte pyrrolopyrazolderivate als kinaseinhibitoren - Google Patents

Substituierte pyrrolopyrazolderivate als kinaseinhibitoren

Info

Publication number: ATE514699T1
Authority: AT; Austria
Prior art keywords: substituted; kinase inhibitors; derivatives; pyrrolopyrazole; pyrrolopyrazole derivatives
Prior art date: 2006-10-11

Application number

AT07821056T

Other languages

English (en)

Inventor

Michele Caruso

Italo Beria

Maria Gabriella Brasca

Ron Ferguson

Helena Posteri

Original Assignee

Nerviano Medical Sciences Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-11

Filing date

2007-10-09

Publication date

2011-07-15

2007-10-09 Application filed by Nerviano Medical Sciences Srl filed Critical Nerviano Medical Sciences Srl

2011-07-15 Application granted granted Critical

2011-07-15 Publication of ATE514699T1 publication Critical patent/ATE514699T1/de

Links

GZTPJDLYPMPRDF-UHFFFAOYSA-N pyrrolo[3,2-c]pyrazole Chemical class N1=NC2=CC=NC2=C1 GZTPJDLYPMPRDF-UHFFFAOYSA-N 0.000 title abstract 2
229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1
206010028980 Neoplasm Diseases 0.000 abstract 1
102000001253 Protein Kinase Human genes 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
108060006633 protein kinase Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Communicable Diseases (AREA)
Transplantation (AREA)
Virology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT07821056T 2006-10-11 2007-10-09 Substituierte pyrrolopyrazolderivate als kinaseinhibitoren ATE514699T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06122136		2006-10-11
PCT/EP2007/060685 WO2008043745A1 (en)	2006-10-11	2007-10-09	Substituted pyrrolo-pyrazole derivatives as kinase inhibitors

Publications (1)

Publication Number	Publication Date
ATE514699T1 true ATE514699T1 (de)	2011-07-15

Family

ID=38950774

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07821056T ATE514699T1 (de)	2006-10-11	2007-10-09	Substituierte pyrrolopyrazolderivate als kinaseinhibitoren

Country Status (6)

Country	Link
US (2)	US8227472B2 (de)
EP (1)	EP2089394B1 (de)
JP (1)	JP5415271B2 (de)
AT (1)	ATE514699T1 (de)
ES (1)	ES2367416T3 (de)
WO (1)	WO2008043745A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR071780A1 (es) *	2008-05-15	2010-07-14	Nerviano Medical Sciences Srl	Derivados de carbamoilo de carbonilamino-pirazoles biciclicos como profarmacos
JP6062633B2 (ja) *	2009-01-28	2017-01-18	カラセラピューティクスインコーポレイテッド	二環式ピラゾロ複素環類
US9180127B2 (en)	2009-12-29	2015-11-10	Dana-Farber Cancer Institute, Inc.	Type II Raf kinase inhibitors
US9056867B2 (en)	2011-09-16	2015-06-16	Novartis Ag	N-substituted heterocyclyl carboxamides
CA2856291C (en)	2011-11-17	2020-08-11	Dana-Farber Cancer Institute, Inc.	Inhibitors of c-jun-n-terminal kinase (jnk)
EP2909194A1 (de)	2012-10-18	2015-08-26	Dana-Farber Cancer Institute, Inc.	Hemmer der cyclinabhängigen kinase 7 (cdk7)
WO2014063054A1 (en)	2012-10-19	2014-04-24	Dana-Farber Cancer Institute, Inc.	Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
US9758522B2 (en)	2012-10-19	2017-09-12	Dana-Farber Cancer Institute, Inc.	Hydrophobically tagged small molecules as inducers of protein degradation
WO2014138979A1 (en)	2013-03-13	2014-09-18	Canadian Blood Services	Pyrazole derivatives and their uses thereof
US10047070B2 (en)	2013-10-18	2018-08-14	Dana-Farber Cancer Institute, Inc.	Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
AU2014337122B2 (en)	2013-10-18	2019-01-03	Dana-Farber Cancer Institute, Inc.	Heteroaromatic compounds useful for the treatment of proliferative diseases
WO2015164614A1 (en)	2014-04-23	2015-10-29	Dana-Farber Cancer Institute, Inc.	Janus kinase inhibitors and uses thereof
US9862688B2 (en)	2014-04-23	2018-01-09	Dana-Farber Cancer Institute, Inc.	Hydrophobically tagged janus kinase inhibitors and uses thereof
CA2966164C (en)	2014-10-31	2023-10-17	Ube Industries, Ltd.	Substituted dihydropyrrolopyrazole compound
EP3236959B1 (de)	2014-12-23	2025-09-24	Dana-Farber Cancer Institute, Inc.	Hemmer der cyclinabhängigen kinase 7 (cdk7)
AU2016243529B2 (en)	2015-03-27	2021-03-25	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinases
WO2016161571A1 (en)	2015-04-08	2016-10-13	Merck Sharp & Dohme Corp.	Indazole and azaindazole btk inhibitors
EP3302448B1 (de)	2015-06-04	2023-10-25	Aurigene Oncology Limited	Substituierte heterocyclylderivate als cdk-inhibitoren
US10702527B2 (en)	2015-06-12	2020-07-07	Dana-Farber Cancer Institute, Inc.	Combination therapy of transcription inhibitors and kinase inhibitors
EP3309163A4 (de)	2015-06-15	2019-01-09	UBE Industries, Ltd.	Substituiertes dihydropyrrolopyrazolderivat
EP4019515A1 (de)	2015-09-09	2022-06-29	Dana-Farber Cancer Institute, Inc.	Hemmer von cyclinabhängigen kinasen
JP2019112305A (ja) *	2016-04-28	2019-07-11	宇部興産株式会社	アトピー性皮膚炎の治療または予防のための医薬組成物
JP2019112307A (ja) *	2016-04-28	2019-07-11	宇部興産株式会社	置換ジヒドロピロロピラゾール化合物および他の乾癬治療薬が組み合わせて投与される医薬組成物
JP2019112306A (ja) *	2016-04-28	2019-07-11	宇部興産株式会社	慢性閉塞性肺疾患の治療または予防のための医薬組成物
JP7590185B2 (ja)	2018-06-25	2024-11-26	ダナ－ファーバーキャンサーインスティテュート，インコーポレイテッド	Ｔａｉｒｅファミリーキナーゼインヒビターおよびそれらの使用
EP3885347B1 (de) *	2018-11-14	2023-11-22	UBE Corporation	Dihydropyrrolopyrazol-derivat
AU2019413694B2 (en)	2018-12-28	2025-03-20	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100904157B1 (ko)	2000-08-10	2009-06-23	파마시아 이탈리아 에스.피.에이.	키나제 억제제로서 활성인 비사이클로-피라졸, 이의제조방법 및 이를 포함하는 약제학적 조성물
UA81790C2 (uk)	2002-12-19	2008-02-11	Фармация Италия С.П.А.	Заміщені піролопіразольні похідні як інгібітори кінази

2007
- 2007-10-09 EP EP07821056A patent/EP2089394B1/de active Active
- 2007-10-09 AT AT07821056T patent/ATE514699T1/de active
- 2007-10-09 JP JP2009531820A patent/JP5415271B2/ja not_active Expired - Fee Related
- 2007-10-09 ES ES07821056T patent/ES2367416T3/es active Active
- 2007-10-09 US US12/444,792 patent/US8227472B2/en not_active Expired - Fee Related
- 2007-10-09 WO PCT/EP2007/060685 patent/WO2008043745A1/en not_active Ceased
2012
- 2012-06-13 US US13/495,688 patent/US8623876B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2010505905A (ja)	2010-02-25
EP2089394A1 (de)	2009-08-19
EP2089394B1 (de)	2011-06-29
ES2367416T3 (es)	2011-11-03
US8623876B2 (en)	2014-01-07
US8227472B2 (en)	2012-07-24
US20120277248A1 (en)	2012-11-01
JP5415271B2 (ja)	2014-02-12
WO2008043745A1 (en)	2008-04-17
US20100010008A1 (en)	2010-01-14

Legal Events

Date

Code

Title

Description

2012-01-15

UEP

Publication of translation of european patent specification

Ref document number: 2089394

Country of ref document: EP

Publication	Publication Date	Title
ATE514699T1 (de)	2011-07-15	Substituierte pyrrolopyrazolderivate als kinaseinhibitoren
ATE557015T1 (de)	2012-05-15	3,4-diarylpyrazole als proteinkinaseinhibitoren
MX2009006613A (es)	2009-07-02	Derivados de pirazolo-quinazolina sustituidos, proceso para su preparacion y su uso como inhibidores de cinasa.
PH12013501594A1 (en)	2014-05-12	Substituted indazole derivatives active as kinase inhibitors
EA200970595A1 (ru)	2010-02-26	Производные замещенных индазолов, активные в качестве ингибиторов киназ
WO2009071480A3 (en)	2009-11-05	Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors
ATE411022T1 (de)	2008-10-15	Pyridylpyrrol-derivate als wirksame kinase-hemmer
DK1636236T3 (da)	2013-12-09	Pyrazolo-quinazolin-derivater, en fremgangsmåde til fremstilling deraf, og deres anvendelse som kinase-inhibitorer
EA201100971A1 (ru)	2012-01-30	Производные пиримидининдола для лечения злокачественного новообразования
EA201000091A1 (ru)	2010-06-30	ПРОИЗВОДНЫЕ МОРФОЛИНОПИРИМИДИНА, ИСПОЛЬЗУЕМЫЕ ПРИ ЗАБОЛЕВАНИЯХ, СВЯЗАННЫХ С mTOR КИНАЗОЙ И/ИЛИ PI3K
EA201000090A1 (ru)	2010-06-30	Тризамещенные производные пиримидина для лечения пролиферативных заболеваний
MXPA06000302A (es)	2006-04-18	Derivados de pirazolil-indol activos como inhibidores de cinasa, procedimientos para su preparacion y composiciones farmaceuticas que los comprenden.
EA201000092A1 (ru)	2010-06-30	Тризамещенные пиримидиновые производные для лечения пролиферативных заболеваний
EA201001368A1 (ru)	2011-04-29	Гетероциклические производные мочевины и способы их применения-211
EA201001769A1 (ru)	2011-06-30	Производные хинолинов и хиноксалинов в качестве ингибиторов протеинтирозинкиназы
EA201001196A1 (ru)	2011-02-28	Соединения 4-пиридинона и их применение для лечения рака
BRPI0413438A (pt)	2006-10-17	derivados de pirimidilpirrol ativos como inibidores de cinase
UA102219C2 (ru)	2013-06-25	Замещенные пиразолохиназолиновые производные, способ их получения и их применения как ингибиторов киназы
EA201001858A1 (ru)	2011-08-30	Гетероциклические производные мочевины для лечения бактериальных инфекций
ECSP066767A (es)	2006-11-24	Derivados 1h-tieno[2,3-c]pirazol útiles como inhibidores de quinasa
CU23596A3 (es)	2010-11-11	Derivados de pirazol-quinazolina y proceso para su preparación
CU20060152A7 (es)	2010-07-20	Derivados 1h-tieno[2,3-c]pirazol útiles como inhibidores de quinasa