ATE514699T1 - Substituierte pyrrolopyrazolderivate als kinaseinhibitoren - Google Patents

Substituierte pyrrolopyrazolderivate als kinaseinhibitoren

Info

Publication number: ATE514699T1
Authority: AT; Austria
Prior art keywords: substituted; kinase inhibitors; derivatives; pyrrolopyrazole; pyrrolopyrazole derivatives
Prior art date: 2006-10-11

Application number

AT07821056T

Other languages

English (en)

Inventor

Michele Caruso

Italo Beria

Maria Gabriella Brasca

Ron Ferguson

Helena Posteri

Original Assignee

Nerviano Medical Sciences Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-11

Filing date

2007-10-09

Publication date

2011-07-15

2007-10-09 Application filed by Nerviano Medical Sciences Srl filed Critical Nerviano Medical Sciences Srl

2011-07-15 Application granted granted Critical

2011-07-15 Publication of ATE514699T1 publication Critical patent/ATE514699T1/de

Links

GZTPJDLYPMPRDF-UHFFFAOYSA-N pyrrolo[3,2-c]pyrazole Chemical class N1=NC2=CC=NC2=C1 GZTPJDLYPMPRDF-UHFFFAOYSA-N 0.000 title abstract 2
229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1
206010028980 Neoplasm Diseases 0.000 abstract 1
102000001253 Protein Kinase Human genes 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
108060006633 protein kinase Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)
Transplantation (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT07821056T 2006-10-11 2007-10-09 Substituierte pyrrolopyrazolderivate als kinaseinhibitoren ATE514699T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06122136		2006-10-11
PCT/EP2007/060685 WO2008043745A1 (en)	2006-10-11	2007-10-09	Substituted pyrrolo-pyrazole derivatives as kinase inhibitors

Publications (1)

Publication Number	Publication Date
ATE514699T1 true ATE514699T1 (de)	2011-07-15

Family

ID=38950774

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07821056T ATE514699T1 (de)	2006-10-11	2007-10-09	Substituierte pyrrolopyrazolderivate als kinaseinhibitoren

Country Status (6)

Country	Link
US (2)	US8227472B2 (de)
EP (1)	EP2089394B1 (de)
JP (1)	JP5415271B2 (de)
AT (1)	ATE514699T1 (de)
ES (1)	ES2367416T3 (de)
WO (1)	WO2008043745A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CL2009001158A1 (es) *	2008-05-15	2009-10-23	Nerviano Medical Sciences Srl	Compuestos derivados de los acidos carboxilicos, tales como 5,6-dihiro-4h-pirrolo[3,4-c]pirazol, furo[3,2-c]pirazol, tieno[2,3-c]pirazol, 4,5,6,7-tetrahidropirazol[4,3-c]piridina e indazol; composicion farmaceutica; y su uso en el tratamiento de trastornos proliferativos celulares asociados a la actividad de proteina quinasa alterada, tal como el cancer.
WO2010088050A2 (en) *	2009-01-28	2010-08-05	Cara Therapeutics, Inc.	Bicyclic pyrazolo-heterocycles
EP2937345B1 (de)	2009-12-29	2018-03-21	Dana-Farber Cancer Institute, Inc.	Typ-ii-raf-kinase-hemmer
ES2882807T3 (es)	2011-09-16	2021-12-02	Novartis Ag	Heterociclil carboxamidas N-sustituidas
WO2013074986A1 (en)	2011-11-17	2013-05-23	Dana-Farber Cancer Institute, Inc.	Inhibitors of c-jun-n-terminal kinase (jnk)
US10112927B2 (en)	2012-10-18	2018-10-30	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 (CDK7)
US10000483B2 (en)	2012-10-19	2018-06-19	Dana-Farber Cancer Institute, Inc.	Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
US9758522B2 (en)	2012-10-19	2017-09-12	Dana-Farber Cancer Institute, Inc.	Hydrophobically tagged small molecules as inducers of protein degradation
WO2014138979A1 (en)	2013-03-13	2014-09-18	Canadian Blood Services	Pyrazole derivatives and their uses thereof
WO2015058126A1 (en)	2013-10-18	2015-04-23	Syros Pharmaceuticals, Inc.	Heteroaromatic compounds useful for the treatment of prolferative diseases
WO2015058140A1 (en)	2013-10-18	2015-04-23	Dana-Farber Cancer Institute, Inc.	Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7)
US10017477B2 (en)	2014-04-23	2018-07-10	Dana-Farber Cancer Institute, Inc.	Janus kinase inhibitors and uses thereof
WO2015164604A1 (en)	2014-04-23	2015-10-29	Dana-Farber Cancer Institute, Inc.	Hydrophobically tagged janus kinase inhibitors and uses thereof
JP6690543B2 (ja) *	2014-10-31	2020-04-28	宇部興産株式会社	置換ジヒドロピロロピラゾール化合物
AU2015371251B2 (en) *	2014-12-23	2020-06-11	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 (CDK7)
CN107427521B (zh)	2015-03-27	2021-08-03	达纳-法伯癌症研究所股份有限公司	细胞周期蛋白依赖性激酶的抑制剂
WO2016161571A1 (en)	2015-04-08	2016-10-13	Merck Sharp & Dohme Corp.	Indazole and azaindazole btk inhibitors
WO2016193939A1 (en)	2015-06-04	2016-12-08	Aurigene Discovery Technologies Limited	Substituted heterocyclyl derivatives as cdk inhibitors
EP3307728A4 (de)	2015-06-12	2019-07-17	Dana Farber Cancer Institute, Inc.	Kombinationstherapie von transkriptionshemmern und kinasehemmern
US10273252B2 (en)	2015-06-15	2019-04-30	Ube Industries, Ltd.	Substituted dihydropyrrolopyrazole derivative
JP7028766B2 (ja)	2015-09-09	2022-03-02	ダナ－ファーバーキャンサーインスティテュート，インコーポレイテッド	サイクリン依存性キナーゼの阻害剤
JP2019112305A (ja) *	2016-04-28	2019-07-11	宇部興産株式会社	アトピー性皮膚炎の治療または予防のための医薬組成物
JP2019112306A (ja) *	2016-04-28	2019-07-11	宇部興産株式会社	慢性閉塞性肺疾患の治療または予防のための医薬組成物
JP2019112307A (ja) *	2016-04-28	2019-07-11	宇部興産株式会社	置換ジヒドロピロロピラゾール化合物および他の乾癬治療薬が組み合わせて投与される医薬組成物
JP7590185B2 (ja)	2018-06-25	2024-11-26	ダナ－ファーバーキャンサーインスティテュート，インコーポレイテッド	Ｔａｉｒｅファミリーキナーゼインヒビターおよびそれらの使用
WO2020100944A1 (ja) *	2018-11-14	2020-05-22	宇部興産株式会社	ジヒドロピロロピラゾール誘導体
WO2020140098A1 (en)	2018-12-28	2020-07-02	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4555547B2 (ja) *	2000-08-10	2010-10-06	ファイザーイタリアソシエタアレスポンサビリタリミタータ	キナーゼ阻害剤としての二環式ピラゾール、それらを製造するための方法およびそれらを含む医薬組成物
UA81790C2 (uk)	2002-12-19	2008-02-11	Фармация Италия С.П.А.	Заміщені піролопіразольні похідні як інгібітори кінази

2007
- 2007-10-09 JP JP2009531820A patent/JP5415271B2/ja not_active Expired - Fee Related
- 2007-10-09 US US12/444,792 patent/US8227472B2/en not_active Expired - Fee Related
- 2007-10-09 ES ES07821056T patent/ES2367416T3/es active Active
- 2007-10-09 EP EP07821056A patent/EP2089394B1/de active Active
- 2007-10-09 WO PCT/EP2007/060685 patent/WO2008043745A1/en not_active Ceased
- 2007-10-09 AT AT07821056T patent/ATE514699T1/de active
2012
- 2012-06-13 US US13/495,688 patent/US8623876B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US8623876B2 (en)	2014-01-07
JP2010505905A (ja)	2010-02-25
ES2367416T3 (es)	2011-11-03
US20100010008A1 (en)	2010-01-14
JP5415271B2 (ja)	2014-02-12
WO2008043745A1 (en)	2008-04-17
EP2089394B1 (de)	2011-06-29
US8227472B2 (en)	2012-07-24
EP2089394A1 (de)	2009-08-19
US20120277248A1 (en)	2012-11-01

Legal Events

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2012-01-15

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