ATE515491T1 - Herstellung von 3-ä(1r,2r)-3-(dimethylamino)- 1ethyl-2-methylpropylüphenol - Google Patents
Herstellung von 3-ä(1r,2r)-3-(dimethylamino)- 1ethyl-2-methylpropylüphenolInfo
- Publication number
- ATE515491T1 ATE515491T1 AT07786259T AT07786259T ATE515491T1 AT E515491 T1 ATE515491 T1 AT E515491T1 AT 07786259 T AT07786259 T AT 07786259T AT 07786259 T AT07786259 T AT 07786259T AT E515491 T1 ATE515491 T1 AT E515491T1
- Authority
- AT
- Austria
- Prior art keywords
- methylpropyl
- dimethylamino
- preparation
- phenol
- 1ethyl
- Prior art date
Links
- ZELFLGGRLLOERW-YECZQDJWSA-N 3-[(2r,3r)-1-(dimethylamino)-2-methylpentan-3-yl]phenol;hydrochloride Chemical compound Cl.CN(C)C[C@H](C)[C@@H](CC)C1=CC=CC(O)=C1 ZELFLGGRLLOERW-YECZQDJWSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06015317 | 2006-07-24 | ||
| PCT/EP2007/006514 WO2008012046A1 (en) | 2006-07-24 | 2007-07-23 | Preparation of 3-[(1r,2r)-3-(dimethylamino)-1ethyl-2-methylpropyl]phenol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE515491T1 true ATE515491T1 (de) | 2011-07-15 |
Family
ID=37492362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07786259T ATE515491T1 (de) | 2006-07-24 | 2007-07-23 | Herstellung von 3-ä(1r,2r)-3-(dimethylamino)- 1ethyl-2-methylpropylüphenol |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8263809B2 (de) |
| EP (1) | EP2049464B1 (de) |
| JP (1) | JP5357756B2 (de) |
| KR (1) | KR101433685B1 (de) |
| CN (1) | CN101495446B (de) |
| AT (1) | ATE515491T1 (de) |
| AU (1) | AU2007278463B2 (de) |
| BR (1) | BRPI0714648B8 (de) |
| CA (1) | CA2658648C (de) |
| CY (1) | CY1111829T1 (de) |
| DK (1) | DK2049464T3 (de) |
| ES (1) | ES2366390T3 (de) |
| HR (1) | HRP20110572T1 (de) |
| IL (1) | IL196626A (de) |
| MX (1) | MX2008016380A (de) |
| NO (1) | NO341683B1 (de) |
| NZ (1) | NZ573906A (de) |
| PL (1) | PL2049464T3 (de) |
| RU (1) | RU2463290C2 (de) |
| SI (1) | SI2049464T1 (de) |
| TW (1) | TWI401237B (de) |
| WO (1) | WO2008012046A1 (de) |
| ZA (1) | ZA200901279B (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009000911A (es) * | 2006-07-24 | 2009-02-04 | Janssen Pharmaceutica Nv | Preparacion de (2r,3r)-3-(3-metoxifenil)-n,n,2-trimetilpentanamina . |
| CA2739936C (en) | 2008-10-17 | 2017-12-12 | Pharmacofore, Inc. | Pharmaceutical compositions with attenuated release of phenolic opioids |
| CN102002065B (zh) * | 2009-09-02 | 2014-09-10 | 上海特化医药科技有限公司 | 他喷他多的制备方法及其中间体 |
| US8288592B2 (en) * | 2009-09-22 | 2012-10-16 | Actavis Group Ptc Ehf | Solid state forms of tapentadol salts |
| IT1397189B1 (it) * | 2009-12-01 | 2013-01-04 | Archimica Srl | Nuovo processo per la preparazione di tapentadol e suoi intermedi. |
| WO2011080756A1 (en) * | 2009-12-29 | 2011-07-07 | Ind-Swift Laboratories Limited | Process for the preparation of 1-phenyl-3-dimethylaminopropane derivatives |
| US20130096346A1 (en) | 2010-03-05 | 2013-04-18 | Actavis Group Ptc Ehf | Resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol |
| WO2011128784A2 (en) | 2010-04-05 | 2011-10-20 | Actavis Group Ptc Ehf | Novel process for preparing highly pure tapentadol or a pharmaceutically acceptable salt thereof |
| WO2011133348A1 (en) | 2010-04-21 | 2011-10-27 | Pharmacofore, Inc. | Compositions comprising enzyme-cleavable amphetamine prodrugs and inhibitors thereof |
| US20110262355A1 (en) | 2010-04-21 | 2011-10-27 | Jenkins Thomas E | Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof |
| US9238020B2 (en) | 2010-04-21 | 2016-01-19 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable phenol-modified tapentadol prodrug |
| ITMI20100924A1 (it) * | 2010-05-21 | 2011-11-22 | Fidia Farmaceutici | Nuovo metodo di sintesi delle due forme enantiomeriche del tapentadol |
| CN103168025B (zh) * | 2010-06-15 | 2015-02-25 | 格吕伦塔尔有限公司 | 用于制备取代的3-(1-氨基-2-甲基戊烷-3-基)苯基化合物的方法 |
| IT1401109B1 (it) * | 2010-07-02 | 2013-07-12 | Archimica Srl | Nuovo processo per la preparazione di tapentadol e suoi intermedi. |
| ES2860676T3 (es) * | 2010-07-23 | 2021-10-05 | Gruenenthal Gmbh | Sales o cocristales de 3- (3-dimetilamino-1-etil-2-metil-propil) -fenol |
| EP2606030B1 (de) * | 2010-08-16 | 2016-05-18 | Indoco Remedies Limited | Verfahren zur herstellung von tapentadol |
| US8552219B2 (en) | 2010-09-20 | 2013-10-08 | Ind-Swift Laboratories Limited | Process for preparing L-phenyl-3-dimethylaminopropane derivative |
| HUP1300623A2 (en) * | 2010-12-30 | 2014-03-28 | Zentiva Ks | O-substituted (2r,3r)-3-(3-hidroxiphenil)-2-metyil-4-pentenoic acids and a method of obtaining the same |
| WO2012096887A2 (en) | 2011-01-11 | 2012-07-19 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable oxycodone prodrug |
| WO2012101649A1 (en) | 2011-01-27 | 2012-08-02 | Symed Labs Limited | A novel stereospecific synthesis of (-) (2s,3s)-1-dimethylamino-3-(3-methoxyphenyl)-2-methyl pentan-3-ol |
| CN102617501A (zh) | 2011-01-31 | 2012-08-01 | 中国科学院上海药物研究所 | 取代正戊酰胺类化合物、其制备方法及用途 |
| MX369121B (es) * | 2011-03-04 | 2019-10-30 | Gruenenthal Gmbh | Formulacion farmaceutica acuosa de tapentadol para administracion oral. |
| AU2012225337B2 (en) | 2011-03-09 | 2016-04-28 | Signature Therapeutics, Inc. | Active agent prodrugs with heterocyclic linkers |
| WO2012146978A2 (en) | 2011-04-28 | 2012-11-01 | Actavis Group Ptc Ehf | A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof |
| WO2013105109A1 (en) | 2011-11-09 | 2013-07-18 | Indoco Remedies Limited | Process for the preparation of tapentadol |
| US20130150622A1 (en) | 2011-12-12 | 2013-06-13 | Boehringer Ingelheim International Gmbh | Stereoselective synthesis of tapentadol and its salts |
| WO2013120466A1 (en) | 2012-02-17 | 2013-08-22 | Zentiva, K.S. | A new solid form of tapentadol and a method of its preparation |
| EP2674414A1 (de) | 2012-06-15 | 2013-12-18 | Siegfried AG | Verfahren zur Herstellung von 1-aryl-1-alkyl-3-dialkylaminopropan-Verbindungen |
| CN103159633B (zh) * | 2012-07-06 | 2015-08-12 | 江苏恩华药业股份有限公司 | 他喷他多的制备方法及用于制备他喷他多的化合物 |
| CN102924303B (zh) * | 2012-10-31 | 2013-11-20 | 合肥市新星医药化工有限公司 | 盐酸他喷他多晶型c及其制备方法和应用 |
| WO2014141296A2 (en) * | 2013-03-09 | 2014-09-18 | Ind-Swift Laboratories Limited | Process for the preparation of tapentadol via novel intermediate |
| IN2013MU03478A (de) * | 2013-11-01 | 2015-07-17 | Sun Pharma Advanced Res Co Ltd | |
| CN103553940A (zh) * | 2013-11-07 | 2014-02-05 | 南京艾德凯腾生物医药有限责任公司 | 一种新晶型盐酸他喷他多的制备方法 |
| IN2013MU03670A (de) | 2013-11-21 | 2015-07-31 | Unimark Remedies Ltd | |
| SI3083551T1 (en) | 2013-12-16 | 2018-04-30 | Farma Grs, D.O.O. | CRYSTAL FORM INTERMEDIATE TAPENTADOL |
| CZ307492B6 (cs) | 2014-02-04 | 2018-10-17 | Zentiva, K.S. | Pevná forma maleátu tapentadolu a způsob její přípravy |
| WO2016007823A1 (en) | 2014-07-10 | 2016-01-14 | Mallinckrodt Llc | Process for preparing substituted phenylalkanes |
| CA2991421C (en) | 2015-07-10 | 2019-04-30 | Mallinckrodt Llc | A two-step process for preparing 3-substituted phenylalkylamines |
| SK812017A3 (sk) | 2017-08-18 | 2019-03-01 | Saneca Pharmaceuticals A. S. | Spôsob prípravy tapentadolu a jeho medziproduktov |
| EP3947342A4 (de) | 2019-03-28 | 2022-12-28 | Council of Scientific and Industrial Research | Neues verfahren zur herstellung von tapentadol und zwischenprodukten draus |
| MX2023010506A (es) | 2021-03-09 | 2023-09-20 | Ensysce Biosciences Inc | Composiciones que comprenden profarmacos de escision enzimatica y nafamostat de liberacion controlada y metodos de uso de estos. |
| EP4116288A1 (de) | 2021-07-08 | 2023-01-11 | KRKA, d.d., Novo mesto | Racemisierung von (s) und/oder (r)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methylpropan-1-on und mischungen davon |
| CA3230025A1 (en) | 2021-09-29 | 2023-04-06 | Lynn Kirkpatrick | Enzyme-cleavable methadone prodrugs and methods of use thereof |
| CN119192000B (zh) * | 2024-11-26 | 2025-07-15 | 苏州盛迪亚生物医药有限公司 | 连续流反应制备他喷他多或其可药用盐的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4426245A1 (de) | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
| JP4202327B2 (ja) * | 1996-04-09 | 2008-12-24 | ヤマサ醤油株式会社 | １−（２−デオキシ−２−フルオロ−４−チオ−β−Ｄ−アラビノフラノシル）シトシン |
| DE19805370A1 (de) * | 1997-03-14 | 1998-09-17 | Gruenenthal Gmbh | Substituierte Aminoverbindungen und ihre Verwendung als analgetisch wirksame Substanzen |
| US6399828B1 (en) * | 2001-10-29 | 2002-06-04 | Boehringer Ingelheim Chemicals, Inc. | Preparation of amphetamines from phenylpropanolamines |
| DE10326097A1 (de) | 2003-06-06 | 2005-01-05 | Grünenthal GmbH | Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen |
| DE10328316A1 (de) | 2003-06-23 | 2005-01-20 | Grünenthal GmbH | Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe |
| MX2009000911A (es) * | 2006-07-24 | 2009-02-04 | Janssen Pharmaceutica Nv | Preparacion de (2r,3r)-3-(3-metoxifenil)-n,n,2-trimetilpentanamina . |
-
2007
- 2007-06-08 TW TW096120622A patent/TWI401237B/zh not_active IP Right Cessation
- 2007-07-23 MX MX2008016380A patent/MX2008016380A/es active IP Right Grant
- 2007-07-23 US US12/374,910 patent/US8263809B2/en active Active
- 2007-07-23 RU RU2009106169/04A patent/RU2463290C2/ru active
- 2007-07-23 AT AT07786259T patent/ATE515491T1/de active
- 2007-07-23 AU AU2007278463A patent/AU2007278463B2/en not_active Ceased
- 2007-07-23 ES ES07786259T patent/ES2366390T3/es active Active
- 2007-07-23 CA CA2658648A patent/CA2658648C/en active Active
- 2007-07-23 EP EP07786259A patent/EP2049464B1/de active Active
- 2007-07-23 CN CN2007800281516A patent/CN101495446B/zh not_active Expired - Fee Related
- 2007-07-23 DK DK07786259.7T patent/DK2049464T3/da active
- 2007-07-23 WO PCT/EP2007/006514 patent/WO2008012046A1/en not_active Ceased
- 2007-07-23 JP JP2009521155A patent/JP5357756B2/ja not_active Expired - Fee Related
- 2007-07-23 HR HR20110572T patent/HRP20110572T1/hr unknown
- 2007-07-23 BR BRPI0714648A patent/BRPI0714648B8/pt not_active IP Right Cessation
- 2007-07-23 PL PL07786259T patent/PL2049464T3/pl unknown
- 2007-07-23 KR KR1020097003816A patent/KR101433685B1/ko not_active Expired - Fee Related
- 2007-07-23 SI SI200730708T patent/SI2049464T1/sl unknown
- 2007-07-23 NZ NZ573906A patent/NZ573906A/en not_active IP Right Cessation
-
2009
- 2009-01-21 IL IL196626A patent/IL196626A/en active IP Right Grant
- 2009-02-12 NO NO20090691A patent/NO341683B1/no unknown
- 2009-02-23 ZA ZA2009/01279A patent/ZA200901279B/en unknown
-
2011
- 2011-08-02 CY CY20111100741T patent/CY1111829T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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