ATE515566T1 - Skalierbares fermentationsverfahren - Google Patents

Skalierbares fermentationsverfahren

Info

Publication number
ATE515566T1
ATE515566T1 AT06777243T AT06777243T ATE515566T1 AT E515566 T1 ATE515566 T1 AT E515566T1 AT 06777243 T AT06777243 T AT 06777243T AT 06777243 T AT06777243 T AT 06777243T AT E515566 T1 ATE515566 T1 AT E515566T1
Authority
AT
Austria
Prior art keywords
capsid protein
fermentation process
expression
scalable
vlp
Prior art date
Application number
AT06777243T
Other languages
English (en)
Inventor
Marcel Emmerling
Frank Hennecke
Holger Pfruender
Martin Rhiel
Philipp Steiner
Original Assignee
Cytos Biotechnology Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05011416A external-priority patent/EP1726642A1/de
Priority claimed from EP05106729A external-priority patent/EP1746165A1/de
Application filed by Cytos Biotechnology Ag filed Critical Cytos Biotechnology Ag
Application granted granted Critical
Publication of ATE515566T1 publication Critical patent/ATE515566T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10061—Methods of inactivation or attenuation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/18011—Details ssRNA Bacteriophages positive-sense
    • C12N2795/18022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/18011—Details ssRNA Bacteriophages positive-sense
    • C12N2795/18051—Methods of production or purification of viral material
    • C12N2795/18052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT06777243T 2005-05-26 2006-05-24 Skalierbares fermentationsverfahren ATE515566T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05011416A EP1726642A1 (de) 2005-05-26 2005-05-26 Grossschaliger Fermentationsverfahren für Bakteriophagen
EP05106729A EP1746165A1 (de) 2005-07-21 2005-07-21 Skalierbares Fermentations-Verfahren
PCT/EP2006/062628 WO2006125821A2 (en) 2005-05-26 2006-05-24 Scalable fermentation process

Publications (1)

Publication Number Publication Date
ATE515566T1 true ATE515566T1 (de) 2011-07-15

Family

ID=37434299

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06777243T ATE515566T1 (de) 2005-05-26 2006-05-24 Skalierbares fermentationsverfahren

Country Status (10)

Country Link
US (7) US20110008831A1 (de)
EP (1) EP1885847B1 (de)
JP (1) JP5442251B2 (de)
CN (1) CN101213294B (de)
AT (1) ATE515566T1 (de)
AU (1) AU2006251098B2 (de)
CA (1) CA2608579C (de)
IL (1) IL187341A (de)
NZ (1) NZ563708A (de)
WO (1) WO2006125821A2 (de)

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SI2032592T1 (sl) 2006-06-12 2013-10-30 Cytos Biotechnology Ag Postopki za pakiranje oligonukleotidov v virusu-podobne delce RNA bakteriofagov
US11889986B2 (en) 2010-12-09 2024-02-06 Endochoice, Inc. Flexible electronic circuit board for a multi-camera endoscope
CN121826088A (zh) * 2015-04-02 2026-04-10 斯卡拉布基因组有限责任公司 用于基因组减少的细菌的延长连续流发酵的材料和方法
JP6674028B2 (ja) 2016-01-06 2020-04-01 アウトルック セラピューティクス，インコーポレイティド モノクローナル抗体組成物中のアフコシル化種の調節
EP3411401A1 (de) 2016-02-03 2018-12-12 Oncobiologics, Inc. Pufferformulierungen für verstärkte antikörperstabilität
IL316539B1 (en) * 2016-03-15 2026-05-01 Rnaissance Ag Llc Methods and compositions for the enhanced production of double-stranded RNA
WO2019160866A2 (en) 2018-02-13 2019-08-22 Checkmate Pharmaceuticals, Inc. Compositions and methods for tumor immunotherapy
US12325737B2 (en) 2018-03-26 2025-06-10 Amgen Inc. Total afucosylated glycoforms of antibodies produced in cell culture
BR112020020479A2 (pt) 2018-04-09 2021-01-12 Checkmate Pharmaceuticals Empacotamento de oligonucleotídeos em partículas similares a vírus
CN119286871A (zh) 2018-04-19 2025-01-10 查美特制药公司 合成rig-i样受体激动剂
EP3960870A4 (de) * 2019-03-29 2023-06-07 Ajinomoto Co., Inc. Verfahren zur herstellung von allolactose
CA3155202A1 (en) 2019-10-23 2021-04-29 Arthur M. Krieg Synthetic rig-i-like receptor agonists
CN117202926A (zh) * 2021-02-02 2023-12-08 普罗瓦克萨斯股份有限公司 新型免疫调节平台及其使用方法
WO2025010306A2 (en) * 2023-07-03 2025-01-09 Biosolution Designs Vectors and methods for building polycistronic and/or multigenic transgenes

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GB8924883D0 (en) * 1989-11-03 1989-12-20 Shell Int Research Expression vector and polypeptide synthesis
DE4017595A1 (de) * 1990-05-31 1991-12-05 Consortium Elektrochem Ind Maltopentaose produzierende amylasen
GB9022190D0 (en) * 1990-10-12 1990-11-28 Perham Richard N Immunogenic material
GB9101550D0 (en) * 1991-01-24 1991-03-06 Mastico Robert A Antigen-presenting chimaeric protein
US5356792A (en) * 1991-11-22 1994-10-18 Nakano Vinegar Co., Ltd. Biochemical oxygen demand analyzer and methods of analysis using Klebsiella microorganisms
GB9213601D0 (en) * 1992-06-26 1992-08-12 Mastico Robert A Protein based delivery system
BR9907691B1 (pt) * 1998-02-05 2011-05-31 derivado de antìgeno e antìgeno da famìlia mage associado a tumor, seqüência de ácido nucléico, codificando os mesmos, seus usos na preparação de vacina, processo para produção de vacina e vacina.
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MXPA05006117A (es) * 2002-12-13 2005-09-30 Zymogenetics Inc Produccion de il-21 en hospederos procarioticos.
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NZ554386A (en) * 2004-10-25 2009-12-24 Cytos Biotechnology Ag Gastric inhibtory polypeptide (GIP) antigen arrays with VLPs and uses thereof
WO2006067793A1 (en) * 2004-12-21 2006-06-29 Usv Limited Low cell density fermentation process for the production of heterologous recombinant proteins in microorganisms
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Also Published As

Publication number Publication date
CN101213294B (zh) 2013-03-27
US20150104827A1 (en) 2015-04-16
WO2006125821A3 (en) 2007-03-22
IL187341A (en) 2012-08-30
AU2006251098A1 (en) 2006-11-30
US20120322103A1 (en) 2012-12-20
EP1885847A2 (de) 2008-02-13
AU2006251098B2 (en) 2011-09-15
JP5442251B2 (ja) 2014-03-12
US20110008831A1 (en) 2011-01-13
NZ563708A (en) 2010-08-27
CA2608579A1 (en) 2006-11-30
JP2008545401A (ja) 2008-12-18
CN101213294A (zh) 2008-07-02
US20250333449A1 (en) 2025-10-30
CA2608579C (en) 2019-09-10
WO2006125821A2 (en) 2006-11-30
US9518095B2 (en) 2016-12-13
EP1885847B1 (de) 2011-07-06
IL187341A0 (en) 2008-04-13
US20200223891A1 (en) 2020-07-16
US20170305972A1 (en) 2017-10-26
US20220089648A1 (en) 2022-03-24

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