ATE516308T1 - Neue immunogene lipopeptide, die t-helfer- und b- zell-epitope enthalten - Google Patents

Neue immunogene lipopeptide, die t-helfer- und b- zell-epitope enthalten

Info

Publication number
ATE516308T1
ATE516308T1 AT03783851T AT03783851T ATE516308T1 AT E516308 T1 ATE516308 T1 AT E516308T1 AT 03783851 T AT03783851 T AT 03783851T AT 03783851 T AT03783851 T AT 03783851T AT E516308 T1 ATE516308 T1 AT E516308T1
Authority
AT
Austria
Prior art keywords
helper
cell epitopes
lysine
internal
new immunogenic
Prior art date
Application number
AT03783851T
Other languages
English (en)
Inventor
David Jackson
Weiguang Zeng
Original Assignee
Queensland Inst Med Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Queensland Inst Med Res filed Critical Queensland Inst Med Res
Application granted granted Critical
Publication of ATE516308T1 publication Critical patent/ATE516308T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775Apolipopeptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0006Contraceptive vaccins; Vaccines against sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/09Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16Masculine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • A61K2039/543Mucosal route intranasal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6018Lipids, e.g. in lipopeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6068Other bacterial proteins, e.g. OMP
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT03783851T 2002-08-12 2003-08-12 Neue immunogene lipopeptide, die t-helfer- und b- zell-epitope enthalten ATE516308T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40283802P 2002-08-12 2002-08-12
PCT/AU2003/001018 WO2004014956A1 (en) 2002-08-12 2003-08-12 Novel immunogenic lipopeptides comprising t-helper and b-cell epitopes

Publications (1)

Publication Number Publication Date
ATE516308T1 true ATE516308T1 (de) 2011-07-15

Family

ID=31715903

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03783851T ATE516308T1 (de) 2002-08-12 2003-08-12 Neue immunogene lipopeptide, die t-helfer- und b- zell-epitope enthalten

Country Status (12)

Country Link
US (2) US7569225B2 (de)
EP (2) EP2301972A1 (de)
JP (2) JP4619120B2 (de)
KR (1) KR101240547B1 (de)
CN (3) CN101121754B (de)
AT (1) ATE516308T1 (de)
AU (1) AU2003250586B2 (de)
BR (1) BR0313154A (de)
CA (1) CA2494192C (de)
DK (1) DK1543039T3 (de)
ES (1) ES2369664T3 (de)
WO (1) WO2004014956A1 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7255867B2 (en) * 2002-11-15 2007-08-14 Id Biomedical Corporation Of Quebec Vaccine
WO2006021048A1 (en) * 2004-08-26 2006-03-02 The Macfarlane Burnet Institute For Medical Research And Public Health Limited Immunotherapy of virus infection
WO2006026834A1 (en) 2004-09-10 2006-03-16 The Council Of The Queensland Institute Of Medical Research (Qimr) Truncated lhrh formulations
NZ556004A (en) * 2004-12-21 2010-05-28 Vaxinnate Corp Compositions of influenza viral proteins comprising at least one flagellin and at least one influenza M2 protein
US8420102B2 (en) 2006-03-07 2013-04-16 Vaxinnate Corporation Compositions that include hemagglutinin
US20080233143A1 (en) * 2005-02-07 2008-09-25 Lipotek Pty Ltd. Adjuvanting Material
CN101151280A (zh) 2005-02-08 2008-03-26 昆士兰医学研究学院委员会 免疫原性分子
CA2605321A1 (en) 2005-04-19 2006-10-26 Eli Lilly And Company Monovalent and polyvalent synthetic polysaccharide antigens for immunological intervention in disease
AU2007284656A1 (en) * 2006-08-14 2008-02-21 Thymon, L.L.C. Compositions and methods for the treatment and prophylaxis of multiple strains and subtypes of HIV-1
WO2008021296A2 (en) * 2006-08-14 2008-02-21 Thymon, L.L.C. Compositions and methods for the treatment and prophylaxis of alzheimer's disease
BRPI0604997A (pt) * 2006-11-30 2007-05-22 Fundacao Zerbini vacina contra o estreptococo beta hemolìtico do grupo a, e respectivo processo de obtenção
US9289485B2 (en) 2006-11-30 2016-03-22 Luiza Guilherme Guglielmi Therapeutic application of S. pyogenes C-terminal peptide
AU2008310313C1 (en) * 2007-10-09 2015-02-12 Ena Respiratory Pty Ltd A method of transfection and compositions therefor
US9138470B2 (en) 2007-11-02 2015-09-22 The Johns Hopkins University Multi-component L2 vaccine for prevention of human papilloma virus infection
US8466259B2 (en) * 2007-12-07 2013-06-18 National Health Research Institutes Adjuvants
WO2010003178A1 (en) * 2008-07-07 2010-01-14 The University Of Melbourne A synthetic vaccine component
CN102256997A (zh) 2008-10-16 2011-11-23 美国辉瑞有限公司 细环病毒分离株和组合物
US8563690B2 (en) * 2008-11-03 2013-10-22 The Board Of Trustees Of The University Of Illinois Modulation of platelet aggregation
CN103864895A (zh) * 2008-12-29 2014-06-18 隆萨布莱纳公司 制备比伐卢定的方法
JP2012523379A (ja) 2009-04-09 2012-10-04 ザ ユニバーシティー オブ メルボルン 免疫原性組成物およびその使用
US8287880B2 (en) 2009-06-02 2012-10-16 National Health Research Institutes Lipidated vaccine against dengue virus infection
EP2445927B1 (de) * 2009-06-22 2014-04-23 National Health Research Institutes Lipidierte tumorassoziierte antigene und immuntherapiezusammensetzungen
DE102009034779A1 (de) 2009-07-25 2011-02-03 Emc Microcollections Gmbh Synthetische Analoga bakterieller Lipopeptide und ihre Anwendung zur Therapie und Prophylaxe allergischer Erkrankungen
US8846388B2 (en) 2009-10-16 2014-09-30 Zoetis Llc Infectious clones of torque teno virus
EP2338521A1 (de) 2009-12-28 2011-06-29 Helmholtz-Zentrum für Infektionsforschung GmbH Lipopeptid- und Lipoproteinkonjugate und ihre Verwendung
WO2011163593A2 (en) * 2010-06-25 2011-12-29 Philadelphia Health & Education Corporation D/B/A Drexel Induction of immune response
US9295720B2 (en) * 2010-08-27 2016-03-29 Pantarhei Bioscience B.V. Immunotherapeutic method for treating prostate cancer
EP2618842B1 (de) 2010-09-22 2019-04-24 Ena Therapeutics Pty Ltd Neues immunstimulierendes verfahren
TW201221642A (en) 2010-11-15 2012-06-01 Nat Health Research Institutes Method of producing lipidated polypeptides
TWI507413B (zh) 2010-11-15 2015-11-11 Nat Health Research Institutes 脂質化多抗原表位疫苗
DE102011018499A1 (de) 2011-04-23 2012-10-25 Emc Microcollections Gmbh Topische Nanopartikel-Vakzine zur Immunstimulation der dendritischen Zellen in der Haut
WO2012162628A2 (en) * 2011-05-25 2012-11-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lipopeptide inhibitors of ras oncoproteins
EP2718429A1 (de) 2011-06-08 2014-04-16 Zoetis LLC Infektiöse klone des torque-teno-virus
IN2014KN02769A (de) * 2012-06-06 2015-05-08 Bionor Immuno As
MX382968B (es) * 2012-11-16 2025-03-12 United Biomedical Inc Vacuna de emergencia basada en péptidos sintéticos contra la fiebre aftosa.
EP3604271A1 (de) 2013-06-28 2020-02-05 Auckland Uniservices Limited Peptide für aminosäure- und peptidkonjugate und konjugationsverfahren
WO2015157189A1 (en) * 2014-04-07 2015-10-15 The Regents Of The University Of California Vaccines and uses thereof
CN107250103A (zh) 2014-12-23 2017-10-13 玛格丽特·安妮·布林布尔 氨基酸缀合物和肽缀合物以及其用途
GB201513921D0 (en) * 2015-08-05 2015-09-23 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers
WO2017073797A1 (en) * 2015-10-28 2017-05-04 Ajinomoto Co., Inc. Immunostimulating agent
TW201735952A (zh) 2016-02-26 2017-10-16 瑪格蕾特 安 布萊博 胺基酸及肽共軛物以及共軛過程
US11013798B2 (en) 2016-03-21 2021-05-25 South Dakota Board Of Regents Orf virus-based platform for vaccine delivery
DE102016005550B4 (de) 2016-05-09 2024-09-26 Hans-Georg Rammensee Adjuvans zur lnduzierung einer zellulären lmmunantwort
KR20190129032A (ko) 2016-12-28 2019-11-19 인벡스, 인크. 인플루엔자 백신
CN107703294B (zh) * 2017-10-12 2019-06-04 华派生物工程集团有限公司 一种用于检测鸡血清中cLHRH抗体效价的ELISA方法
AU2018391325B2 (en) 2017-12-21 2024-07-11 Axelia Oncology Pty Ltd Optimised compounds
CN109991422A (zh) * 2017-12-29 2019-07-09 复旦大学 基于特异抗血清的棕榈酰化修饰蛋白质的检测方法
JP7550762B2 (ja) * 2018-12-20 2024-09-13 ヴァイロメティックス アーゲー リポペプチドビルディングブロックおよび合成ウイルス様粒子
MX2021015961A (es) 2019-06-26 2022-03-22 Ena Respiratory Pty Ltd Moleculas novedosas.
WO2021231767A1 (en) 2020-05-13 2021-11-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rsv vaccine bearing one or more p gene mutations
CN114315985A (zh) 2020-09-29 2022-04-12 硕腾服务有限责任公司 减毒猪流行性腹泻病毒
TW202233647A (zh) * 2020-11-17 2022-09-01 挪威商霍夫賽思生物保健有限公司 呼吸治療
CN113009141A (zh) * 2021-02-05 2021-06-22 深圳市国赛生物技术有限公司 化学发光免疫检测试剂盒、用途和检测方法
CA3210091A1 (en) * 2021-02-05 2022-08-11 Amgen Inc. Non-terminal antibody discovery methods and single cell assays
CN115216451A (zh) 2021-04-16 2022-10-21 硕腾服务有限责任公司 伪狂犬病病毒疫苗
CN118267462A (zh) 2022-12-29 2024-07-02 硕腾服务有限责任公司 接种猪以抗伪狂犬病病毒的方法
WO2024149888A1 (en) * 2023-01-12 2024-07-18 Isa Pharmaceuticals B.V. Improved lipopeptide quantification
WO2025128971A1 (en) 2023-12-14 2025-06-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rsv vaccine bearing a polynucleotide which is de-optimised and de-attenuated

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4196265A (en) 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US6024964A (en) 1985-06-24 2000-02-15 Hoechst Aktiengesellschaft Membrane anchor/active compound conjugate, its preparation and its uses
US5864008A (en) 1988-03-25 1999-01-26 James; Stephen Peptides derived from foot-and-mouth disease virus, pharmaceutical compositions, and methods for using the peptides
DE4119856A1 (de) 1991-06-17 1992-12-24 Hoechst Ag N-acyl-s-(2-hydroxyalkyl)-cysteine, deren herstellung sowie deren verwendung als zwischenprodukte zur herstellung von synthetischen immunadjuvantien und synthetischen impfstoffen
GB9202219D0 (en) * 1992-02-03 1992-03-18 Connaught Lab A synthetic heamophilus influenzae conjugate vaccine
WO1993022343A1 (en) 1992-05-01 1993-11-11 The Rockfeller University Multiple antigen peptide system having adjuvant properties and vaccines prepared therefrom
AUPM885194A0 (en) 1994-10-14 1994-11-10 Council Of The Queensland Institute Of Medical Research, The Synthetic peptides and vaccines comprising same
US5807978A (en) 1995-06-07 1998-09-15 Kokolus; William J. Immunogenic peptides of prostate specific antigen
US6048538A (en) 1997-10-03 2000-04-11 United Biomedical, Inc. Peptides derived from the non-structural proteins of foot and mouth disease virus as diagnostic reagents
US6107021A (en) 1998-06-20 2000-08-22 United Biomedical, Inc. Synthetic peptide vaccines for foot-and-mouth disease
JP4699612B2 (ja) 1999-02-05 2011-06-15 ザ ユニバーシティ オブ メルボーン Tヘルパー細胞エピトープ
WO2001070265A2 (en) 2000-03-24 2001-09-27 Biomira, Inc. Lipopeptide adjuvants

Also Published As

Publication number Publication date
EP1543039A1 (de) 2005-06-22
JP2010155832A (ja) 2010-07-15
WO2004014956A1 (en) 2004-02-19
AU2003250586B2 (en) 2010-09-23
AU2003250586A1 (en) 2004-02-25
CA2494192C (en) 2013-01-22
JP4619120B2 (ja) 2011-01-26
BR0313154A (pt) 2005-08-02
US8367067B2 (en) 2013-02-05
CN1688606B (zh) 2013-12-25
US20100092500A1 (en) 2010-04-15
JP2006513140A (ja) 2006-04-20
DK1543039T3 (da) 2011-10-31
US7569225B2 (en) 2009-08-04
CN101121754B (zh) 2012-02-29
EP1543039B1 (de) 2011-07-13
KR101240547B1 (ko) 2013-03-08
CN101121754A (zh) 2008-02-13
ES2369664T3 (es) 2011-12-02
US20070066534A1 (en) 2007-03-22
EP1543039A4 (de) 2007-09-19
HK1113163A1 (en) 2008-09-26
KR20050053608A (ko) 2005-06-08
EP2301972A1 (de) 2011-03-30
CA2494192A1 (en) 2004-02-19
JP5265511B2 (ja) 2013-08-14
CN1688606A (zh) 2005-10-26

Similar Documents

Publication Publication Date Title
ATE516308T1 (de) Neue immunogene lipopeptide, die t-helfer- und b- zell-epitope enthalten
ES2196305T3 (es) Composiciones que contienen moleculas inmunogenas y factor de estimulacion de colonias de granulocitos magrofagos como adyuvante.
PL366826A1 (en) Reducing the immunogenicity of fusion proteins
BRPI0208183B8 (pt) peptídeo antígeno de câncer modificado por wt1 e vacinas para câncer
DE69531204D1 (de) Formulierungen fuer faktor ix
BR0209434A (pt) Peptìdeos antimicrobianos e composições
BR9912176A (pt) Epìtopos de célula auxiliar t artificial como estimuladores imunes para imunógenos de peptìdeo sintéticos incluindo peptìdeos de lhrh imunogênicos
DE69734605D1 (de) Abgeschwächter salmonellenstamm, gebraucht als vehikel zur oralen immunisierung
AU6160201A (en) Human polypeptides causing or leading to the killing of cells including lymphoidtumor cells
ATE267211T1 (de) Impfstoff gegen hpv
BR9912177A (pt) Epìtopos de célula auxiliar t artificiais como imunoestimuladores para imunógenos de peptìdeo sintéticos
MXPA02006029A (es) Lipopeptidos novedosos como agentes antibacterianos.
CY1109230T1 (el) Ισομεραση συζευγμενου λινελαϊκου οξεος και μια διαδικασια για την παρασκευη συζευγμενου λινελαϊκου οξεος
AR002043A1 (es) Utilizacion de agonistas de alfa (1l) para el tratamiento de la incontinencia urinaria.
CY1114944T1 (el) Σταθεροποιημενα αλφα ελικοειδη πεπτιδια και χρησεις αυτων
MXPA02006030A (es) Lipopeptidos como agentes antibacterianos.
DK0506748T3 (da) Aminosyrer, peptider eller derivater deraf bundet til fedtstoffer
DE60015508D1 (de) C-16 ungesätigte fp-selektive prostaglandin analoge
ATE258933T1 (de) Übergangszustand-analoga des kokains, ihre verwendung zur herstellung von kataltischen antikörpern gegen kokain und verwendung derselben in diagnose und therapie
GB9612214D0 (en) Vaccine
BR0316782A (pt) Produto de leite fermentado, processo para preparação de um produto de leite fermentado e uso da linhagem cnrz 244 de lactobacillus helveticus
EA200501204A1 (ru) Производные 3-(1-[3-(1,3-бензотиазол-6-ил)пропилкарбамоил]циклоалкил)пропановой кислоты в качестве ингибиторов нейтральной эндопептидазы (nep)
DE69530380D1 (de) Retropeptide, antikörper dagegen und deren verwendungen in der impfung und in vitro diagnostik
DK1420757T3 (da) Kosmetiske mikroemulsioner indeholdende ectoin eller derivater
AU2003267551A1 (en) Thieno-pyrrole compounds as antagonists of gonadotropin releasing hormone

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1543039

Country of ref document: EP