ATE516504T1 - Um den einfluss von störfaktoren korrigierte messung des zeitlichen verlaufs einer enzymatischen aktivität bei der reaktion eines enzyms mit einem substrat - Google Patents
Um den einfluss von störfaktoren korrigierte messung des zeitlichen verlaufs einer enzymatischen aktivität bei der reaktion eines enzyms mit einem substratInfo
- Publication number
- ATE516504T1 ATE516504T1 AT08151181T AT08151181T ATE516504T1 AT E516504 T1 ATE516504 T1 AT E516504T1 AT 08151181 T AT08151181 T AT 08151181T AT 08151181 T AT08151181 T AT 08151181T AT E516504 T1 ATE516504 T1 AT E516504T1
- Authority
- AT
- Austria
- Prior art keywords
- enzyme
- substrate
- signal
- activity
- measurement
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title abstract 7
- 108090000790 Enzymes Proteins 0.000 title abstract 7
- 239000000758 substrate Substances 0.000 title abstract 6
- 238000006243 chemical reaction Methods 0.000 title abstract 3
- 230000002255 enzymatic effect Effects 0.000 title abstract 3
- 238000005259 measurement Methods 0.000 title abstract 3
- 230000002452 interceptive effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 3
- 238000000338 in vitro Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 206010053567 Coagulopathies Diseases 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000035602 clotting Effects 0.000 abstract 1
- 230000020764 fibrinolysis Effects 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08151181A EP2088435B1 (de) | 2008-02-07 | 2008-02-07 | Um den Einfluss von Störfaktoren korrigierte Messung des zeitlichen Verlaufs einer enzymatischen Aktivität bei der Reaktion eines Enzyms mit einem Substrat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE516504T1 true ATE516504T1 (de) | 2011-07-15 |
Family
ID=39203204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08151181T ATE516504T1 (de) | 2008-02-07 | 2008-02-07 | Um den einfluss von störfaktoren korrigierte messung des zeitlichen verlaufs einer enzymatischen aktivität bei der reaktion eines enzyms mit einem substrat |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8551722B2 (de) |
| EP (1) | EP2088435B1 (de) |
| AT (1) | ATE516504T1 (de) |
| WO (1) | WO2009098313A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8293493B2 (en) * | 2010-01-27 | 2012-10-23 | Adventist Health System/Sunbelt, Inc. | Thrombin generation determination method |
| RU2518247C2 (ru) * | 2011-07-26 | 2014-06-10 | Общество с ограниченной ответственностью "ГемаКор Лабс" (ООО "ГемаКор Лабс") | Способ определения пространственно-временного распределения активности протеолитического фермента в гетерогенной системе, устройство для реализации указанного способа и способ диагностики нарушений системы гемостаза по изменению пространственно-временного распределения активности протеолитического фермента в гетерогенной системе |
| EP2677037B1 (de) | 2012-06-21 | 2016-04-13 | Synapse B.V. | Gleichzeitige Messung der Thrombinerzeugung und Gerinnselfestigkeit in Plasma und im gesamten Blut |
| JP7009998B2 (ja) | 2016-01-29 | 2022-01-26 | ソニーグループ株式会社 | 血液凝固系解析装置、血液凝固系解析システム、血液凝固系解析方法及び血液凝固系解析装置用パラメーターの決定方法 |
| EP3363912B1 (de) | 2017-02-17 | 2020-10-28 | Synapse B.V. | Selbstkalibrierter assay zur bestimmung der erzeugung von proteolytischem enzym, dedizierte mittel und verwendungen davon |
| CN116793976B (zh) * | 2023-06-29 | 2024-05-10 | 徐詹程 | 一种酶促反应分析底物浓度拟合标准曲线的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4287180A (en) * | 1980-01-28 | 1981-09-01 | Baxter Travenol Laboratories, Inc. | Method for treating blood clotting factor inhibitors |
| DE69530043T2 (de) | 1994-11-08 | 2003-10-16 | Tosoh Corp., Shinnanyo | Verfahren zur Bestimmung einer fluoreszierenden Substanz, sowie Verfahren zur Enzym-Aktivität-Bestimmung |
| CA2484554C (en) * | 2002-05-01 | 2012-12-04 | Synapse B.V. | Diagnostic test for determining the concentration of transient proteolytic activity in composite biological media |
| EP1717588A1 (de) | 2005-04-29 | 2006-11-02 | Synapse B.V. | Bestimmung der Thrombinaktivität in Vollblut |
| EP2029768B1 (de) | 2006-06-06 | 2013-02-13 | Thrombinoscope B.V. | Verfahren zur bestimmung der thrombinaktivität in plasma |
| CA2668356A1 (en) * | 2006-11-02 | 2008-05-08 | Thrombinoscope B.V. | Method for measuring the concentration of transient proteolytic activity in composite biological media containing cells |
-
2008
- 2008-02-07 EP EP08151181A patent/EP2088435B1/de not_active Not-in-force
- 2008-02-07 AT AT08151181T patent/ATE516504T1/de not_active IP Right Cessation
-
2009
- 2009-02-06 US US12/866,777 patent/US8551722B2/en not_active Expired - Fee Related
- 2009-02-06 WO PCT/EP2009/051413 patent/WO2009098313A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP2088435B1 (de) | 2011-07-13 |
| WO2009098313A1 (en) | 2009-08-13 |
| US8551722B2 (en) | 2013-10-08 |
| US20110045512A1 (en) | 2011-02-24 |
| EP2088435A1 (de) | 2009-08-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |