ATE516T1 - HEMOLYSIS SOLUTION, USE OF SUCH FOR THE DETERMINATION OF GLUCOSE IN BLOOD, AND HEMOLYSIS METHODS. - Google Patents

HEMOLYSIS SOLUTION, USE OF SUCH FOR THE DETERMINATION OF GLUCOSE IN BLOOD, AND HEMOLYSIS METHODS.

Info

Publication number
ATE516T1
ATE516T1 AT79104098T AT79104098T ATE516T1 AT E516 T1 ATE516 T1 AT E516T1 AT 79104098 T AT79104098 T AT 79104098T AT 79104098 T AT79104098 T AT 79104098T AT E516 T1 ATE516 T1 AT E516T1
Authority
AT
Austria
Prior art keywords
hemolysis
glucose
determination
solution
blood
Prior art date
Application number
AT79104098T
Other languages
German (de)
Inventor
Rolf Dr. Vormbrock
Roland Dr. Helger
Original Assignee
Merck Patent Gesellschaft Mit Beschraenkter Haftung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gesellschaft Mit Beschraenkter Haftung filed Critical Merck Patent Gesellschaft Mit Beschraenkter Haftung
Application granted granted Critical
Publication of ATE516T1 publication Critical patent/ATE516T1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y10T436/144444—Glucose
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2525—Stabilizing or preserving

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A hemolysing solution for use in the determination of glucose in a whole blood sample which comprises (a) a buffer providing a pH of about 6-8, (b) sodium chloride, (c) a surface active agent and, (d) a chelating agent which in the presence of component (c) serves as a stabilizer against glycolysis in the hemolysate obtained by contacting the blood sample with said hemolysing solution.
AT79104098T 1978-11-22 1979-10-23 HEMOLYSIS SOLUTION, USE OF SUCH FOR THE DETERMINATION OF GLUCOSE IN BLOOD, AND HEMOLYSIS METHODS. ATE516T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782850603 DE2850603A1 (en) 1978-11-22 1978-11-22 HAEMOLYSIS SOLUTION AND METHOD FOR HAEMOLYSING BLOOD
EP79104098A EP0012184B1 (en) 1978-11-22 1979-10-23 Hemolytic solution, application of such a solution for determining the presence of glucose in blood, and hemolytic process

Publications (1)

Publication Number Publication Date
ATE516T1 true ATE516T1 (en) 1982-01-15

Family

ID=6055321

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79104098T ATE516T1 (en) 1978-11-22 1979-10-23 HEMOLYSIS SOLUTION, USE OF SUCH FOR THE DETERMINATION OF GLUCOSE IN BLOOD, AND HEMOLYSIS METHODS.

Country Status (5)

Country Link
US (1) US4297238A (en)
EP (1) EP0012184B1 (en)
JP (1) JPS5582053A (en)
AT (1) ATE516T1 (en)
DE (2) DE2850603A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2803109C2 (en) * 1978-01-25 1987-02-26 Werner Dr. rer.nat. 6500 Mainz Lang Method and reagent for determining the hemoglobin content of blood
US4333734A (en) * 1980-01-18 1982-06-08 Sloan-Kettering Institute For Cancer Research Diagnostic device for fecal occult blood and method of use
US4906561A (en) * 1981-09-14 1990-03-06 Thornthwaite Jerry T Nuclear isolation medium and procedure for separating cell nuclei
US4668618A (en) * 1981-09-14 1987-05-26 Thornthwaite Jerry T Nuclear isolation medium and procedure for separating cell nuclei
US4528274A (en) * 1982-07-06 1985-07-09 Coulter Electronics, Inc. Multi-purpose blood diluent and lysing agent for differential determination of lymphoid-myeloid population of leukocytes
US4493892A (en) * 1982-12-20 1985-01-15 Memorial Hospital For Cancer & Allied Diseases Solvent system for peroxidase inhibitor reagent for fecal occult blood determinations
US4610961A (en) * 1982-12-27 1986-09-09 Eastman Kodak Company Inhibition of reduction activities of leukocytes
DE3303098A1 (en) * 1983-01-31 1984-08-02 Boehringer Mannheim Gmbh, 6800 Mannheim METHOD AND REAGENT FOR DETERMINING GLUCOSE IN HAEMOLYSED BLOOD
US4529705A (en) * 1983-06-06 1985-07-16 Coulter Electronics, Inc. Reagent for combined diluting and lysing whole blood
GB2154735B (en) * 1984-01-27 1987-07-15 Menarini Sas Reagent for determining blood glucose content
US4935346A (en) 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
US5292663A (en) * 1987-11-30 1994-03-08 Sekisui Kagaku Kogyo Kabushiki Kaisha Method of treating blood containing labile glycosylated hemoglobin A1C
CA1338348C (en) * 1987-11-30 1996-05-28 Kazutoshi Yamazaki Eliminating agent for glycosylated hemoglobin
US5008202A (en) * 1988-11-29 1991-04-16 Sequoia Turner Corporation Blood diluent for red blood cell analysis
JP2836865B2 (en) * 1989-10-23 1998-12-14 東亜医用電子株式会社 Reagents for measuring leukocytes and hemoglobin in blood
US5739037A (en) * 1992-09-29 1998-04-14 Drew Scientific Limited Process for eliminating labile glycohaemoglobin from a sample
US6077660A (en) * 1998-06-10 2000-06-20 Abbott Laboratories Diagnostic assay requiring a small sample of biological fluid
US6458326B1 (en) 1999-11-24 2002-10-01 Home Diagnostics, Inc. Protective test strip platform
US6485923B1 (en) * 2000-02-02 2002-11-26 Lifescan, Inc. Reagent test strip for analyte determination having hemolyzing agent
US6525330B2 (en) 2001-02-28 2003-02-25 Home Diagnostics, Inc. Method of strip insertion detection
US6541266B2 (en) 2001-02-28 2003-04-01 Home Diagnostics, Inc. Method for determining concentration of an analyte in a test strip
US6562625B2 (en) 2001-02-28 2003-05-13 Home Diagnostics, Inc. Distinguishing test types through spectral analysis
EP2030013B1 (en) * 2006-06-06 2009-12-16 Roche Diagnostics GmbH Ready-to-use whole blood collection vessel

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3519572A (en) * 1966-10-03 1970-07-07 Pfizer & Co C Blood control
US3634290A (en) * 1969-08-06 1972-01-11 Tipton L Golias Method of preparing hemolysates for hemoglobin and other types of electrophoresis using chelating agents
US3953295A (en) * 1971-10-20 1976-04-27 Mallinckrodt, Inc. Reagent formulations for glucose assay
US3918905A (en) * 1973-07-20 1975-11-11 Biolog Corp Of America Diagnostic test for the determination of sickling hemoglobinopathies
US3874851A (en) * 1973-11-15 1975-04-01 Robert John Wilkins Method and apparatus for the detection of microfilariae
US3977995A (en) * 1974-10-17 1976-08-31 Baxter Laboratories, Inc. Calibrating fluid for blood cell counting and hemoglobin determination
US3962125A (en) * 1975-01-13 1976-06-08 Coulter Diagnostics, Inc. Multi-purpose diluent for use in blood analysis by electronic instrumentation of the coulter type
US3964865A (en) * 1975-01-30 1976-06-22 Sigma Chemical Company Lyophilized human hemoglobin standard for colorimetric determination of total hemoglobin
US4185964A (en) * 1977-02-08 1980-01-29 Central Laboratories of Associated Maryland Pathologists, Ltd. Lysing reagent
US4142857A (en) * 1977-12-02 1979-03-06 Isolab, Incorporated Method to determine a diagnostic indicator of blood sugar condition, and, a liquid chromatographic microcolumn therefor
US4200435A (en) * 1978-12-26 1980-04-29 Abbott Laboratories Determination of glycosylated hemoglobin in blood

Also Published As

Publication number Publication date
DE2961715D1 (en) 1982-02-18
EP0012184A1 (en) 1980-06-25
JPS634145B2 (en) 1988-01-27
DE2850603A1 (en) 1980-06-19
US4297238A (en) 1981-10-27
EP0012184B1 (en) 1981-12-30
JPS5582053A (en) 1980-06-20

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