ATE517899T1 - Hiv-integrasehemmer - Google Patents

Hiv-integrasehemmer

Info

Publication number: ATE517899T1
Authority: AT; Austria
Prior art keywords: compounds; hiv; inhibitors; hiv integrase; integrase inhibitors
Prior art date: 2005-10-04

Application number

AT06792296T

Other languages

English (en)

Inventor

Monica Donghi

Vincenzo Summa

Olaf Kinzel

Original Assignee

Angeletti P Ist Richerche Bio

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-10-04

Filing date

2006-09-26

Publication date

2011-08-15

2006-09-26 Application filed by Angeletti P Ist Richerche Bio filed Critical Angeletti P Ist Richerche Bio

2011-08-15 Application granted granted Critical

2011-08-15 Publication of ATE517899T1 publication Critical patent/ATE517899T1/de

Links

229940099797 HIV integrase inhibitor Drugs 0.000 title 1
239000003084 hiv integrase inhibitor Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
208000030507 AIDS Diseases 0.000 abstract 2
239000003112 inhibitor Substances 0.000 abstract 2
238000011321 prophylaxis Methods 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
238000011282 treatment Methods 0.000 abstract 2
208000031886 HIV Infections Diseases 0.000 abstract 1
108010002459 HIV Integrase Proteins 0.000 abstract 1
208000037357 HIV infectious disease Diseases 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
239000002955 immunomodulating agent Substances 0.000 abstract 1
229940121354 immunomodulator Drugs 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
239000004615 ingredient Substances 0.000 abstract 1
229940042443 other antivirals in atc Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
VVYKOQMHEKQGOO-UHFFFAOYSA-N pyrido[3,2-d]pyrimidine-2-carboxamide Chemical class N1=CC=CC2=NC(C(=O)N)=NC=C21 VVYKOQMHEKQGOO-UHFFFAOYSA-N 0.000 abstract 1
230000010076 replication Effects 0.000 abstract 1
229960005486 vaccine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT06792296T 2005-10-04 2006-09-26 Hiv-integrasehemmer ATE517899T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US72356705P	2005-10-04	2005-10-04
PCT/EP2006/009410 WO2007039218A1 (en)	2005-10-04	2006-09-26	Hiv integrase inhibitors

Publications (1)

Publication Number	Publication Date
ATE517899T1 true ATE517899T1 (de)	2011-08-15

Family

ID=37621988

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06792296T ATE517899T1 (de)	2005-10-04	2006-09-26	Hiv-integrasehemmer

Country Status (7)

Country	Link
US (1)	US7939537B2 (de)
EP (1)	EP1937678B1 (de)
JP (1)	JP5094725B2 (de)
AT (1)	ATE517899T1 (de)
AU (1)	AU2006299042B8 (de)
CA (1)	CA2622639C (de)
WO (1)	WO2007039218A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR064517A1 (es) *	2006-12-22	2009-04-08	Avexa Ltd	Pirimidinionas biciclicas y sus usos
CA2677493A1 (en) *	2007-02-05	2008-08-14	Xenon Pharmaceuticals Inc.	Pyridopyrimidinone compounds useful in treating sodium channel-mediated diseases or conditions
SI2220076T1 (sl)	2007-11-15	2012-05-31	Gilead Sciences Inc	Inhibitorji replikacije virusa humane imunske pomankljivosti
KR20100108337A (ko)	2007-11-15	2010-10-06	베링거 인겔하임 인터내셔날 게엠베하	사람 면역결핍 바이러스 복제의 억제제
US8354429B2 (en)	2007-11-16	2013-01-15	Gilead Sciences, Inc.	Inhibitors of human immunodeficiency virus replication
US8318732B2 (en) *	2008-07-02	2012-11-27	Avexa Limited	Compounds having antiviral properties
CN102336751A (zh) *	2010-07-16	2012-02-01	爱维艾珂瑟有限公司	新型抗病毒剂
US9089574B2 (en)	2011-11-30	2015-07-28	Emory University	Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections
US12195458B2 (en)	2019-12-02	2025-01-14	Storm Therapeutics Limited	Polyheterocyclic compounds as METTL3 inhibitors
CN119504744B (zh) *	2024-11-21	2025-10-14	山西医科大学	一种C3芳甲酰氧基化4H-吡啶并[1,2-a]嘧啶-4-酮衍生物及其合成方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0017676D0 (en) *	2000-07-19	2000-09-06	Angeletti P Ist Richerche Bio	Inhibitors of viral polymerase
JP2004517860A (ja) *	2000-10-12	2004-06-17	メルク　エンド　カムパニー　インコーポレーテッド	Ｈｉｖインテグラーゼ阻害薬として有用なアザ−およびポリアザ−ナフタレニルカルボキサミド類
AU2002230392A1 (en) *	2000-10-12	2002-05-15	Merck & Co., Inc.	AZA-and polyaza-naphthalenyl ketones useful as HIV integrase inhibitors
AU1532802A (en) *	2000-10-12	2002-04-22	Merck & Co Inc	Aza- and polyaza-naphthalenyl-carboxamides useful as hiv integrase inhibitors
EP1326865B1 (de) *	2000-10-12	2009-05-06	Merck & Co., Inc.	Aza- und polyaza naphthalenyl karboxamide als inhibitoren der hiv-integrase
CN1659143A (zh) *	2001-03-01	2005-08-24	盐野义制药株式会社	具有hiv整合酶抑制活性的含氮杂芳基化合物
ATE530520T1 (de) *	2001-08-10	2011-11-15	Shionogi & Co	Antivirales mittel
DE122009000048I1 (de) *	2001-10-26	2010-04-08	Angeletti P Ist Richerche Bio	N-substituierte hydroxypyrimidinoncarboxamid-hemmer der hiv-integrase
CA2463975A1 (en) *	2001-10-26	2003-05-01	Maria Emilia Di Francesco	Dihydroxypyrimidine carboxamide inhibitors of hiv integrase
JP4170633B2 (ja) *	2001-11-12	2008-10-22	独立行政法人科学技術振興機構	拡張型心筋症の原因となる新規点突然変異を有するデスミン遺伝子
EP1467970B1 (de)	2002-01-17	2007-08-22	Merck & Co., Inc.	Hydroxynaphthyridinoncarbonsäureamide, die sich als inhibitoren der hiv-integrase eignen
GB0201179D0 (en) *	2002-01-18	2002-03-06	Angeletti P Ist Richerche Bio	Therapeutic agents
WO2004004657A2 (en) *	2002-07-09	2004-01-15	Bristol-Myers Squibb Company	Hiv integrase inhibitors
WO2004058756A1 (en) *	2002-12-27	2004-07-15	Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa	Tetrahydro-4h-pyrido[1,2-a]pyrimidines and related compounds useful as hiv integrase inhibitors
TW200510425A (en) *	2003-08-13	2005-03-16	Japan Tobacco Inc	Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
TW200526635A (en) *	2003-12-22	2005-08-16	Shionogi & Co	Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
AU2005221864A1 (en) *	2004-03-09	2005-09-22	Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa	HIV integrase inhibitors
EP1725535A4 (de)	2004-03-09	2009-11-25	Merck & Co Inc	Hiv-integrasehemmer
WO2005087768A1 (en) *	2004-03-09	2005-09-22	Merck & Co., Inc.	Hiv integrase inhibitors
US7176196B2 (en) *	2004-05-28	2007-02-13	Bristol-Myers Squibb Company	Bicyclic heterocycles as HIV integrase inhibitors
US7192948B2 (en)	2004-05-28	2007-03-20	Bristol-Myers Squibb Company	Bicyclic heterocycles as HIV integrase inhibitors
DK3187225T3 (da)	2005-04-28	2022-02-28	Viiv Healthcare Co	Polycyklisk carbamoylpyridonderivat med hiv-integrasehæmmende aktivitet

2006
- 2006-09-26 JP JP2008533912A patent/JP5094725B2/ja not_active Expired - Fee Related
- 2006-09-26 AT AT06792296T patent/ATE517899T1/de not_active IP Right Cessation
- 2006-09-26 WO PCT/EP2006/009410 patent/WO2007039218A1/en not_active Ceased
- 2006-09-26 AU AU2006299042A patent/AU2006299042B8/en not_active Ceased
- 2006-09-26 EP EP06792296A patent/EP1937678B1/de not_active Not-in-force
- 2006-09-26 US US11/992,531 patent/US7939537B2/en active Active
- 2006-09-26 CA CA2622639A patent/CA2622639C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU2006299042A1 (en)	2007-04-12
JP2009510148A (ja)	2009-03-12
JP5094725B2 (ja)	2012-12-12
EP1937678B1 (de)	2011-07-27
US7939537B2 (en)	2011-05-10
US20090221571A1 (en)	2009-09-03
AU2006299042B8 (en)	2011-09-15
AU2006299042B2 (en)	2011-09-01
CA2622639C (en)	2012-01-03
EP1937678A1 (de)	2008-07-02
WO2007039218A1 (en)	2007-04-12
CA2622639A1 (en)	2007-04-12
AU2006299042A8 (en)	2011-09-15

Legal Events

Date	Code	Title	Description
2012-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
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WO2005086700A3 (en)	2006-09-08	Hiv integrase inhibitors
WO2006103399A8 (en)	2007-11-01	Hiv integrase inhibitors
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MY163979A (en)	2017-11-15	Non-nucleoside reverse transcriptase inhibitors
WO2005074513A3 (en)	2005-09-29	N-benzyl-3,4-dihyroxypyridine-2-carboxamide and n-benzyl-2,3-dihydroxypyridine-4-carboxamide compounds useful as hiv integrase inhibitors
MD4625B1 (ro)	2019-04-30	Derivaţi de 5-fenoxi-3H-pirimidin-4-onă şi utilizarea acestora ca inhibitori ai transcriptazei inverse a HIV
EA200601654A1 (ru)	2007-02-27	Ингибиторы интегразы вич
TW200738702A (en)	2007-10-16	HIV reverse transcriptase inhibitors
WO2010042391A3 (en)	2010-06-03	Hiv integrase inhibitors
WO2006121831A3 (en)	2007-10-25	Hiv integrase inhibitors
HK1249107A1 (zh)	2018-10-26	抗病毒β-氨基酸酯磷酸二酰胺化合物
WO2005110414A3 (en)	2006-02-16	Hiv integrase inhibitors
WO2009042094A3 (en)	2009-07-30	Hiv protease inhibitors
WO2011025683A8 (en)	2011-09-22	Hiv integrase inhibitors
WO2005120516A3 (en)	2007-02-22	Hiv integrase inhibitors
WO2007050510A3 (en)	2007-10-04	Hiv integrase inhibitors
AU2006299042A8 (en)	2011-09-15	HIV integrase inhibitors
WO2007002458A3 (en)	2007-10-11	Non-nucleoside reverse transcriptase inhibitors
WO2007002481A3 (en)	2007-11-15	Non-nucleoside reverse transcriptase inhibitors
WO2007002368A3 (en)	2007-05-03	Non-nucleoside reverse transcriptase inhibitors
WO2007021629A3 (en)	2007-06-21	Non-nucleoside reverse transcriptase inhibitors
TW200640460A (en)	2006-12-01	HIV integrase inhibitors