ATE517899T1 - Hiv-integrasehemmer - Google Patents
Hiv-integrasehemmerInfo
- Publication number
- ATE517899T1 ATE517899T1 AT06792296T AT06792296T ATE517899T1 AT E517899 T1 ATE517899 T1 AT E517899T1 AT 06792296 T AT06792296 T AT 06792296T AT 06792296 T AT06792296 T AT 06792296T AT E517899 T1 ATE517899 T1 AT E517899T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- hiv
- inhibitors
- hiv integrase
- integrase inhibitors
- Prior art date
Links
- 229940099797 HIV integrase inhibitor Drugs 0.000 title 1
- 239000003084 hiv integrase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000030507 AIDS Diseases 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 108010002459 HIV Integrase Proteins 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 229940042443 other antivirals in atc Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- VVYKOQMHEKQGOO-UHFFFAOYSA-N pyrido[3,2-d]pyrimidine-2-carboxamide Chemical class N1=CC=CC2=NC(C(=O)N)=NC=C21 VVYKOQMHEKQGOO-UHFFFAOYSA-N 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72356705P | 2005-10-04 | 2005-10-04 | |
| PCT/EP2006/009410 WO2007039218A1 (en) | 2005-10-04 | 2006-09-26 | Hiv integrase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE517899T1 true ATE517899T1 (de) | 2011-08-15 |
Family
ID=37621988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06792296T ATE517899T1 (de) | 2005-10-04 | 2006-09-26 | Hiv-integrasehemmer |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7939537B2 (de) |
| EP (1) | EP1937678B1 (de) |
| JP (1) | JP5094725B2 (de) |
| AT (1) | ATE517899T1 (de) |
| AU (1) | AU2006299042B8 (de) |
| CA (1) | CA2622639C (de) |
| WO (1) | WO2007039218A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5208962B2 (ja) | 2006-12-22 | 2013-06-12 | アベキサ・リミテッド | 二環式ピリミジノンおよびその使用 |
| AU2008213836A1 (en) * | 2007-02-05 | 2008-08-14 | Xenon Pharmaceuticals Inc. | Pyridopyrimidinone compounds useful in treating sodium channel-mediated diseases or conditions |
| ATE541841T1 (de) | 2007-11-15 | 2012-02-15 | Boehringer Ingelheim Int | Inhibitoren der replikation des human immunodeficiency virus |
| ES2402322T3 (es) * | 2007-11-15 | 2013-04-30 | Gilead Sciences, Inc. | Inhibidores de la replicación del virus de la inmunodeficiencia humana |
| EA019259B1 (ru) | 2007-11-16 | 2014-02-28 | Джилид Сайенсиз, Инк. | Ингибиторы репликации вируса иммунодефицита человека |
| PL2212324T3 (pl) * | 2008-07-02 | 2014-11-28 | Avexa Ltd | Związki posiadające właściwości przeciwwirusowe |
| CN102336751A (zh) * | 2010-07-16 | 2012-02-01 | 爱维艾珂瑟有限公司 | 新型抗病毒剂 |
| ES3018133T3 (en) | 2011-11-30 | 2025-05-14 | Univ Emory | Jak inhibitors for use in the prevention or treatment of a viral disease caused by a coronaviridae |
| CN115151540A (zh) | 2019-12-02 | 2022-10-04 | 风暴治疗有限公司 | 作为mettl3抑制剂的多杂环化合物 |
| CN119504744B (zh) * | 2024-11-21 | 2025-10-14 | 山西医科大学 | 一种C3芳甲酰氧基化4H-吡啶并[1,2-a]嘧啶-4-酮衍生物及其合成方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0017676D0 (en) | 2000-07-19 | 2000-09-06 | Angeletti P Ist Richerche Bio | Inhibitors of viral polymerase |
| PL360944A1 (en) | 2000-10-12 | 2004-09-20 | Merck & Co, Inc. | Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors |
| WO2002036734A2 (en) | 2000-10-12 | 2002-05-10 | Merck & Co., Inc. | Aza-and polyaza-naphthalenyl ketones useful as hiv integrase inhibitors |
| EP1326611B1 (de) | 2000-10-12 | 2007-06-13 | Merck & Co., Inc. | Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer |
| ATE345129T1 (de) | 2000-10-12 | 2006-12-15 | Merck & Co Inc | Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer |
| JP3616628B2 (ja) * | 2001-03-01 | 2005-02-02 | 塩野義製薬株式会社 | Ｈｉｖインテグラーゼ阻害活性を有する含窒素芳香族複素環化合物 |
| ES2572030T3 (es) * | 2001-08-10 | 2017-07-19 | Shionogi & Co., Ltd. | Agente antiviral |
| ATE355064T1 (de) | 2001-10-26 | 2006-03-15 | Angeletti P Ist Richerche Bio | Dihydroxypyrimidin-carbonsäueramid-hemmer der hiv-integrase |
| IL161337A0 (en) | 2001-10-26 | 2004-09-27 | Angeletti P Ist Richerche Bio | N-substituted hydroxypyrimidinone carboxamide inhibitors of hiv integrase |
| JP4170633B2 (ja) * | 2001-11-12 | 2008-10-22 | 独立行政法人科学技術振興機構 | 拡張型心筋症の原因となる新規点突然変異を有するデスミン遺伝子 |
| EP1467970B1 (de) | 2002-01-17 | 2007-08-22 | Merck & Co., Inc. | Hydroxynaphthyridinoncarbonsäureamide, die sich als inhibitoren der hiv-integrase eignen |
| GB0201179D0 (en) | 2002-01-18 | 2002-03-06 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| US7109186B2 (en) | 2002-07-09 | 2006-09-19 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| NZ540729A (en) | 2002-12-27 | 2008-03-28 | Angeletti P Ist Richerche Bio | Tetrahydro-4H-pyrido[1,2-a]pyrimidines and related compounds useful as HIV integrase inhibitors |
| TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| TW200526635A (en) * | 2003-12-22 | 2005-08-16 | Shionogi & Co | Hydroxypyrimidinone derivative having HIV integrase inhibitory activity |
| US20070161639A1 (en) | 2004-03-09 | 2007-07-12 | Philip Jones | Hiv integrase inhibitors |
| CN101014574A (zh) | 2004-03-09 | 2007-08-08 | 默克公司 | Hiv整合酶抑制剂 |
| JP4625838B2 (ja) | 2004-03-09 | 2011-02-02 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｈｉｖインテグラーゼ阻害薬 |
| US7192948B2 (en) * | 2004-05-28 | 2007-03-20 | Bristol-Myers Squibb Company | Bicyclic heterocycles as HIV integrase inhibitors |
| US7176196B2 (en) | 2004-05-28 | 2007-02-13 | Bristol-Myers Squibb Company | Bicyclic heterocycles as HIV integrase inhibitors |
| KR101363875B1 (ko) | 2005-04-28 | 2014-02-21 | 시오노기세야쿠 가부시키가이샤 | Ｈｉｖ 통합효소 억제 활성을 가지는 다환식카르바모일피리돈 유도체 |
-
2006
- 2006-09-26 US US11/992,531 patent/US7939537B2/en active Active
- 2006-09-26 EP EP06792296A patent/EP1937678B1/de not_active Not-in-force
- 2006-09-26 JP JP2008533912A patent/JP5094725B2/ja not_active Expired - Fee Related
- 2006-09-26 CA CA2622639A patent/CA2622639C/en not_active Expired - Fee Related
- 2006-09-26 AU AU2006299042A patent/AU2006299042B8/en not_active Ceased
- 2006-09-26 WO PCT/EP2006/009410 patent/WO2007039218A1/en not_active Ceased
- 2006-09-26 AT AT06792296T patent/ATE517899T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP5094725B2 (ja) | 2012-12-12 |
| EP1937678A1 (de) | 2008-07-02 |
| JP2009510148A (ja) | 2009-03-12 |
| US20090221571A1 (en) | 2009-09-03 |
| EP1937678B1 (de) | 2011-07-27 |
| AU2006299042B2 (en) | 2011-09-01 |
| US7939537B2 (en) | 2011-05-10 |
| CA2622639A1 (en) | 2007-04-12 |
| AU2006299042A8 (en) | 2011-09-15 |
| AU2006299042A1 (en) | 2007-04-12 |
| CA2622639C (en) | 2012-01-03 |
| AU2006299042B8 (en) | 2011-09-15 |
| WO2007039218A1 (en) | 2007-04-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO2020026I1 (no) | Raltegravir eller et farmasøytisk akseptabelt salt derav, spesielt kaliumsaltet | |
| WO2005086700A3 (en) | Hiv integrase inhibitors | |
| WO2006103399A8 (en) | Hiv integrase inhibitors | |
| TN2009000243A1 (en) | Non-nucleoside reverse transcriptase inhibitors | |
| WO2008054605A3 (en) | Non-nucleoside reverse transcriptase inhibitors | |
| WO2007146230A3 (en) | Non-nucleoside reverse transcriptase inhibitors | |
| MY163979A (en) | Non-nucleoside reverse transcriptase inhibitors | |
| WO2005074513A3 (en) | N-benzyl-3,4-dihyroxypyridine-2-carboxamide and n-benzyl-2,3-dihydroxypyridine-4-carboxamide compounds useful as hiv integrase inhibitors | |
| MD4625B1 (ro) | Derivaţi de 5-fenoxi-3H-pirimidin-4-onă şi utilizarea acestora ca inhibitori ai transcriptazei inverse a HIV | |
| EA200601654A1 (ru) | Ингибиторы интегразы вич | |
| TW200738702A (en) | HIV reverse transcriptase inhibitors | |
| WO2010042391A3 (en) | Hiv integrase inhibitors | |
| WO2006121831A3 (en) | Hiv integrase inhibitors | |
| WO2005110414A3 (en) | Hiv integrase inhibitors | |
| WO2009042094A3 (en) | Hiv protease inhibitors | |
| WO2011025683A8 (en) | Hiv integrase inhibitors | |
| ATE517899T1 (de) | Hiv-integrasehemmer | |
| WO2005120516A3 (en) | Hiv integrase inhibitors | |
| WO2007050510A3 (en) | Hiv integrase inhibitors | |
| WO2007002458A3 (en) | Non-nucleoside reverse transcriptase inhibitors | |
| WO2007002481A3 (en) | Non-nucleoside reverse transcriptase inhibitors | |
| WO2007002368A3 (en) | Non-nucleoside reverse transcriptase inhibitors | |
| WO2007021629A3 (en) | Non-nucleoside reverse transcriptase inhibitors | |
| TW200640460A (en) | HIV integrase inhibitors | |
| TNSN06270A1 (en) | Hiv integrase inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |