ATE517903T1 - Verbindungen mit eingeschränkter konformation als cgrp rezeptor antagonisten. - Google Patents

Verbindungen mit eingeschränkter konformation als cgrp rezeptor antagonisten.

Info

Publication number: ATE517903T1
Authority: AT; Austria
Prior art keywords: receptor antagonists; compounds; cgrp; cgrp receptor; treatment
Prior art date: 2006-05-02

Application number

AT07761624T

Other languages

English (en)

Inventor

Stephen E Mercer

Prasad V Chaturvedula

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-05-02

Filing date

2007-05-01

Publication date

2011-08-15

2007-05-01 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2011-08-15 Application granted granted Critical

2011-08-15 Publication of ATE517903T1 publication Critical patent/ATE517903T1/de

Links

108010078311 Calcitonin Gene-Related Peptide Receptors Proteins 0.000 title abstract 3
102000008323 calcitonin gene-related peptide receptor activity proteins Human genes 0.000 title abstract 2
239000002464 receptor antagonist Substances 0.000 title abstract 2
229940044551 receptor antagonist Drugs 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 title 1
238000000034 method Methods 0.000 abstract 2
102000014468 Calcitonin Gene-Related Peptide Receptors Human genes 0.000 abstract 1
208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
206010019233 Headaches Diseases 0.000 abstract 1
208000019695 Migraine disease Diseases 0.000 abstract 1
208000007920 Neurogenic Inflammation Diseases 0.000 abstract 1
208000027418 Wounds and injury Diseases 0.000 abstract 1
230000008485 antagonism Effects 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
230000005796 circulatory shock Effects 0.000 abstract 1
230000006378 damage Effects 0.000 abstract 1
238000011010 flushing procedure Methods 0.000 abstract 1
231100000869 headache Toxicity 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
208000014674 injury Diseases 0.000 abstract 1
230000009245 menopause Effects 0.000 abstract 1
206010027599 migraine Diseases 0.000 abstract 1
230000001272 neurogenic effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
230000024883 vasodilation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT07761624T 2006-05-02 2007-05-01 Verbindungen mit eingeschränkter konformation als cgrp rezeptor antagonisten. ATE517903T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US79670206P	2006-05-02	2006-05-02
PCT/US2007/067857 WO2007130927A2 (en)	2006-05-02	2007-05-01	Condensed tricyclic compounds as cgrp-receptor antagonists

Publications (1)

Publication Number	Publication Date
ATE517903T1 true ATE517903T1 (de)	2011-08-15

Family

ID=38561983

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07761624T ATE517903T1 (de)	2006-05-02	2007-05-01	Verbindungen mit eingeschränkter konformation als cgrp rezeptor antagonisten.

Country Status (5)

Country	Link
US (1)	US7470679B2 (de)
EP (1)	EP2013213B1 (de)
AT (1)	ATE517903T1 (de)
ES (1)	ES2368456T3 (de)
WO (1)	WO2007130927A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7951795B2 (en) *	2006-12-08	2011-05-31	Merck Sharp & Dohme Corp.	Constrained spirocyclic compounds as CGRP receptor antagonists
JP2011512410A (ja) *	2008-02-19	2011-04-21	メルク・シャープ・エンド・ドーム・コーポレイション	イミダゾベンゾアゼピンｃｇｒｐ受容体アンタゴニスト
WO2010006168A2 (en) *	2008-07-09	2010-01-14	University Of Rochester	Methods of treating cancer using and agent that modulates activity of the calcitonin-gene related peptide ("cgrp") receptor
EP3028703B1 (de)	2013-07-29	2019-12-04	Kyowa Kirin Co., Ltd.	Piperidin abkömmlinge als wnt-signalisierungsinhibitor
EP3366286A1 (de)	2017-02-22	2018-08-29	Johannes Keller	Verbindungen zur behandlung von sepsis
GB201707938D0 (en)	2017-05-17	2017-06-28	Univ Sheffield	Compounds
CN112110824B (zh) *	2020-09-17	2023-04-07	上海凌凯医药科技有限公司	一种制备2-溴-5-氟苯胺的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1606286B1 (de)	2003-03-14	2011-05-11	Merck Sharp & Dohme Corp.	Benzodiazepinspirohydantoine als cgrp-rezeptorantagonisten
US7288559B2 (en)	2003-03-14	2007-10-30	Merck + Co, Inc.	Carboxamide spirohydantoin CGRP receptor antagonists
WO2004091514A2 (en) *	2003-04-15	2004-10-28	Merck & Co., Inc.	Cgrp receptor antagonists
JO2355B1 (en) *	2003-04-15	2006-12-12	ميرك شارب اند دوم كوربوريشن	Hereditary calcitonin polypeptide receptor antagonists
EP1641781B1 (de) *	2003-06-26	2013-03-06	Merck Sharp & Dohme Corp.	Benzodiazepin-CGRP-Rezeptor-Antagonisten
US7476665B2 (en) *	2003-06-26	2009-01-13	Merck & Co., Inc.	Benzodiazepine CGRP receptor antagonists
CN101124217A (zh)	2004-01-29	2008-02-13	默克公司	Cgrp受体拮抗剂
US7390798B2 (en)	2004-09-13	2008-06-24	Merck & Co., Inc.	Carboxamide spirolactam CGRP receptor antagonists
US7659264B2 (en)	2004-10-07	2010-02-09	Merck Sharp & Dohme Corp.	CGRP receptor antagonists
EP1802637B1 (de)	2004-10-13	2008-10-15	Merck & Co., Inc.	Cgrp-rezeptorantagonisten
DE602005027870D1 (de)	2004-10-14	2011-06-16	Merck Sharp & Dohme	Cgrp-rezeptorantagonisten
US7745427B2 (en)	2004-10-22	2010-06-29	Merck Sharp & Dohme Corp.	CGRP receptor antagonists
US7384931B2 (en) *	2004-11-03	2008-06-10	Bristol-Myers Squibb Company	Constrained compounds as CGRP-receptor antagonists
US7384930B2 (en) *	2004-11-03	2008-06-10	Bristol-Myers Squibb Company	Constrained compounds as CGRP-receptor antagonists
EP1856100B1 (de)	2005-01-18	2010-05-05	Merck Sharp & Dohme Corp.	Cgrp-rezeptorantagonisten
EP1861399B1 (de)	2005-03-14	2011-12-14	Merck Sharp & Dohme Corp.	Cgrp-rezeptorantagonisten
CA2615463A1 (en)	2005-07-29	2007-02-08	Merck & Co., Inc.	Heterocyclic benzodiazepine cgrp receptor antagonists
CA2672230A1 (en)	2006-12-20	2008-07-17	Merck & Co., Inc.	Benzazepine compounds as cgrp receptor antagonists

2007
- 2007-05-01 EP EP07761624A patent/EP2013213B1/de active Active
- 2007-05-01 AT AT07761624T patent/ATE517903T1/de not_active IP Right Cessation
- 2007-05-01 ES ES07761624T patent/ES2368456T3/es active Active
- 2007-05-01 US US11/742,615 patent/US7470679B2/en active Active
- 2007-05-01 WO PCT/US2007/067857 patent/WO2007130927A2/en not_active Ceased

Also Published As

Publication number	Publication date
WO2007130927A3 (en)	2009-09-11
ES2368456T3 (es)	2011-11-17
EP2013213B1 (de)	2011-07-27
EP2013213A2 (de)	2009-01-14
US7470679B2 (en)	2008-12-30
US20070259850A1 (en)	2007-11-08
WO2007130927A2 (en)	2007-11-15

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Legal Events

Date	Code	Title	Description
2012-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties