ATE517986T1 - Enzymatische umwandlung von roten blutzellen der blutgruppen b und ab unter verwendung von einem alpha-galactosidase mit einzigartigen substratspezifitäten und kinetischen eigenschaften - Google Patents

Enzymatische umwandlung von roten blutzellen der blutgruppen b und ab unter verwendung von einem alpha-galactosidase mit einzigartigen substratspezifitäten und kinetischen eigenschaften

Info

Publication number
ATE517986T1
ATE517986T1 AT02763720T AT02763720T ATE517986T1 AT E517986 T1 ATE517986 T1 AT E517986T1 AT 02763720 T AT02763720 T AT 02763720T AT 02763720 T AT02763720 T AT 02763720T AT E517986 T1 ATE517986 T1 AT E517986T1
Authority
AT
Austria
Prior art keywords
galactosidase
alpha
blood group
enzymatic conversion
substrate specificities
Prior art date
Application number
AT02763720T
Other languages
English (en)
Inventor
Henrik Clausen
La Vega Humberto De
Cheryl Hill
Qiyong Liu
Original Assignee
Velico Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Velico Medical Inc filed Critical Velico Medical Inc
Application granted granted Critical
Publication of ATE517986T1 publication Critical patent/ATE517986T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0641—Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01022—Alpha-galactosidase (3.2.1.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01049—Alpha-N-acetylgalactosaminidase (3.2.1.49)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT02763720T 2001-09-25 2002-09-25 Enzymatische umwandlung von roten blutzellen der blutgruppen b und ab unter verwendung von einem alpha-galactosidase mit einzigartigen substratspezifitäten und kinetischen eigenschaften ATE517986T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US32497001P 2001-09-25 2001-09-25
US36176902P 2002-03-05 2002-03-05
US10/251,271 US7767415B2 (en) 2001-09-25 2002-09-20 Compositions and methods for modifying blood cell carbohydrates
PCT/US2002/030403 WO2003027245A2 (en) 2001-09-25 2002-09-25 CONVERSION OF RED BLOOD CELLS A, B, AND AB USING a-N-ACETYLGALACTOSAMINIDASES AND a-GALACTOSIDASE

Publications (1)

Publication Number Publication Date
ATE517986T1 true ATE517986T1 (de) 2011-08-15

Family

ID=27400431

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02763720T ATE517986T1 (de) 2001-09-25 2002-09-25 Enzymatische umwandlung von roten blutzellen der blutgruppen b und ab unter verwendung von einem alpha-galactosidase mit einzigartigen substratspezifitäten und kinetischen eigenschaften

Country Status (7)

Country Link
US (5) US7767415B2 (de)
EP (2) EP2302045A1 (de)
JP (2) JP4371810B2 (de)
AT (1) ATE517986T1 (de)
AU (1) AU2008203095B2 (de)
CA (1) CA2460575C (de)
WO (1) WO2003027245A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767415B2 (en) 2001-09-25 2010-08-03 Velico Medical, Inc. Compositions and methods for modifying blood cell carbohydrates
US20070141646A1 (en) * 2003-02-17 2007-06-21 Henry Stephen M Preparation of red blood cells with a modified level of blood group antigen expression and their use in the quality control of blood typing reagents
EP1765987A4 (de) * 2004-06-11 2008-05-07 Kiwi Ingenuity Ltd Enzymatische modifikation von zelloberflächenantigen h durch glykosyltransferasen
JP2009506801A (ja) * 2005-07-26 2009-02-19 ザイムクエスト インコーポレイティッド 血液処理装置ならびに関連するシステムおよび方法
US20070100557A1 (en) * 2005-10-24 2007-05-03 Yi Zhang Selection of genotyped transfusion donors by cross-matching to genotyped recipients
EP2502492A3 (de) * 2005-10-31 2012-12-19 Velico Medical, Inc. Neue a-galactosidasen
WO2007053565A2 (en) * 2005-10-31 2007-05-10 Zymequest, Inc. Novel a-galactosidases
US8875714B2 (en) * 2007-02-22 2014-11-04 The Invention Science Fund I, Llc Coded-sequence activation of surgical implants
US8691544B2 (en) * 2007-05-04 2014-04-08 Glycorex Transplantation Ab Material for separation of a biomolecule
CN100569942C (zh) * 2007-11-02 2009-12-16 中国人民解放军军事医学科学院野战输血研究所 一种α-N-乙酰半乳糖胺酶及其编码基因与应用
GB0817908D0 (en) 2008-10-01 2008-11-05 Univ Ghent Blood group a/b/h determinant on type 1 core glycosphinglipids chain as recognition point for the fedf protein of f18-fimbriated enterotoxigenic
US9095436B2 (en) 2009-04-14 2015-08-04 The Invention Science Fund I, Llc Adjustable orthopedic implant and method for treating an orthopedic condition in a subject
US9788539B2 (en) 2011-05-17 2017-10-17 Velico Medical, Inc. Platelet protection solution having beta-galactosidase and sialidase inhibitors
EP2903430A1 (de) 2012-10-05 2015-08-12 Velico Medical, Inc. Plättchenadditivlösung mit beta-galactosidase-inhibitor
JP7684216B2 (ja) * 2018-08-17 2025-05-27 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア ドナー臓器における糖鎖抗原除去のための酵素組成物、それに関連する方法および使用
WO2020132688A1 (en) 2018-12-21 2020-06-25 The Curators Of The University Of Missouri Methods and systems for drawn fused filament fabrication printing

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GB2017079B (en) * 1978-02-08 1982-07-28 Meiji Seika Kaisha Substance sf-1739 derivatives
US4427777A (en) 1980-08-14 1984-01-24 New York Blood Center, Inc. Enzymatic conversion of red cells for transfusion
US4330619A (en) 1980-08-14 1982-05-18 New York Blood Center, Inc. Enzymatic conversion of red cells for transfusion
US4609627A (en) 1983-08-01 1986-09-02 New York Blood Center, Inc. Enzymatic conversion of certain sub-type A and AB erythrocytes
CA1339101C (en) 1986-06-03 1997-07-29 Nicolaas Overbeeke Production of guar alpha-galactosidase and immunologically related alpha-galactosidases by host organisms transformed with recombinant dna methods
US5382524A (en) 1990-10-24 1995-01-17 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of biologically active α-n-acetylgalactosaminidase
US5401650A (en) 1990-10-24 1995-03-28 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of biologically active α-galactosidase A
WO1994009121A1 (en) 1992-10-22 1994-04-28 The New York Blood Center, Inc. Preparation of enzyme for conversion of sub-type a and ab erythrocytes
US6228631B1 (en) 1992-10-22 2001-05-08 New York Blood Center, Inc. Recombinant α-N-acetylgalactosaminidase enzyme and cDNA encoding said enzyme
AU5365094A (en) 1992-10-22 1994-05-09 New York Blood Center, Inc., The Recycling of enzymes used to convert sub-type a, b and ab erythrocytes
JPH06285701A (ja) 1993-04-05 1994-10-11 Fanuc Ltd Ｎｃ旋削加工装置
US6329191B1 (en) 1993-08-30 2001-12-11 Hawaii Biotechnology Group, Inc. DNA encoding recombinant coffee bean alpha-galactosidase
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US5606042A (en) 1994-09-08 1997-02-25 The Curators Of The University Of Missouri Glycine α-D-galactosidases
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US7767415B2 (en) * 2001-09-25 2010-08-03 Velico Medical, Inc. Compositions and methods for modifying blood cell carbohydrates

Also Published As

Publication number Publication date
US8697411B2 (en) 2014-04-15
CA2460575A1 (en) 2003-04-03
US20140220553A1 (en) 2014-08-07
US7767415B2 (en) 2010-08-03
JP2005503808A (ja) 2005-02-10
WO2003027245A2 (en) 2003-04-03
CA2460575C (en) 2013-07-30
WO2003027245B1 (en) 2003-08-21
EP2302045A1 (de) 2011-03-30
US20120202273A1 (en) 2012-08-09
US7993896B2 (en) 2011-08-09
AU2008203095A1 (en) 2010-03-18
US20050208655A1 (en) 2005-09-22
EP1436387A2 (de) 2004-07-14
AU2008203095B2 (en) 2012-02-02
JP4371810B2 (ja) 2009-11-25
US20030157474A1 (en) 2003-08-21
EP1436387A4 (de) 2005-12-21
US20110045569A1 (en) 2011-02-24
WO2003027245A3 (en) 2003-07-10
EP1436387B1 (de) 2011-07-27
JP2009153525A (ja) 2009-07-16

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