ATE519749T1 - Neue klasse von histondeacetylaseinhibitoren - Google Patents

Neue klasse von histondeacetylaseinhibitoren

Info

Publication number: ATE519749T1
Authority: AT; Austria
Prior art keywords: histone deacetylase; deacetylase inhibitors; new class; bond; alkyl
Prior art date: 2007-08-28

Application number

AT08787488T

Other languages

English (en)

Inventor

Florian Thaler

Mario Varasi

Ciro Mercurio

Saverio Minucci

Andrea Colombo

Stefania Gagliardi

Original Assignee

Dac Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-08-28

Filing date

2008-08-26

Publication date

2011-08-15

2008-08-26 Application filed by Dac Srl filed Critical Dac Srl

2011-08-15 Application granted granted Critical

2011-08-15 Publication of ATE519749T1 publication Critical patent/ATE519749T1/de

Links

229940121372 histone deacetylase inhibitor Drugs 0.000 title abstract 2
239000003276 histone deacetylase inhibitor Substances 0.000 title abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract 1
125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Oncology (AREA)
Hematology (AREA)
Physical Education & Sports Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Transplantation (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT08787488T 2007-08-28 2008-08-26 Neue klasse von histondeacetylaseinhibitoren ATE519749T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP07115103A EP2033956A1 (de)	2007-08-28	2007-08-28	Neue Klasse von Histon-Deacetylase-Hemmern
PCT/EP2008/061140 WO2009027395A1 (en)	2007-08-28	2008-08-26	A new class of histone deacetylase inhibitors

Publications (1)

Publication Number	Publication Date
ATE519749T1 true ATE519749T1 (de)	2011-08-15

Family

ID=39529816

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08787488T ATE519749T1 (de)	2007-08-28	2008-08-26	Neue klasse von histondeacetylaseinhibitoren

Country Status (6)

Country	Link
US (1)	US20100305123A1 (de)
EP (2)	EP2033956A1 (de)
JP (1)	JP2010536927A (de)
AT (1)	ATE519749T1 (de)
ES (1)	ES2371133T3 (de)
WO (1)	WO2009027395A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20150141470A1 (en)	2012-05-08	2015-05-21	The Broad Institute, Inc.	Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy
CN103102332B (zh) *	2013-01-17	2015-05-27	浙江大学	含哌嗪环的查尔酮类化合物及其制备和应用
CN103102331B (zh) *	2013-01-17	2015-05-27	浙江大学	含哌嗪环的查尔酮类化合物的药物用途
US20190068108A1 (en) *	2015-11-05	2019-02-28	Nippon Steel & Sumitomo Metal Corporation	Thermophotovoltaic conversion member
WO2023011513A1 (zh) *	2021-08-04	2023-02-09	北京泰德制药股份有限公司	Shp2抑制剂、包含其的药物组合物及其用途
CN115974719B (zh) *	2022-12-06	2025-01-07	小江生物技术有限公司	化合物、包括所述化合物的药物组合物及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20041869A1 (it) *	2004-10-01	2005-01-01	Dac Srl	Nuovi inibitori delle istone deacetilasi

2007
- 2007-08-28 EP EP07115103A patent/EP2033956A1/de not_active Withdrawn
2008
- 2008-08-26 US US12/675,305 patent/US20100305123A1/en not_active Abandoned
- 2008-08-26 WO PCT/EP2008/061140 patent/WO2009027395A1/en not_active Ceased
- 2008-08-26 AT AT08787488T patent/ATE519749T1/de not_active IP Right Cessation
- 2008-08-26 ES ES08787488T patent/ES2371133T3/es active Active
- 2008-08-26 JP JP2010522345A patent/JP2010536927A/ja not_active Ceased
- 2008-08-26 EP EP08787488A patent/EP2197854B1/de not_active Not-in-force

Also Published As

Publication number	Publication date
EP2197854B1 (de)	2011-08-10
EP2197854A1 (de)	2010-06-23
JP2010536927A (ja)	2010-12-02
US20100305123A1 (en)	2010-12-02
ES2371133T3 (es)	2011-12-27
EP2033956A1 (de)	2009-03-11
WO2009027395A1 (en)	2009-03-05

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Legal Events

Date	Code	Title	Description
2012-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties