ATE520786T1 - Verfahren zur herstellung von phospholipiden - Google Patents

Verfahren zur herstellung von phospholipiden

Info

Publication number: ATE520786T1
Authority: AT; Austria
Prior art keywords: sub; glycerophospholipid; carboxylic acid; fatty acid; desired carboxylic
Prior art date: 2001-05-03

Application number

AT02728001T

Other languages

English (en)

Inventor

Sobhi Basheer

Rassan Zuabi

Avidor Shulman

Neta Scheinman

Original Assignee

Enzymotec Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-03

Filing date

2002-05-02

Publication date

2011-09-15

2002-05-02 Application filed by Enzymotec Ltd filed Critical Enzymotec Ltd

2011-09-15 Application granted granted Critical

2011-09-15 Publication of ATE520786T1 publication Critical patent/ATE520786T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 3
239000008777 Glycerylphosphorylcholine Substances 0.000 abstract 4
SUHOQUVVVLNYQR-MRVPVSSYSA-N choline alfoscerate Chemical compound C[N+](C)(C)CCOP([O-])(=O)OC[C@H](O)CO SUHOQUVVVLNYQR-MRVPVSSYSA-N 0.000 abstract 4
229960004956 glycerylphosphorylcholine Drugs 0.000 abstract 4
238000000034 method Methods 0.000 abstract 4
150000001735 carboxylic acids Chemical class 0.000 abstract 3
235000014113 dietary fatty acids Nutrition 0.000 abstract 3
229930195729 fatty acid Natural products 0.000 abstract 3
239000000194 fatty acid Substances 0.000 abstract 3
150000004665 fatty acids Chemical class 0.000 abstract 3
ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 abstract 2
102000004190 Enzymes Human genes 0.000 abstract 2
108090000790 Enzymes Proteins 0.000 abstract 2
102000015439 Phospholipases Human genes 0.000 abstract 2
108010064785 Phospholipases Proteins 0.000 abstract 2
230000010933 acylation Effects 0.000 abstract 2
238000005917 acylation reaction Methods 0.000 abstract 2
230000032050 esterification Effects 0.000 abstract 2
238000005886 esterification reaction Methods 0.000 abstract 2
150000002327 glycerophospholipids Chemical class 0.000 abstract 2
238000005809 transesterification reaction Methods 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
150000003904 phospholipids Chemical class 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6481—Phosphoglycerides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oil, Petroleum & Natural Gas (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Enzymes And Modification Thereof (AREA)

AT02728001T 2001-05-03 2002-05-02 Verfahren zur herstellung von phospholipiden ATE520786T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IL14295201A IL142952A (en)	2001-05-03	2001-05-03	Process for enzyme-catalyzed production of 1,2 diacylated phospholipids
PCT/IL2002/000344 WO2002090560A2 (en)	2001-05-03	2002-05-02	Process for the production of phospholipids

Publications (1)

Publication Number	Publication Date
ATE520786T1 true ATE520786T1 (de)	2011-09-15

Family

ID=11075371

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02728001T ATE520786T1 (de)	2001-05-03	2002-05-02	Verfahren zur herstellung von phospholipiden

Country Status (7)

Country	Link
US (1)	US7034168B2 (de)
EP (1)	EP1412511B1 (de)
JP (1)	JP4216082B2 (de)
AT (1)	ATE520786T1 (de)
AU (1)	AU2002258129A1 (de)
IL (1)	IL142952A (de)
WO (1)	WO2002090560A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2006270921A1 (en) *	2005-07-19	2007-01-25	Asahi Kasei Pharma Corporation	Novel phospholipid processing agent
IL183084A0 (en) *	2007-05-09	2007-09-20	Trans Biodisel Ltd	Modified-immobilized enzymes of high tolerance to hydrophilic substrates in organic media
US8846338B2 (en)	2008-08-07	2014-09-30	Lipogen Ltd.	Processes for the preparation of phosphatides
ES2468799T3 (es) *	2009-07-06	2014-06-17	Kaneka Corporation	Procedimiento para producir fosfol�pido
US20130295171A1 (en)	2009-07-23	2013-11-07	U.S NUTRACEUTICALS, LLC d/b/a Valensa International	Krill oil and reacted astaxanthin composition and associated method
WO2011050474A1 (en)	2009-10-29	2011-05-05	Acasti Pharma, Inc.	Concentrated therapeutic phospholipid compositions
US8663704B2 (en)	2010-04-30	2014-03-04	U.S. Nutraceuticals, LLC	Composition and method to improve blood lipid profiles and optionally reduce low density lipoprotein (LDL) per-oxidation in humans
WO2011137160A2 (en) *	2010-04-30	2011-11-03	U.S. Nutraceuticals, Llc D/B/A Valensa International	Composition and method to improve blood lipid profiles and optionally reduce low density lipoprotein (ldl) per-oxidation in humans
US9763897B2 (en)	2010-04-30	2017-09-19	U.S. Nutraceuticals, LLC	Therapeutic astaxanthin and phospholipid composition and associated method
CN103140587B (zh)	2010-09-30	2016-06-22	国立大学法人东京海洋大学	含2-酰基-溶血磷脂酰丝氨酸的组合物及其制造方法
WO2013136183A2 (en)	2012-03-12	2013-09-19	Innolipid, As	Oxidixable fatty acid composition delivery form
AU2013319911B2 (en)	2012-09-19	2016-07-07	Aker Biomarine Antarctic As	Omega-3 phospholipid supplements for females
AU2014229540A1 (en)	2013-03-14	2015-10-08	Aker Biomarine Antarctic As	Omega- 3 phospholipid supplements for improved brain maturity
DK4242305T3 (en) *	2014-05-20	2026-03-23	Bunge Loders Croklaan B V	Process for immobilization of a lipase
CZ308596B6 (cs) *	2017-04-03	2020-12-23	Ústav molekulární genetiky AV ČR, v. v. i.	Deriváty fosfolipidů a jejich použití jako léčiva
PL232663B1 (pl) *	2017-06-30	2019-07-31	Univ Przyrodniczy We Wroclawiu	Fosfatydylocholiny oraz sposób ich otrzymywania
PL232298B1 (pl) *	2017-06-30	2019-06-28	Univ Przyrodniczy We Wroclawiu	Sposób otrzymywania fosfatydylocholiny zawierającej ibuprofen w pozycji sn-1
CN112067735A (zh) *	2020-08-31	2020-12-11	陕西科技大学	一种卵磷脂脂肪酸位置分布的分析方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5191213A (en) *	1975-02-04	1976-08-10		Jiashiru ll3** guriserohosuhorirukorinruino seizoho
WO1991000918A1 (en) *	1989-07-12	1991-01-24	Berol Nobel Ab	A METHOD FOR THE PREPARATION OF A PHOSPHOLIPID WITH A CARBOXYLIC ACID RESIDUE IN THE 2-POSITION AND A PHOSPHOLIPID WITH AN φ-3-FATTY ACID RESIDUE IN THE 2-POSITION
ES2180541T5 (es) *	1992-06-16	2008-12-01	Sankyo Lifetech Company Limited	Nueva fosfolipasa a1, procedimiento para su preparacion y uso de la misma.
FR2698269B1 (fr) *	1992-11-24	1995-01-06	Inst Nat Sante Rech Med	Nouveaux médicaments à base d'acides gras insaturés, utilisables notamment comme antiagrégants plaquettaires et/ou comme transporteurs privilégiés vers le cerveau.
US6268187B1 (en) *	1997-07-24	2001-07-31	Doosan Corporation	Process for preparing lysophospholipid using enzyme
WO1999015689A1 (en) *	1997-09-24	1999-04-01	Enzymothec Ltd.	Surfactant-lipase complex immobilized on insoluble matrix
IL129086A0 (en)	1999-03-22	2000-02-17	Enzymotec Ltd	Surfactant-lipase complex immobilized on insoluble matrix
JP4412427B2 (ja) *	1999-03-29	2010-02-10	日油株式会社	混合酸型１，２−ジアシル−３−グリセロリン脂質の製造方法

2001
- 2001-05-03 IL IL14295201A patent/IL142952A/xx active IP Right Grant
2002
- 2002-05-02 EP EP02728001A patent/EP1412511B1/de not_active Expired - Lifetime
- 2002-05-02 AU AU2002258129A patent/AU2002258129A1/en not_active Abandoned
- 2002-05-02 WO PCT/IL2002/000344 patent/WO2002090560A2/en not_active Ceased
- 2002-05-02 AT AT02728001T patent/ATE520786T1/de not_active IP Right Cessation
- 2002-05-02 JP JP2002587619A patent/JP4216082B2/ja not_active Expired - Fee Related
2003
- 2003-11-03 US US10/700,320 patent/US7034168B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO2002090560A2 (en)	2002-11-14
WO2002090560A3 (en)	2004-02-19
US7034168B2 (en)	2006-04-25
IL142952A0 (en)	2002-04-21
EP1412511A2 (de)	2004-04-28
JP4216082B2 (ja)	2009-01-28
US20040171126A1 (en)	2004-09-02
JP2004532857A (ja)	2004-10-28
EP1412511B1 (de)	2011-08-17
AU2002258129A1 (en)	2002-11-18
IL142952A (en)	2005-12-18

Legal Events

Date	Code	Title	Description
2012-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE520786T1 (de)	2011-09-15	Verfahren zur herstellung von phospholipiden
DE59401356D1 (de)	1997-01-30	Verfahren zur herstellung von fettsäurealkylestern
DE69838768D1 (de)	2008-01-03	Biologische Systeme zur Herstellung von Polyhydroxyalkanoate Polymeren die 4-Hydroxysäure enthalten
DE602004027250D1 (de)	2010-07-01	Verfahren zur herstellung von symmetrischem triglycerid
ATE243261T1 (de)	2003-07-15	Verfahren zur herstellung von pflanzlichen lysolecithinen
DE69840022D1 (de)	2008-10-30	Verfahren zur herstellung von hochungesättigten fettsäuren und hochungesättigte fettsäuren enthaltendes lipid
ES2052564T3 (es)	1994-07-16	Procedimiento para la produccion de acido bishomo-gamma-linolenico y acido eicosapanteonico.
US4665029A (en)	1987-05-12	Heat-resistant lipase
CA2669108A1 (en)	2008-05-15	Cyclopentene diol monoacetate derivatives
ATE56975T1 (de)	1990-10-15	Verfahren zur herstellung von macrolid-derivaten.
Blasco et al.	2014	Enzymatic resolution of racemates with a ‘remote’stereogenic center as an efficient tool in drug, flavor and vitamin synthesis
RU2124506C1 (ru)	1999-01-10	Способ стереоизбирательного получения гетеробициклического спиртового энантиомера, существенно чистый спиртовой энантиомер, способ получения производного пиперазина
Wallace et al.	1990	Resolution of a chiral ester by lipase-catalyzed transesterification with polyethylene glycol in organic media
DE50108194D1 (de)	2005-12-29	Verfahren zur herstellung von rohstoffen für die gewinnung von konjugierter linolsäure
Guanti et al.	2004	Efficient chemoenzymatic enantioselective synthesis of diacylglycerols (DAG)
Baldessari et al.	1998	Lipase‐Catalyzed Acylation and Deacylation Reactions of Pyridoxine, a Member of Vitamin‐B6 Group
Devi et al.	2008	Enzymatic synthesis of designer lipids
US8637278B2 (en)	2014-01-28	Method for the enzymatic production of emulsifiers containing mono- and diacylglycerides
JP2707642B2 (ja)	1998-02-04	リゾリン脂質の製造法
US7138256B2 (en)	2006-11-21	Processes for preparing conjugated linoleic acid from conjugated linoleic acid esters
DE3724721A1 (de)	1989-04-13	Verfahren zur enzymatischen racematspaltung von 1-acyloxy-2-cyclopenten-4-on(2,2- dimethylpropandiol)-ketal
EP1582595A1 (de)	2005-10-05	Enzymatisches Verfahren zur Herstellung von Triglyzeriden, ausgehend von Alkylestern mehrfach ungesättigter Fettsäuren
JPWO2013094499A1 (ja)	2015-04-27	光学活性なα−置換−β−アミノ酸の製造方法
WO2001044492A2 (de)	2001-06-21	Verfahren zur kinetischen racematspaltung von alkoholen oder carbonsäureestern
KR100243554B1 (ko)	2000-02-01	글리세로인산 유도체로부터 라이소인지질 제조방법