ATE522528T1 - VIRAL INHIBITORS - Google Patents

VIRAL INHIBITORS

Info

Publication number
ATE522528T1
ATE522528T1 AT03762361T AT03762361T ATE522528T1 AT E522528 T1 ATE522528 T1 AT E522528T1 AT 03762361 T AT03762361 T AT 03762361T AT 03762361 T AT03762361 T AT 03762361T AT E522528 T1 ATE522528 T1 AT E522528T1
Authority
AT
Austria
Prior art keywords
viral inhibitors
imidazo
virus
class
relates
Prior art date
Application number
AT03762361T
Other languages
German (de)
Inventor
Johan Neyts
Gerhard Puerstinger
Clercq Erik De
Original Assignee
Leuven K U Res & Dev
Gilead Sciences Inc
Gerhard Puerstinger
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0313251A external-priority patent/GB0313251D0/en
Application filed by Leuven K U Res & Dev, Gilead Sciences Inc, Gerhard Puerstinger filed Critical Leuven K U Res & Dev
Application granted granted Critical
Publication of ATE522528T1 publication Critical patent/ATE522528T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

This invention relates to a class of imidazo[4,5-c]pyridine compounds which are useful for the treatment or prevention of a viral infection, and for inhibiting the replication of a virus of the family of the Flaviviridae or the Picornaviridae such as BVDV, HCV or Cocxsackie virus. This invention relates to a process for preparing this class of imidazo[4,5-c]pyridine compounds.
AT03762361T 2002-07-03 2003-07-03 VIRAL INHIBITORS ATE522528T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0215293.2A GB0215293D0 (en) 2002-07-03 2002-07-03 Viral inhibitors
GB0313251A GB0313251D0 (en) 2003-06-10 2003-06-10 Viral inhibitors
PCT/BE2003/000117 WO2004005286A2 (en) 2002-07-03 2003-07-03 Viral inhibitors

Publications (1)

Publication Number Publication Date
ATE522528T1 true ATE522528T1 (en) 2011-09-15

Family

ID=30117086

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03762361T ATE522528T1 (en) 2002-07-03 2003-07-03 VIRAL INHIBITORS

Country Status (21)

Country Link
US (2) US7737162B2 (en)
EP (2) EP1521754B1 (en)
JP (2) JP4907082B2 (en)
KR (2) KR101131591B1 (en)
CN (1) CN1328279C (en)
AT (1) ATE522528T1 (en)
AU (2) AU2003243846B9 (en)
BR (2) BR122018077110B1 (en)
CA (1) CA2491243C (en)
CY (1) CY1112042T1 (en)
DK (1) DK1521754T3 (en)
EA (1) EA013562B1 (en)
ES (2) ES2372277T3 (en)
GB (1) GB0215293D0 (en)
IL (1) IL166055A (en)
MX (1) MXPA04012965A (en)
NO (1) NO330766B1 (en)
NZ (1) NZ537473A (en)
PT (2) PT2332938E (en)
SI (1) SI1521754T1 (en)
WO (1) WO2004005286A2 (en)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2335700A1 (en) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
US7223785B2 (en) 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7098231B2 (en) 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
CA2534649A1 (en) 2003-08-01 2005-02-10 Genelabs Technologies, Inc. Bicyclic imidazol derivatives against flaviviridae
CN101538267B (en) * 2003-12-22 2015-04-29 鲁汶天主教大学研究开发部 Imidazo[4,5-c]pyridine compounds and methods of antiviral therapy
ATE544765T1 (en) * 2003-12-22 2012-02-15 Leuven K U Res & Dev IMIDAZOÄ4,5-CUPYRIDINE COMPOUNDS AND METHOD FOR ANTIVIRAL TREATMENT
UY28758A1 (en) 2004-02-20 2005-09-30 Boehringer Ingelheim Int VIRAL POLYMERASE INHIBITORS
BRPI0513811A (en) * 2004-07-27 2008-07-15 Gilead Sciences Inc imidazo [4,5-d] pyrimidines, their uses and processes of preparation
NZ556624A (en) * 2004-12-21 2010-06-25 Gilead Sciences Inc 5-((3-(2,4-trifluoromethyphenyl)isoxazol-5-yl)methyl)-2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine and method of antiviral treatment
US7763715B2 (en) 2005-04-22 2010-07-27 The Procter & Gamble Company Extracting biopolymers from a biomass using ionic liquids
MX2007014114A (en) 2005-05-10 2008-03-14 Intermune Inc DERIVATIVES OF PIRIDONA TO MODULATE THE SYSTEM OF PROTEIN KINASE ACTIVATED BY STRESS.
WO2007014174A2 (en) * 2005-07-25 2007-02-01 Gilead Sciences, Inc. Drug-resistant mutants of hepatitis c virus
JP5015154B2 (en) 2005-08-12 2012-08-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Viral polymerase inhibitor
SG175604A1 (en) * 2006-07-07 2011-11-28 Gilead Sciences Inc Novel pyridazine compound and use thereof
SI2094702T1 (en) 2006-12-14 2016-03-31 Gilead Sciences, Inc. Viral inhibitors
UA99466C2 (en) 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound
UY31685A (en) * 2008-03-04 2009-11-10 Smithkline Beecham Corp ANTIVIRAL COMPOUNDS, COMPOSITIONS AND METHODS TO USE THEM
GB0809314D0 (en) * 2008-05-22 2008-07-02 Summit Corp Plc Compounds for treating muscular dystrophy
JP5627574B2 (en) 2008-06-03 2014-11-19 インターミューン, インコーポレイテッド Compounds and methods for treating inflammatory and fibrotic diseases
US20100204265A1 (en) * 2009-02-09 2010-08-12 Genelabs Technologies, Inc. Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections
MX2012007367A (en) * 2009-12-30 2013-04-03 Arqule Inc Substituted imidazopyridinyl-aminopyridine compounds.
EP2571882A1 (en) 2010-05-21 2013-03-27 Gilead Sciences, Inc. Heterocyclic flaviviridae virus inhibitors
GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
AR092742A1 (en) 2012-10-02 2015-04-29 Intermune Inc ANTIFIBROTIC PYRIDINONES
US10233195B2 (en) 2014-04-02 2019-03-19 Intermune, Inc. Anti-fibrotic pyridinones
IL296496B2 (en) 2014-12-26 2024-10-01 Univ Emory N4-hydroxycytidine, history and related antiviral uses
JOP20160086B1 (en) 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
JOP20160198B1 (en) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc Single or di-substituted indole derivatives as inhibitors of viral replication of fennel fever
JO3633B1 (en) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development Single or binary substituted indole derivatives as inhibitors of viral replication of fennel fever
SG11201808138YA (en) 2016-03-31 2018-10-30 Janssen Pharmaceuticals Inc Substituted indole derivatives as dengue viral replication inhibitors
MA44498A (en) 2016-03-31 2019-02-06 Janssen Pharmaceuticals Inc SUBSTITUTED INDOLINE DERIVATIVES USED AS DENGUE VIRUS REPLICATION INHIBITORS
JOP20170069B1 (en) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc Substituted indoline derivatives as dengue viral replication inhibitors
EP3436004B1 (en) 2016-04-01 2024-12-11 Janssen Pharmaceuticals, Inc. Substituted indole compound derivatives as dengue viral replication inhibitors
WO2017168333A1 (en) * 2016-04-02 2017-10-05 Shilpa Medicare Limited Amifampridine dihydrochloride
CN109562107A (en) 2016-05-10 2019-04-02 C4医药公司 Heterocycle degron body for target protein degradation
EP3455219A4 (en) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. AMINE-LINKED C3-GLUTARIMIDE DEGRONIMERS FOR THE DEGRADATION OF TARGET PROTEINS
EP4483875A3 (en) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
CN109641874A (en) 2016-05-10 2019-04-16 C4医药公司 C for target protein degradation3The glutarimide degron body of carbon connection
JOP20180025B1 (en) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc Substituted indoline derivatives as dengue viral replication inhibitors
JOP20180026A1 (en) 2017-03-31 2019-01-30 Univ Leuven Kath Indolein derivatives substituted as viral reproductive inhibitors of Fennec fever
SI3630724T1 (en) 2017-05-22 2021-08-31 Janssen Pharmaceuticals, Inc. Substituted indoline derivatives as dengue viral replication inhibitors
CA3060583C (en) 2017-05-22 2024-06-04 Janssen Pharmaceuticals, Inc. Substituted indoline derivatives as dengue viral replication inhibitors
EP3641762B1 (en) 2017-06-20 2026-02-18 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation
KR102626210B1 (en) 2017-12-07 2024-01-18 에모리 유니버시티 N4-hydroxycytidine and derivatives and anti-viral uses related thereto
EP3876939A4 (en) 2018-11-07 2022-08-10 Dana-Farber Cancer Institute, Inc. BENZOTHIAZOLE DERIVATIVES AND 7-AZA-BENZOTHIAZOLE DERIVATIVES AS JANUS KINASE-2 INHIBITORS AND USES THEREOF
WO2020097400A1 (en) 2018-11-07 2020-05-14 Dana-Farber Cancer Institute, Inc. Imidazopyridine derivatives and aza-imidazopyridine derivatives as janus kinase 2 inhibitors and uses thereof
EP3876930A4 (en) 2018-11-07 2022-07-20 Dana-Farber Cancer Institute, Inc. BENZIMIDAZOLE DERIVATIVES AND AZA-BENZIMIDAZOLE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND THEIR USES
AU2021225333A1 (en) * 2020-02-24 2022-08-11 Katholieke Universiteit Leuven Pyrrolopyridine and imidazopyridine antiviral compounds
BR112022022409A2 (en) 2020-05-06 2023-02-07 Ajax Therapeutics Inc 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS
WO2022140527A1 (en) 2020-12-23 2022-06-30 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
CA3234638A1 (en) 2021-11-09 2023-05-19 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
WO2023086320A1 (en) 2021-11-09 2023-05-19 Ajax Therapeutics, Inc. Forms and compositions of inhibitors of jak2

Family Cites Families (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2191978A (en) * 1935-10-10 1940-02-27 Ig Farbenindustrie Ag Quaternary nitrogen compounds and process of preparing them
US2411662A (en) * 1943-05-13 1946-11-26 Geigy Ag J R Imino-di-fatty acid amide
US2548863A (en) * 1946-05-29 1951-04-17 Wyeth Corp Substituted glycinamides
US2516674A (en) * 1948-10-29 1950-07-25 Wyeth Corp Substituted glycinamide
US3985891A (en) * 1973-02-03 1976-10-12 Boehringer Ingelheim Gmbh 2-Phenyl-imidazo (4,5-b)pyridines and salts thereof
SU813921A1 (en) 1979-10-26 1986-12-23 Институт физико-органической химии и углехимии АН УССР Sterile derivatives of imidazo (4,5-c) pyridiniodide possessing fungicide activ ity
SU851940A1 (en) 1980-03-20 1988-04-30 Институт физико-органической химии и углехимии АН УССР Quaternary salts of imidazo [4,5-c] pyridine possessing antimicrobial and fungistatic activity
SU860463A1 (en) 1980-04-09 1998-05-27 Институт физико-органической химии и углехимии АН Украинской ССР Derivatives of 4-amino-1,3-dimethylimidazo-[4,5-c]-pyridine-2-on'e exhibiting acaricide effect
SU1048742A1 (en) 1981-03-30 1986-12-23 Институт физико-органической химии и углехимии АН УССР 2,-4-distiryl-derivatives of imidazo-(4,5-c)pyridine possessing bacteriostatic and fungistatic activity
US4358387A (en) * 1981-08-10 1982-11-09 Texaco Inc. Cylinder lubricating oil composition
US5137896A (en) * 1981-10-01 1992-08-11 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)benzamide derivatives
CA1183847A (en) 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
FR2527608B1 (en) * 1982-05-28 1986-10-10 Sandoz Sa NOVEL HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
US4692443A (en) * 1983-10-17 1987-09-08 Eli Lilly And Company 3-bicyclicpyridinium-methyl cephalosporins
ZA847926B (en) 1983-10-17 1986-05-28 Lilly Co Eli 3-bicyclicpyridinium-methyl cephalosporins
GB8501542D0 (en) 1985-01-22 1985-02-20 Erba Farmitalia 4 5 6 7-tetrahydro-imidazo(4 5-clpyridine derivatives
GB8530602D0 (en) 1985-12-12 1986-01-22 Fujisawa Pharmaceutical Co Heterocyclic compounds
CA1327579C (en) 1986-02-03 1994-03-08 Frans Eduard Janssens Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines
US4804658A (en) * 1986-09-15 1989-02-14 G. D. Searle & Co. Imidazopyridine derivatives and pharmaceutical compositions
US5057517A (en) * 1987-07-20 1991-10-15 Merck & Co., Inc. Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents
NZ225447A (en) 1987-07-20 1991-12-23 Merck & Co Inc Piperazinyl derivatives of purine and purine isosteres and pharmaceutical compositions
US4914108A (en) 1988-03-14 1990-04-03 G. D. Searle & Co. 5-substituted(4,5-c)imidazopyridine compounds which have useful platelet activating factor antagonistic activity
US5019581A (en) * 1988-03-14 1991-05-28 G. D. Searle & Co. 5-substituted (4,5-c) imidazopyridine compounds which have useful platelet activating factor antagonistic activity
US5302601A (en) * 1988-03-14 1994-04-12 G. D. Searle & Co. 5-substituted imidazo[4,5-c]pyridines
US5227384A (en) 1988-03-14 1993-07-13 G. D. Searle & Co. 5-substituted [4,5-c] imidazopyridines and pharmaceutical use thereof
US5011382A (en) * 1989-01-26 1991-04-30 Thompson George A Reciprocating piston pump
US5332744A (en) * 1989-05-30 1994-07-26 Merck & Co., Inc. Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists
US4990518A (en) 1989-09-13 1991-02-05 G. D. Searle & Co. Pharmacologically active heteroaryl substituted imidazo (4,5-c) pyridines
US4988707A (en) * 1989-09-13 1991-01-29 G. D. Searle & Co. Pharmacologically active phenylalkanoyl substituted imidazo (4,5-C) pyridines
FR2663332B1 (en) 1990-06-15 1997-11-07 Roussel Uclaf NOVEL CEPHALOSPORINS COMPRISING IN POSITION 3 A RADICAL PROPENYL SUBSTITUTED BY A QUATERNARY AMMONIUM, THEIR PREPARATION PROCESS, THEIR APPLICATION AS MEDICAMENTS, THE COMPOSITIONS CONTAINING THEM AND THE NEW INTERMEDIATES OBTAINED.
US5011832A (en) 1990-06-26 1991-04-30 Merck & Co., Inc. 2-biphenyl-carbapenem antibacterial agents
US5372808A (en) * 1990-10-17 1994-12-13 Amgen Inc. Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect
JPH04327587A (en) 1991-04-26 1992-11-17 Asahi Chem Ind Co Ltd 6'-c-alkyl-3-deazaneplanocin a derivative, its production and use
AU1786192A (en) 1991-06-15 1993-01-12 Cheil Foods & Chemicals, Inc. Novel 3-fused pyridiniummethyl cephalosporins
GB9116056D0 (en) 1991-07-24 1991-09-11 British Bio Technology Compounds
US5587372A (en) * 1991-12-12 1996-12-24 Roussel Uclaf Cephalosporins
GB9200245D0 (en) 1992-01-07 1992-02-26 British Bio Technology Compounds
GB9202792D0 (en) 1992-02-11 1992-03-25 British Bio Technology Compounds
GB9202791D0 (en) 1992-02-11 1992-03-25 British Bio Technology Compounds
DE4211474A1 (en) 1992-04-06 1993-10-07 Merck Patent Gmbh imidazopyridines
US5208242A (en) 1992-08-26 1993-05-04 G. D. Searle & Co. 5-substituted-4-phenyl-5H-imidazo[4,5-c]pyridine derivatives
DE4230464A1 (en) 1992-09-11 1994-03-17 Merck Patent Gmbh New imidazolyl-benzimidazole or related cpds. - useful as angiotensin II antagonists for treating cardiovascular or CNS disorders, etc.
DE4236026A1 (en) * 1992-10-24 1994-04-28 Merck Patent Gmbh imidazopyridines
BR9307570A (en) 1992-12-02 1999-05-25 Pfizer Catechol ethers as selective pdeiv inhibitors
JP3115455B2 (en) 1992-12-18 2000-12-04 明治製菓株式会社 New cephalosporin derivatives
US5374638A (en) * 1993-03-19 1994-12-20 Merck & Co., Inc. Six membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives used to treat asthma
DE4309969A1 (en) 1993-03-26 1994-09-29 Bayer Ag Substituted hetero-fused imidazoles
KR100194994B1 (en) 1993-06-05 1999-06-15 손경식 New cefem compound
DE4318813A1 (en) * 1993-06-07 1994-12-08 Merck Patent Gmbh imidazopyridines
KR100341341B1 (en) 1993-07-15 2002-11-25 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 IMIDAZO[4,5-c]PYRIDIN-4-AMINES
DE4324580A1 (en) * 1993-07-22 1995-01-26 Thomae Gmbh Dr K Bicyclic heterocycles, pharmaceutical compositions containing them and methods for their preparation
US5486525A (en) 1993-12-16 1996-01-23 Abbott Laboratories Platelet activating factor antagonists: imidazopyridine indoles
WO1996001192A1 (en) 1994-07-05 1996-01-18 Asc Incorporated Automobile sunroof assembly and control system
US5563143A (en) 1994-09-21 1996-10-08 Pfizer Inc. Catechol diether compounds as inhibitors of TNF release
US6506876B1 (en) * 1994-10-11 2003-01-14 G.D. Searle & Co. LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use
US5585492A (en) 1994-10-11 1996-12-17 G. D. Searle & Co. LTA4 Hydrolase inhibitors
US5635514A (en) 1994-10-25 1997-06-03 G. D. Searle & Company Heteroaralkyl and heteroarylthioalkyl thiophenolic compounds as 5-lipoxgenase inhibitors
US5543523A (en) 1994-11-15 1996-08-06 Regents Of The University Of Minnesota Method and intermediates for the synthesis of korupensamines
HUT78019A (en) * 1995-03-31 1999-05-28 András Horváth Process for the preparation of substituted, nitrogen containing heterocyclic compounds
US6063930A (en) * 1996-04-03 2000-05-16 Merck & Co., Inc. Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US5872136A (en) * 1996-04-03 1999-02-16 Merck & Co., Inc. Arylheteroaryl inhibitors of farnesyl-protein transferase
US5880140A (en) * 1996-04-03 1999-03-09 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
US5874452A (en) * 1996-04-03 1999-02-23 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
US6080870A (en) * 1996-04-03 2000-06-27 Merck & Co., Inc. Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
US5939557A (en) * 1996-04-03 1999-08-17 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5854265A (en) * 1996-04-03 1998-12-29 Merck & Co., Inc. Biheteroaryl inhibitors of farnesyl-protein transferase
US5883105A (en) * 1996-04-03 1999-03-16 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
US5859035A (en) * 1996-04-03 1999-01-12 Merck & Co., Inc. Arylheteroaryl inhibitors of farnesyl-protein transferase
US6015817A (en) 1996-12-05 2000-01-18 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2311742C (en) * 1997-11-28 2009-06-16 Sumitomo Pharmaceuticals Co., Ltd. 6-amino-9-benzyl-8-hydroxypurine derivatives
DE19845153A1 (en) 1998-10-01 2000-04-06 Merck Patent Gmbh Imidazo [4,5] pyridin-4-one derivatives
FR2784679B1 (en) 1998-10-06 2001-03-30 Rhodia Chimie Sa BORONATE FUNCTION (S) SILANES AND POLYORGANOSILOXANES
US6271380B1 (en) 1998-12-30 2001-08-07 Dupont Pharmaceuticals Company 1H-imidazo[4,5-d]pyridazin-7-ones, 3H-imidazo-[4,5-c]pyridin-4-ones and corresponding thiones as corticotropin releasing factor (CRF) receptor ligands
WO2000040586A1 (en) 1999-01-08 2000-07-13 Chisso Corporation Borane derivatives and organic electroluminescents
DE19900471A1 (en) 1999-01-08 2000-07-13 Merck Patent Gmbh Imidazo [4,5c] pyridin-4-one derivatives
US6627651B1 (en) * 1999-05-07 2003-09-30 Takeda Chemical Industries, Ltd. Cyclic compounds and uses thereof
US6844367B1 (en) * 1999-09-17 2005-01-18 Millennium Pharmaceuticals, Inc. Benzamides and related inhibitors of factor Xa
US6770666B2 (en) * 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
EP1162196A4 (en) 1999-12-27 2003-04-16 Japan Tobacco Inc Fused-ring compounds and use thereof as drugs
CN1427722A (en) 2000-02-18 2003-07-02 希拉生物化学股份有限公司 Method for treatment or prevention of flavivirus infections using nucleoside analogues
ES2254385T3 (en) * 2000-02-29 2006-06-16 Millennium Pharmaceuticals, Inc. RELATED BENZAMIDS AND INHIBITORS OF FACTOR XA.
EP1132381A1 (en) * 2000-03-08 2001-09-12 Cermol S.A. Ester derivatives of dimethylpropionic acid and pharmaceutical compositions containing them
WO2001085172A1 (en) 2000-05-10 2001-11-15 Smithkline Beecham Corporation Novel anti-infectives
US6448281B1 (en) * 2000-07-06 2002-09-10 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
SI1355916T1 (en) 2001-01-22 2007-04-30 Merck & Co Inc Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
JP4331944B2 (en) 2001-04-17 2009-09-16 大日本住友製薬株式会社 New adenine derivatives
AR035543A1 (en) 2001-06-26 2004-06-16 Japan Tobacco Inc THERAPEUTIC AGENT FOR HEPATITIS C THAT INCLUDES A CONDENSED RING COMPOUND, CONDENSED RING COMPOUND, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS, BENZIMIDAZOL, THIAZOL AND BIFENYL COMPOUNDS USED AS INTERMEDIARY COMPARTMENTS OF COMPARTMENTS
US20030073836A1 (en) * 2001-07-05 2003-04-17 Boehringer Ingelheim Pharma Kg Heteroarylcarboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions
WO2003007945A1 (en) 2001-07-20 2003-01-30 Boehringer Ingelheim (Canada) Ltd. Viral polymerase inhibitors
EP2335700A1 (en) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
US7294457B2 (en) * 2001-08-07 2007-11-13 Boehringer Ingelheim (Canada) Ltd. Direct binding assay for identifying inhibitors of HCV polymerase
DE10140246A1 (en) * 2001-08-09 2003-03-06 Forsch Pigmente Und Lacke E V Process for treating surfaces of substrates
US20030134853A1 (en) 2001-09-26 2003-07-17 Priestley Eldon Scott Compounds useful for treating hepatitis C virus
CA2471566A1 (en) 2002-01-10 2003-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Combination of mtp inhibitors or apob-secretion inhibitors with fibrates for use as pharmaceuticals
GB0215293D0 (en) * 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
US7362349B2 (en) * 2002-07-10 2008-04-22 Seiko Epson Corporation Multi-participant conference system with controllable content delivery using a client monitor back-channel
CN102964347B (en) 2002-08-21 2015-11-18 勃林格殷格翰制药两合公司 8-[3-amino-piperadine-1-base]-Xanthine compounds, its preparation method and the purposes as pharmaceutical preparation
JP4619786B2 (en) 2002-08-29 2011-01-26 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド 3- (Sulfonamidoethyl) -indole derivatives for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases
RU2005118407A (en) * 2002-12-13 2006-03-10 СмитКлайн Бичем Корпорейшн (US) PIPERIDINE DERIVATIVES AS CCR5 ANTAGONISTS
US7223785B2 (en) * 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US7098231B2 (en) * 2003-01-22 2006-08-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
DE602004022633D1 (en) 2003-01-30 2009-10-01 Boehringer Ingelheim Pharma 2,4-DIAMINOPYRIMIDIN DERIVATIVES SUITABLE AS INHIBITORS OF PKC-THETA
US7566707B2 (en) * 2003-06-18 2009-07-28 Boehringer Ingelheim International Gmbh Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions
WO2005049573A1 (en) * 2003-11-05 2005-06-02 F. Hoffmann-La Roche Ag Phenyl derivatives as ppar agonists
ATE544765T1 (en) * 2003-12-22 2012-02-15 Leuven K U Res & Dev IMIDAZOÄ4,5-CUPYRIDINE COMPOUNDS AND METHOD FOR ANTIVIRAL TREATMENT
BRPI0513811A (en) 2004-07-27 2008-07-15 Gilead Sciences Inc imidazo [4,5-d] pyrimidines, their uses and processes of preparation
WO2006029966A1 (en) 2004-09-13 2006-03-23 Ciba Specialty Chemicals Holding Inc. Alkylaminoacetamide lubricant additives
NZ556624A (en) * 2004-12-21 2010-06-25 Gilead Sciences Inc 5-((3-(2,4-trifluoromethyphenyl)isoxazol-5-yl)methyl)-2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine and method of antiviral treatment
SG175604A1 (en) * 2006-07-07 2011-11-28 Gilead Sciences Inc Novel pyridazine compound and use thereof
UA99466C2 (en) * 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound

Also Published As

Publication number Publication date
JP2010248262A (en) 2010-11-04
KR20110011749A (en) 2011-02-08
ES2372277T3 (en) 2012-01-17
BRPI0312547B8 (en) 2021-05-25
US8779141B2 (en) 2014-07-15
DK1521754T3 (en) 2011-12-05
IL166055A (en) 2012-08-30
NO330766B1 (en) 2011-07-11
IL166055A0 (en) 2006-01-15
HK1161231A1 (en) 2012-08-24
EP1521754A2 (en) 2005-04-13
BR0312547A (en) 2005-04-26
EA200500150A1 (en) 2005-06-30
EP2332938A1 (en) 2011-06-15
AU2003243846A1 (en) 2004-01-23
WO2004005286A3 (en) 2004-03-18
BRPI0312547B1 (en) 2020-01-21
BR122018077110B1 (en) 2021-04-20
AU2003243846B2 (en) 2008-11-20
AU2009200648B2 (en) 2012-07-26
US20100004281A1 (en) 2010-01-07
NZ537473A (en) 2007-02-23
WO2004005286A2 (en) 2004-01-15
PT2332938E (en) 2014-12-12
CY1112042T1 (en) 2015-11-04
KR20050069937A (en) 2005-07-05
PT1521754E (en) 2011-12-13
EA013562B1 (en) 2010-06-30
CN1678612A (en) 2005-10-05
CA2491243A1 (en) 2004-01-15
EP1521754B1 (en) 2011-08-31
JP4907082B2 (en) 2012-03-28
CA2491243C (en) 2011-12-06
CN1328279C (en) 2007-07-25
KR101131591B1 (en) 2012-04-13
GB0215293D0 (en) 2002-08-14
JP5174097B2 (en) 2013-04-03
KR101184032B1 (en) 2012-09-17
NO20045731L (en) 2005-03-17
HK1082734A1 (en) 2006-06-16
US7737162B2 (en) 2010-06-15
JP2005537248A (en) 2005-12-08
AU2009200648A1 (en) 2009-03-12
ES2525483T3 (en) 2014-12-23
SI1521754T1 (en) 2011-12-30
MXPA04012965A (en) 2005-05-16
AU2003243846B9 (en) 2009-03-19
EP2332938B1 (en) 2014-10-01
US20050239821A1 (en) 2005-10-27

Similar Documents

Publication Publication Date Title
DK1521754T3 (en) Viral inhibitors
ATE491459T1 (en) MODIFIED NUCLEOSIDES FOR THE TREATMENT OF VIRUS INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION
DK1719773T3 (en) Condensed heterotetracyclic compounds and their use as HCV polymerase inhibitor
CO5630024A2 (en) INHIBITING COMPOUNDS OF HEPATITIS C
MXPA05006196A (en) Compounds and methods for the treatment or prevention of flavivirus.
ATE512976T1 (en) HEPATITIS C VIRUS INHIBITORS
BRPI0515596A (en) pharmaceutical composition used for the treatment and / or prevention of hcv, and methods of inhibiting hepatitis c polymerase ns5b from treating or preventing hepatitis c infection in a mammal
WO2004009020A3 (en) Pyrrolopyrimidine thionucleoside analogs as antivirals
NZ595000A (en) Imidazo[4,5-c]pyridine derivative for treating viral infections
BR0309581A (en) Nucleoside derivatives for treatment of hepatitis c virus infection
MY164469A (en) Hcv ns3 protease inhibitors
EP1924593B8 (en) Hcv ns3 protease inhibitors
TW200518746A (en) Novel inhibitors of hepatitis C virus NS3/NS4A serine protease
NO20062146L (en) Nucleoside compounds for the treatment of viral infections
WO2002100851A3 (en) Thiophene derivatives as antiviral agents for flavivirus infection
WO2004002940A8 (en) Inhibitors of hcv ns5b polymerase
MY151199A (en) Substituted diphenyl heterocycles useful for treating hcv infection
ATE498398T1 (en) CYCLOALKYL HETEROCYCLES FOR THE TREATMENT OF HEPATITIS C VIRUS
ATE493408T1 (en) ANTINIFECTIVE AGENTS

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1521754

Country of ref document: EP