ATE522542T1 - Methyliertes rekombinantes mykobakterielles antigen, dass einem heparin-bindenden hämagglutinin (hbha) entspricht - Google Patents

Methyliertes rekombinantes mykobakterielles antigen, dass einem heparin-bindenden hämagglutinin (hbha) entspricht

Info

Publication number
ATE522542T1
ATE522542T1 AT02795382T AT02795382T ATE522542T1 AT E522542 T1 ATE522542 T1 AT E522542T1 AT 02795382 T AT02795382 T AT 02795382T AT 02795382 T AT02795382 T AT 02795382T AT E522542 T1 ATE522542 T1 AT E522542T1
Authority
AT
Austria
Prior art keywords
hbha
recombinant
cfu
methylated
heparin
Prior art date
Application number
AT02795382T
Other languages
English (en)
Inventor
Kevin Pethe
Franco Menozzi
Camille Locht
Original Assignee
Pasteur Institut
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8869548&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE522542(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pasteur Institut, Inst Nat Sante Rech Med filed Critical Pasteur Institut
Application granted granted Critical
Publication of ATE522542T1 publication Critical patent/ATE522542T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT02795382T 2001-11-19 2002-11-18 Methyliertes rekombinantes mykobakterielles antigen, dass einem heparin-bindenden hämagglutinin (hbha) entspricht ATE522542T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0114953A FR2832410B1 (fr) 2001-11-19 2001-11-19 Antigene mycobacterien recombinant de type hemagglutinine de liaison a l'heparine methylee, procedes de preparation et compositions immunogenes comprenant un tel antigene
PCT/FR2002/003942 WO2003044048A2 (fr) 2001-11-19 2002-11-18 Antigene mycobacterien recombinant de type hemagglutinine de liaison a l'heparine (hbha) methylee

Publications (1)

Publication Number Publication Date
ATE522542T1 true ATE522542T1 (de) 2011-09-15

Family

ID=8869548

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02795382T ATE522542T1 (de) 2001-11-19 2002-11-18 Methyliertes rekombinantes mykobakterielles antigen, dass einem heparin-bindenden hämagglutinin (hbha) entspricht

Country Status (11)

Country Link
US (2) US7829103B2 (de)
EP (2) EP1446422B1 (de)
JP (2) JP2005526006A (de)
AT (1) ATE522542T1 (de)
AU (1) AU2002360178B2 (de)
CA (1) CA2466937C (de)
DK (1) DK1446422T3 (de)
ES (1) ES2371597T3 (de)
FR (1) FR2832410B1 (de)
PT (1) PT1446422E (de)
WO (1) WO2003044048A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2872579B1 (fr) * 2004-06-30 2006-11-24 Pasteur Institut Detection de la tuberculose et de l'infection par mycobacterium tuberculosis a l'aide de hbha
RU2461390C2 (ru) * 2005-01-28 2012-09-20 Галенбио, Инк. Иммунологически активные составы
WO2010149657A1 (en) 2009-06-22 2010-12-29 Px Therapeutics Method for the purification of hbha
CN101816783B (zh) * 2010-04-15 2013-02-06 中国人民解放军第四军医大学 一种表达hbha-il-12融合蛋白的重组耻垢分枝杆菌疫苗
WO2012038486A1 (en) * 2010-09-21 2012-03-29 Inserm (Institut National De La Sante Et De La Recherche Medicale) Method for obtaining a purified hbha polypeptide or fragment thereof
US9327013B2 (en) 2011-03-11 2016-05-03 Tokyo University Of Science Foundation Activity enhancer for anticancer agent
GB201116248D0 (en) 2011-09-20 2011-11-02 Glaxosmithkline Biolog Sa Liposome production using isopropanol
EP2838990A4 (de) * 2012-04-16 2016-08-10 Aeras Global Tb Vaccine Found Rekombinantes mycobakterium zur codierung eines heparin-bindenden hämagglutinin (hbha)-fusionsproteins und verwendungen davon
US10695424B2 (en) 2016-12-07 2020-06-30 Glaxosmithkline Biologicals S.A. Method of making a liposome composition
GB201621686D0 (en) 2016-12-20 2017-02-01 Glaxosmithkline Biologicals Sa Novel methods for inducing an immune response
GB201707700D0 (en) 2017-05-12 2017-06-28 Glaxosmithkline Biologicals Sa Dried composition
GB2600653B (en) 2017-05-30 2022-11-02 Glaxosmithkline Biologicals Sa Novel methods
BR112020010790A2 (pt) 2017-12-01 2020-11-10 Glaxosmithkline Biologicals S.A. purificação da saponina
US11591375B2 (en) 2018-01-22 2023-02-28 Oregon State University Immunogenic compositions comprising Mycobacterium bovis surface proteins and uses thereof
WO2020245207A1 (en) 2019-06-05 2020-12-10 Glaxosmithkline Biologicals Sa Saponin purification
EP3757161A1 (de) 2019-06-27 2020-12-30 Schill + Seilacher "Struktol" GmbH Kautschukzusammensetzungen mit polyorganosiloxanen als weichmacher
CN112746051A (zh) * 2020-12-24 2021-05-04 中国人民解放军空军特色医学中心 一种表达甲基化hbha蛋白的重组耻垢分枝杆菌菌株、制备方法及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995013085A1 (en) * 1993-11-08 1995-05-18 Demeter Biotechnologies Ltd. Methylated lysine-rich lytic peptides and method of making same by reductive alkylation
FR2748748B1 (fr) 1996-05-17 1998-11-06 Pasteur Institut Identification et clonage d'un antigene mycobacterien correspondant a une hemagglutine de liaison a l'heparine
FR2748749A1 (fr) * 1996-05-17 1997-11-21 Pasteur Institut Identification et clonage d'un antigene mycobacterien correspondant a une hemagglutinine de liaison a l'heparine
FR2793492A1 (fr) * 1999-05-11 2000-11-17 Pasteur Institut Nouveau procede de purification par affinite

Also Published As

Publication number Publication date
US20120034257A1 (en) 2012-02-09
JP2010043087A (ja) 2010-02-25
AU2002360178B2 (en) 2008-04-17
JP2005526006A (ja) 2005-09-02
EP2354154A1 (de) 2011-08-10
DK1446422T3 (da) 2011-11-14
WO2003044048A2 (fr) 2003-05-30
CA2466937C (fr) 2014-09-02
US8303963B2 (en) 2012-11-06
US7829103B2 (en) 2010-11-09
CA2466937A1 (fr) 2003-05-30
US20060292168A1 (en) 2006-12-28
AU2002360178A1 (en) 2003-06-10
FR2832410A1 (fr) 2003-05-23
EP1446422A2 (de) 2004-08-18
WO2003044048A3 (fr) 2003-12-11
FR2832410B1 (fr) 2004-04-02
EP1446422B1 (de) 2011-08-31
ES2371597T3 (es) 2012-01-05
PT1446422E (pt) 2011-11-15

Similar Documents

Publication Publication Date Title
ATE522542T1 (de) Methyliertes rekombinantes mykobakterielles antigen, dass einem heparin-bindenden hämagglutinin (hbha) entspricht
Morris et al. The immunogenicity of single and combination DNA vaccines against tuberculosis
Westerlund-Wikström Peptide display on bacterial flagella: principles and applications
US7288261B2 (en) Mid-life vaccine and methods for boosting anti-mycobacterial immunity
Huygen On the use of DNA vaccines for the prophylaxis of mycobacterial diseases
JPH10500099A (ja) 非毒性の粘膜アジュバント
Lopez et al. Analysis of anamnestic immune responses in adult horses and priming in neonates induced by a DNA vaccine expressing the vapA gene of Rhodococcus equi
CA2325566A1 (en) Vaccine formulations comprising antiidiotypic antibodies which immunologically mimic group b streptococcal carbohydrates
DE69716240D1 (de) Neue methode zur impfung sowie impfstoffe dafür, die eine epitopkodierende nukleinsäure und ein epitopenthaltende peptid beinhalten
Ni et al. Protection against scrub typhus by a plasmid vaccine encoding the 56-KD outer membrane protein antigen gene
US20050058661A1 (en) Methods and compositions for vaccination comprising nucleic acid and/or polypeptide sequences of the genus Borrelia
Ha et al. Enhanced immunogenicity and protective efficacy with the use of interleukin-12-encapsulated microspheres plus AS01B in tuberculosis subunit vaccination
Tripathi et al. Inducing systemic and mucosal immune responses to BT construct of F1 antigen of Yersinia pestis in microsphere delivery
Khan et al. Identifying B and T cell epitopes and studying humoral, mucosal and cellular immune responses of peptides derived from V antigen of Yersinia pestis
Brown et al. Identification and characterization of a neutralizing monoclonal antibody against botulinum neurotoxin, serotype F, following vaccination with active toxin
Orme Tuberculosis vaccines: current progress
Takahashi et al. Intranasal immunization of mice with recombinant protein antigen of serotype cStreptococcus mutans and cholera toxin B subunit
Negi et al. Antibody response of cattle to Leptospira pomona: response as measured by hemagglutination, microscopic agglutination, and hamster protection tests
Chowdhury et al. Generation of high titer antisera in rabbits by DNA immunization
CA2114125A1 (en) Self-adjuvanting peptide vaccine delivery system and production thereof
Cunha et al. Parenteral adjuvant potential of recombinant B subunit of Escherichia coli heat-labile enterotoxin
das Graças Luna et al. Salmonella flagellin fused with a linear epitope of colonization factor antigen I (CFA/I) can prime antibody responses against homologous and heterologous fimbriae of enterotoxigenic Escherichia coli
WO2003018053A1 (en) Vaccine against mycobacterial-induced diseases
Xie et al. Characterization of SeseC_01411 as a surface protective antigen of Streptococcus equi ssp. zooepidemicus
US20100291104A1 (en) Bordetella outer-membrane protein antigens and methods of making and using the same

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1446422

Country of ref document: EP