ATE523519T1 - Makrolidverbindungen mit biotin und fotoaffinitätsgruppe zur identifizierung eines makrolid-targets - Google Patents
Makrolidverbindungen mit biotin und fotoaffinitätsgruppe zur identifizierung eines makrolid-targetsInfo
- Publication number
- ATE523519T1 ATE523519T1 AT06755941T AT06755941T ATE523519T1 AT E523519 T1 ATE523519 T1 AT E523519T1 AT 06755941 T AT06755941 T AT 06755941T AT 06755941 T AT06755941 T AT 06755941T AT E523519 T1 ATE523519 T1 AT E523519T1
- Authority
- AT
- Austria
- Prior art keywords
- macrolide
- biotin
- affinity group
- target
- identifying
- Prior art date
Links
- 239000003120 macrolide antibiotic agent Substances 0.000 title abstract 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 229960002685 biotin Drugs 0.000 title abstract 2
- 235000020958 biotin Nutrition 0.000 title abstract 2
- 239000011616 biotin Substances 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64433305P | 2005-01-14 | 2005-01-14 | |
| PCT/IB2006/001484 WO2006106440A1 (en) | 2005-01-14 | 2006-01-13 | Macrolide compounds containing biotin and photo-affinity group for macrolide target identification |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE523519T1 true ATE523519T1 (de) | 2011-09-15 |
Family
ID=36808715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06755941T ATE523519T1 (de) | 2005-01-14 | 2006-01-13 | Makrolidverbindungen mit biotin und fotoaffinitätsgruppe zur identifizierung eines makrolid-targets |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7989600B2 (de) |
| EP (1) | EP1836212B1 (de) |
| JP (1) | JP5065910B2 (de) |
| AT (1) | ATE523519T1 (de) |
| ES (1) | ES2371931T3 (de) |
| WO (1) | WO2006106440A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7601695B2 (en) | 2003-03-10 | 2009-10-13 | Optimer Pharmaceuticals, Inc. | Antibacterial agents |
| DE602006015919D1 (de) | 2005-01-13 | 2010-09-16 | Glaxosmithkline Zagreb | Makrolide mit entzündungshemmender wirkung |
| JP5126685B2 (ja) | 2006-05-01 | 2013-01-23 | 大正製薬株式会社 | マクロライド誘導体 |
| CA2691987C (en) * | 2007-06-12 | 2016-08-16 | Achaogen, Inc. | Antibacterial agents |
| AU2008316830B2 (en) | 2007-10-25 | 2016-03-17 | Cempra Pharmaceuticals, Inc. | Process for the preparation of macrolide antibacterial agents |
| CN107854477A (zh) | 2008-10-24 | 2018-03-30 | 森普拉制药公司 | 使用含三唑的大环内酯治疗抗性疾病的方法 |
| JP5437394B2 (ja) * | 2009-01-30 | 2014-03-12 | グラクソ グループ リミテッド | 抗炎症性マクロライド |
| US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
| US9480679B2 (en) | 2009-09-10 | 2016-11-01 | Cempra Pharmaceuticals, Inc. | Methods for treating malaria, tuberculosis and MAC diseases |
| KR20130120458A (ko) | 2010-09-10 | 2013-11-04 | 셈프라 파마슈티컬스, 인크. | 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드 |
| WO2013148891A1 (en) | 2012-03-27 | 2013-10-03 | Cempra Pharmaceuticals, Inc. | Parenteral formulations for administering macrolide antibiotics |
| WO2014152326A1 (en) | 2013-03-14 | 2014-09-25 | Cempra Pharmaceuticals, Inc. | Methods for treating respiratory diseases and formulations therefor |
| AU2014233240B2 (en) | 2013-03-15 | 2018-08-09 | Cempra Pharmaceuticals, Inc. | Convergent processes for preparing macrolide antibacterial agents |
| EP3612177A4 (de) | 2017-04-21 | 2021-01-13 | Lunella Biotech, Inc. | Targeting von hypoxischen krebsstammzellen (cscs) mit doxycyclin: implikationen zur verbesserung der anti-angiogenesetherapie |
| CA3060510A1 (en) | 2017-04-21 | 2018-10-25 | Lunella Biotech, Inc. | Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs) |
| JP6938682B2 (ja) | 2017-05-19 | 2021-09-22 | ルネラ・バイオテック・インコーポレーテッド | アンチミトシン：癌幹細胞を根絶するためのミトコンドリア生合成の標的阻害薬 |
| US12006553B2 (en) | 2017-05-19 | 2024-06-11 | Lunella Biotech, Inc. | Companion diagnostics for mitochondrial inhibitors |
| CU20190106A7 (es) | 2017-06-26 | 2020-11-30 | Lunella Biotech Inc | Mitocetoscinas: agentes terapéuticos basados en mitocondrias que fijan como objetivo el metabolismo de cetonas en células cancerosas |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005095014A (ja) | 2003-09-22 | 2005-04-14 | Science Univ Of Tokyo | マクロライド系抗生物質結合ペプチド及びこれをコードする遺伝子 |
-
2006
- 2006-01-13 EP EP06755941A patent/EP1836212B1/de not_active Expired - Lifetime
- 2006-01-13 ES ES06755941T patent/ES2371931T3/es not_active Expired - Lifetime
- 2006-01-13 JP JP2007550882A patent/JP5065910B2/ja not_active Expired - Fee Related
- 2006-01-13 AT AT06755941T patent/ATE523519T1/de not_active IP Right Cessation
- 2006-01-13 WO PCT/IB2006/001484 patent/WO2006106440A1/en not_active Ceased
- 2006-01-13 US US11/813,871 patent/US7989600B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1836212B1 (de) | 2011-09-07 |
| EP1836212A1 (de) | 2007-09-26 |
| US20080241959A1 (en) | 2008-10-02 |
| ES2371931T3 (es) | 2012-01-11 |
| JP5065910B2 (ja) | 2012-11-07 |
| JP2008526952A (ja) | 2008-07-24 |
| US7989600B2 (en) | 2011-08-02 |
| WO2006106440A1 (en) | 2006-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |