ATE523587T1 - Eigenschaften neuronaler vorläuferzellen zeigende zellen - Google Patents

Eigenschaften neuronaler vorläuferzellen zeigende zellen

Info

Publication number
ATE523587T1
ATE523587T1 AT05735066T AT05735066T ATE523587T1 AT E523587 T1 ATE523587 T1 AT E523587T1 AT 05735066 T AT05735066 T AT 05735066T AT 05735066 T AT05735066 T AT 05735066T AT E523587 T1 ATE523587 T1 AT E523587T1
Authority
AT
Austria
Prior art keywords
cells
pronector
neuronal
showing characteristics
stem cells
Prior art date
Application number
AT05735066T
Other languages
English (en)
Inventor
Mari Dezawa
Original Assignee
Sanbio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanbio Inc filed Critical Sanbio Inc
Application granted granted Critical
Publication of ATE523587T1 publication Critical patent/ATE523587T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT05735066T 2004-04-12 2005-04-07 Eigenschaften neuronaler vorläuferzellen zeigende zellen ATE523587T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56161304P 2004-04-12 2004-04-12
PCT/US2005/011670 WO2005100552A2 (en) 2004-04-12 2005-04-07 Cells exhibiting neuronal progenitor cell characteristics

Publications (1)

Publication Number Publication Date
ATE523587T1 true ATE523587T1 (de) 2011-09-15

Family

ID=35150551

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05735066T ATE523587T1 (de) 2004-04-12 2005-04-07 Eigenschaften neuronaler vorläuferzellen zeigende zellen

Country Status (13)

Country Link
US (5) US20060251624A1 (de)
EP (2) EP1737950B9 (de)
JP (2) JP2007532112A (de)
KR (2) KR101277310B1 (de)
CN (1) CN1973031B (de)
AT (1) ATE523587T1 (de)
AU (1) AU2005233582B2 (de)
CA (2) CA2929754A1 (de)
DK (1) DK1737950T3 (de)
ES (1) ES2372501T3 (de)
PL (1) PL1737950T3 (de)
PT (1) PT1737950E (de)
WO (1) WO2005100552A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE523587T1 (de) * 2004-04-12 2011-09-15 Sanbio Inc Eigenschaften neuronaler vorläuferzellen zeigende zellen
US20060110440A1 (en) * 2004-10-22 2006-05-25 Kiminobu Sugaya Method and system for biasing cellular development
US20060216276A1 (en) * 2005-03-07 2006-09-28 Mari Dezawa Use of materials for treatment of central nervous system lesions
EP2089061B1 (de) * 2006-10-27 2015-09-02 The University Of Western Ontario Hemmung der sox9-funktion bei der behandlung von pathophysiologischen zuständen im zusammenhang mit proteoglykan
JP5662147B2 (ja) * 2007-08-15 2015-01-28 サンバイオ，インコーポレイティド 神経変性を治療するための方法及び組成物
ES2551356T3 (es) 2007-12-03 2015-11-18 Sanbio, Inc. Métodos y composiciones para modular la diferenciación de células pluripotenciales
US10702554B2 (en) * 2007-12-03 2020-07-07 Sanbio, Inc. Extracellular matrix from pluripotent cells
US10316288B2 (en) * 2008-04-30 2019-06-11 Sanbio, Inc. Neural regenerating cells with alterations in DNA methylation
EP2694080B1 (de) 2011-04-06 2018-03-14 SanBio, Inc. Verfahren und zusammensetzungen zur modulierung der peripheren immunfunktionen
EP2806881A1 (de) 2012-01-27 2014-12-03 SanBio, Inc. Verfahren und zusammensetzungen zur modulation der angiogenese und vaskulogenese
CN104519891B (zh) 2012-05-16 2019-03-22 桑比欧公司 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物
WO2014058464A1 (en) 2012-10-09 2014-04-17 Sanbio, Inc. Methods and compositions for treatment of retinal degeneration
AU2014256876B2 (en) 2013-04-26 2020-11-12 Cornell, University Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
ES2890123T3 (es) 2015-04-01 2022-01-17 Sanbio Inc Métodos y composiciones para la estimulación de la proliferación celular y el suministro de mezclas biológicamente activas de isoformas FGF2
WO2018017538A1 (en) 2016-07-21 2018-01-25 Sanbio, Inc. Msc growth predictor assays
CN110382020A (zh) 2016-12-28 2019-10-25 桑比欧公司 细胞递送系统及操作细胞递送系统的方法
KR20240012562A (ko) 2021-05-27 2024-01-29 샌바이오, 인크. 소규모 뇌졸중에 대한 세포 치료법 및 치료 방법
US20250381230A1 (en) 2024-06-14 2025-12-18 SanBio Co. Ltd. Methods and compositions for treatment of neurodegenerative disorders and reducing tau protein aggregates

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5276204A (en) 1988-11-09 1994-01-04 Henkel Kommanditgesellschaft Auf Aktien Fatty alcohol mixtures and ethoxylates thereof showing improved low-temperature behavior
JPH031260A (ja) 1989-05-30 1991-01-07 Hitachi Ltd 計算機方式
US6653134B2 (en) 1995-03-28 2003-11-25 Cp Hahnemann University Isolated stromal cells for use in the treatment of diseases of the central nervous system
US6395205B1 (en) * 1996-07-17 2002-05-28 Chemical Lime Company Method of manufacturing an aerated autoclaved concrete material
JP2002513545A (ja) 1998-05-07 2002-05-14 ザ ユニヴァーシティー オブ サウス フロリダ 脳および脊髄修復のためのニューロン源としての骨髄細胞
US7105150B2 (en) * 1999-02-12 2006-09-12 Stemcells California, Inc. In vivo screening methods using enriched neural stem cells
US6080747A (en) * 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
US7015037B1 (en) * 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US7468277B2 (en) 1999-12-23 2008-12-23 Cornell Research Foundation, Inc. Enriched preparation of human fetal multipotential neural stem cells
PT1782800E (pt) * 2000-01-24 2014-03-25 Genzyme Corp Métodos para detectar inibidores de jak3
US20040052762A1 (en) * 2001-09-10 2004-03-18 Hua Yu Stat3 agonists and antagonists and therapeutic uses thereof
KR100449141B1 (ko) * 2001-04-19 2004-09-21 (주)라이프코드 간엽 간세포를 신경세포로 분화시키는 방법
US20030003090A1 (en) 2001-05-31 2003-01-02 Prockop Darwin J. Directed in vitro differentiation of marrow stromal cells into neural cell progenitors
DE60233805D1 (de) * 2001-08-08 2009-11-05 Levesque Biosciences Inc Zusammensetzungen und verfahren zur isolierung, vermehrung und differenzierung nicht-embryonale menschlicher stammzellen und deren verwendungen
AU2003207064B2 (en) * 2002-02-06 2006-07-13 Sanbio, Inc. Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferring Notch gene
US20040062753A1 (en) * 2002-09-27 2004-04-01 Alireza Rezania Composite scaffolds seeded with mammalian cells
ATE523587T1 (de) * 2004-04-12 2011-09-15 Sanbio Inc Eigenschaften neuronaler vorläuferzellen zeigende zellen

Also Published As

Publication number Publication date
CN1973031A (zh) 2007-05-30
KR101277310B1 (ko) 2013-06-25
EP1737950A2 (de) 2007-01-03
US20060251624A1 (en) 2006-11-09
CN1973031B (zh) 2011-11-02
KR20130062359A (ko) 2013-06-12
CA2929754A1 (en) 2005-10-27
CA2562198C (en) 2017-05-30
JP2007532112A (ja) 2007-11-15
DK1737950T3 (da) 2011-12-05
AU2005233582A1 (en) 2005-10-27
US9441199B2 (en) 2016-09-13
US20130071924A1 (en) 2013-03-21
CA2562198A1 (en) 2005-10-27
PL1737950T3 (pl) 2012-02-29
JP5756039B2 (ja) 2015-07-29
EP2314674A1 (de) 2011-04-27
JP2012130348A (ja) 2012-07-12
US20150267169A1 (en) 2015-09-24
US20110229442A1 (en) 2011-09-22
AU2005233582B2 (en) 2009-01-29
KR20070015542A (ko) 2007-02-05
ES2372501T3 (es) 2012-01-20
WO2005100552A3 (en) 2006-10-12
US20090324561A1 (en) 2009-12-31
EP1737950B9 (de) 2012-04-18
EP1737950B1 (de) 2011-09-07
WO2005100552A2 (en) 2005-10-27
PT1737950E (pt) 2011-12-22

Similar Documents

Publication Publication Date Title
ATE523587T1 (de) Eigenschaften neuronaler vorläuferzellen zeigende zellen
WO2009007852A3 (en) Multipotent/pluripotent cells and methods
WO2008118392A3 (en) Synthetic cell platforms and methods of use thereof
MX2009010847A (es) Reprogramacion de celulas somaticas.
WO2006083782A3 (en) Directed differentiation of embryonic stem cells and uses thereof
WO2010011944A3 (en) Protein screeing methods
EP1970446A4 (de) Nukleärer reprogrammierungsfaktor
DE602005017518D1 (de) Membran-elektrodenbaugruppen für brennstoffzellen, ihre herstellung, verwendung und diese enthaltende brennstoffzellen
WO2009137674A3 (en) Treating myelin diseases with optimized cell preparations
WO2005047524A3 (en) Compositions and methods for inducing cell dedifferentiation
BRPI0822044A2 (pt) Combinação de uma proteina de fusão anti anticorpo para edb da fibronectina-il-2 e uma molécula de ligação a células b, progenitores de células b e/ou seu correspondente canceroso
WO2007087139A3 (en) MESENCHYMAL STEM CELLS EXPRESSING TNF-α RECEPTOR
WO2005003320A3 (en) Neuronal differentiation of stem cells
WO2009143421A3 (en) Methods for promoting fusion and reprogramming of somatic cells
WO2004015077A3 (en) Compositions and methods for neural differentiation of embryonic stem cells
BRPI0819649A2 (pt) método, organismo geneticamente modificado, e, célula de levedura recinbinante
CY1111769T1 (el) Παρασκευη κυτταρων
CY1111486T1 (el) Μιμητικα αντισωματα (mimetibodies) δεσμευμενα με υποδοχεα μελανοκορτινης, συνθεσεις, μεθοδοι και χρησεις
WO2007026255A3 (en) Dedifferentiated cells and methods of making and using dedifferentiated cells
WO2010083203A3 (en) Non-embryonic stem cells and uses thereof
GB0713428D0 (en) Sense amplifiers with high voltage swing
WO2006071891A3 (en) Evaluating central nervous system
WO2010138873A8 (en) Long term expansion of human hematopoietic stem cells
DE602006014676D1 (de) Festpolymerelektrolyt-membran, herstellungsverfahren dafür und brennstoffzelle
DK1645626T3 (da) Cellelinie

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1737950

Country of ref document: EP