ATE523601T1 - Verfahren und zusammensetzungen zur vorhersage der reaktion auf warfarin - Google Patents
Verfahren und zusammensetzungen zur vorhersage der reaktion auf warfarinInfo
- Publication number
- ATE523601T1 ATE523601T1 AT05804256T AT05804256T ATE523601T1 AT E523601 T1 ATE523601 T1 AT E523601T1 AT 05804256 T AT05804256 T AT 05804256T AT 05804256 T AT05804256 T AT 05804256T AT E523601 T1 ATE523601 T1 AT E523601T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- methods
- warfarin
- predicting response
- present
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 title abstract 2
- 229960005080 warfarin Drugs 0.000 title abstract 2
- 101150025072 VKORC1 gene Proteins 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 102000054766 genetic haplotypes Human genes 0.000 abstract 1
- 102000054765 polymorphisms of proteins Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Stringed Musical Instruments (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/967,879 US7445896B2 (en) | 2004-10-18 | 2004-10-18 | Methods and compositions for detecting VKORC1 single nucleotide polymorphisms |
| US11/141,288 US20060084081A1 (en) | 2004-10-18 | 2005-05-31 | Methods and compositions for predicting drug responses |
| PCT/US2005/037058 WO2006044686A2 (en) | 2004-10-18 | 2005-10-17 | Methods and compositions for predicting drug responses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE523601T1 true ATE523601T1 (de) | 2011-09-15 |
Family
ID=36181207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05804256T ATE523601T1 (de) | 2004-10-18 | 2005-10-17 | Verfahren und zusammensetzungen zur vorhersage der reaktion auf warfarin |
Country Status (5)
| Country | Link |
|---|---|
| US (8) | US7445896B2 (de) |
| AT (1) | ATE523601T1 (de) |
| DK (1) | DK1809767T3 (de) |
| ES (1) | ES2373044T3 (de) |
| IL (1) | IL182519A0 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004025157D1 (de) * | 2003-09-23 | 2010-03-04 | Univ North Carolina | Zellen, die Vitamin-K-Reduktase und Vitamin-K-abhängiges Protein coexprimieren und deren Anwendung zur Verbesserung der Produktivität von diesem Vitamin-K-abhängigen Protein |
| WO2006012902A2 (en) * | 2004-08-02 | 2006-02-09 | Novozymes A/S | Creation of diversity in polypeptides |
| ES2347167T3 (es) * | 2004-12-21 | 2010-10-26 | Academia Sinica | Variantes geneticas de vkorc1 que predicen la sensibilidad a warfarina. |
| CA2601574C (en) | 2005-03-15 | 2014-12-02 | University Of North Carolina At Chapel Hill | Methods and compositions for producing active vitamin k-dependent proteins |
| EP1987146A4 (de) * | 2006-01-27 | 2009-08-19 | Paragondx Llc | Verfahren zur erzeugung von referenzkontrollen für pharmakogenomische tests |
| WO2007110869A2 (en) | 2006-03-28 | 2007-10-04 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Methods and kits for determining predisposition to warfarin resistance |
| US8380539B2 (en) * | 2006-05-09 | 2013-02-19 | University Of Louisville Research Foundation, Inc. | Personalized medicine management software |
| US20070298426A1 (en) * | 2006-06-02 | 2007-12-27 | Academia Sinica | Warfarin dosage prediction |
| US20090216561A1 (en) * | 2008-02-22 | 2009-08-27 | Swedish Health Services | Methods for management of anticoagulation therapy |
| US20100137426A1 (en) * | 2008-05-01 | 2010-06-03 | Paragon | Method for generating reference controls for pharmacogenomic testing |
| WO2010048020A1 (en) * | 2008-10-20 | 2010-04-29 | Epitome Pharmaceuticals Limited | Methods and systems for improved pharmaceutical intervention in coagulation control |
| US9631002B2 (en) | 2010-12-21 | 2017-04-25 | The University Of North Carolina At Chapel Hill | Methods and compositions for producing active vitamin K-dependent proteins |
| US9417210B2 (en) | 2011-09-30 | 2016-08-16 | Pandora Genomics, LLC | System, apparatus and method for evaluating samples or analytes using a point-of-care device |
| CN108570498B (zh) * | 2018-05-25 | 2021-11-23 | 山东维真生物科技有限公司 | 用于检测人类cyp2c9和vkorc1基因多态性的引物探针组合物、试剂盒及应用 |
| EP3935581A4 (de) | 2019-03-04 | 2022-11-30 | Iocurrents, Inc. | Datenkompression und -kommunikation mit maschinenlernung |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4998617A (en) * | 1986-09-15 | 1991-03-12 | Laura Lupton Inc | Facial cosmetic liquid make up kit |
| US5605798A (en) * | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| DE69433811T2 (de) * | 1993-01-07 | 2005-06-23 | Sequenom, Inc., San Diego | Dns - sequenzierung durch massenspektronomie |
| US5593826A (en) * | 1993-03-22 | 1997-01-14 | Perkin-Elmer Corporation, Applied Biosystems, Inc. | Enzymatic ligation of 3'amino-substituted oligonucleotides |
| WO1995034679A2 (en) | 1994-06-16 | 1995-12-21 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Defects in drug metabolism |
| GB9415492D0 (en) * | 1994-08-01 | 1994-09-21 | Celltech Ltd | Biological products |
| US6379670B1 (en) * | 1994-11-18 | 2002-04-30 | Neurocrine Biosciences, Inc. | Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein |
| DE602004025157D1 (de) | 2003-09-23 | 2010-03-04 | Univ North Carolina | Zellen, die Vitamin-K-Reduktase und Vitamin-K-abhängiges Protein coexprimieren und deren Anwendung zur Verbesserung der Produktivität von diesem Vitamin-K-abhängigen Protein |
| DE602004026897D1 (de) | 2003-10-14 | 2010-06-10 | Baxter Healthcare Sa | Vkorc1 (vitamin k epoxide recycling polypeptide), ein therapeutisches ziel für coumarin und deren derivate |
| WO2006044686A2 (en) | 2004-10-18 | 2006-04-27 | University Of Washington | Methods and compositions for predicting drug responses |
| ES2347167T3 (es) * | 2004-12-21 | 2010-10-26 | Academia Sinica | Variantes geneticas de vkorc1 que predicen la sensibilidad a warfarina. |
-
2004
- 2004-10-18 US US10/967,879 patent/US7445896B2/en not_active Expired - Fee Related
-
2005
- 2005-05-31 US US11/141,288 patent/US20060084081A1/en not_active Abandoned
- 2005-10-17 AT AT05804256T patent/ATE523601T1/de active
- 2005-10-17 DK DK05804256.5T patent/DK1809767T3/da active
- 2005-10-17 ES ES05804256T patent/ES2373044T3/es not_active Expired - Lifetime
-
2007
- 2007-03-16 US US11/687,123 patent/US7829282B2/en not_active Expired - Fee Related
- 2007-03-16 US US11/687,153 patent/US8153366B2/en not_active Expired - Fee Related
- 2007-03-16 US US11/687,217 patent/US7888016B2/en not_active Expired - Fee Related
- 2007-03-16 US US11/687,179 patent/US20080318219A1/en not_active Abandoned
- 2007-04-12 IL IL182519A patent/IL182519A0/en unknown
-
2011
- 2011-01-18 US US13/008,473 patent/US8614060B2/en not_active Expired - Fee Related
-
2013
- 2013-11-07 US US14/074,289 patent/US9074257B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US8153366B2 (en) | 2012-04-10 |
| US20080050732A1 (en) | 2008-02-28 |
| US20110251272A1 (en) | 2011-10-13 |
| US20080057500A1 (en) | 2008-03-06 |
| US20080318219A1 (en) | 2008-12-25 |
| US20060084081A1 (en) | 2006-04-20 |
| US7888016B2 (en) | 2011-02-15 |
| DK1809767T3 (da) | 2011-12-12 |
| US7829282B2 (en) | 2010-11-09 |
| US7445896B2 (en) | 2008-11-04 |
| US9074257B2 (en) | 2015-07-07 |
| US20060084070A1 (en) | 2006-04-20 |
| US20140148505A1 (en) | 2014-05-29 |
| HK1105437A1 (en) | 2008-02-15 |
| US8614060B2 (en) | 2013-12-24 |
| IL182519A0 (en) | 2007-09-20 |
| ES2373044T3 (es) | 2012-01-30 |
| US20080050733A1 (en) | 2008-02-28 |
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| UEP | Publication of translation of european patent specification |
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