ATE524428T1 - Verfahren zur herstellung von pharmazeutischen zwischenprodukten - Google Patents

Verfahren zur herstellung von pharmazeutischen zwischenprodukten

Info

Publication number
ATE524428T1
ATE524428T1 AT08853527T AT08853527T ATE524428T1 AT E524428 T1 ATE524428 T1 AT E524428T1 AT 08853527 T AT08853527 T AT 08853527T AT 08853527 T AT08853527 T AT 08853527T AT E524428 T1 ATE524428 T1 AT E524428T1
Authority
AT
Austria
Prior art keywords
halogenation
aqueous hydrogen
general formula
mixture
intermediate products
Prior art date
Application number
AT08853527T
Other languages
English (en)
Inventor
Tibor Mezei
Cs Gyula Luk
R Eniko Moln
Joszef Barkaczy
Balazs Volk
Marta Porcs-Makkay
Gyi Janos Szul
Maria Vajjon
Original Assignee
Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag filed Critical Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag
Application granted granted Critical
Publication of ATE524428T1 publication Critical patent/ATE524428T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/567—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT08853527T 2007-11-27 2008-11-27 Verfahren zur herstellung von pharmazeutischen zwischenprodukten ATE524428T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0700757A HU230261B1 (hu) 2007-11-27 2007-11-27 Eljárás gyógyszeripari intermedierek előállítására
PCT/HU2008/000139 WO2009068924A1 (en) 2007-11-27 2008-11-27 Process for the preparation of pharmaceutical i nterm ediates

Publications (1)

Publication Number Publication Date
ATE524428T1 true ATE524428T1 (de) 2011-09-15

Family

ID=89987892

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08853527T ATE524428T1 (de) 2007-11-27 2008-11-27 Verfahren zur herstellung von pharmazeutischen zwischenprodukten

Country Status (9)

Country Link
US (1) US20110040093A1 (de)
EP (1) EP2242736B1 (de)
CN (1) CN101888988A (de)
AT (1) ATE524428T1 (de)
EA (1) EA016762B1 (de)
ES (1) ES2374787T3 (de)
HU (1) HU230261B1 (de)
UA (1) UA100397C2 (de)
WO (1) WO2009068924A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101928208B (zh) * 2010-08-05 2013-06-05 河北大学 一种过氧化氢氧化溴化法合成α-溴代酮类化合物的方法
HUP1000565A2 (en) 2010-10-22 2012-05-02 Egis Gyogyszergyar Nyrt Process for the preparation of pharmaceutically active compound and intermediers
CN102268009A (zh) * 2011-06-13 2011-12-07 陕西瑞科新材料股份有限公司 氢化吡啶衍生物的制备方法
CN107602365B (zh) * 2017-09-27 2021-01-05 长治市晋宁化工有限公司 一种2-氯-1-(1-氯环丙基)乙酮的制备方法
CN112661659A (zh) * 2021-01-08 2021-04-16 浙江苏泊尔制药有限公司 一种盐酸安非他酮的制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI101150B (fi) * 1991-09-09 1998-04-30 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi
IN182838B (de) * 1994-07-27 1999-07-31 Council Scient Ind Res
US5670582A (en) * 1996-07-24 1997-09-23 Exxon Chemical Patents Inc. Process for halogenation of isomonoolefin/para-alkylstyrene copolymers
DK1298132T3 (da) * 2000-07-06 2007-03-12 Sankyo Co Hydropyridinderivatsyreadditionssalte
SI2007362T1 (sl) * 2006-04-04 2018-12-31 Kg Acquisition Llc Peroralne odmerne oblike, ki vključujejo antitrombocitno sredstvo in inhibitor kisline
TWI392681B (zh) * 2006-04-06 2013-04-11 Daiichi Sankyo Co Ltd 高純度普拉格雷及其酸加成鹽之製法

Also Published As

Publication number Publication date
WO2009068924A1 (en) 2009-06-04
HU0700757D0 (en) 2008-02-28
UA100397C2 (uk) 2012-12-25
EP2242736B1 (de) 2011-09-14
US20110040093A1 (en) 2011-02-17
EA201000820A1 (ru) 2010-10-29
HU230261B1 (hu) 2015-11-30
WO2009068924A8 (en) 2010-06-24
EP2242736A1 (de) 2010-10-27
CN101888988A (zh) 2010-11-17
HUP0700757A2 (en) 2010-04-28
ES2374787T3 (es) 2012-02-22
EA016762B1 (ru) 2012-07-30

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