ATE524554T1 - Nicht integrativer und nicht replikativer lentivirus, herstellung und verwendungen - Google Patents

Nicht integrativer und nicht replikativer lentivirus, herstellung und verwendungen

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Publication number
ATE524554T1
ATE524554T1 AT05779704T AT05779704T ATE524554T1 AT E524554 T1 ATE524554 T1 AT E524554T1 AT 05779704 T AT05779704 T AT 05779704T AT 05779704 T AT05779704 T AT 05779704T AT E524554 T1 ATE524554 T1 AT E524554T1
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Austria
Prior art keywords
integrative
production
vivo
nervous system
central nervous
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AT05779704T
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English (en)
Inventor
Jacques Mallet
Che Serguera
Stephanie Philippe
Chamsy Sarkis
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Centre Nat Rech Scient
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    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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AT05779704T 2004-06-25 2005-06-24 Nicht integrativer und nicht replikativer lentivirus, herstellung und verwendungen ATE524554T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0407017A FR2872170B1 (fr) 2004-06-25 2004-06-25 Lentivirus non interactif et non replicatif, preparation et utilisations
PCT/FR2005/001604 WO2006010834A1 (fr) 2004-06-25 2005-06-24 Lentivirus non integratif et non replicatif, preparation et utilisations

Publications (1)

Publication Number Publication Date
ATE524554T1 true ATE524554T1 (de) 2011-09-15

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AT05779704T ATE524554T1 (de) 2004-06-25 2005-06-24 Nicht integrativer und nicht replikativer lentivirus, herstellung und verwendungen

Country Status (10)

Country Link
US (1) US8119119B2 (de)
EP (1) EP1761635B1 (de)
JP (1) JP4861314B2 (de)
CN (1) CN101023177A (de)
AT (1) ATE524554T1 (de)
AU (1) AU2005266221B2 (de)
CA (1) CA2579753C (de)
FR (1) FR2872170B1 (de)
IL (1) IL179740A0 (de)
WO (1) WO2006010834A1 (de)

Families Citing this family (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0526211D0 (en) * 2005-12-22 2006-02-01 Oxford Biomedica Ltd Viral vectors
WO2007091066A1 (en) * 2006-02-07 2007-08-16 Ucl Business Plc Applications of non-integrating lentiviral vectors
DK2020444T3 (en) * 2007-08-03 2017-09-11 Pasteur Institut DEFECTIVE NON-INTEGRATIVE LENTIVIRAL TRANSMISSION VECTORS FOR VACCINES
AU2013203404B2 (en) * 2007-08-03 2016-10-13 Centre National De La Recherche Scientifique (Cnrs) Lentiviral gene transfer vectors and their medicinal applications
BRPI0813194B8 (pt) 2007-08-03 2021-05-25 Centre Nat Rech Scient kit, partículas de vetor lentiviral, composição de vetores plasmídicos, antígeno derivado de hiv-1 quimérico, proteína de envelope de vsv-g, moléculas de ácido nucleico, composição imunogênica e uso de um vetor lentiviral
CA2703045C (en) 2007-10-25 2017-02-14 Sangamo Biosciences, Inc. Methods and compositions for targeted integration
US20110142880A1 (en) * 2008-03-28 2011-06-16 Franck Yann Lemiale Lentivirus-based immunogenic vectors
WO2009131706A1 (en) * 2008-04-26 2009-10-29 Yung-Nien Chang Site-specific-integration lentiviral vectors
EP2405945A4 (de) * 2009-03-13 2012-09-12 Lentigen Corp Impfstoffe mit nicht-integrierenden retroviralen vektoren
JP6215533B2 (ja) 2009-04-09 2017-10-18 サンガモ セラピューティクス, インコーポレイテッド 幹細胞への標的組込み
US8956828B2 (en) 2009-11-10 2015-02-17 Sangamo Biosciences, Inc. Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
EP2534163B1 (de) 2010-02-09 2015-11-04 Sangamo BioSciences, Inc. Gezielte genommodifikation mit partiell einsträngigen donatormolekülen
DK2385107T3 (en) 2010-05-03 2016-12-12 Pasteur Institut Lentiviral vector-based immunological compounds against malaria
WO2012152912A1 (en) 2011-05-12 2012-11-15 Newvectys Genetically modified pig as a cancer prone model
EP2592091B1 (de) 2011-11-08 2017-09-20 Institut Pasteur Polypeptide mit hoher MAST2-Affinität und deren Verwendungen
GB201202516D0 (en) 2012-02-13 2012-03-28 Ucl Business Plc Materials and methods relating to packaging cell lines
JP2015512263A (ja) 2012-03-30 2015-04-27 イミューン デザイン コーポレイション Dc−signを発現する細胞に対して改善された形質導入の有効性を有するレンチウイルスベクター粒子
US9713635B2 (en) 2012-03-30 2017-07-25 Immune Design Corp. Materials and methods for producing improved lentiviral vector particles
WO2014093701A1 (en) 2012-12-12 2014-06-19 The Broad Institute, Inc. Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
EP3434776A1 (de) 2012-12-12 2019-01-30 The Broad Institute, Inc. Verfahren, modelle, systeme und vorrichtungen zur identifikation von zielsequenzen für cas-enzyme oder crispr-cas-systeme für zielsequenzen und förderresultate davon
WO2014093622A2 (en) 2012-12-12 2014-06-19 The Broad Institute, Inc. Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
AU2013204922B2 (en) 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
JP6493692B2 (ja) 2013-03-15 2019-04-10 セルジーン コーポレイション 修飾されたtリンパ球
EP3011033B1 (de) 2013-06-17 2020-02-19 The Broad Institute, Inc. Funktionale genomik unter verwendung von crispr-cas-systemen, zusammensetzungen, verfahren, schirme und anwendungen davon
KR20240172759A (ko) 2013-06-17 2024-12-10 더 브로드 인스티튜트, 인코퍼레이티드 간의 표적화 및 치료를 위한 CRISPR­Cas 시스템, 벡터 및 조성물의 전달 및 용도
EP3597755A1 (de) * 2013-06-17 2020-01-22 The Broad Institute, Inc. Freisetzung, verwendung und therapeutische anwendungen der crispr-cas-systeme und zusammensetzungen zur abzielung auf störungen und erkrankungen mit viralen komponenten
EP3674411A1 (de) 2013-06-17 2020-07-01 The Broad Institute, Inc. Bereitstellung, technische konzeption und optimierung von tandemführungssystemen, verfahren und zusammensetzungen zur sequenzmanipulation
CA2915837A1 (en) 2013-06-17 2014-12-24 The Broad Institute, Inc. Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
SG11201510327TA (en) * 2013-06-17 2016-01-28 Broad Inst Inc Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells
WO2015040063A1 (en) * 2013-09-17 2015-03-26 Inserm (Institut National De La Sante Et De La Recherche Medicale) Lentiviral vectors having a mutated integrase protein and uses thereof
EP2878667A1 (de) 2013-11-29 2015-06-03 Institut Pasteur TAL-Effektormittel zur partiellen oder vollständigen Deletion von DNA-Tandem-Repeats
WO2015089364A1 (en) 2013-12-12 2015-06-18 The Broad Institute Inc. Crystal structure of a crispr-cas system, and uses thereof
CN105899658B (zh) 2013-12-12 2020-02-18 布罗德研究所有限公司 针对hbv和病毒性疾病以及障碍的crispr-cas系统和组合物的递送、用途和治疗应用
WO2015089354A1 (en) 2013-12-12 2015-06-18 The Broad Institute Inc. Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders
EP3080271B1 (de) 2013-12-12 2020-02-12 The Broad Institute, Inc. Systeme, verfahren und zusammensetzungen zur sequenzmanipulation mit optimierten funktionellen crispr-cas-systemen
EP3653229A1 (de) 2013-12-12 2020-05-20 The Broad Institute, Inc. Abgabe, verwendung und therapeutische anwendungen der crispr-cas-systeme und zusammensetzungen zur genomeditierung
EP3080259B1 (de) 2013-12-12 2023-02-01 The Broad Institute, Inc. Konstruktion von systemen, verfahren und optimierte führungszusammensetzungen mit neuen architekturen zur sequenzmanipulation
GB201322798D0 (en) 2013-12-20 2014-02-05 Oxford Biomedica Ltd Production system
CA2946552A1 (en) 2014-04-25 2015-10-29 Bluebird Bio, Inc. Improved methods for manufacturing adoptive cell therapies
PL3689899T3 (pl) 2014-04-25 2022-01-31 2Seventy Bio, Inc. Chimeryczne receptory antygenowe promotora mnd
DK3151672T3 (da) 2014-06-06 2021-02-01 Bluebird Bio Inc Forbedrede t-celle-sammensætninger
MX2017001079A (es) 2014-07-24 2017-09-12 Bluebird Bio Inc Receptores de antígeno quiméricos de antígeno de maduración de células b (bcma).
EP3031923A1 (de) 2014-12-11 2016-06-15 Institut Pasteur Lentivirale, vektorbasierte immunogene Zusammensetzung gegen Japanische Enzephalitis
EP3889260A1 (de) 2014-12-12 2021-10-06 The Broad Institute, Inc. Geschützte guide-rnas (pgrnas)
SMT201900596T1 (it) 2014-12-12 2019-11-13 Bluebird Bio Inc Recettori chimerici di antigene per bcma
CA2970370A1 (en) 2014-12-24 2016-06-30 Massachusetts Institute Of Technology Crispr having or associated with destabilization domains
WO2016205759A1 (en) 2015-06-18 2016-12-22 The Broad Institute Inc. Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
MX392008B (es) 2015-06-18 2025-03-21 Broad Inst Inc Mutaciones de la enzima crispr que reducen los efectos fuera del blanco
EP3353669A4 (de) 2015-09-23 2019-04-24 Sensoriant, Inc. Verfahren und system zur verwendung von vorrichtungszuständen und benutzerpräferenzen zur erstellung von benutzerfreundlichen umgebungen
WO2017060662A1 (en) * 2015-10-07 2017-04-13 The Secretary Of State For Health Method for providing a control for use in a screen for pathogenic virus
WO2017099712A1 (en) 2015-12-07 2017-06-15 Bluebird Bio, Inc. Improved t cell compositions
CN109311963A (zh) 2016-04-14 2019-02-05 蓝鸟生物公司 救助嵌合抗原受体系统
WO2017214938A1 (zh) * 2016-06-16 2017-12-21 毛侃琅 特异促进 bace1 基因高表达的慢病毒表达载体及应用
EP3500696A4 (de) 2016-08-16 2020-04-08 Bluebird Bio, Inc. Il-10-rezeptor-alpha-homing-endonuklease-varianten, zusammensetzungen und verfahren zur verwendung
MA46059A (fr) 2016-08-23 2019-07-03 Bluebird Bio Inc Variants de l'endonucléase homing tim3, compositions et procédés d'utilisation
ES2952525T3 (es) 2016-09-08 2023-11-02 2Seventy Bio Inc Variantes de endonucleasa homing PD-1, composiciones y métodos de uso
EP3526334A4 (de) 2016-10-17 2020-09-30 Bluebird Bio, Inc. Tgfbetar2-homing-endonukleasevarianten, zusammensetzungen und verfahren zur verwendung
BR112019009099A2 (pt) 2016-11-04 2019-07-16 Bluebird Bio Inc composições de células t car anti-bcma
IL309526B2 (en) 2016-11-17 2025-02-01 2Seventy Bio Inc TGFBeta signal converter
AU2017370662A1 (en) * 2016-12-06 2019-06-27 Bluebird Bio, Inc. Gene therapy for mucopolysaccharidosis, type I
KR20190088554A (ko) * 2016-12-06 2019-07-26 블루버드 바이오, 인코포레이티드. Ii형 점액다당류증에 대한 유전자 요법
EP3357504A1 (de) 2017-02-02 2018-08-08 Institut Pasteur Funktionelles screening von antigenen polypeptiden verwendung zur identifizierung von antigenen zur anregung einer schützenden immunantwort und zur auswahl von antigenen mit optimaler schutzwirkung
EP3357506A1 (de) 2017-02-02 2018-08-08 Institut Pasteur Mehrere malaria-prä-erythrozyten-antigene und deren verwendung bei der auslösung einer schützenden immunantwort in einem wirt
ES2969213T3 (es) 2017-02-15 2024-05-17 2Seventy Bio Inc Plantillas de reparación de donantes para edición multiplex del genoma
KR102742817B1 (ko) 2017-05-25 2024-12-17 리제너론 파마슈티칼스 인코포레이티드 Cblb 엔도뉴클레아제 변이체, 조성물 및 사용 방법
WO2019070974A1 (en) 2017-10-04 2019-04-11 Bluebird Bio, Inc. PCSK9 ENDONUCLEASE VARIANTS, COMPOSITIONS AND METHODS OF USE
FI3633040T3 (fi) 2017-12-22 2023-08-03 Oxford Biomedica Ltd Retrovirusvektori
DE102018010282A1 (de) 2018-01-17 2019-07-18 Immatics US, Inc. Verfahren zur Feststellung der Wirksamkeit von viralen Vektoren
DE102018100967B4 (de) 2018-01-17 2019-08-14 Immatics US, Inc. Verfahren zur feststellung der wirksamkeit von viralen vektoren
US12060419B2 (en) 2018-06-14 2024-08-13 Regeneron Pharmaceuticals, Inc. CD79A chimeric antigen receptors
EA202190243A1 (ru) 2018-07-11 2021-06-16 Селджин Корпорейшн Применение химерных антигенных рецепторов к bcma
KR20210102870A (ko) 2018-08-30 2021-08-20 테나야 테라퓨틱스, 인코포레이티드 미오카르딘 및 ascl1을 사용한 심장 세포 재프로그래밍
WO2020072059A1 (en) 2018-10-04 2020-04-09 Bluebird Bio, Inc. Cblb endonuclease variants, compositions, and methods of use
US12404500B2 (en) 2018-12-10 2025-09-02 Novo Nordisk A/S Homing endonuclease variants
AU2019395334A1 (en) 2018-12-10 2021-06-24 Regeneron Pharmaceuticals, Inc. PDCD-1 homing endonuclease variants
CN113366479A (zh) 2018-12-14 2021-09-07 蓝鸟生物公司 二聚化剂调节的免疫受体复合物
SG11202110607WA (en) 2019-04-01 2021-10-28 Tenaya Therapeutics Inc Adeno-associated virus with engineered capsid
EP3997226A1 (de) 2019-07-11 2022-05-18 Tenaya Therapeutics, Inc. Umprogrammierung von herzzellen mit mikrornas und anderen faktoren
EP3770264A1 (de) 2019-07-22 2021-01-27 Genethon Genaue integration unter verwendung von auf nuklease abgerichtete idlv
JP2023501871A (ja) 2019-09-20 2023-01-20 上海吉倍生物技術有限公司 Bcma標的化抗体及びキメラ抗原受容体
US20210128619A1 (en) 2019-11-05 2021-05-06 Celgene Corporation Uses of anti-bcma chimeric antigen receptors
WO2021094752A1 (en) 2019-11-12 2021-05-20 Oxford Biomedica (Uk) Limited Production system
CN115667533A (zh) 2020-02-13 2023-01-31 牛津生物医学(英国)有限公司 慢病毒载体的生产
JP2023516493A (ja) 2020-03-13 2023-04-19 オックスフォード バイオメディカ(ユーケー)リミテッド レンチウイルスベクター
WO2021212279A1 (zh) * 2020-04-20 2021-10-28 广东东阳光药业有限公司 慢病毒的滴度提高型转移质粒
CN114807228B (zh) * 2020-04-27 2023-12-15 北京化工大学 一种t7rna聚合酶和t7启动子的表达系统及使用其在真核生物中表达蛋白质的方法
GB202007199D0 (en) 2020-05-15 2020-07-01 Oxford Biomedica Ltd Viral vector production
CN115698304A (zh) 2020-10-09 2023-02-03 特纳亚治疗股份有限公司 亲斑蛋白-2基因疗法的方法和组合物
US11781156B2 (en) 2020-10-09 2023-10-10 Tenaya Therapeutics, Inc. Plakophillin-2 gene therapy methods and compositions
EP3984548A1 (de) 2020-10-16 2022-04-20 Institut Pasteur Generation von lentiviralen vektoren, die es ermöglichen, antigene zum mhc-ii-weg zu leiten und cd4+- und cd8+-t-zellantworten als immunantwort in einem wirt zu induzieren
EP4241278A2 (de) 2020-11-04 2023-09-13 Celgene Corporation Car-t-zelltherapie bei patienten mit vorheriger antikrebs-alkylatortherapie
GB202017725D0 (en) 2020-11-10 2020-12-23 Oxford Biomedica Ltd Method
JP2023552773A (ja) 2020-12-04 2023-12-19 セルジーン コーポレーション 炎症関連可溶性因子の阻害剤と組み合わせたキメラ抗原受容体(car)t細胞療法の使用
WO2022189656A1 (en) 2021-03-12 2022-09-15 Institut Pasteur Lentiviral vectors targeting antigens to mhc-ii pathway and inducing protective cd8+ and cd4+ t-cell immunity in a host
CA3214280A1 (en) 2021-04-16 2022-10-20 Julie Ann RYTLEWSKI T cell therapy in patients who have had prior stem cell transplant
KR20240034234A (ko) 2021-07-14 2024-03-13 2세븐티 바이오, 인코포레이티드 항체로부터의 결합 도메인에 융합된 조작된 t 세포 수용체
GB202114534D0 (en) 2021-10-12 2021-11-24 Oxford Biomedica Ltd Novel viral regulatory elements
GB202114528D0 (en) 2021-10-12 2021-11-24 Oxford Biomedica Ltd Lentiviral vectors
GB202114530D0 (en) 2021-10-12 2021-11-24 Oxford Biomedica Ltd Retroviral vectors
GB202114532D0 (en) 2021-10-12 2021-11-24 Oxford Biomedica Ltd Lentiviral Vectors
GB202114529D0 (en) 2021-10-12 2021-11-24 Oxford Biomedica Ltd Lentiviral vectors
CN114181972A (zh) * 2021-11-23 2022-03-15 上海本导基因技术有限公司 适用于难治性血管新生性眼疾病基因治疗的慢病毒载体
GB202117844D0 (en) 2021-12-09 2022-01-26 Oxford Biomedica Ltd Purification method
CN119546327A (zh) 2022-04-08 2025-02-28 再生元制药公司 多部分受体和信号传导复合物
KR20250005214A (ko) 2022-04-13 2025-01-09 우니버시타트 아우토노마 데 바르셀로나 클로토 단백질을 발현시키는 유전자 요법을 통한 신경근 질환의 치료
KR20250008774A (ko) 2022-05-11 2025-01-15 셀진 코포레이션 T 세포 요법 및 그의 생산과 관련된 방법 및 용도
CN119585438A (zh) 2022-05-26 2025-03-07 再生元制药公司 用于维持慢病毒载体的组合物及其用途
GB202211935D0 (en) 2022-08-16 2022-09-28 Oxford Biomedica Ltd envelope proteins
EP4604993A2 (de) 2022-10-21 2025-08-27 Institut Pasteur Nichtstrukturelle flavivirus-antigene exprimierende polynukleotide und lentivirale vektoren aus der gruppe von denv, zikv und yfv, die schützende cd8+-t-zellimmunität in einem wirt induzieren
WO2024102954A1 (en) 2022-11-10 2024-05-16 Massachusetts Institute Of Technology Activation induced clipping system (aics)
WO2024200573A1 (en) 2023-03-27 2024-10-03 LAVA Therapeutics N.V. Nectin-4 binding agents and methods of use
WO2025012118A2 (en) 2023-07-07 2025-01-16 LAVA Therapeutics N.V. 5t4 binding agents and methods of use
WO2025059162A1 (en) 2023-09-11 2025-03-20 Dana-Farber Cancer Institute, Inc. Car-engager containing il-2 variants to enhance the functionality of car t cells
WO2025153530A1 (en) 2024-01-16 2025-07-24 Novo Nordisk A/S Albumin-targeted endonucleases, compositions, and methods of use
WO2025235862A1 (en) 2024-05-10 2025-11-13 Inndura Therapeutics Inc. A modified immune cell receptor comprising a target-binding domain and the extracellular domain of cd16a

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5665577A (en) 1989-02-06 1997-09-09 Dana-Farber Cancer Institute Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof
JP3140757B2 (ja) 1989-02-06 2001-03-05 デイナ・フアーバー・キヤンサー・インステイテユート パッケージング欠陥hivプロウイルス、細胞系及びその使用
US5981276A (en) 1990-06-20 1999-11-09 Dana-Farber Cancer Institute Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
WO1997031119A1 (en) * 1996-02-21 1997-08-28 Res Inst For Genetic And Human Methods and compositions for protective and therapeutic genetic immunization
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
WO1999058701A1 (en) 1998-05-13 1999-11-18 Genetix Pharmaceuticals, Inc. Novel lentiviral packaging cells
AU2487300A (en) * 1998-12-31 2000-07-31 Chiron Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
WO2000072886A1 (en) * 1999-05-26 2000-12-07 Dana-Farber Cancer Institute, Inc. Episomally replicating lentiviral vectors
DE60033045T2 (de) 1999-10-12 2007-11-08 Institut Pasteur Lentivirale triplex-dns, und vektoren und rekombinante zellen, die lentivirale triplex-dns enthalten
AU9307501A (en) * 2000-09-22 2002-04-02 Virxsys Improved conditionally replicating vectors, methods for their production and use
FR2825372B1 (fr) 2001-06-01 2004-06-18 Centre Nat Rech Scient Pseudotypage des vecteurs vih-1 par des enveloppes de rhabdovirus
US20070042494A1 (en) * 2005-05-31 2007-02-22 Tal Kafri Heterologous retroviral packaging system

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CN101023177A (zh) 2007-08-22
US8119119B2 (en) 2012-02-21
US20080089863A1 (en) 2008-04-17
JP2008503230A (ja) 2008-02-07
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FR2872170A1 (fr) 2005-12-30
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