ATE524732T1 - Wirkstoffresistenz gegen pflanzenalkaloide basieren auf dem myd88-status in einer zelle und verfahren zum hemmen der signalgebung durch den tlr-4:myd88-signalweg - Google Patents

Wirkstoffresistenz gegen pflanzenalkaloide basieren auf dem myd88-status in einer zelle und verfahren zum hemmen der signalgebung durch den tlr-4:myd88-signalweg

Info

Publication number
ATE524732T1
ATE524732T1 AT07751467T AT07751467T ATE524732T1 AT E524732 T1 ATE524732 T1 AT E524732T1 AT 07751467 T AT07751467 T AT 07751467T AT 07751467 T AT07751467 T AT 07751467T AT E524732 T1 ATE524732 T1 AT E524732T1
Authority
AT
Austria
Prior art keywords
myd88
plant alkaloids
signaling
tlr
status
Prior art date
Application number
AT07751467T
Other languages
English (en)
Inventor
Gil Mor
Original Assignee
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale filed Critical Univ Yale
Application granted granted Critical
Publication of ATE524732T1 publication Critical patent/ATE524732T1/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57545—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the ovaries
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57595—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving intracellular compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/44—Multiple drug resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT07751467T 2006-02-23 2007-02-23 Wirkstoffresistenz gegen pflanzenalkaloide basieren auf dem myd88-status in einer zelle und verfahren zum hemmen der signalgebung durch den tlr-4:myd88-signalweg ATE524732T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77630406P 2006-02-23 2006-02-23
US78816806P 2006-03-31 2006-03-31
PCT/US2007/004707 WO2007100650A2 (en) 2006-02-23 2007-02-23 Drug resistance to plant alkaloids based upon myd88 status in a cell and methods of inhibiting signaling through the tlr-4:myd88 pathway

Publications (1)

Publication Number Publication Date
ATE524732T1 true ATE524732T1 (de) 2011-09-15

Family

ID=38349578

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07751467T ATE524732T1 (de) 2006-02-23 2007-02-23 Wirkstoffresistenz gegen pflanzenalkaloide basieren auf dem myd88-status in einer zelle und verfahren zum hemmen der signalgebung durch den tlr-4:myd88-signalweg

Country Status (4)

Country Link
US (1) US7985538B2 (de)
EP (1) EP1996935B1 (de)
AT (1) ATE524732T1 (de)
WO (1) WO2007100650A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0606096D0 (en) 2006-03-27 2006-05-03 Cbmm Sa Screening method
EP2316032A1 (de) * 2008-08-20 2011-05-04 INSERM - Institut National de la Santé et de la Recherche Médicale Verfahren zur vorhersage des ansprechens auf eine antikrebsbehandlung mit einem agonisten von tlr7 oder einem agonisten von tlr8
JP2012527631A (ja) * 2009-05-22 2012-11-08 ザ・ユナイテッド・ステイツ・オブ・アメリカ・アズ・リプリゼンティド・バイ・ザ・セクレタリー・デパートメント・オブ・ヘルス・アンド・ヒューマン・サービシズ タキサン型化学療法剤用のインジケータとしてのｓｅｒ４７３でのａｋｔリン酸化反応
TWI481401B (zh) 2010-01-27 2015-04-21 Takeda Pharmaceutical 藥劑
WO2019055597A1 (en) * 2017-09-13 2019-03-21 National Tuberous Sclerosis Association, Inc. Methods and compositions for the treatment of tsc
CN111643677B (zh) * 2020-05-26 2023-06-27 四川省肿瘤医院 一种包封TLR4/MyD88信号通路拮抗剂的纳米脂质体及其制备方法和应用
CN115715802A (zh) * 2022-09-09 2023-02-28 上海市普陀区中心医院 MyD88抑制剂在制备治疗乳腺癌和逆转乳腺癌紫杉醇耐药的药物中的应用
CN117418013A (zh) * 2023-12-19 2024-01-19 四川省肿瘤医院 用于检测卵巢癌细胞MyD88基因5'URR CpG岛甲基化水平的引物、方法及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7674579B2 (en) * 2003-11-26 2010-03-09 Yale University Apoptosis-based evaluation of chemosensitivity in cancer patients
KR20080065656A (ko) 2005-10-12 2008-07-14 캔써 리서치 테크놀로지 리미티드 면역질환을 치료하기 위한 방법 및 조성물

Also Published As

Publication number Publication date
EP1996935B1 (de) 2011-09-14
US20090220427A1 (en) 2009-09-03
US7985538B2 (en) 2011-07-26
WO2007100650A2 (en) 2007-09-07
WO2007100650A3 (en) 2008-04-03
EP1996935A2 (de) 2008-12-03

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