ATE525361T1 - Verfahren zum erhalt von reinen enantiomeren eines pyridazinonderivats - Google Patents

Verfahren zum erhalt von reinen enantiomeren eines pyridazinonderivats

Info

Publication number
ATE525361T1
ATE525361T1 AT09013140T AT09013140T ATE525361T1 AT E525361 T1 ATE525361 T1 AT E525361T1 AT 09013140 T AT09013140 T AT 09013140T AT 09013140 T AT09013140 T AT 09013140T AT E525361 T1 ATE525361 T1 AT E525361T1
Authority
AT
Austria
Prior art keywords
pure enantiomers
obtaining pure
pyridazinone derivative
pyridazinone
derivative
Prior art date
Application number
AT09013140T
Other languages
English (en)
Inventor
Mika Timmerbacka
Jorma Lehtonen
Veli Pekka Tanninen
Jukka Kaukonen
Riikka Hyppoelae
Reijo Baeckstroem
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corp filed Critical Orion Corp
Application granted granted Critical
Publication of ATE525361T1 publication Critical patent/ATE525361T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT09013140T 1996-03-27 1997-03-27 Verfahren zum erhalt von reinen enantiomeren eines pyridazinonderivats ATE525361T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9606474.6A GB9606474D0 (en) 1996-03-27 1996-03-27 Method for obtaining pure enantiomers of a pyridazinone derivative

Publications (1)

Publication Number Publication Date
ATE525361T1 true ATE525361T1 (de) 2011-10-15

Family

ID=10791141

Family Applications (3)

Application Number Title Priority Date Filing Date
AT05010245T ATE465154T1 (de) 1996-03-27 1997-03-27 Verfahren um reine enantiomere eines pyridazinonderivates zu erhalten
AT97914347T ATE299867T1 (de) 1996-03-27 1997-03-27 Verfahren um reine enantiomere eines pyridazinonderivates zu erhalten
AT09013140T ATE525361T1 (de) 1996-03-27 1997-03-27 Verfahren zum erhalt von reinen enantiomeren eines pyridazinonderivats

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT05010245T ATE465154T1 (de) 1996-03-27 1997-03-27 Verfahren um reine enantiomere eines pyridazinonderivates zu erhalten
AT97914347T ATE299867T1 (de) 1996-03-27 1997-03-27 Verfahren um reine enantiomere eines pyridazinonderivates zu erhalten

Country Status (23)

Country Link
US (1) US6180789B1 (de)
EP (3) EP2143715B1 (de)
JP (3) JP4179630B2 (de)
AT (3) ATE465154T1 (de)
AU (1) AU715887B2 (de)
BR (1) BR9708353A (de)
CA (1) CA2250062C (de)
CZ (3) CZ295002B6 (de)
DE (2) DE69739858D1 (de)
DK (2) DK0894087T3 (de)
ES (3) ES2343525T3 (de)
GB (1) GB9606474D0 (de)
HU (1) HU227541B1 (de)
MX (1) MXPA98007851A (de)
NO (1) NO312193B1 (de)
NZ (1) NZ332010A (de)
PL (3) PL190573B1 (de)
PT (3) PT1619186E (de)
SI (2) SI2143715T1 (de)
SK (3) SK285363B6 (de)
TR (1) TR199801921T2 (de)
WO (1) WO1997035841A2 (de)
ZA (1) ZA972729B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9606474D0 (en) * 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
FI973804A7 (fi) * 1997-09-26 1999-03-27 Orion Yhtymae Oy Levosimendaanin oraalisia koostumuksia
FI105389B (fi) * 1998-04-23 2000-08-15 Orion Yhtymae Oyj Menetelmä levosimendaaniannon siedettävyyden seuraamiseksi
FI104718B (fi) * 1998-06-18 2000-03-31 Orion Yhtymae Oyj [[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä
US5905078A (en) * 1998-06-19 1999-05-18 Orion Corporation Use of a pyridazinone derivative
FI109659B (fi) 1999-09-10 2002-09-30 Orion Yhtymae Oyj Levosimendaanin farmaseuttisia liuoksia
WO2008019055A2 (en) * 2006-08-03 2008-02-14 Teva Pharmaceutical Industries Ltd. Processes for optical resolution of 1-phenyl-1,2,3,4-tetrahydroisoquinoline
EP2454241B1 (de) 2009-07-14 2014-04-02 Cipla Limited Verfahren für die zubereitung von levosimendan und zwischenprodukte zur verwendung in dem verfahren
JP5482926B2 (ja) * 2011-02-28 2014-05-07 株式会社リコー 伝送管理装置
CN103554033A (zh) * 2013-11-12 2014-02-05 江苏正大清江制药有限公司 一种消旋体(±)- 6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的拆分方法
CN103554032A (zh) * 2013-11-12 2014-02-05 江苏正大清江制药有限公司 高光学纯度(-)-6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的制备方法
ITMI20132185A1 (it) * 2013-12-23 2015-06-24 Edmond Pharma Srl Polimorfi di levosimendan
EP3424908A1 (de) * 2017-07-07 2019-01-09 Melody Healthcare Pvt. Ltd. Verfahren zur herstellung von levosimendan
US11760730B2 (en) 2021-01-11 2023-09-19 Navinta, Llc Process for the preparation of high purity Levosimendan

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1211589A (en) * 1968-08-06 1970-11-11 Ici Ltd Enantiomer isolation process
US4946842A (en) 1985-07-05 1990-08-07 Smith Kline & French Laboratories Limited Novel guanidino pyridazinones as cardiac stimulants
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
GB2251615B (en) 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB9606474D0 (en) * 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
FI973804A7 (fi) * 1997-09-26 1999-03-27 Orion Yhtymae Oy Levosimendaanin oraalisia koostumuksia

Also Published As

Publication number Publication date
CZ294964B6 (cs) 2005-04-13
TR199801921T2 (xx) 1998-12-21
NO984487D0 (no) 1998-09-25
DE69739858D1 (de) 2010-06-02
JP2008179645A (ja) 2008-08-07
JP2011236251A (ja) 2011-11-24
JP4179630B2 (ja) 2008-11-12
CZ295002B6 (cs) 2005-05-18
HU227541B1 (en) 2011-08-29
AU2162697A (en) 1997-10-17
CA2250062A1 (en) 1997-10-02
ES2343525T3 (es) 2010-08-03
SK285362B6 (sk) 2006-11-03
EP1619186B1 (de) 2010-04-21
CZ304198A3 (cs) 1999-03-17
DE69733748D1 (de) 2005-08-25
PL190573B1 (pl) 2005-12-30
EP2143715A1 (de) 2010-01-13
SI0894087T1 (en) 2005-10-31
BR9708353A (pt) 1999-08-03
EP0894087B1 (de) 2005-07-20
SK285364B6 (sk) 2006-11-03
NZ332010A (en) 2000-02-28
ES2370760T3 (es) 2011-12-22
EP0894087A2 (de) 1999-02-03
SK131698A3 (en) 2000-04-10
DE69733748T2 (de) 2006-04-20
PL190574B1 (pl) 2005-12-30
WO1997035841A3 (en) 1998-01-22
PT1619186E (pt) 2010-06-04
EP2143715B1 (de) 2011-09-21
ES2243988T3 (es) 2005-12-01
JP4825825B2 (ja) 2011-11-30
NO984487L (no) 1998-11-26
PL329068A1 (en) 1999-03-15
DK2143715T3 (da) 2011-12-05
HUP9904150A3 (en) 2000-11-28
EP1619186A1 (de) 2006-01-25
ATE299867T1 (de) 2005-08-15
CA2250062C (en) 2006-11-14
JP5277295B2 (ja) 2013-08-28
ZA972729B (en) 1997-10-30
DK0894087T3 (da) 2005-09-19
SK285363B6 (sk) 2006-11-03
CZ295001B6 (cs) 2005-05-18
SI2143715T1 (sl) 2012-01-31
US6180789B1 (en) 2001-01-30
GB9606474D0 (en) 1996-06-05
ATE465154T1 (de) 2010-05-15
AU715887B2 (en) 2000-02-10
PT894087E (pt) 2005-09-30
HUP9904150A2 (hu) 2000-09-28
NO312193B1 (no) 2002-04-08
JP2000515492A (ja) 2000-11-21
WO1997035841A2 (en) 1997-10-02
PT2143715E (pt) 2011-10-11
MXPA98007851A (es) 2006-06-07
PL189963B1 (pl) 2005-10-31

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