ATE525378T1 - Himbacinanaloga als thrombinrezeptorantagonisten - Google Patents

Himbacinanaloga als thrombinrezeptorantagonisten

Info

Publication number: ATE525378T1
Authority: AT; Austria
Prior art keywords: receptor antagonists; thrombin receptor; himbacin; analogs; himbacin analogs
Prior art date: 2001-10-18

Application number

AT02801732T

Other languages

English (en)

Inventor

Samuel Chackalamannil

Mariappan Chelliah

Martin Clasby

Yan Xia

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-18

Filing date

2002-10-16

Publication date

2011-10-15

2002-10-16 Application filed by Schering Corp filed Critical Schering Corp

2011-10-15 Application granted granted Critical

2011-10-15 Publication of ATE525378T1 publication Critical patent/ATE525378T1/de

Links

FMPNFDSPHNUFOS-LPJDIUFZSA-N himbacine Chemical class C(/[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@H]([C@H]12)C)=C\[C@H]1CCC[C@H](C)N1C FMPNFDSPHNUFOS-LPJDIUFZSA-N 0.000 title 1
239000003856 thrombin receptor antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Diabetes (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT02801732T 2001-10-18 2002-10-16 Himbacinanaloga als thrombinrezeptorantagonisten ATE525378T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US33035901P	2001-10-18	2001-10-18
PCT/US2002/032936 WO2003033501A1 (en)	2001-10-18	2002-10-16	Himbacine analogues as thrombin receptor antagonists

Publications (1)

Publication Number	Publication Date
ATE525378T1 true ATE525378T1 (de)	2011-10-15

Family

ID=23289411

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02801732T ATE525378T1 (de)	2001-10-18	2002-10-16	Himbacinanaloga als thrombinrezeptorantagonisten

Country Status (23)

Country	Link
US (2)	US7037920B2 (de)
EP (1)	EP1436298B1 (de)
JP (2)	JP4307260B2 (de)
KR (1)	KR100960170B1 (de)
CN (1)	CN100369917C (de)
AR (1)	AR036832A1 (de)
AT (1)	ATE525378T1 (de)
AU (1)	AU2002335031C1 (de)
BR (1)	BR0213967A (de)
CA (1)	CA2463628A1 (de)
CO (1)	CO5570668A2 (de)
EC (1)	ECSP045064A (de)
HU (1)	HUP0500443A3 (de)
IL (1)	IL160918A0 (de)
MX (1)	MXPA04003610A (de)
MY (1)	MY139335A (de)
NO (1)	NO329349B1 (de)
NZ (1)	NZ531869A (de)
PE (1)	PE20030808A1 (de)
PL (1)	PL371948A1 (de)
RU (1)	RU2319704C9 (de)
WO (1)	WO2003033501A1 (de)
ZA (1)	ZA200402849B (de)

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US7304078B2 (en) *	2002-04-16	2007-12-04	Schering Corporation	Thrombin receptor antagonists
US7235567B2 (en) *	2000-06-15	2007-06-26	Schering Corporation	Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
US7488742B2 (en) *	2000-06-15	2009-02-10	Schering Corporation	Thrombin receptor antagonists
US7790362B2 (en) *	2003-07-08	2010-09-07	Accumetrics, Inc.	Controlled platelet activation to monitor therapy of ADP antagonists
US20070243632A1 (en) *	2003-07-08	2007-10-18	Coller Barry S	Methods for measuring platelet reactivity of patients that have received drug eluting stents
MXPA06013903A (es) *	2004-05-28	2007-01-26	Schering Corp	Analogos restringidos de himbacina como antagonistas del receptor de trombina.
JP2008510726A (ja) *	2004-08-20	2008-04-10	エントレメッドインコーポレイテッド	プロテイナーゼ活性化受容体アンタゴニストを含む組成物および方法
AU2005294265A1 (en) *	2004-10-06	2006-04-20	University Of Rochester	Treatment of pulmonary hypertension using an agent that inhibits a tissue factor pathway
WO2006041872A2 (en) *	2004-10-08	2006-04-20	Schering Corporation	Thrombin receptor antagonists
JP4681617B2 (ja) *	2005-01-14	2011-05-11	シェーリングコーポレイション	ヒンバシンアナログの合成
ATE530516T1 (de)	2005-01-14	2011-11-15	Schering Corp	Exo- und diastereoselektive synthese von himbacin-analoga
JP4775971B2 (ja) *	2005-01-14	2011-09-21	シェーリングコーポレイション	ヒンバシンアナログのエキソ−選択的合成
WO2006105217A2 (en) *	2005-03-31	2006-10-05	Schering Corporation	Spirocyclic thrombin receptor antagonists
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EP1971336A2 (de) *	2005-12-22	2008-09-24	Shering Corporation	Thrombin-rezeptor-antagonisten zur prophylaxe vor komplikationen einer kardiopulmonalen operation
WO2007075809A2 (en) *	2005-12-22	2007-07-05	Schering Corporation	Oxazoloisoquinoline derivatives as thrombin receptor antagonists
MX2008012574A (es) *	2006-03-29	2008-10-10	Schering Corp	Derivados de himbacina monociclitos y biciclicos utiles como antagonistas del receptor de trombina.
EP2007755B1 (de) *	2006-04-13	2012-06-27	Schering Corporation	Kondensierte ringthrombinrezeptor-antagonisten
CA2655720A1 (en)	2006-06-29	2008-01-10	Schering Corporation	Substituted bicyclic and tricyclic thrombin receptor antagonists
AR061727A1 (es) *	2006-06-30	2008-09-17	Schering Corp	Sintesis de dietil [[ 5- ( 3-fluorofenil) -piridin -2il] metil] fosfonato
TWI367112B (en) *	2006-06-30	2012-07-01	Schering Corp	Immediate-release tablet formulations of a thrombin receptor antagonist
TWI343262B (en) *	2006-09-26	2011-06-11	Schering Corp	Rapidly disintegrating lyophilized oral formulations of a thrombin receptor antagonist
CA2666903A1 (en) *	2006-10-04	2008-05-22	Schering Corporation	Thrombin receptor antagonists based on the modified tricyclic unit of himbacine
CN101541782A (zh) *	2006-10-04	2009-09-23	先灵公司	作为凝血酶受体拮抗剂的二环和三环衍生物
WO2008079260A2 (en) *	2006-12-22	2008-07-03	Schering Corporation	Disintegration promoters in solid dose wet granulation formulations
WO2008118320A1 (en) *	2007-03-23	2008-10-02	Schering Corporation	Reduction of adverse events.after percutaneous intervention by use of a thrombin receptor antagonist
CN101675342A (zh) *	2007-05-03	2010-03-17	阿库米特里克斯股份有限公司	测量凝血酶受体拮抗剂对血小板聚集的抑制的方法
WO2009097970A1 (de)	2008-02-05	2009-08-13	Sanofi-Aventis	Triazolopyridazine als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel
CL2009001214A1 (es)	2008-05-19	2010-12-31	Schering Corp	Compuestos derivados de heterociclo, moduladores de serina proteasas composicion fa<rmacaeutica que los comprende; y su uso en el tratamiento de trastornos tromboembolicos
ES2437100T3 (es)	2009-06-04	2014-01-08	Merck Sharp & Dohme Corp.	Metabolito activo de un antagonista de los receptores de la trombina
MX2011013091A (es)	2009-06-08	2012-01-12	Schering Corp	Un antagonista del receptor de trombina y tableta con dosificacion fija de clopidogrel.
WO2011017296A1 (en)	2009-08-04	2011-02-10	Schering Corporation	4, 5, 6-trisubstituted pyrimidine derivatives as factor ixa inhibitors
US9340530B2 (en)	2012-03-06	2016-05-17	Merck Sharp & Dohme Corp.	Preparation and use of bicyclic himbacine derivatives as PAR-1 receptor antagonists
WO2015026685A1 (en)	2013-08-22	2015-02-26	Merck Sharp & Dohme Corp.	7a-heterocycle substituted- 6, 6-difluoro bicyclic himbacine derivatives
WO2015026686A1 (en)	2013-08-22	2015-02-26	Merck Sharp & Dohme Corp.	3'-pyridyl substituted- 6,6-difluoro bicyclic himbacine derivatives
WO2015026693A1 (en)	2013-08-22	2015-02-26	Merck Sharp & Dohme Corp.	7a-amide substituted-6,6-difluoro bicyclic himbacine derivatives
WO2015160636A1 (en)	2014-04-16	2015-10-22	Merck Sharp & Dohme Corp.	Factor ixa inhibitors
CN104610330A (zh) *	2015-02-25	2015-05-13	成都安斯利生物医药有限公司	一种制备(e)-3-丙烯酸乙酯频呐硼酸酯的方法
JP2023534704A (ja)	2020-07-22	2023-08-10	ヤンセンファーマシューティカエヌ．ベー．	第ｘｉａ因子阻害剤として有用な化合物
US11814364B2 (en)	2021-03-18	2023-11-14	Janssen Pharmaceutica Nv	Pyridine N-oxide derivatives useful as factor XIa inhibitors
US11919881B2 (en)	2021-03-18	2024-03-05	Janssen Pharmaceutica Nv	Substituted pyridine N-oxide derivatives useful as a factor XIa inhibitors
US11845748B2 (en)	2021-03-18	2023-12-19	Janssen Pharmaceutica Nv	Bicyclic pyridine N-oxide derivatives useful as a factor XIa inhibitors
US11897880B2 (en)	2021-04-30	2024-02-13	Janssen Pharmaceutica Nv	7,8-dihydrobenzo[e]pyrido[3,4-c]azocine-2,5(3H,6H)-dione derivatives useful as a factor XIa inhibitors
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US12286429B2 (en)	2021-07-22	2025-04-29	Janssen Pharmaceutica Nv	5-oxo-1,2,3,5,8,8a-hexahydroindolizine-3-carboxamide derivatives useful as a factor XIa inhibitors

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2002
- 2002-10-16 BR BR0213967-7A patent/BR0213967A/pt not_active IP Right Cessation
- 2002-10-16 NZ NZ531869A patent/NZ531869A/en not_active IP Right Cessation
- 2002-10-16 AU AU2002335031A patent/AU2002335031C1/en not_active Ceased
- 2002-10-16 RU RU2004115114/04A patent/RU2319704C9/ru not_active IP Right Cessation
- 2002-10-16 JP JP2003536240A patent/JP4307260B2/ja not_active Expired - Fee Related
- 2002-10-16 PL PL02371948A patent/PL371948A1/xx not_active Application Discontinuation
- 2002-10-16 PE PE2002001022A patent/PE20030808A1/es not_active Application Discontinuation
- 2002-10-16 KR KR1020047005435A patent/KR100960170B1/ko not_active Expired - Fee Related
- 2002-10-16 IL IL16091802A patent/IL160918A0/xx not_active IP Right Cessation
- 2002-10-16 MY MYPI20023859A patent/MY139335A/en unknown
- 2002-10-16 AR ARP020103876A patent/AR036832A1/es unknown
- 2002-10-16 HU HU0500443A patent/HUP0500443A3/hu unknown
- 2002-10-16 US US10/271,715 patent/US7037920B2/en not_active Expired - Fee Related
- 2002-10-16 MX MXPA04003610A patent/MXPA04003610A/es active IP Right Grant
- 2002-10-16 CN CNB028206665A patent/CN100369917C/zh not_active Expired - Fee Related
- 2002-10-16 AT AT02801732T patent/ATE525378T1/de not_active IP Right Cessation
- 2002-10-16 CA CA002463628A patent/CA2463628A1/en not_active Abandoned
- 2002-10-16 EP EP02801732A patent/EP1436298B1/de not_active Expired - Lifetime
- 2002-10-16 WO PCT/US2002/032936 patent/WO2003033501A1/en not_active Ceased
2004
- 2004-04-15 ZA ZA200402849A patent/ZA200402849B/xx unknown
- 2004-04-15 EC EC2004005064A patent/ECSP045064A/es unknown
- 2004-04-16 CO CO04034781A patent/CO5570668A2/es not_active Application Discontinuation
- 2004-05-14 NO NO20042021A patent/NO329349B1/no not_active IP Right Cessation
2005
- 2005-12-19 US US11/311,083 patent/US20060106050A1/en not_active Abandoned
2008
- 2008-09-17 JP JP2008238716A patent/JP2009029820A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
IL160918A0 (en)	2004-08-31
JP2009029820A (ja)	2009-02-12
CO5570668A2 (es)	2005-10-31
BR0213967A (pt)	2005-08-30
MY139335A (en)	2009-09-30
AU2002335031C1 (en)	2006-11-16
CA2463628A1 (en)	2003-04-24
RU2004115114A (ru)	2005-10-27
US7037920B2 (en)	2006-05-02
JP2005529841A (ja)	2005-10-06
PL371948A1 (en)	2005-07-11
JP4307260B2 (ja)	2009-08-05
WO2003033501A1 (en)	2003-04-24
EP1436298B1 (de)	2011-09-21
NO329349B1 (no)	2010-10-04
HUP0500443A3 (en)	2009-12-28
CN100369917C (zh)	2008-02-20
NO20042021L (no)	2004-05-14
US20060106050A1 (en)	2006-05-18
RU2319704C9 (ru)	2008-08-20
KR100960170B1 (ko)	2010-05-26
AR036832A1 (es)	2004-10-06
CN1571789A (zh)	2005-01-26
AU2002335031B2 (en)	2005-06-30
ECSP045064A (es)	2004-05-28
NZ531869A (en)	2006-11-30
MXPA04003610A (es)	2004-07-27
PE20030808A1 (es)	2003-09-22
HUP0500443A2 (hu)	2005-08-29
US20030203927A1 (en)	2003-10-30
RU2319704C2 (ru)	2008-03-20
KR20050036845A (ko)	2005-04-20
EP1436298A1 (de)	2004-07-14
ZA200402849B (en)	2005-01-14

Legal Events

Date	Code	Title	Description
2012-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE525378T1 (de)	2011-10-15	Himbacinanaloga als thrombinrezeptorantagonisten
ATE368659T1 (de)	2007-08-15	Thrombinrezeptorantagonisten
CY2015029I1 (el)	2016-04-13	Τρικυκλικοι ανταγωνιστες υποδοχεα θρομβινης
IS8055A (is)	2005-09-29	CGRP viðtaka mótlyf
ATE328871T1 (de)	2006-06-15	4-phenyl-pyridin-derivate verwendbar als neurokinin-1 rezeptor antagonisten
NO20050429D0 (no)	2005-01-26	Substituert kinolin-CCR5-reseptorantagonister
IL174538A0 (en)	2006-08-01	Thrombin receptor antagonists
DE60216229D1 (de)	2007-01-04	Il-8-rezeptorantagonisten
DE60316411D1 (de)	2007-10-31	Thiazolderivate als npy-rezeptorantagonisten
DE60332816D1 (de)	2010-07-15	Nk1-antagonisten
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