ATE525386T1 - 3'-ethynylcytidinderivat - Google Patents

3'-ethynylcytidinderivat

Info

Publication number
ATE525386T1
ATE525386T1 AT07790281T AT07790281T ATE525386T1 AT E525386 T1 ATE525386 T1 AT E525386T1 AT 07790281 T AT07790281 T AT 07790281T AT 07790281 T AT07790281 T AT 07790281T AT E525386 T1 ATE525386 T1 AT E525386T1
Authority
AT
Austria
Prior art keywords
substituted
group
hydrogen atom
represented
ethynylcytidine derivative
Prior art date
Application number
AT07790281T
Other languages
English (en)
Inventor
Motoaki Tanaka
Masakazu Fukushima
Original Assignee
Taiho Pharmaceutical Co Ltd
Sasaki Takuma
Matsuda Akira
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd, Sasaki Takuma, Matsuda Akira filed Critical Taiho Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE525386T1 publication Critical patent/ATE525386T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT07790281T 2006-07-24 2007-07-23 3'-ethynylcytidinderivat ATE525386T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006200587 2006-07-24
PCT/JP2007/000787 WO2008012945A1 (en) 2006-07-24 2007-07-23 3'-ethynylcytidine derivative

Publications (1)

Publication Number Publication Date
ATE525386T1 true ATE525386T1 (de) 2011-10-15

Family

ID=38981261

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07790281T ATE525386T1 (de) 2006-07-24 2007-07-23 3'-ethynylcytidinderivat

Country Status (14)

Country Link
US (1) US8058261B2 (de)
EP (1) EP2045258B1 (de)
JP (1) JP4989649B2 (de)
KR (1) KR101426101B1 (de)
CN (1) CN101490076B (de)
AT (1) ATE525386T1 (de)
AU (1) AU2007278000B2 (de)
BR (1) BRPI0714705A2 (de)
CA (1) CA2658917C (de)
MX (1) MX2009001003A (de)
NZ (1) NZ574362A (de)
RU (1) RU2441876C2 (de)
TW (1) TWI449528B (de)
WO (1) WO2008012945A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102219817A (zh) * 2011-04-12 2011-10-19 连云港杰瑞药业有限公司 活性偶联剂用于氟化嘧啶化合物烷氧羰酰化的方法
WO2015167620A1 (en) * 2014-04-29 2015-11-05 Biosearch Technologies, Inc. Compounds compositions and methods including thermally labile moieties
WO2018230479A1 (ja) * 2017-06-13 2018-12-20 大原薬品工業株式会社 ヌクレオシド系抗がん剤又は抗ウィルス剤の５'位シリルエーテル誘導体
CN115536710B (zh) * 2022-10-18 2024-04-16 南京工业大学 一种高品质胞苷硫酸盐晶体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA859008B (en) * 1984-12-04 1987-07-29 Lilly Co Eli The treatment of tumors in mammals
EP0184365B1 (de) 1984-12-04 1993-08-04 Eli Lilly And Company Tumorbehandlung bei Säugetieren
NZ297100A (en) * 1994-12-13 1997-10-24 Akira Matsuda 3'-substituted nucleoside derivatives; medicaments
JP3792005B2 (ja) 1997-04-24 2006-06-28 彰 松田 ２−デオキシ−３−エチニル−β−Ｄ−リボフラノシル誘導体
NZ330360A (en) * 1997-06-02 1999-03-29 Hoffmann La Roche 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents

Also Published As

Publication number Publication date
AU2007278000A1 (en) 2008-01-31
CN101490076A (zh) 2009-07-22
US20090306008A1 (en) 2009-12-10
EP2045258B1 (de) 2011-09-21
WO2008012945A1 (en) 2008-01-31
MX2009001003A (es) 2009-02-06
CA2658917C (en) 2014-10-21
US8058261B2 (en) 2011-11-15
BRPI0714705A2 (pt) 2013-05-14
RU2009106034A (ru) 2010-08-27
KR101426101B1 (ko) 2014-08-13
HK1130496A1 (en) 2009-12-31
TWI449528B (zh) 2014-08-21
TW200817014A (en) 2008-04-16
RU2441876C2 (ru) 2012-02-10
JP4989649B2 (ja) 2012-08-01
AU2007278000B2 (en) 2011-12-15
CA2658917A1 (en) 2008-01-31
EP2045258A1 (de) 2009-04-08
CN101490076B (zh) 2012-05-30
JPWO2008012945A1 (ja) 2009-12-17
NZ574362A (en) 2010-10-29
EP2045258A4 (de) 2010-10-06
KR20090033875A (ko) 2009-04-06

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties