ATE525635T1 - Ionenmobilitätsanalyse biologischer partikel - Google Patents

Ionenmobilitätsanalyse biologischer partikel

Info

Publication number
ATE525635T1
ATE525635T1 AT02789660T AT02789660T ATE525635T1 AT E525635 T1 ATE525635 T1 AT E525635T1 AT 02789660 T AT02789660 T AT 02789660T AT 02789660 T AT02789660 T AT 02789660T AT E525635 T1 ATE525635 T1 AT E525635T1
Authority
AT
Austria
Prior art keywords
densities
biological particles
lipoprotein
analytical
ion mobility
Prior art date
Application number
AT02789660T
Other languages
English (en)
Inventor
W Benner
Ronald Krauss
Patricia Blanche
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE525635T1 publication Critical patent/ATE525635T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02Investigating particle size or size distribution
    • G01N15/0266Investigating particle size or size distribution with electrical classification
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622Ion mobility spectrometry
    • G01N27/624Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/10Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/104165Lipid, cholesterol, or triglyceride standard or control
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/24Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
AT02789660T 2001-11-13 2002-11-12 Ionenmobilitätsanalyse biologischer partikel ATE525635T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33821401P 2001-11-13 2001-11-13
PCT/US2002/036645 WO2003042704A1 (en) 2001-11-13 2002-11-12 Ion mobility analysis of biological particles

Publications (1)

Publication Number Publication Date
ATE525635T1 true ATE525635T1 (de) 2011-10-15

Family

ID=23323894

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02789660T ATE525635T1 (de) 2001-11-13 2002-11-12 Ionenmobilitätsanalyse biologischer partikel

Country Status (7)

Country Link
US (4) US7259018B2 (de)
EP (1) EP1444526B1 (de)
JP (1) JP4705754B2 (de)
AT (1) ATE525635T1 (de)
AU (2) AU2002352712B2 (de)
CA (1) CA2467420A1 (de)
WO (1) WO2003042704A1 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2206019B1 (es) * 2002-04-11 2005-07-16 Consejo Sup. Investig. Cientificas Procedimiento para la mejora de la resolucion del analizador diferencial de movilidad electrica mediante el intercambio de los flujos de entrada.
US7416895B2 (en) * 2002-06-21 2008-08-26 Berkeley Heartlab, Inc. Method for identifying at risk cardiovascular disease patients
US20040043496A1 (en) * 2002-06-21 2004-03-04 Berkeley Heartlab, Inc. Method for identifying patients who will require multiple invasive cardiovascular procedures
EP1614141A4 (de) * 2003-04-09 2007-09-12 Univ Brigham Young Querströmungsionenmobilitätsanalysator
JP2007524964A (ja) * 2003-06-20 2007-08-30 ブリガム・ヤング・ユニバーシティ イオン移動度分析及びイオントラップ質量分析のための単一装置
JP3819895B2 (ja) * 2003-10-29 2006-09-13 大塚電子株式会社 動脈硬化評価装置
CA2547389A1 (en) * 2003-11-25 2005-06-09 Sionex Corporation Mobility based apparatus and methods using dispersion characteristics, sample fragmentation, and/or pressure control to improve analysis of a sample
US20050109856A1 (en) * 2003-11-25 2005-05-26 Alexander James N.Iv Method for preparing polymer electrosprays
EP1564780A3 (de) * 2003-12-08 2006-05-31 Rohm And Haas Company Vorrichtung zur Bestimmung der Molekulargewichte von Polymeren
US20050164398A1 (en) * 2004-01-26 2005-07-28 Alexander James N.Iv Method for determining molecular weight of polymers
KR100567788B1 (ko) * 2004-02-13 2006-04-05 주식회사 현대교정인증기술원 입자측정기 및 입자측정방법
US8884221B2 (en) * 2006-01-05 2014-11-11 Excellims Corporation High performance ion mobility spectrometer apparatus and methods
AU2008261868B2 (en) * 2007-06-08 2014-03-13 Quest Diagnostics Investments Llc Lipoprotein analysis by differential charged-particle mobility
US20080302666A1 (en) * 2007-06-08 2008-12-11 Benner W Henry Apparatus for differential charged-particle mobility
US8247235B2 (en) 2007-06-08 2012-08-21 Quest Diagnostics Investments Incorporated Lipoprotein analysis by differential charged-particle mobility
US20090078064A1 (en) * 2007-08-06 2009-03-26 Abraham Oommen Instrument for simultaneous analysis of multiple samples using multiple differential mobility analyzers
EP2250490B9 (de) * 2008-03-07 2015-04-08 The University of British Columbia Autonomes kapillarelektrophoresesystem zur kopplung mit massenspektrometrie
US9354200B1 (en) 2008-08-07 2016-05-31 Quest Diagnostics Investments Incorporated Detection apparatus for differential-charged particle mobility analyzer
WO2010047767A2 (en) * 2008-10-20 2010-04-29 Liposcience, Inc. Lipoprotein insulin resistance indexes and related methods, systems and computer programs for generating same
WO2010136633A1 (en) * 2009-05-26 2010-12-02 Tampereen Teknillinen Yliopisto Method and apparatus for generating test aerosol
US20100323376A1 (en) * 2009-06-17 2010-12-23 Maine Standards Company, Llc Method for Measuring Lipoprotein-Specific Apolipoproteins
US9638705B2 (en) 2010-11-01 2017-05-02 Quest Diagnostics Investments Incorporated Prognostic assays for maintenance hemodialysis patients
US9250211B2 (en) 2010-12-30 2016-02-02 Quest Diagnostics Investments Incorporated Magnetic separation of lipoproteins using dextran sulfate
US9239279B1 (en) * 2011-06-03 2016-01-19 Arkansas State University—Jonesboro Sequential differential mobility analyzer and method of using same
US9322833B2 (en) 2011-06-16 2016-04-26 Children's Hospital & Research Center At Oakland Ultra-small ApoB-containing particles and methods of use thereof
US9702807B2 (en) 2012-06-16 2017-07-11 Ningbo Alabama, Llc Measurement of serum lipoproteins
US9239280B2 (en) * 2012-06-16 2016-01-19 Atherotech, Inc. Measurement of serum lipoproteins
US9459194B2 (en) * 2013-03-14 2016-10-04 Cardio Metrix Apparatuses, processes, and systems for measuring particle size distribution and concentration
US9551768B2 (en) 2013-03-15 2017-01-24 East Carolina University NMR method for monitoring changes in the core of lipoprotein particles in metabolism and disease
WO2014168043A1 (ja) * 2013-04-09 2014-10-16 東京エレクトロン株式会社 測定装置及び測定方法
TWI549745B (zh) 2014-05-16 2016-09-21 財團法人工業技術研究院 溶液混合裝置與混合方法以及溶液粒子監測系統與監測方法
CN107110939B (zh) 2014-09-11 2021-05-14 力保科学公司 用于测定心血管疾病或事件的风险参数的系统
EP4560288A3 (de) * 2016-04-01 2025-08-20 TSI Incorporated Verringerung von falschzählungen bei kondensationspartikelzählern
US11668719B2 (en) * 2017-09-20 2023-06-06 The Trustees Of Indiana University Methods for resolving lipoproteins with mass spectrometry
US11232941B2 (en) 2018-01-12 2022-01-25 The Trustees Of Indiana University Electrostatic linear ion trap design for charge detection mass spectrometry
US10775458B2 (en) 2018-03-05 2020-09-15 Texas Tech University System Method and system for non-invasive measurement of metabolic health
WO2019236139A1 (en) 2018-06-04 2019-12-12 The Trustees Of Indiana University Interface for transporting ions from an atmospheric pressure environment to a low pressure environment
EP4376051A3 (de) 2018-06-04 2024-09-25 The Trustees of Indiana University Ladungsdetektionsmassenspektrometrie mit echtzeitanalyse und signaloptimierung
WO2019236142A1 (en) 2018-06-04 2019-12-12 The Trustees Of Indiana University Ion trap array for high throughput charge detection mass spectrometry
WO2019236143A1 (en) 2018-06-04 2019-12-12 The Trustees Of Indiana University Apparatus and method for calibrating or resetting a charge detector
WO2019236141A1 (en) 2018-06-04 2019-12-12 The Trustees Of Indiana University Apparatus and method for capturing ions in an electrostatic linear ion trap
EP3884510A1 (de) 2018-11-20 2021-09-29 The Trustees of Indiana University Orbitrap für einzelteilchen-massenspektrometrie
US11562896B2 (en) 2018-12-03 2023-01-24 The Trustees Of Indiana University Apparatus and method for simultaneously analyzing multiple ions with an electrostatic linear ion trap
US11942317B2 (en) 2019-04-23 2024-03-26 The Trustees Of Indiana University Identification of sample subspecies based on particle mass and charge over a range of sample temperatures
WO2021061650A1 (en) 2019-09-25 2021-04-01 The Trustees Of Indiana University Apparatus and method for pulsed mode charge detection mass spectrometry
KR102849777B1 (ko) 2019-10-10 2025-08-22 더 트러스티즈 오브 인디애나 유니버시티 입자들을 식별, 선택 및 정제하기 위한 시스템 및 방법
CA3165106A1 (en) 2019-12-18 2021-06-24 The Trustees Of Indiana University Mass spectrometer with charge measurement arrangement
EP4100991B1 (de) 2020-02-03 2025-01-29 The Trustees of Indiana University Ein massenspektrometer zur ladungsdetektion und entsprechende methode
WO2021191266A1 (en) * 2020-03-25 2021-09-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Aerosolization of hdl for the treatment of lung infections
CN112798481B (zh) * 2020-10-27 2022-02-18 美康生物科技股份有限公司 一种用于检测脂蛋白颗粒浓度的试剂及其使用方法
WO2022109732A1 (en) * 2020-11-26 2022-06-02 12535441 Canada Ltd. Spectral diagnostic system
CN115773977B (zh) * 2022-12-01 2023-07-18 中国计量科学研究院 基于es-dma-cpc颗粒计数的蛋白质定量方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4933844A (en) * 1988-09-26 1990-06-12 Otvos James D Measurement of blood lipoprotein constituents by analysis of data acquired from an NMR spectrometer
US5076097A (en) 1990-06-28 1991-12-31 Tsi Incorporated Method and apparatus for determining concentration of macromolecules and colloids in a liquid sample
WO1993003450A1 (en) 1991-07-30 1993-02-18 North Carolina State University Method and apparatus for measuring blood lipoprotein levels by nmr spectroscopy
US5247842A (en) 1991-09-30 1993-09-28 Tsi Incorporated Electrospray apparatus for producing uniform submicrometer droplets
FR2684998B1 (fr) * 1991-12-11 1994-10-28 Sebia Sa Procede de separation de la lp(a) par electrophorese, gels pour la mise en óoeuvre de ce procede, et application a la determination in vitro du risque atherogene lie a la presence de la lp(a).
JP3356556B2 (ja) 1993-10-22 2002-12-16 第一化学薬品株式会社 変性リポプロテイン類の測定法
US5856196A (en) 1993-10-25 1999-01-05 Beth Israel Hospital Processes for quantitating phosphoglycerides in a lipid mixture and diagnostic uses therefor
US5925229A (en) 1996-05-03 1999-07-20 The Regents Of The University Of California Low density lipoprotein fraction assay for cardiac disease risk
US5788166A (en) 1996-08-27 1998-08-04 Cornell Research Foundation, Inc. Electrospray ionization source and method of using the same
US6051189A (en) 1997-10-01 2000-04-18 The United States Of America As Represented By The Secretary Of The Army System and method for detection, identification and monitoring of submicron-sized particles
US5992244A (en) * 1998-03-04 1999-11-30 Regents Of The University Of Minnesota Charged particle neutralizing apparatus and method of neutralizing charged particles
AU1704200A (en) * 1998-09-23 2000-04-10 Wisconsin Alumni Research Foundation Charge reduction in electrospray mass spectrometry
US6267579B1 (en) * 1998-12-23 2001-07-31 Clinical Laboratory Development Group, Inc. Apparatus for making a gradient gel
JP4058828B2 (ja) * 1999-01-26 2008-03-12 東ソー株式会社 リポ蛋白質の分析装置
AU2054000A (en) 1999-02-26 2000-09-14 Lipomed, Inc. Methods, systems, and computer program products for analyzing and presenting risk assessment results based on nmr lipoprotein analysis of blood
JP4588835B2 (ja) * 1999-04-14 2010-12-01 株式会社ヘレナ研究所 リポ蛋白分離分析法、リポ蛋白分離分析装置、およびリポ蛋白分離分析システム
ES2256000T3 (es) * 1999-04-22 2006-07-16 Liposcience, Inc. Procedimiento de rmn para determinar el riesgo de desarrollar diabetes tipo 2.
US6491872B1 (en) 1999-09-17 2002-12-10 The United States Of America As Represented By The Secretary Of The Army Method and system for detecting and recording submicron sized particles
US6485686B1 (en) * 1999-09-17 2002-11-26 The United States Of America As Represented By The Secretary Of The Army Method and apparatus for counting submicron sized particles

Also Published As

Publication number Publication date
AU2002352712A2 (en) 2003-05-26
US20110089037A1 (en) 2011-04-21
EP1444526A4 (de) 2007-08-22
US20070287187A1 (en) 2007-12-13
AU2009200225A1 (en) 2009-02-12
US7259018B2 (en) 2007-08-21
CA2467420A1 (en) 2003-05-22
WO2003042704A1 (en) 2003-05-22
US20100213061A1 (en) 2010-08-26
JP2005509860A (ja) 2005-04-14
EP1444526A1 (de) 2004-08-11
AU2002352712B2 (en) 2008-10-30
US20030136680A1 (en) 2003-07-24
US7851224B2 (en) 2010-12-14
US7713744B2 (en) 2010-05-11
JP4705754B2 (ja) 2011-06-22
EP1444526B1 (de) 2011-09-21
US8097462B2 (en) 2012-01-17

Similar Documents

Publication Publication Date Title
EP1444526A4 (de) Ionenmobilitätsanalyse biologischer partikel
Qian et al. New method of lung cancer detection by saliva test using surface‐enhanced Raman spectroscopy
D'amico et al. Identification of melanoma with a gas sensor array
Cooper et al. Society of Hair Testing guidelines for drug testing in hair
WO2005012553A3 (en) Optical in vivo probe of analyte concentration within the sterile matrix under the human nail
CN103940924B (zh) 呼气中的胃癌气体标志物在制备胃癌诊断试剂中的用途
Lima‐Oliveira et al. Transillumination: a new tool to eliminate the impact of venous stasis during the procedure for the collection of diagnostic blood specimens for routine haematological testing
Zhang et al. Identifying robust and reliable volatile organic compounds in human sebum for biomarker discovery
Wolfgang et al. Detection of axillary perspiration metabolites using ion mobility spectrometry coupled to rapid gas chromatography
WO2023164672A3 (en) Sample preparation for glycoproteomic analysis that includes diagnosis of disease
Badjagbo Exhaled breath analysis for early cancer detection: principle and progress in direct mass spectrometry techniques.
Seredin et al. Comparative analysis of dentine and gingival fluid molecular composition and protein conformations during development of dentine caries: A pilot study
JP4452783B2 (ja) 呼気分析装置を用いた肝硬変検査方法及び装置
CN108489925A (zh) 一种用呼吸检测胃肠道恶性致病细菌的仪器
Alam et al. Characterization of pH variation in lysed blood by near-infrared spectroscopy
Yaghmaei et al. Developing" quality of life in infertile couples questionnaire" and measuring its psychometric properties
ATE237805T1 (de) Vorrichtung zur untersuchung von atemwegserkrankungen und diagnostische mittel
Wang et al. Development of electronic nose for diagnosis of lung cancer at early atage
Metz-Favre et al. Skin test diagnosis of grass pollen allergy with a recombinant hybrid molecule
Hervé et al. A device for volatile organic compound (VOC) analysis from skin using heated dynamic headspace sampling
CN212185543U (zh) 一种便携式医学检验箱
EP2771686A1 (de) Saugfähiges papier und seine verwendung zum nachweis von brustkrebs
Spiliopoulou et al. The role of the bone marrow microenvironment in physical function and quality of life in patients with multiple myeloma after first-line treatment with novel agents and autologous transplantation
JP2018508084A (ja) 逆指向分析(Reversed−directedanalysis)による証拠に基づく植物の有効成分の検出方法
RU2246898C2 (ru) Способ диагностики заболеваний предстательной железы

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties