ATE525655T1 - Nanostrukturen zur polarisierten abbildung und rezeptor-/liganden-quantifizierung: überschreitung der diffraktionsgrenze für abbildungen - Google Patents

Nanostrukturen zur polarisierten abbildung und rezeptor-/liganden-quantifizierung: überschreitung der diffraktionsgrenze für abbildungen

Info

Publication number
ATE525655T1
ATE525655T1 AT06851637T AT06851637T ATE525655T1 AT E525655 T1 ATE525655 T1 AT E525655T1 AT 06851637 T AT06851637 T AT 06851637T AT 06851637 T AT06851637 T AT 06851637T AT E525655 T1 ATE525655 T1 AT E525655T1
Authority
AT
Austria
Prior art keywords
imaging
nanostructures
receptor
exceeding
polarized
Prior art date
Application number
AT06851637T
Other languages
English (en)
Inventor
Chris D Geddes
Original Assignee
Univ Maryland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Maryland filed Critical Univ Maryland
Application granted granted Critical
Publication of ATE525655T1 publication Critical patent/ATE525655T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
AT06851637T 2005-08-02 2006-08-02 Nanostrukturen zur polarisierten abbildung und rezeptor-/liganden-quantifizierung: überschreitung der diffraktionsgrenze für abbildungen ATE525655T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70466005P 2005-08-02 2005-08-02
PCT/US2006/030268 WO2008048221A2 (en) 2005-08-02 2006-08-02 Nanostructures for polarized imaging and receptor/ligand quantization: breaking the diffraction limit for imaging

Publications (1)

Publication Number Publication Date
ATE525655T1 true ATE525655T1 (de) 2011-10-15

Family

ID=39314502

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06851637T ATE525655T1 (de) 2005-08-02 2006-08-02 Nanostrukturen zur polarisierten abbildung und rezeptor-/liganden-quantifizierung: überschreitung der diffraktionsgrenze für abbildungen

Country Status (5)

Country Link
US (1) US8987004B2 (de)
EP (1) EP1957987B1 (de)
AT (1) ATE525655T1 (de)
CA (1) CA2659640C (de)
WO (1) WO2008048221A2 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8101424B2 (en) * 2005-06-15 2012-01-24 University Of Maryland, Baltimore County Bioassays using plasmonic scattering from noble metal nanostructures
WO2012075220A2 (en) 2010-12-01 2012-06-07 University Of Maryland, Baltimore County Assays for pathogen detection using microwaves for lysing and accelerating metal-enhanced fluorescence
US9339485B2 (en) 2007-03-02 2016-05-17 University Of Maryland, Baltimore County Plasmonic engineering of singlet oxygen and/or superoxide generation
US9023372B2 (en) 2007-07-18 2015-05-05 University Of Maryland Metal-enhanced fluorescence nanoparticles
WO2009039466A1 (en) 2007-09-20 2009-03-26 Vanderbilt University Free solution measurement of molecular interactions by backscattering interferometry
US8120777B2 (en) 2007-12-10 2012-02-21 Molecular Sensing, Inc. Temperature-stable interferometer
US8822228B2 (en) * 2008-01-30 2014-09-02 University Of Maryland, Baltimore County Conversion of just-continuous metallic films to large particulate substrates for metal-enhanced fluorescence
WO2009134527A2 (en) 2008-03-03 2009-11-05 University Of Maryland Biotechnology Institute Voltage-gated metal-enhanced fluorescence, chemiluminescence or bioluminescence methods and systems
CN102308211B (zh) 2008-09-11 2014-07-09 马里兰大学,巴尔的摩县 基于超声辅助金属增强荧光(samef)的生物分析
CN102216757B (zh) 2008-09-17 2014-02-12 马里兰大学,巴尔的摩县 等离激元电学
US20100188665A1 (en) * 2009-01-12 2010-07-29 Molecular Sensing, Inc. Methods and systems for interferometric analysis
WO2010080710A2 (en) * 2009-01-12 2010-07-15 Molecular Sensing, Inc. Sample collection and measurement in a single container by back scattering interferometry
US10024850B2 (en) 2009-02-17 2018-07-17 University Of Maryland, Baltimore County Metal-enhanced bioluminescence: an approach for monitoring biological bioluminescent processes
WO2010096204A2 (en) 2009-02-23 2010-08-26 University Of Maryland Biotechnology Institute Directional surface plasmon coupled fluorescence and chemiluminescence from thin films of nickel, iron or palladium and uses thereof
US8450118B2 (en) * 2009-05-04 2013-05-28 Molecular Sensing, Inc. Method for detecting binding interactions between membrane proteins and analytes in a homogenous assay
EP2504687B1 (de) 2009-11-25 2017-04-05 University of Maryland, Baltimore County System zur detektion von metallverstärkter fluoreszenz aus metallischen nanoburger-strukturen
US9810637B2 (en) 2009-12-14 2017-11-07 University Of Maryland, Baltimore County Plasmonic electricity
WO2011084671A2 (en) 2009-12-17 2011-07-14 University Of Maryland, Baltimore County Mixed-metal substrates for metal-enhanced fluorescence
EP2569394B1 (de) 2010-05-11 2015-11-04 University of Maryland, Baltimore County Methode zur verbesserung der emissionen langlebiger lumineszierende verbindungen
US8962345B2 (en) * 2010-05-21 2015-02-24 The United States Of America As Represented By The Secretary Of Commerce Method of characterizing glycans attached to glycoproteins
WO2011156713A1 (en) 2010-06-11 2011-12-15 Vanderbilt University Multiplexed interferometric detection system and method
WO2012060882A2 (en) * 2010-11-02 2012-05-10 Molecular Sensing, Inc. Interferometric detection using nanoparticles
US9562853B2 (en) 2011-02-22 2017-02-07 Vanderbilt University Nonaqueous backscattering interferometric methods
US9829436B2 (en) 2011-03-18 2017-11-28 Chris Geddes Metal-enhanced photoluminescence from carbon nanodots
US8735175B2 (en) 2011-03-18 2014-05-27 Chris D. Geddes Multicolor microwave-accelerated metal-enhanced fluorescence (M-MAMEF)
GB2497317A (en) 2011-12-06 2013-06-12 Univ Dublin System and method for the detection of analytes using rod-shaped nanoparticles
US9244012B2 (en) 2011-09-26 2016-01-26 University Of Maryland, Baltimore County Enhanced luminescence from nanopolished surfaces and plate wells
US9273949B2 (en) 2012-05-11 2016-03-01 Vanderbilt University Backscattering interferometric methods
US9816990B2 (en) 2013-02-28 2017-11-14 University Of Maryland, Baltimore County Ultra-fast pathogen toxin detection assay based on microwave-accelerated metal-enhanced fluorescence
US10379050B2 (en) 2015-01-13 2019-08-13 University Of Maryland, Baltimore County Spectral shifts and modifications in metal-enhanced fluorescence, phosphorescence and alpha-fluorescence
WO2016118812A1 (en) 2015-01-23 2016-07-28 Vanderbilt University A robust interferometer and methods of using same
US10294451B2 (en) 2015-04-22 2019-05-21 University Of Maryland, Baltimore County Flow and static lysing systems and methods for ultra-rapid isolation and fragmentation of biological materials by microwave irradiation
US11561180B2 (en) 2015-07-22 2023-01-24 University Of Maryland, Baltimore County Hydrophilic coatings of plasmonic metals to enable low volume metal-enhanced fluorescence
EP3408649B1 (de) 2016-01-29 2023-06-14 Vanderbilt University Interferometrie mit antwortfunktion in freier lösung
US12055471B2 (en) 2019-08-30 2024-08-06 Centre National De La Recherche Scientifique Method and device for the optical characterization of particles

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4174952A (en) * 1978-01-23 1979-11-20 Massachusetts Institute Of Technology Immunoassay by light scattering intensity anisotropy measurements
NL7807532A (nl) * 1978-07-13 1980-01-15 Akzo Nv Metaal-immunotest.
US4444879A (en) * 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
US5017009A (en) 1986-06-26 1991-05-21 Ortho Diagnostic Systems, Inc. Scattered total internal reflectance immunoassay system
GB8807488D0 (en) 1988-03-29 1988-05-05 Ares Serono Res & Dev Ltd Method of assay
CA2076709A1 (en) 1992-08-24 1994-02-25 Ulrich J. Krull Amplified fluorescence emission for chemical transduction
AT403961B (de) 1995-03-17 1998-07-27 Avl Verbrennungskraft Messtech Optochemisches messsystem mit einem fluoreszenzsensor
IL126544A (en) 1996-04-25 2004-08-31 Genicon Sciences Inc Analyte assay using scattered-light detectable particles
WO1998037417A1 (en) * 1997-02-20 1998-08-27 The Regents Of The University Of California Plasmon resonant particles, methods and apparatus
US20010053521A1 (en) * 1999-09-27 2001-12-20 Kreimer David I. Amplification of analyte detection by substrates having particle structures with receptors
US7348182B2 (en) 2000-10-03 2008-03-25 Mirari Biosciences, Inc. Directed microwave chemistry
JP4833498B2 (ja) 2000-10-03 2011-12-07 ミラリ バイオサイエンシズ,インコーポレーテッド 指向性マイクロ波化学のための方法および組成物
US20040009540A1 (en) 2001-04-27 2004-01-15 Genoptix, Inc Detection and evaluation of cancer cells using optophoretic analysis
JP2005524084A (ja) 2002-04-30 2005-08-11 ユニバーシティ オブ メリーランド,ボルチモア 蛍光検出法
US7095502B2 (en) 2002-08-06 2006-08-22 Joseph Lakowicz Optical structures for metal-enhanced sensing
AU2003268537A1 (en) 2002-09-10 2004-04-30 University Of Maryland, Baltimore Use of metallic particles to improve fluorescence imaging
US7122384B2 (en) * 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
EP2248912B8 (de) 2002-11-26 2013-04-17 University of Maryland, Baltimore County Hochempfindliche Assays für die Pathogendetektion unter Verwendung der metallverstärkten Fluoreszenz
EP1671118B1 (de) 2003-09-17 2011-11-02 University of Maryland, Baltimore County Cyanid wahrnehmende verbindungen und verwendungen davon
US7846412B2 (en) * 2003-12-22 2010-12-07 Emory University Bioconjugated nanostructures, methods of fabrication thereof, and methods of use thereof
US7253452B2 (en) 2004-03-08 2007-08-07 Massachusetts Institute Of Technology Blue light emitting semiconductor nanocrystal materials
US20060148104A1 (en) * 2004-10-29 2006-07-06 Massachusetts Institute Of Technology Detection of ion channel or receptor activity
US8034633B2 (en) 2004-11-19 2011-10-11 University Of Maryland, Baltimore County Microwave accelerated assays
CA2635454C (en) 2005-01-03 2013-01-08 University Of Maryland Biotechnology Institute Microwave accelerated plasmonics
US8101424B2 (en) 2005-06-15 2012-01-24 University Of Maryland, Baltimore County Bioassays using plasmonic scattering from noble metal nanostructures
CA2656004A1 (en) 2005-06-17 2006-12-28 University Of Maryland Biotechnology Institute Metal-enhanced fluorescence-based sensing methods
WO2007095527A2 (en) 2006-02-13 2007-08-23 University Of Maryland Biotechnology Institute Metal-enhanced chemiluminescence (mec)
US8980179B2 (en) 2006-05-17 2015-03-17 University Of Maryland, Baltimore County Angular-dependent metal-enhanced fluorescence
US9023372B2 (en) 2007-07-18 2015-05-05 University Of Maryland Metal-enhanced fluorescence nanoparticles

Also Published As

Publication number Publication date
US8987004B2 (en) 2015-03-24
EP1957987B1 (de) 2011-09-21
US20090325199A1 (en) 2009-12-31
EP1957987A4 (de) 2009-08-26
WO2008048221A3 (en) 2008-12-11
CA2659640C (en) 2011-11-15
EP1957987A2 (de) 2008-08-20
CA2659640A1 (en) 2008-04-24
WO2008048221A2 (en) 2008-04-24

Similar Documents

Publication Publication Date Title
EP1957987A4 (de) Nanostrukturen zur polarisierten abbildung und rezeptor-/liganden-quantifizierung: überschreitung der diffraktionsgrenze für abbildungen
Li et al. A gold nanoparticle-based lateral flow immunosensor for ultrasensitive detection of tetrodotoxin
WO2007053201A3 (en) Bioassays using plasmonic scattering from noble metal nanostructures
TW200745554A (en) Diagnostic methods using magnetic nanoparticles
WO2010046443A3 (en) Methods for detection and diagnosis of a bone or cartilage disorder
ATE556030T1 (de) Ultrasensitiver nachweis von analyten
MX2009005963A (es) Anticuerpos humanos contra el ligando 4 de tipo delta humano.
MEP11109A (en) High affinity human antibodies to human il-4 receptor
DE602005013225D1 (de) Aptamer-nanopartikelkonjugate und verwendungsverfahren zur detektion von zielanalyten
WO2005098446A3 (en) Biomarkers for ovarian cancer
WO2008106648A3 (en) Immunoassays exhibiting a reduction in prozone phenomena
MX2009013009A (es) Inmunoensayos de alta sensibilidad y kits para la determinacion de peptidos y proteinas de interes biologico.
DE602007010032D1 (de) Immunoassay mit mehreren analyten
JP2015230280A5 (de)
EP2641093A4 (de) Glycopeptid-funktionalisierte nanopartikel-arrays zur erfassung und erkennung von biomolekülen
WO2009055382A8 (en) One-step immunoassays exhibiting increased sensitivity and specificity
CA2701341A1 (en) Method of assessing colorectal cancer from a stool sample by use of the marker combination calprotectin and hemoglobin/haptoglobin complex
WO2007078635A3 (en) Method to detect small molecules binding to proteins using surface enhanced raman scattering (sers)
WO2009078465A1 (ja) エンドトキシンの測定方法及びエンドトキシンの測定用試薬キット
Wang et al. Sensitive detection of platelet-derived growth factor through surface-enhanced Raman scattering
ATE354635T1 (de) Substrat und verfahren zum messen elektrophysiologischer eigenschaften von zellmembranen
MX2010004335A (es) Metodo y sistema para la deteccion de un tipo seleccionado de moleculas en una muestra.
Lee-Montiel et al. Engineering quantum dot calibration standards for quantitative fluorescent profiling
DE602005014386D1 (de) Verwendung von cyfra 21-1 und osteopontin als marker für kolorektalkarzinome
ATE468535T1 (de) Verwendung von nnmt als marker für lungenkrebs

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties