ATE526032T1 - Stabilisierte flüssige interferon-formulierungen - Google Patents

Stabilisierte flüssige interferon-formulierungen

Info

Publication number: ATE526032T1
Authority: AT; Austria
Prior art keywords: interferon; formulations; stabilized liquid; cyclodextrin; room temperature
Prior art date: 2003-12-11

Application number

AT04820468T

Other languages

English (en)

Inventor

Curto Maria Del

Original Assignee

Ares Trading Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-11

Filing date

2004-12-10

Publication date

2011-10-15

2004-12-10 Application filed by Ares Trading Sa filed Critical Ares Trading Sa

2011-10-15 Application granted granted Critical

2011-10-15 Publication of ATE526032T1 publication Critical patent/ATE526032T1/de

Links

239000000203 mixture Substances 0.000 title abstract 5
108010050904 Interferons Proteins 0.000 title abstract 4
102000014150 Interferons Human genes 0.000 title abstract 4
229940079322 interferon Drugs 0.000 title abstract 4
239000007788 liquid Substances 0.000 title abstract 2
238000009472 formulation Methods 0.000 abstract 4
229920000858 Cyclodextrin Polymers 0.000 abstract 3
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 2
108010005716 Interferon beta-1a Proteins 0.000 abstract 1
102000001708 Protein Isoforms Human genes 0.000 abstract 1
108010029485 Protein Isoforms Proteins 0.000 abstract 1
230000002411 adverse Effects 0.000 abstract 1
239000003963 antioxidant agent Substances 0.000 abstract 1
230000003078 antioxidant effect Effects 0.000 abstract 1
235000006708 antioxidants Nutrition 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000007857 degradation product Substances 0.000 abstract 1
230000005847 immunogenicity Effects 0.000 abstract 1
229960004461 interferon beta-1a Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/215—IFN-beta
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Inorganic Chemistry (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Oncology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

AT04820468T 2003-12-11 2004-12-10 Stabilisierte flüssige interferon-formulierungen ATE526032T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP03104646		2003-12-11
EP04103349		2004-07-13
PCT/EP2004/053407 WO2005058346A1 (en)	2003-12-11	2004-12-10	Stabilized interferon liquid formulations

Publications (1)

Publication Number	Publication Date
ATE526032T1 true ATE526032T1 (de)	2011-10-15

Family

ID=34702349

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04820468T ATE526032T1 (de)	2003-12-11	2004-12-10	Stabilisierte flüssige interferon-formulierungen

Country Status (18)

Country	Link
US (1)	US7846427B2 (de)
EP (1)	EP1691825B1 (de)
JP (1)	JP4658961B2 (de)
AT (1)	ATE526032T1 (de)
AU (1)	AU2004298781B2 (de)
BR (1)	BRPI0416980A (de)
CA (1)	CA2547822A1 (de)
CY (1)	CY1112193T1 (de)
DK (1)	DK1691825T3 (de)
ES (1)	ES2374530T3 (de)
HR (1)	HRP20110699T1 (de)
IL (1)	IL176021A0 (de)
NO (1)	NO20063108L (de)
PL (1)	PL1691825T3 (de)
PT (1)	PT1691825E (de)
RS (1)	RS52218B (de)
SI (1)	SI1691825T1 (de)
WO (1)	WO2005058346A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI272948B (en) *	2003-05-01	2007-02-11	Ares Trading Sa	HSA-free stabilized interferon liquid formulations
ZA200609412B (en) *	2004-05-17	2008-07-30	Ares Trading Sa	Hydrogel interferon formulations
WO2007130453A2 (en)	2006-05-02	2007-11-15	Allozyne, Inc.	Non-natural amino acid substituted polypeptides
EP2076533B1 (de)	2007-05-02	2014-10-08	Ambrx, Inc.	Modifizierte interferon-beta-polypeptide und ihre verwendungen
WO2009002521A2 (en)	2007-06-25	2008-12-31	Amgen Inc.	Compositions of specific binding agents to hepatocyte growth factor
CA2707840A1 (en)	2007-08-20	2009-02-26	Allozyne, Inc.	Amino acid substituted molecules
ES2387236T3 (es) *	2007-12-20	2012-09-18	Merck Serono S.A.	Formulaciones de interferón beta pegilado
US20100203014A1 (en) *	2009-02-04	2010-08-12	Aegis Therapeutics Llc	Zwitterionic buffered acidic peptide and protein formulations
KR20150074167A (ko) *	2012-10-26	2015-07-01	루핀 리미티드	Ｐｅｇ 인터페론 알파-2ｂ의 안정한 약학 조성물
GB201604124D0 (en) *	2016-03-10	2016-04-27	Ucb Biopharma Sprl	Pharmaceutical formulation
AU2018341136A1 (en)	2017-09-27	2020-03-12	Novartis Ag	Parenteral formulation comprising siponimod
CN111494611A (zh) *	2020-06-08	2020-08-07	长春生物制品研究所有限责任公司	一种卡式瓶多剂量笔式注射组合包装的干扰素注射液
CN113797317B (zh) *	2021-10-26	2024-01-09	科兴生物制药股份有限公司	一种组合物及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5997856A (en) *	1988-10-05	1999-12-07	Chiron Corporation	Method and compositions for solubilization and stabilization of polypeptides, especially proteins
US6582728B1 (en)	1992-07-08	2003-06-24	Inhale Therapeutic Systems, Inc.	Spray drying of macromolecules to produce inhaleable dry powders
US5814485A (en) *	1995-06-06	1998-09-29	Chiron Corporation	Production of interferon-β (IFN-β) in E. coli
ZA9610374B (en) *	1995-12-11	1997-06-23	Elan Med Tech	Cartridge-based drug delivery device
JP2001526033A (ja) *	1997-12-08	2001-12-18	ジェネンテク・インコーポレイテッド	ヒトインターフェロン−イプシロンというｉ型インターフェロン
US6887462B2 (en) *	2001-04-09	2005-05-03	Chiron Corporation	HSA-free formulations of interferon-beta
JP2004522803A (ja) *	2001-06-29	2004-07-29	マキシゲン・エイピーエス	インターフェロン製剤
TWI272948B (en)	2003-05-01	2007-02-11	Ares Trading Sa	HSA-free stabilized interferon liquid formulations
ZA200609412B (en)	2004-05-17	2008-07-30	Ares Trading Sa	Hydrogel interferon formulations
EP1750751B1 (de)	2004-06-01	2013-04-10	Ares Trading S.A.	Stabilisierte flüssige interferon-formulierungen

2004
- 2004-12-10 US US10/582,027 patent/US7846427B2/en active Active
- 2004-12-10 BR BRPI0416980-8A patent/BRPI0416980A/pt not_active IP Right Cessation
- 2004-12-10 SI SI200431761T patent/SI1691825T1/sl unknown
- 2004-12-10 PL PL04820468T patent/PL1691825T3/pl unknown
- 2004-12-10 ES ES04820468T patent/ES2374530T3/es not_active Expired - Lifetime
- 2004-12-10 EP EP04820468A patent/EP1691825B1/de not_active Expired - Lifetime
- 2004-12-10 PT PT04820468T patent/PT1691825E/pt unknown
- 2004-12-10 AT AT04820468T patent/ATE526032T1/de active
- 2004-12-10 JP JP2006543556A patent/JP4658961B2/ja not_active Expired - Lifetime
- 2004-12-10 CA CA002547822A patent/CA2547822A1/en not_active Withdrawn
- 2004-12-10 WO PCT/EP2004/053407 patent/WO2005058346A1/en not_active Ceased
- 2004-12-10 HR HR20110699T patent/HRP20110699T1/hr unknown
- 2004-12-10 AU AU2004298781A patent/AU2004298781B2/en not_active Expired
- 2004-12-10 DK DK04820468.9T patent/DK1691825T3/da active
- 2004-12-10 RS RS20110581A patent/RS52218B/sr unknown
2006
- 2006-05-30 IL IL176021A patent/IL176021A0/en active IP Right Grant
- 2006-07-04 NO NO20063108A patent/NO20063108L/no not_active Application Discontinuation
2011
- 2011-12-06 CY CY20111101217T patent/CY1112193T1/el unknown

Also Published As

Publication number	Publication date
PT1691825E (pt)	2011-10-12
EP1691825A1 (de)	2006-08-23
HRP20110699T1 (hr)	2011-10-31
AU2004298781A1 (en)	2005-06-30
JP4658961B2 (ja)	2011-03-23
US20070104682A1 (en)	2007-05-10
AU2004298781B2 (en)	2010-04-01
US7846427B2 (en)	2010-12-07
ES2374530T3 (es)	2012-02-17
CA2547822A1 (en)	2005-06-30
RS52218B (sr)	2012-10-31
EP1691825B1 (de)	2011-09-28
BRPI0416980A (pt)	2007-02-21
IL176021A0 (en)	2006-10-05
PL1691825T3 (pl)	2012-02-29
SI1691825T1 (sl)	2011-12-30
NO20063108L (no)	2006-07-04
DK1691825T3 (da)	2011-12-05
WO2005058346A1 (en)	2005-06-30
JP2007513925A (ja)	2007-05-31
CY1112193T1 (el)	2015-12-09

Legal Events

Date

Code

Title

Description

2012-05-15

UEP

Publication of translation of european patent specification

Ref document number: 1691825

Country of ref document: EP

Publication	Publication Date	Title
CY1112193T1 (el)	2015-12-09	Σταθεροποιημενα υγρα σκευασματα ιντερφερονης
DE502004012418D1 (de)	2011-06-01	Formulierung für proteinarzneimittel ohne zusatz von humanem serumalbumin (hsa)
KR970706017A (ko)	1997-11-03	안정한 알파 인터페론 수용액 제형(Stable, aqueous alfainterfer on solution for mulations)
BRPI0410488B8 (pt)	2021-09-08	Composição farmacêutica líquida estabilizada e livre de hsa, método para preparação de composição farmacêutica líquida estabilizada e livre de hsa, e recipiente vedado hermeticamente
NO953278L (no)	1995-10-13	Fremgangsmåter for in vivo-levering av biologisk aktive stoffer og sammensetninger som er nyttige for dette
FI971776A0 (fi)	1997-04-25	Yhdisteet ja koostumukset aktiivisten aineiden antamiseksi
CA2304808A1 (en)	1999-04-01	Liquid interferon-.beta. formulations
UY25055A1 (es)	2000-12-29	Formulaciones farmacéuticas que contienen voriconazol
DK1372608T3 (da)	2007-12-27	Medicinske aerosolformuleringer
DK0722313T3 (da)	1999-11-15	Viskoelastiske sammensætninger af fluorerede organiske forbindelser
ES2418833T3 (es)	2013-08-16	Formulaciones líquidas de interferón estabilizadas
ATE275974T1 (de)	2004-10-15	Zusammensetzungen enthaltend glykolderivate, alkohole und vitamin d
AR017066A1 (es)	2001-08-22	Cristales de glicoproteina, de enlazamiento cruzado con carbohidrato
JP4871720B2 (ja)	2012-02-08	血清アルブミンを含まない、安定なヒトエリスロポエチン水溶液
KR101699677B1 (ko)	2017-01-24	고나도트로핀을 위한 제제
JP2010120966A (ja)	2010-06-03	安定化されたタンパク組成物
CN101657187B (zh)	2012-07-18	稳定的水性g-csf制剂
CO4830457A1 (es)	1999-08-30	Preparados efervescentes
DE60134883D1 (de)	2008-08-28	Interferon- und interleukin-derivate mit langzeitwirkung und diese enthaltende pharmazeutische zusammensetzungen
RU2238758C2 (ru)	2004-10-27	Водный раствор интерферона-альфа-два человека для инъекций
JP2008050320A (ja)	2008-03-06	インターフェロン−β含有医薬組成物
ATE223700T1 (de)	2002-09-15	Ramoplaninhaltige neue injizierbare arzneizubereitungen
CY1114273T1 (el)	2016-10-05	Σταθεροποιημενα υγρα σκευασματα ιντερφερονης χωρις ανθρωπινη οροαλβουμινη